Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	K219E
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	31
Patients	77
Isolates	95

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP26	JIDP26W88	AF021308	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M, K219E		T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245M	B
	JIDP25	JIDP25W104	AF021296	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E		V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K	B
Ruiz (1996)	JCS-C31	C31B	Z99324	AZT, DDI	None	D67IN, T215TS, K219E		K70*, K122E, K166R, D177N, T200A	B
		C31W24	Z99325	AZT, DDI, 3TC	None	M41L, D67N, K70R, M184V, T215Y, K219E		T69S, K122E, K166R, D177N, T200A	B
Hammer (1997)	ACTG320_361	361		DDC, AZT	None	D67NT, K70R, T215F, K219E		E6D, T39TP, T69N, K102Q, S162C, I202V, L210F, R211K, L228H, K277R, T286A, P294T, E297K, Y342F, M357I, R358K, A376V, K390R, A400T, T403TM, N447S, L452I, T470A, H483C	B
Nijhuis (1997)	PT-C0034	C0034W94		3TC, AZT	None	M41L, D67N, K70R, M184V, T215F, K219E		K20R, T69N, I135T, R211K, E248D	B
		C0034W142		3TC, AZT	None	M41L, D67T, K70R, M184V, T215F, K219E		K20R, T69N, I135T, R211K, E248D	B
Cabana (1999)	Cab-f	F22	AF102347	AZT, DDI, 3TC, D4T	None	M41L, D67N, M184V, T215Y, K219E		K122E, R211K	B
Lawrence (1999)	JL-Pt6	JL-6-pre		AZT, 3TC	None	M41L, D67N, K70R, M184V, T215Y, K219E		K122KE, D123E, I135V, I178M, V245E	B
		JL-6-post		AZT, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E		K122E, D123E, I135V, I178M, V245E, T286A	B
Zolopa (1999)	CA622	CA3188	AF088125	AZT, DDC, DDI, 3TC, D4T	None	M41L, D67N, K70R, V75VA, L210W, T215Y, K219E		V35I, E44D, V118I, K122E, I202V, H208Y, R211K, L228H, I257L, I293V, E297K	B
	CA1170	CA2657	AF088118	AZT, DDI, 3TC, D4T, DDC	None	D67N, K70R, M184V, T215V, K219E		T69N, I135T, T200A, Q207E	B
Albrecht (2000)	ACTG303_1349	1349RT_bl		AZT, DDI	None	M41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245M	B
		1349RT_f1		AZT, DDI, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293V	B
	ACTG303_782	782RT_bl		AZT, DDI	None	M41L, D67N, K70R, T215Y, K219E		V60I, D123E, S162Y, V179I, I195L, R211K, L228H, K277KR, K281R, T286A, I293IV, E297K, E302X	B
		782RT_f1		AZT, DDI, 3TC	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219E		V60I, D123E, S162Y, V179I, I195L, R211K, L228H, K281R, T286A, E297K, A304G, L325X	B
Bacheler (2000)	LB3-P35	P35-0		NRTI	None	K219E		V35L, S48T, K49R, T107A, K122E, D123N, S162C, Q174E, T200A, R211G	B
Balotta (2000)	CB-208	CB-208	AF252057	AZT, D4T, 3TC, DDI	None	M41L, D67N, M184V, T215Y, K219E		V35M, T39A, R83K, S162C, G196E, T200A, R211G	B
	CB-218	CB-218	AF252072	D4T, 3TC, DDC, AZT, DDI	None	M41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E		V35T, V60I, V118I, K122E, Y146X, N147X, D177E, G196E, I202V, E203K, Q207E, R211K, D218E	B
Baxter (2000)	GART-NG45	GART-45		NRTI, AZT, 3TC	None	D67G, K70R, M184V, T215F, K219E	V179E	K20R, S68G, K122R, D123E, I135T, D177E, Q207E, R211K	B
	GART-NG77	GART-77		NRTI, AZT, 3TC	None	M41L, D67N, K70R, L210W, T215Y, K219E		K22R, V106I, K122E, I135V, S162Y, H208Y, R211K, L228R, V245EK	B
	GART-NG79	GART-79		NRTI, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E		K43Q, K104N, K122E, K126N, T200A, K238R, V245E, E248D	B
	GART-G87	GART-87		NRTI, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234X	B
	GART-NG146	GART-146		NRTI, AZT, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219E		K122E, V245VM	B
	GART-G153	GART-153		NRTI, 3TC, D4T	None	D67N, K70R, M184V, T215Y, K219E			B
Shulman (2000)	CA622	CA1185	AY802611	AZT, DDC, DDI, 3TC, D4T	None	M41L, D67N, K70R, V75A, L210W, T215Y, K219E		V35I, E44D, L109I, V118I, K122E, M164X, I202V, H208Y, R211K, L228H	B
Albrecht (2001)	ACTG364_1242	1242		AZT, DDC, 3TC	None	D67G, K70R, M184V, T215Y, K219E		V35T, S68G, K166KR, Q207E, A272P, V276X, Q278A	B
	ACTG364_5555	5555		DDC, AZT, 3TC	None	D67N, K70R, M184V, K219E		K20KR, K64R, S162C, Q207H, R211K, L228R, V245M, K277R, A288S, I293V	B
Eshleman (2001)	A119	AF357718	AF357718	AZT, DDI	None	D67AT, K70R, T215F, K219E	V108VI	T69N, D123E, D177E, I178V, I195IT, I202V, Q207E, R211K, V241I, A272S, K277KR, K281R, T286A, I293IV, E297K	B
	A129	AF357728	AF357728	AZT, DDI	None	D67N, K70R, T215I, K219E		D121Y, K122E, T200A, V245M, D250E, A272P, K281R	B
Gonzales (2001)	CA1115	CA2515	AY030433	D4T, AZT, 3TC	None	M41L, D67N, K70R, M184V, T215Y, K219E		R83X, D123E, V245K	B
	CA1322	CA3318	AY030522	AZT, NRTI, 3TC, D4T	None	D67DN, K70R, M184V, T215I, K219E		T39A, K122E, I142V, T165I, G196E, R211K, V261VI, Q278X, A288S	B
	CA1432	CA3830	AY030571	AZT, 3TC, D4T, DDI	None	M41L, D67NT, K70R, M184V, L210W, T215Y, K219E		K20R, I31IL, V35I, T39A, V60I, K64KR, K122E, S134SR, I135T, Q174K, Q207E, R211K, L228H	B
	CA1445	CA3859	AY030583	D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		K11KR, K43Q, V60I, V118I, I135V, K166R, R211K, L234LR, V245T	B
	CA1819	CA4881	AY030733	DDC, AZT, 3TC	None	M41L, D67N, K70R, M184V, T215Y, K219E		V245K	B
	CA2080	CA7700	AY030788	AZT, 3TC, DDI	None	M184V, K219E		V35I, A98S, T200A, K277R, I293V, T296S, E297K	B
	CA4571	CA11197	AY031368	AZT, 3TC, DDI, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E		V35I, D123E, I135T, I178L, R211K, V245E, I293V	B
	CA4584	CA11212	AY031381	DDC, AZT, D4T, 3TC	None	M41L, D67S, K70R, M184V, L210W, T215Y, K219E		T39A, T69N, V106I, K122E, I178IM, E203D, H208Y, Q278H, A304G	B
	CA5047	CA12324	AY031617	AZT, 3TC, D4T	None	M41L, D67N, K70R, Q151M, M184V, T215F, K219E		V35I, T39A, R83K, K104R, G112A, T200I, I202IT, H208Y, R211K, L228H	B
	CA5235	CA12827	AY031792	D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		E44D, V60I, V118I, I135M, S162Y, G196E, Q207D, R211K, V245E, A272P	B
	CA5758	CA14191	AY032148	D4T, DDI	None	M41L, D67N, K70R, T215Y, K219E		K11KR, K20KR, E44D, V118VI, Q174QE, K201K*, Q207E, K220KN, L228H, S251SR, N265NS, Q278QE	B
	CA5990	CA14766	AY032236	AZT, 3TC, D4T	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219E		K20R, V35K, T39A, T69TN, W88C, A98AS, K122E, D123E, N136NS, K154KE, S163SR, G196E, T200A, E203K, R211*K, F214L	B
	CA6324	CA15795	AY032284	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E	K101E	V60I, I135T, S162C, I178M, R211K, L228H, A272P, K281R, A288S, I293V, E297A	B
	CA6403	CA15904	AY032358	AZT, 3TC, D4T	None	D67N, K70R, M184V, T215SY, K219E		M41X, K122E, D123N, I135T, N175H, I178M, Q197E, I202V, V245M, A272P, K277GR, A288S, I293V, E297A	B
Masquelier (2001)	BM-50	BM-50	AF315273	NRTI, AZT, 3TC	None	M41L, D67~, T69G, K70R, M184V, T215Y, K219E		V35I, E36K, K122E, D123N, I135T, A158S, G196E, E203K, R211G	B
	BM-51	BM-51	AF315274	NRTI, D4T, DDI	None	D67~, T69G, K70R, T215F, K219E		L109LV, G196R, T200A, I202T, R211K, L228H	B
	BM-52	BM-52	AF311157	NRTI, D4T, 3TC	None	D67~, T69G, M184V, T215L, K219E		R83K, I135T, S162C, T200I	B
Brindeiro (2002)	TVSP15	TVSP15	AY145821	AZT, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215F, K219E		I135T, R211K, A272P, K281R, I293V, E297K	B
	TVGG1	TVGG1	AY145782	AZT, DDI, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219E	A98G	K20R, K32R, S162C, G196E, I293V, E297K	B
	TVGG4	TVGG4	AY145784	AZT, 3TC, D4T	None	D67N, K70R, M184V, K219E		I5V, K64R, D177G, R211K, K277R, P294S	B
	TVGG8	TVGG8	AY145786	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297A	B
Naugler (2002)	WES-25	HIV25ES	AF422747	AZT, DDI	None	D67N, K70R, T215Y, K219E		T69N, I135V, S162C, R211K	B
Gonzales (2003)	CA5235	CA16875	AF514224	D4T, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		E44D, V60I, V118I, K122KE, I135M, S162Y, G196E, Q207D, R211K, T240TA, V245E, N265NS, A272P, V276VG	B
Dumans (2004)	256	256	AY390167	AZT, DDI	None	D67N, K70R, L210W, T215Y, K219E		K122E, D123N, T139V, Q174R	B
	265	265	AY390090	AZT, DDI, 3TC	None	D67N, K70R, M184V, T215F, K219E		D123E, A158S, K173Q, Q174R, F214L	B
	267	267	AY390113	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E		S68G, I135T, E169K, K173E, T200I, H208X, R211K	B
	208	208	AY390155	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		S68G, D177E	B
Gulick (2004)	RG252	RG252w74		ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E		T39N, E40K, K64N, K102R, T139TR, I142IT, T200A, R211G, F214L	B
		RG252w121		ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E	Y188YD	E6EG, K11KN, V35T, T39N, E40K, K64N, K102R, S134SR, T139R, I142T, S163ST, K166KE, E169EQ, T200A, E203K, R211G, F214L	B
Machado (2004)	cs120	cs120	AY313373	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		E44D, E194K, G196E, T200A, H208Y, R211K	B
	cs124	cs124	AY313374	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		V118I, D123E, I135T, A158S, D177E, R211K	B
	con61	con61	AY313447	AZT, DDI	None	K219E		I135T, D177E, I178M, R211K	B
	con32	con32	AY313408	AZT, DDI, 3TC, D4T	None	M41L, M184V, L210W, T215Y, K219E		K122E, I135V	B
Montes (2004)	MB_patTICHET P	00_TIC715	AJ578168	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E		K49R, S68G, S162D, E169D, D177E, T240A	B
Garcia-Bujalance (2005)	GBS_26	GBS_26	AY872361	D4T, 3TC	None	D67G, K70R, M184V, K219E		S68G, T69N, T84P, D113H, D123DE, I135T, S162C, Q174QR, G196E, R211K	B
Mo (2005)	9053	9053_d1		NRTI	None	D67HN, K70KR, M184V, T215FV, K219E		K20KR, T69TN, W88C, V118VI, A158S, S162D, K166R, E169D, R211K, F214L, V245M, E297K	B
Non-B Workgroup (2005)	TH_146	TH_146	AY605559	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E	Y188YD	E28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245R	B
	TH_228	TH_228	AY605634	AZT, DDI	None	M41L, D67N, K70R, L210W, T215Y, K219E		V35T, D121H, K122E, I142L, I178M, T200V	B
Rhee (2005)	CA622	CA3190	AY802722	AZT, DDC, DDI, 3TC, D4T	None	M41L, D67NT, K70R, V75VA, M184MV, L210W, T215Y, K219E		M16ML, V35I, E44D, A62AP, K64KR, N81NT, V90VA, L109LI, V118I, K122E, V179VI, I202V, H208Y, R211K, L228H, I257L	B
	CA1170	CA11998	AY800798	AZT, DDI, 3TC, D4T, DDC	None	D67N, K70R, M184V, T215V, K219E		T69N, I135T, T200A, Q207E, E297K	B
	CA4756	CA34766	AY801390	AZT, 3TC, ABC	None	D67N, K70R, M184V, T215F, K219E		V60I, I135L, F214L, E248D, A288AT, I293V	B
	CA5433	CA34379	AY801578	D4T, 3TC	None	V75T, Q151M, M184V, K219E		I5IV, K11KR, K20KR, A33V, S68G, V111I, I142V, S162Y, E203D, R211RK, F214L, V245E, D250DE, V292I, I293V	B
	CA5551	CA37828	AY801595	AZT, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219E		E28A, K32Q, V35I, D123E, I135T, I142V, I167IV, D177E, V179I, T200IM, I202V, H208HY, R211K, L228H, K277R, T286A, A288T, I293IV, E297A	B
	CA5990	CA38037	AY801625	AZT, 3TC, D4T, ABC	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219E		K20R, V35K, T39A, K49KQ, T69N, W88C, A98S, K122E, D123E, I135IT, V179I, G196E, T200A, E203K, Q207E, R211RK, F214L, L228H, V245M, A272S, K277R, A288S, E297K	B
	CA6324	CA16906	AY801634	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E	K101E	V60I, I135T, S162C, I178M, V179VI, R211K, L228H, A272P, K281R, A288S, L289LR, I293V, E297A	B
		CA34924	AY801635	AZT, DDI, 3TC, D4T	None	M41L, D67N, K70R, M184V, T215Y, K219E	K101EQ	V60I, S68SG, I135T, S162C, I178IM, V179VI, R211K, L228H, A272P, K281R, A288S, I293V, E297A	B
	CA7062	CA42582	AY801745	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E, N348I		V21I, A98S, R211K, V245E, A272P, K281R, E291D, I293V, E297N, N306D, Q334E, G335S, I341F, G359S, K366R, T369A, A371V, A376N, T377L, K390R, A400T, V435A, S468P, A554N	B
	CA9749	CA23924	AY802098	3TC, D4T	None	D67N, M184MV, T215S, K219E		K20R, S68X, D123N, I135T, I142T, S162A, V179VI, R211G, K277R, R284K, I293V, E297K	B
	CA9807	CA24090	AY802127	AZT, 3TC, ABC	None	D67N, K70R, M184V, T215FY, K219E		K102Q, K122E, I135V, S162C, E204D, K277R, E297K	B
		CA34551	AY802128	AZT, 3TC, ABC	None	M41ML, D67N, K70R, M184V, T215FY, K219E		T7TA, K102Q, K122E, I135V, S162C, K277R, R284RK, E297K	B
	CA9977	CA24736	AY802224	AZT, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		V21I, V35I, T39TA, E44D, S68G, R83K, A98S, K122E, D218E, I293V, E297K	B
	CA9986	CA24776	AY802225	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		S68G, D123E, S162C, D177E, I178L, G196K, R211G, V245E, A272P, K277R, E297A	B
		CA24778	AY802226	AZT, DDI, 3TC	None	M41L, D67N, M184V, L210W, T215Y, K219E		S3SR, S68G, D123E, S162C, D177E, I178L, G196K, R211G, V245E, A272P, K277R, E297A	B
	CA14196	CA34323	AY802263	AZT, 3TC, ABC	None	D67DN, K70KR, M184V, T215FS, K219E		V35I, T39S, R83K, D121HY, K122E, I135T, G196E, F214FL, A272P, K275R, R284RK, T286A, I293V, P294T	B
		CA35216	AY802264	AZT, 3TC, ABC	None	M41L, D67N, K70R, M184V, T215F, K219E		V35I, T39S, V60VI, R83RK, D121Y, K122E, I135T, G196E, F214L, A272P, K275R, R284K, T286A, I293V, P294T	B
	CA14385	CA34645	AY802329	AZT, 3TC, ABC	None	M41L, D67T, K70R, L74LI, M184V, L210LW, T215F, K219E		V35M, K43X, T69N, I135IT, I167IV, G196E, I202IT, E203ED, K277R, R284K, I293V	B
	CA14500	CA34831	AY802360	D4T, 3TC	None	D67N, K70R, M184V, K219E		T39TA, V60I, A158S, T200TA, R211RK, F214L, R284RK, T286TA	B
		CA38261	AY802361	D4T, 3TC	None	D67N, K70R, M184V, K219E		T39TA, V60I, A158S, T200TA, R211K, F214L, R284K	B
		CA38263	AY802362	D4T, 3TC	None	D67N, K70R, M184V, K219E		T39TA, V60I, A158S, T200TA, R211K, F214L, L228LH, R284K	B
	CA16488	CA39164	AY802519	ABC, AZT, 3TC	None	M41L, D67N, K70R, M184V, T215F, K219E	A98G	I135T, V245K	B
Lama (2006)	Pt3150	3150		NRTI	None	M41L, D67N, K70R, M184V, T215F, K219E		K122E, I135T, V245M, A272P, K277R, R284K, A288P, K311KR, I326V	B
Rhee (2006)	CA8331	CA50907	FJ983270	D4T, DDI, ABC, TDF, 3TC	None	D67N, K70R, M184V, T215Y, K219E		K64R, I135T, V179I, Q197K, T200A, Q207D, R211K, V245K, K277R, I293V	B
Dumans (2009)	RES299_03	RES299_03	FJ405039	AZT, DDI, 3TC, D4T	None	D67N, K70R, M184V, L210W, T215Y, K219E	K103S, G190A	K101R, K122E, D123N, I135T, V245K	B
	RENA686	RENA686	FJ405043	AZT, 3TC	None	D67G, K70R, M184V, T215F, K219E	K103N	K20R, V35M, S68G, R83K, D123E, V245K, A272P, K281R, E297R, Q334D	B
Rhee (2009)	CA7998	CA60854	FJ983258	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215F, K219E	E138K, V179D	K20R, V35VI, V60I, K64HN, K122P, I135V, I142V, R211A, V245K, A272P, K277R, L283I, I293V, G335S, Y339W, R356K	B

Reverse Transcriptase Inhibitors

Database

Resources

Team