<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation K219E
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 32
Patients 78
Isolates 98
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP26JIDP26W88AF021308AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M, K219E T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245MB
 JIDP25JIDP25W104AF021296AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219E V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211KB
Ruiz (1996)JCS-C31C31BZ99324AZT, DDINoneD67IN, T215TS, K219E K70*, K122E, K166R, D177N, T200AB
  C31W24Z99325AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E T69S, K122E, K166R, D177N, T200AB
Hammer (1997)ACTG320_361361 DDC, AZTNoneD67NT, K70R, T215F, K219E E6D, T39TP, T69N, K102Q, S162C, I202V, L210F, R211K, L228H, K277R, T286A, P294T, E297K, Y342F, M357I, R358K, A376V, K390R, A400T, T403TM, N447S, L452I, T470A, H483CB
Nijhuis (1997)PT-C0034C0034W94 3TC, AZTNoneM41L, D67N, K70R, M184V, T215F, K219E K20R, T69N, I135T, R211K, E248DB
  C0034W142 3TC, AZTNoneM41L, D67T, K70R, M184V, T215F, K219E K20R, T69N, I135T, R211K, E248DB
Cabana (1999)Cab-fF22AF102347AZT, DDI, 3TC, D4TNoneM41L, D67N, M184V, T215Y, K219E K122E, R211KB
Lawrence (1999)JL-Pt6JL-6-pre AZT, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E K122KE, D123E, I135V, I178M, V245EB
  JL-6-post AZT, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219E K122E, D123E, I135V, I178M, V245E, T286AB
Zolopa (1999)CA622CA3188AF088125AZT, DDC, DDI, 3TC, D4TNoneM41L, D67N, K70R, V75VA, L210W, T215Y, K219E V35I, E44D, V118I, K122E, I202V, H208Y, R211K, L228H, I257L, I293V, E297KB
 CA1170CA2657AF088118AZT, DDI, 3TC, D4T, DDCNoneD67N, K70R, M184V, T215V, K219E T69N, I135T, T200A, Q207EB
Albrecht (2000)ACTG303_13491349RT_bl AZT, DDINoneM41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245MB
  1349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
 ACTG303_782782RT_bl AZT, DDINoneM41L, D67N, K70R, T215Y, K219E V60I, D123E, S162Y, V179I, I195L, R211K, L228H, K277KR, K281R, T286A, I293IV, E297K, E302XB
  782RT_f1 AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E V60I, D123E, S162Y, V179I, I195L, R211K, L228H, K281R, T286A, E297K, A304G, L325XB
Bacheler (2000)LB3-P35P35-0 NRTINoneK219E V35L, S48T, K49R, T107A, K122E, D123N, S162C, Q174E, T200A, R211GB
Balotta (2000)CB-208CB-208AF252057AZT, D4T, 3TC, DDINoneM41L, D67N, M184V, T215Y, K219E V35M, T39A, R83K, S162C, G196E, T200A, R211GB
 CB-218CB-218AF252072D4T, 3TC, DDC, AZT, DDINoneM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219E V35T, V60I, V118I, K122E, Y146X, N147X, D177E, G196E, I202V, E203K, Q207E, R211K, D218EB
Baxter (2000)GART-NG45GART-45 NRTI, AZT, 3TCNoneD67G, K70R, M184V, T215F, K219EV179EK20R, S68G, K122R, D123E, I135T, D177E, Q207E, R211KB
 GART-NG77GART-77 NRTI, AZT, 3TCNoneM41L, D67N, K70R, L210W, T215Y, K219E K22R, V106I, K122E, I135V, S162Y, H208Y, R211K, L228R, V245EKB
 GART-NG79GART-79 NRTI, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219E K43Q, K104N, K122E, K126N, T200A, K238R, V245E, E248DB
 GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
 GART-NG146GART-146 NRTI, AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219E K122E, V245VMB
 GART-G153GART-153 NRTI, 3TC, D4TNoneD67N, K70R, M184V, T215Y, K219E  B
Shulman (2000)CA622CA1185AY802611AZT, DDC, DDI, 3TC, D4TNoneM41L, D67N, K70R, V75A, L210W, T215Y, K219E V35I, E44D, L109I, V118I, K122E, M164X, I202V, H208Y, R211K, L228HB
Albrecht (2001)ACTG364_12421242 AZT, DDC, 3TCNoneD67G, K70R, M184V, T215Y, K219E V35T, S68G, K166KR, Q207E, A272P, V276X, Q278AB
 ACTG364_55555555 DDC, AZT, 3TCNoneD67N, K70R, M184V, K219E K20KR, K64R, S162C, Q207H, R211K, L228R, V245M, K277R, A288S, I293VB
Eshleman (2001)A119AF357718AF357718AZT, DDINoneD67AT, K70R, T215F, K219EV108VIT69N, D123E, D177E, I178V, I195IT, I202V, Q207E, R211K, V241I, A272S, K277KR, K281R, T286A, I293IV, E297KB
 A129AF357728AF357728AZT, DDINoneD67N, K70R, T215I, K219E D121Y, K122E, T200A, V245M, D250E, A272P, K281RB
Gonzales (2001)CA1115CA2515AY030433D4T, AZT, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E R83X, D123E, V245KB
 CA1322CA3318AY030522AZT, NRTI, 3TC, D4TNoneD67DN, K70R, M184V, T215I, K219E T39A, K122E, I142V, T165I, G196E, R211K, V261VI, Q278X, A288SB
 CA1432CA3830AY030571AZT, 3TC, D4T, DDINoneM41L, D67NT, K70R, M184V, L210W, T215Y, K219E K20R, I31IL, V35I, T39A, V60I, K64KR, K122E, S134SR, I135T, Q174K, Q207E, R211K, L228HB
 CA1445CA3859AY030583D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E K11KR, K43Q, V60I, V118I, I135V, K166R, R211K, L234LR, V245TB
 CA1819CA4881AY030733DDC, AZT, 3TCNoneM41L, D67N, K70R, M184V, T215Y, K219E V245KB
 CA2080CA7700AY030788AZT, 3TC, DDINoneM184V, K219E V35I, A98S, T200A, K277R, I293V, T296S, E297KB
 CA4571CA11197AY031368AZT, 3TC, DDI, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219E V35I, D123E, I135T, I178L, R211K, V245E, I293VB
 CA4584CA11212AY031381DDC, AZT, D4T, 3TCNoneM41L, D67S, K70R, M184V, L210W, T215Y, K219E T39A, T69N, V106I, K122E, I178IM, E203D, H208Y, Q278H, A304GB
 CA5047CA12324AY031617AZT, 3TC, D4TNoneM41L, D67N, K70R, Q151M, M184V, T215F, K219E V35I, T39A, R83K, K104R, G112A, T200I, I202IT, H208Y, R211K, L228HB
 CA5235CA12827AY031792D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E E44D, V60I, V118I, I135M, S162Y, G196E, Q207D, R211K, V245E, A272PB
 CA5758CA14191AY032148D4T, DDINoneM41L, D67N, K70R, T215Y, K219E K11KR, K20KR, E44D, V118VI, Q174QE, K201K*, Q207E, K220KN, L228H, S251SR, N265NS, Q278QEB
 CA5990CA14766AY032236AZT, 3TC, D4TNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E K20R, V35K, T39A, T69TN, W88C, A98AS, K122E, D123E, N136NS, K154KE, S163SR, G196E, T200A, E203K, R211*K, F214LB
 CA6324CA15795AY032284AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219EK101EV60I, I135T, S162C, I178M, R211K, L228H, A272P, K281R, A288S, I293V, E297AB
 CA6403CA15904AY032358AZT, 3TC, D4TNoneD67N, K70R, M184V, T215SY, K219E M41X, K122E, D123N, I135T, N175H, I178M, Q197E, I202V, V245M, A272P, K277GR, A288S, I293V, E297AB
Masquelier (2001)BM-50BM-50AF315273NRTI, AZT, 3TCNoneM41L, D67~, T69G, K70R, M184V, T215Y, K219E V35I, E36K, K122E, D123N, I135T, A158S, G196E, E203K, R211GB
 BM-51BM-51AF315274NRTI, D4T, DDINoneD67~, T69G, K70R, T215F, K219E L109LV, G196R, T200A, I202T, R211K, L228HB
 BM-52BM-52AF311157NRTI, D4T, 3TCNoneD67~, T69G, M184V, T215L, K219E R83K, I135T, S162C, T200IB
Brindeiro (2002)TVSP15TVSP15AY145821AZT, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215F, K219E I135T, R211K, A272P, K281R, I293V, E297KB
 TVGG1TVGG1AY145782AZT, DDI, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219EA98GK20R, K32R, S162C, G196E, I293V, E297KB
 TVGG4TVGG4AY145784AZT, 3TC, D4TNoneD67N, K70R, M184V, K219E I5V, K64R, D177G, R211K, K277R, P294SB
 TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Naugler (2002)WES-25HIV25ESAF422747AZT, DDINoneD67N, K70R, T215Y, K219E T69N, I135V, S162C, R211KB
Gonzales (2003)CA5235CA16875AF514224D4T, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E E44D, V60I, V118I, K122KE, I135M, S162Y, G196E, Q207D, R211K, T240TA, V245E, N265NS, A272P, V276VGB
Dumans (2004)256256AY390167AZT, DDINoneD67N, K70R, L210W, T215Y, K219E K122E, D123N, T139V, Q174RB
 265265AY390090AZT, DDI, 3TCNoneD67N, K70R, M184V, T215F, K219E D123E, A158S, K173Q, Q174R, F214LB
 267267AY390113AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219E S68G, I135T, E169K, K173E, T200I, H208X, R211KB
 208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Gulick (2004)RG252RG252w74 ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E T39N, E40K, K64N, K102R, T139TR, I142IT, T200A, R211G, F214LB
  RG252w121 ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219EY188YDE6EG, K11KN, V35T, T39N, E40K, K64N, K102R, S134SR, T139R, I142T, S163ST, K166KE, E169EQ, T200A, E203K, R211G, F214LB
Machado (2004)cs120cs120AY313373AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E E44D, E194K, G196E, T200A, H208Y, R211KB
 cs124cs124AY313374AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E V118I, D123E, I135T, A158S, D177E, R211KB
 con61con61AY313447AZT, DDINoneK219E I135T, D177E, I178M, R211KB
 con32con32AY313408AZT, DDI, 3TC, D4TNoneM41L, M184V, L210W, T215Y, K219E K122E, I135VB
Montes (2004)MB_patTICHET P00_TIC715AJ578168AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219E K49R, S68G, S162D, E169D, D177E, T240AB
Garcia-Bujalance (2005)GBS_26GBS_26AY872361D4T, 3TCNoneD67G, K70R, M184V, K219E S68G, T69N, T84P, D113H, D123DE, I135T, S162C, Q174QR, G196E, R211KB
Mo (2005)90539053_d1 NRTINoneD67HN, K70KR, M184V, T215FV, K219E K20KR, T69TN, W88C, V118VI, A158S, S162D, K166R, E169D, R211K, F214L, V245M, E297KB
Non-B Workgroup (2005)TH_146TH_146AY605559AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219EY188YDE28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245RB
 TH_228TH_228AY605634AZT, DDINoneM41L, D67N, K70R, L210W, T215Y, K219E V35T, D121H, K122E, I142L, I178M, T200VB
Rhee (2005)CA622CA3190AY802722AZT, DDC, DDI, 3TC, D4TNoneM41L, D67NT, K70R, V75VA, M184MV, L210W, T215Y, K219E M16ML, V35I, E44D, A62AP, K64KR, N81NT, V90VA, L109LI, V118I, K122E, V179VI, I202V, H208Y, R211K, L228H, I257LB
 CA1170CA11998AY800798AZT, DDI, 3TC, D4T, DDCNoneD67N, K70R, M184V, T215V, K219E T69N, I135T, T200A, Q207E, E297KB
 CA4756CA34766AY801390AZT, 3TC, ABCNoneD67N, K70R, M184V, T215F, K219E V60I, I135L, F214L, E248D, A288AT, I293VB
 CA5433CA34379AY801578D4T, 3TCNoneV75T, Q151M, M184V, K219E I5IV, K11KR, K20KR, A33V, S68G, V111I, I142V, S162Y, E203D, R211RK, F214L, V245E, D250DE, V292I, I293VB
 CA5551CA37828AY801595AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219E E28A, K32Q, V35I, D123E, I135T, I142V, I167IV, D177E, V179I, T200IM, I202V, H208HY, R211K, L228H, K277R, T286A, A288T, I293IV, E297AB
 CA5990CA38037AY801625AZT, 3TC, D4T, ABCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E K20R, V35K, T39A, K49KQ, T69N, W88C, A98S, K122E, D123E, I135IT, V179I, G196E, T200A, E203K, Q207E, R211RK, F214L, L228H, V245M, A272S, K277R, A288S, E297KB
 CA6324CA16906AY801634AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219EK101EV60I, I135T, S162C, I178M, V179VI, R211K, L228H, A272P, K281R, A288S, L289LR, I293V, E297AB
  CA34924AY801635AZT, DDI, 3TC, D4TNoneM41L, D67N, K70R, M184V, T215Y, K219EK101EQV60I, S68SG, I135T, S162C, I178IM, V179VI, R211K, L228H, A272P, K281R, A288S, I293V, E297AB
 CA7062CA42582AY801745ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E, N348I V21I, A98S, R211K, V245E, A272P, K281R, E291D, I293V, E297N, N306D, Q334E, G335S, I341F, G359S, K366R, T369A, A371V, A376N, T377L, K390R, A400T, V435A, S468P, A554NB
 CA9749CA23924AY8020983TC, D4TNoneD67N, M184MV, T215S, K219E K20R, S68SDGN, D123N, I135T, I142T, S162A, V179VI, R211G, K277R, R284K, I293V, E297K, I326V, M357T, A360T, A376T, T386I, K390R, A400T, S468P, L469I, H483N, G490E, Q509HB
 CA9807CA24090AY802127AZT, 3TC, ABCNoneD67N, K70R, M184V, T215FY, K219E, N348I K102Q, K122E, I135V, S162C, E204D, K277R, E297K, I326V, I329L, K385R, K390R, E399D, A400T, K431R, V435A, K454R, Q547R, V548I, A554NB
  CA34551AY802128AZT, 3TC, ABCNoneM41ML, D67N, K70R, M184V, T215FY, K219E, N348I T7TA, K102Q, K122E, I135V, S162C, K277R, R284K, E297K, I326V, I329L, K385R, K390R, E399D, A400T, K431R, V435A, K454R, Q547R, V548I, A554NB
 CA9977CA24736AY802224AZT, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E V21I, V35I, T39TA, E44D, S68G, R83K, A98S, K122E, D218E, I293V, E297K, R356K, G359S, A400T, E404D, D460N, V467I, V496I, A538SB
 CA9986CA24776AY802225AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E S68G, D123E, S162C, D177E, I178L, G196K, R211G, V245E, A272P, K277R, E297AB
  CA24778AY802226AZT, DDI, 3TCNoneM41L, D67N, M184V, L210W, T215Y, K219E S3SR, S68G, D123E, S162C, D177E, I178L, G196K, R211G, V245E, A272P, K277R, E297AB
 CA14196CA34323AY802263AZT, 3TC, ABCNoneD67DN, K70KR, M184V, T215FS, K219E V35I, T39S, R83K, D121HY, K122E, I135T, G196E, F214FL, A272P, K275R, R284K, T286A, I293V, P294T, Q334E, M357T, E370M, Q373H, A400T, E404D, D460N, R461K, V467I, H483N, L491S, K512Q, S519N, Q547R, A554S, V559IB
  CA35216AY802264AZT, 3TC, ABCNoneM41L, D67N, K70R, M184V, T215F, K219E V35I, T39S, V60VI, R83RK, D121Y, K122E, I135T, G196E, F214L, A272P, K275R, R284K, T286A, I293V, P294TB
 CA14385CA34645AY802329AZT, 3TC, ABCNoneM41L, D67T, K70R, L74LI, M184V, L210LW, T215F, K219E V35M, K43X, T69N, I135IT, I167IV, G196E, I202IT, E203ED, K277R, R284K, I293V, M357T, A360V, A400T, F416Y, V458I, D460S, K512R, K527KQB
 CA14500CA34831AY802360D4T, 3TCNoneD67N, K70R, M184V, K219E T39TA, V60I, A158S, T200TA, R211RK, F214L, R284K, D324E, I326V, K395R, E399G, L491S, K558RB
  CA38261AY802361D4T, 3TCNoneD67N, K70R, M184V, K219E T39TA, V60I, A158S, T200TA, R211K, F214L, R284KB
  CA38263AY802362D4T, 3TCNoneD67N, K70R, M184V, K219E T39TA, V60I, A158S, T200TA, R211K, F214L, L228LH, R284KB
 CA16488CA39164AY802519ABC, AZT, 3TCNoneM41L, D67N, K70R, M184V, T215F, K219EA98GI135T, V245KB
Lama (2006)Pt31503150 NRTINoneM41L, D67N, K70R, M184V, T215F, K219E K122E, I135T, V245M, A272P, K277R, R284K, A288P, K311KR, I326VB
Rhee (2006)CA8331CA50907FJ983270D4T, DDI, ABC, TDF, 3TCNoneD67N, K70R, M184V, T215Y, K219E K64R, I135T, V179I, Q197K, T200A, Q207D, R211K, V245K, K277R, I293VB
Dumans (2009)RES299_03RES299_03FJ405039AZT, DDI, 3TC, D4TNoneD67N, K70R, M184V, L210W, T215Y, K219EK103S, G190AK101R, K122E, D123N, I135T, V245KB
 RENA686RENA686FJ405043AZT, 3TCNoneD67G, K70R, M184V, T215F, K219EK103NK20R, V35M, S68G, R83K, D123E, V245K, A272P, K281R, E297R, Q334DB
Rhee (2009)CA7998CA60854FJ983258ABC, AZT, 3TCNoneD67N, K70R, M184V, T215F, K219EE138K, V179DK20R, V35VI, V60I, K64HN, K122P, I135V, I142V, R211A, V245K, A272P, K277R, L283I, I293V, G335S, Y339W, R356KB
Grossman (2014)2727KF135038D4T, 3TCNoneM41L, D67N, K70R, M184V, T215FY, K219EK238KTS105A, K122E, R125RW, D177E, I178M, L228HB
  27KF135039D4T, 3TC, DDINoneM41L, D67N, K70R, M184V, T215Y, K219E V60VI, S105A, K122E, I135IV, D177E, I178M, F214FY, L228HB
  27 D4T, 3TC, DDI, TDFNoneM41L, D67N, K70R, M184V, T215Y, K219EK103KNV60I, T69TN, S105AT, K122E, I135V, F171FY, D177E, I178M, L228HB