Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	T215S
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	13
Patients	20
Isolates	28

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Ruiz (1996)	JCS-C27	C27W24	Z99321	DDC, AZT, 3TC	None	D67N, K70R, M184V, T215S, K219Q		K64H, T69N, K122P, D177E, Q207E, L210G, P217Q, L228H	B
Venturi (1999)	GV-3	Vent3W24	AF169047	AZT, DDI	None	K70R, T215S		R83K, D123E, I135T, Y144*, G196E	B
	GV-11	Vent11B	AF169062	AZT	None	D67N, K70R, T215S, K219Q		G51A, T69N, V106I, D123E, I135IT, Y144Y*, F214L	B
		Vent11W24	AF169063	AZT, DDI	None	D67N, K70R, T215S, K219Q		K43R, T69N, V106I, V118M, D123E, I135T, Y144*, F214L	B
Si-Mohamed (2000)	AS_BON	AS_BON	AF199321	AZT	None	T215S		K49R, R83K, I202V	B
Delgado (2001)	ED_V7	ED_V7	AY016917	AZT, 3TC	None	M184V, T215S		S68G, K122E, I135T, A158S, I178M, T200E, R211K, V245MT	B
Gonzales (2001)	CA4330	CA10521	AY031194	AZT, DDI, 3TC	None	M41L, D67N, T69D, K70R, M184V, T215S, K219Q		D17DG, K20R, P25PA, V35L, V60I, K103R, V118I, K122E, S134SC, K173E, Q207E, F214L, L228H, K277R, A288T, I293V, E297K	B
	CA5207	CA12511	AY031770	AZT, 3TC	None	M184V, T215S		V21I, D123E, I135T, V179I, T200E, F214L, K275K*, Q278QE	B
Naugler (2002)	WES-10	HIV10BL	AF422707	AZT	None	K70R, V75I, T215S, K219Q		K64R, D123E, I142T, D177E, I178M, R211K, F214L	B
		HIV10ES	AF422732	AZT, DDI	None	K70R, V75I, T215S, K219Q		K64R, D123E, I142T, D177E, I178M, Q207P, R211K, F214L	B
	WES-11	HIV11BL	AF422708	AZT	None	M41L, L210W, T215S		V35L, V60G, A62P, V106I, I202V, R211K	B
		HIV11ES	AF422733	AZT, DDI	None	M41L, L210W, T215S	K103N	V35L, E42V, V60G, A62P, L100V, V106I, I202V, R211K	B
Dumans (2004)	259	259	AY390161	AZT, DDI	None	T215S		K122E, I135T, S162C, D177E, S191F, G196E, Q207H	B
	260	260	AY390162	AZT, DDI	None	M41L, L210W, T215S	K103N	V118I, D121Y, K122E, D123E, I135T, S162C, D177E, G196E, Q207H, R211K	B
Kuritzkes (2004)	KDR_pat56	A0062	AY527879	D4T, 3TC	None	M41L, M184V, L210W, T215S		K122E, T200A, Q207E, R211K	B
		A0063	AY527880	D4T, 3TC	None	M41L, M184V, L210W, T215S		K122E, T200A, Q207E, R211K	B
Machado (2004)	con15	con15	AY313430	AZT, DDI	None	T215S		K64R, K122T, I135T, E138A, I142V, D177E, I178V, G196R, T200A	B
Montes (2004)	MB_patAVO	01_AVO720	AJ577732	DDC, AZT, 3TC, D4T	None	A62V, M184I, L210W, T215S	A98G	R83K, I135V, S162C, T165V, I202V	B
Holguin (2005)	SP_SK2	SP_SK2	AF466719	AZT, 3TC	None	L210W, T215S		V60I, R83K, I94V, A98S, I135V, E138A	B
Rhee (2005)	CA8441	CA21202	AY802020	D4T, 3TC	None	T215S	A98G	S68G, D123E, I178LV, V179I, E204EK, Q207E, R211K, A272X, Q278QH, T286A, E291D, P294Q	B
	CA9749	CA23924	AY802098	3TC, D4T	None	D67N, M184MV, T215S, K219E		K20R, S68X, D123N, I135T, I142T, S162A, V179VI, R211G, K277R, R284K, I293V, E297K	B
	CA9963	CA34259	AY802215	AZT, 3TC	None	M41L, L210W, T215S		V35M, T39A, R83K, K122E, D123N, T139A, Q174K, D177E, G196E, V245M, I293V, P294Q, E297K, E302D	B
		CA24658	AY802216	AZT, 3TC	None	M41L, L210W, T215S		V35M, T39A, R83K, K122E, D123N, T139A, D177E, G196E, V245M, I293V, P294Q, E297K	B
		CA34403	AY802217	AZT, 3TC, ABC	None	M41L, L210W, T215S		V35M, T39A, R83K, K122E, D123N, T139A, Q174K, D177E, G196E, E204EK, V245M, I293V, P294Q, E297K	B
	CA17600	CA41441	AY802530	AZT, 3TC, DDI	None	M41L, T215S		V60I, D123E, G196E, I202IV, R211K, S251I, A272S, K281KR, I293IV, E297K	B
		CA48566	AY802531	AZT, 3TC, DDI, ABC, TDF	None	M41L, T215S		V60I, D123E, G196E, I202IV, R211K, K238KR, K249KQ, S251I, A272S, K281R, I293V, E297K	B
		CA48568	AY802532	AZT, 3TC, DDI, ABC, TDF	None	M41L, T215S		V60I, K122E, D123E, G196E, R211K, S251I, A272S, K281R, E297K	B
von Wyl (2007)	4	662309	EF449973	NRTI	None	M41L, M184V, T215S		V60I, K122E, D123E, I132V, I135T, T165I, D177E, G196E, I202V	B

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