<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation T215I
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 14
Patients 20
Isolates 22
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_755755 AZT, DDINoneD67N, K70R, T215I, K219Q K20R, V35I, I50V, R83K, K104KE, K122KE, D123DE, I135T, A272P, I293V, P294A, E297R, G359S, K366R, T377L, K390R, E432D, D460N, H483YB
Mulato (1998)GS94ptBGS94ptBW24 AZT, ADVNoneT215I K43R, I142V, E204G, R211KB
Balotta (2000)CB-155CB-155AF252019DDC, AZT, D4T, DDINoneD67N, T69D, K70R, T215I, K219Q I50IM, L80LF, V90I, D123E, I135T, F214LB
Coakley (2000)EC25EC25F D4T, DDINoneT215I V8D, K22N, V35I, R83K, K102Q, A158S, V245M, K277R, T286A, E297K, D324I, K353KN, M357I, G359S, A371V, I375V, K390R, L452K, D460N, L491S, N494H, Q520PB
Venturi (2000)V2000-24V2000-24PAF158789AZT, DDINoneD67N, K70G, T215I, K219Q G45E, I50V, D123E, K166R, D177E, I178LB
Eshleman (2001)A015AF357619AF357619AZT, DDINoneD67N, K70R, T215I, K219Q V35I, K64N, R83K, D218E, A272P, K277R, I293IVB
 A129AF357728AF357728AZT, DDINoneD67N, K70R, T215I, K219E D121Y, K122E, T200A, V245M, D250E, A272P, K281RB
Gonzales (2001)CA1322CA3318AY030522AZT, NRTI, 3TC, D4TNoneD67DN, K70R, M184V, T215I, K219E T39A, K122E, I142V, T165I, G196E, R211K, V261VI, Q278QH, A288SB
 CA5006CA12277AY031581AZT, 3TC, D4T, DDINoneD67N, K70R, T215I, K219Q V60I, T69N, K102KQ, K103R, K122KE, F130FL, I135T, S162C, F214FL, D218E, A272PB
Katzenstein (2001)ACTG302_20862086RT_bl AZT, DDINoneD67N, K70R, T215I, K219EQ T39A, V60I, R83K, S162Y, Q207A, R211SB
Brindeiro (2002)TVGG11TVGG11AY145787AZT, 3TC, D4TNoneD67N, K70R, T215I, K219Q K32R, V35M, S48T, K104N, K122E, T200A, I202V, V245I, K277R, I293V, E297KB
Venturi (2002)GV-43GV-43.1AF517295AZT, DDINoneD67N, K70R, T215I, K219Q K32R, V60I, I135T, G196E, I202V, Q207HB
Gulick (2004)RG13RG13w75 ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219Q V90I, K122E, D123N, I135T, S162Y, I178M, V189I, T200A, E204QB
 RG252RG252w74 ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E T39N, E40K, K64N, K102R, T139TR, I142IT, T200A, R211G, F214LB
  RG252w121 ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219EY188YDE6EG, K11KN, V35T, T39N, E40K, K64N, K102R, S134SR, T139R, I142T, S163ST, K166KE, E169EQ, T200A, E203K, R211G, F214LB
Rhee (2005)CA4565CA37765AY801372AZT, D4T, 3TC, DDINoneD67N, K70R, T215I, K219Q K20KR, S48T, T69S, K122E, I135T, Q197E, F214L, V245KB
 CA7062CA42582AY801745ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E, N348I V21I, A98S, R211K, V245E, A272P, K281R, E291D, I293V, E297N, N306D, Q334E, G335S, I341F, G359S, K366R, T369A, A371V, A376N, T377L, K390R, A400T, V435A, S468P, A554NB
 CA8395CA34441AY801992AZT, 3TC, D4T, DDINoneD67N, K70R, M184MV, T215I, K219Q K122P, I142V, Q174QR, D177E, I178IL, R211K, A272P, T286AB
 CA9925CA24527AY802195D4T, 3TC, ABC, AZTNoneD67N, K70R, T215I, K219Q K122E, I135T, T139M, F214L, L246LWB
Riddler (2008)RG50847RG50847w7 TDF, 3TCNoneD67N, T215I, K219QY181C, Y188LV35L, V60I, T69N, K103R, K122E, S163T, G196E, R211KQ, V245T, E248ED, K249KR, K277R, E297K, L301M, G359S, A376S, T377L, S379A, K390R, Q394LB
  RG50847w15 TDF, 3TCNoneD67N, T215I, K219QY181C, Y188LV35L, V60I, T69N, K103R, K122E, S163T, G196E, R211Q, V245T, K249KR, K277R, E297K, L301M, G359S, A376S, T377L, S379A, K390R, Q394LB
Rhee (2009)CA8081CA37838FJ983266D4T, DDINoneD67N, K70R, T215I, K219Q K20R, V118I, K122E, D123N, I135T, F214L, L228H, V245MB