Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	T215I
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	14
Patients	20
Isolates	22

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_755	755		AZT, DDI	None	D67N, K70R, T215I, K219Q		K20R, V35I, I50V, R83K, K104KE, K122KE, D123DE, I135T, A272P, I293V, P294A, E297R, G359S, K366R, T377L, K390R, E432D, D460N, H483Y	B
Mulato (1998)	GS94ptB	GS94ptBW24		AZT, ADV	None	T215I		K43R, I142V, E204G, R211K	B
Balotta (2000)	CB-155	CB-155	AF252019	DDC, AZT, D4T, DDI	None	D67N, T69D, K70R, T215I, K219Q		I50IM, L80LF, V90I, D123E, I135T, F214L	B
Coakley (2000)	EC25	EC25F		D4T, DDI	None	T215I		V8D, K22N, V35I, R83K, K102Q, A158S, V245M, K277R, T286A, E297K, D324I, K353KN, M357I, G359S, A371V, I375V, K390R, L452K, D460N, L491S, N494H, Q520P	B
Venturi (2000)	V2000-24	V2000-24P	AF158789	AZT, DDI	None	D67N, K70G, T215I, K219Q		G45E, I50V, D123E, K166R, D177E, I178L	B
Eshleman (2001)	A015	AF357619	AF357619	AZT, DDI	None	D67N, K70R, T215I, K219Q		V35I, K64N, R83K, D218E, A272P, K277R, I293IV	B
	A129	AF357728	AF357728	AZT, DDI	None	D67N, K70R, T215I, K219E		D121Y, K122E, T200A, V245M, D250E, A272P, K281R	B
Gonzales (2001)	CA1322	CA3318	AY030522	AZT, NRTI, 3TC, D4T	None	D67DN, K70R, M184V, T215I, K219E		T39A, K122E, I142V, T165I, G196E, R211K, V261VI, Q278X, A288S	B
	CA5006	CA12277	AY031581	AZT, 3TC, D4T, DDI	None	D67N, K70R, T215I, K219Q		V60I, T69N, K102KQ, K103R, K122KE, F130FL, I135T, S162C, F214FL, D218E, A272P	B
Katzenstein (2001)	ACTG302_2086	2086RT_bl		AZT, DDI	None	D67N, K70R, T215I, K219EQ		T39A, V60I, R83K, S162Y, Q207A, R211S	B
Brindeiro (2002)	TVGG11	TVGG11	AY145787	AZT, 3TC, D4T	None	D67N, K70R, T215I, K219Q		K32R, V35M, S48T, K104N, K122E, T200A, I202V, V245I, K277R, I293V, E297K	B
Venturi (2002)	GV-43	GV-43.1	AF517295	AZT, DDI	None	D67N, K70R, T215I, K219Q		K32R, V60I, I135T, G196E, I202V, Q207H	B
Gulick (2004)	RG13	RG13w75		ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219Q		V90I, K122E, D123N, I135T, S162Y, I178M, V189I, T200A, E204Q	B
	RG252	RG252w74		ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E		T39N, E40K, K64N, K102R, T139TR, I142IT, T200A, R211G, F214L	B
		RG252w121		ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E	Y188YD	E6EG, K11KN, V35T, T39N, E40K, K64N, K102R, S134SR, T139R, I142T, S163ST, K166KE, E169EQ, T200A, E203K, R211G, F214L	B
Rhee (2005)	CA4565	CA37765	AY801372	AZT, D4T, 3TC, DDI	None	D67N, K70R, T215I, K219Q		K20KR, S48T, T69S, K122E, I135T, Q197E, F214L, V245K	B
	CA7062	CA42582	AY801745	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E, N348I		V21I, A98S, R211K, V245E, A272P, K281R, E291D, I293V, E297N, N306D, Q334E, G335S, I341F, G359S, K366R, T369A, A371V, A376N, T377L, K390R, A400T, V435A, S468P, A554N	B
	CA8395	CA34441	AY801992	AZT, 3TC, D4T, DDI	None	D67N, K70R, M184MV, T215I, K219Q		K122P, I142V, Q174QR, D177E, I178IL, R211K, A272P, T286A	B
	CA9925	CA24527	AY802195	D4T, 3TC, ABC, AZT	None	D67N, K70R, T215I, K219Q		K122E, I135T, T139M, F214L, L246LW	B
Riddler (2008)	RG50847	RG50847w7		TDF, 3TC	None	D67N, T215I, K219Q	Y181C, Y188L	V35L, V60I, T69N, K103R, K122E, S163T, G196E, R211KQ, V245T, E248ED, K249KR, K277R, E297K, L301M, G359S, A376S, T377L, S379A, K390R, Q394L	B
		RG50847w15		TDF, 3TC	None	D67N, T215I, K219Q	Y181C, Y188L	V35L, V60I, T69N, K103R, K122E, S163T, G196E, R211Q, V245T, K249KR, K277R, E297K, L301M, G359S, A376S, T377L, S379A, K390R, Q394L	B
Rhee (2009)	CA8081	CA37838	FJ983266	D4T, DDI	None	D67N, K70R, T215I, K219Q		K20R, V118I, K122E, D123N, I135T, F214L, L228H, V245M	B

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