<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation T215D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 17
Patients 32
Isolates 34
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_11981198 AZT, DDINoneM41L, L74LV, T215DY181YCV35VI, E44ED, R83RK, I135IT, I195L, V245VM, E297K, I329L, G333E, Q334H, R356RK, M357V, A376T, K390R, A400T, D460NB
 ACTG320_17251725 AZT, DDINoneT215D T27TS, D123E, S162C, D177E, I178IM, G196E, R211G, A272P, K277R, A288S, E297K, L310I, I326IV, Q334Y, A400T, V435IT, D460N, R461KB
 ACTG320_23352335 DDC, AZT, DDINoneM41L, L210W, T215D E6D, K43N, V106I, V118I, D123E, D177E, H208Y, R211K, K223Q, L228R, V245K, T286A, A288T, I329V, K350R, M357T, K390R, A400T, L469F, T470TNSYB
 ACTG320_26442644 AZT, 3TCNoneM41L, T215D T39A, V60I, I135V, I142T, K166R, D177E, I178V, Q207AP, V245T, A272P, K277R, D324DE, I326V, P345Q, K366R, R463KB
 ACTG320_27392739 AZT, DDC, DDINoneT215D E6D, D123DE, I142IV, S162C, G196E, T200TI, Q207DE, L210LF, R211K, V245K, K277R, A288S, E297KB
 ACTG320_30383038 AZT, DDI, D4T, 3TCNoneM41L, D67N, T69D, T215D V60I, K122E, S162A, K277R, A288AS, I293V, E297A, A299T, D324E, I329L, R358K, G359GS, V365VI, T369TI, A376S, K390R, A400AT, S468SPB
 ACTG320_925925 AZT, DDINoneL74V, L210W, T215DY181CS68G, R83K, V90I, D123E, K166KR, I178M, R211K, S251V, K277R, T286A, V292I, D324E, Q334L, K347KR, T377Q, T386TA, K390R, A400L, V435A, K451R, R461RKB
Venturi (1999)GV-30Vent30BAF169100AZTNoneT215DA98G, K103KTR83K, K122E, D123E, I167IL, D177E, I178M, T200A, R211KB
Bacheler (2000)LB3-P92P92-0 NRTINoneM41L, L210W, T215D V35M, T39A, E40D, S68G, K122E, T139M, Q174EB
 LB3-P94P94-0 NRTINoneM41L, T215D V60I, R83K, R211KB
 LB4-P108P108-0 AZT, 3TCNoneM41L, M184V, L210W, T215D T7P, V60I, S68G, Q207E, R211KB
Miller (2000)MV-137MV-137wk04 ABCNoneT215D I50S, D123E, S162C, D177DE, R211KB
 MV-751MV-751wk24 ABCNoneK70R, L74V, M184V, T215D K49R, V60I, K122E, I135T, A158AT, E169EK, G196R, R211KB
Venturi (2000)V2000-22V2000-22PAF158785AZT, DDINoneM41L, T215D V60I, D123E, I135TB
Bacheler (2001)DMP003-9403-94242BAF349369NRTINoneM41L, T215D V60I, R83K, R211K, A272P, I293V, G333E, Q334Y, M357T, K390R, A400LB
Gonzales (2001)CA4058CA9323AY031053NRTINoneL210W, T215D V35M, R83K, V118I, I202V, R211KB
 CA4345CA10543AY031208AZT, D4T, 3TCNoneM41L, L74LV, M184MV, T215D K20R, E44D, S68SG, V90VI, V118I, A158AP, N265ND, A272P, E291DV, V292I, E300EQB
Ait-Khaled (2002)MAK-18581858161AJ425943AZT, 3TCNoneM184V, T215D K20R, D121Y, K122E, I135T, S162C, D177E, G196E, E203V, Q207EB
Venturi (2002)GV-12GV-12.1AF517264D4T, 3TCNoneM41L, D67N, T69D, L210W, T215D E44D, V106I, V118I, K122E, D123E, I135IT, Q207EK, H208HY, R211KB
 GV-41GV-41.1AF517293D4T, 3TCNoneM41L, T215D V60I, D123E, I135T, Q197L, K223KTB
Gonzales (2003)CA8009CA20119AF514261AZT, DDC, 3TC, DDINoneD67N, T69D, M184V, L210W, T215D E6EK, K20R, V60I, V118I, K122E, I135V, E169K, K173E, Q174QR, D177E, T200A, Q207E, R211K, A272P, K275R, T286A, A299AGB
Kuritzkes (2004)KDR_pat130A0158AY527975D4T, 3TCNoneM184V, T215D S68N, I135T, T200A, Q207GB
  A0157AY527974D4T, 3TCNoneM184V, T215D S68N, I135IT, T200A, Q207GB
Montes (2004)MB_patFRAI02_FRA716AJ577892AZT, 3TC, DDI, D4TNoneM41L, M184V, L210W, T215D K43R, R83K, V90I, V118I, I135V, K166R, I202VB
Gallant (2005)JEG25JEG25_w12DQ199598ABC, TDF, 3TCNoneM41L, K65R, M184V, L210W, T215D V60I, S68G, K122E, I135T, D177E, G196E, I202IV, R211K, V245T, D250E, A272P, K277R, E297AB
Rhee (2005)CA1263CA5015AY800818AZT, DDI, D4T, 3TCNoneM184V, T215D I142V, S162C, E203K, Q207E, V245IB
  CA5017AY800819AZT, DDI, D4T, 3TCNoneM184V, T215D I142V, S162C, Q207E, V245IB
 CA1496CA21138AY800990AZT, 3TC, D4T, DDINoneM41L, T215D L34LF, D123E, S162C, D177E, Q207E, A272P, K277R, R284K, T286A, I293IVB
 CA14410CA38239AY802337TDF, 3TC, DDINoneM41L, K65R, M184V, T215D V60I, S68G, D123E, I202V, Q207QR, R211A, K259KR, I293V, E297AB
 CA16425CA39011AY802511ABC, AZT, 3TCNoneT215D K32N, V35IT, K101Q, D123E, I135R, I142AV, S162C, E169AT, K173E, P176PS, D177DE, I178ILM, I202IMV, A272P, T286TAB
Riddler (2008)RG13005RG13005w118 AZT, 3TCNoneA62AV, M184V, T215D E6ED, V60I, R83K, E138Q, N175H, V179L, I202V, Q207K, R211K, K275Q, T286A, I293V, T296S, E297K, V317A, I329V, Q334E, A355S, T369A, K385RB
Rhee (2009)CA14185CA34309FJ983346AZT, D4T, 3TC, DDCNoneM184V, T215D, K219KR K20R, I135V, S162C, Q174H, V179T, T200A, Q207E, V245KB
Mollan (2012)MK85MK85w163 ABC, 3TCNoneM41L, L210W, T215DK101E, Y181CP9PS, V35I, T39A, V118I, K122E, D123E, I142V, D177E, G196E, T200TA, Q207E, F214FL, L228HR, A272P, I293V, E297AB
 MK8MK8w20 ABC, 3TCNoneM41L, L210W, T215D E40K, K43E, K49KR, V60VI, K122P, I135T, I142IT, S162C, I202V, R211K, V245E, T286TA, I293VB