Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	T215D
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	16
Patients	31
Isolates	33

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_1198	1198		AZT, DDI	None	M41L, L74LV, T215D	Y181YC	V35VI, E44ED, R83RK, I135IT, I195L, V245VM, E297K, I329L, G333E, Q334H, R356RK, M357V, A376T, K390R, A400T, D460N	B
	ACTG320_1725	1725		AZT, DDI	None	T215D		T27TS, D123E, S162C, D177E, I178IM, G196E, R211G, A272P, K277R, A288S, E297K, L310I, I326IV, Q334Y, A400T, V435IT, D460N, R461K	B
	ACTG320_2335	2335		DDC, AZT, DDI	None	M41L, L210W, T215D		E6D, K43N, V106I, V118I, D123E, D177E, H208Y, R211K, K223Q, L228R, V245K, T286A, A288T, I329V, K350R, M357T, K390R, A400T, L469F, T470TNSY	B
	ACTG320_2644	2644		AZT, 3TC	None	M41L, T215D		T39A, V60I, I135V, I142T, K166R, D177E, I178V, Q207AP, V245T, A272P, K277R, D324DE, I326V, P345Q, K366R, R463K	B
	ACTG320_2739	2739		AZT, DDC, DDI	None	T215D		E6D, D123DE, I142IV, S162C, G196E, T200TI, Q207DE, L210LF, R211K, V245K, K277R, A288S, E297K	B
	ACTG320_3038	3038		AZT, DDI, D4T, 3TC	None	M41L, D67N, T69D, T215D		V60I, K122E, S162A, K277R, A288AS, I293V, E297A, A299T, D324E, I329L, R358K, G359GS, V365VI, T369TI, A376S, K390R, A400AT, S468SP	B
	ACTG320_3671	3671		AZT, DDI	None	L210LW, T215D	K103N, Y318F	K20R, V35VI, K122E, I135T, S162C, E203D, R211K, E224ED, A272P, K277R, L283I, I293V, Q334DE, R356K, G359S, A371AV, T377MV, K390R, A400T, T403A, K451R, L452S, S468P	B
	ACTG320_925	925		AZT, DDI	None	L74V, L210W, T215D	Y181C	S68G, R83K, V90I, D123E, K166KR, I178M, R211K, S251V, K277R, T286A, V292I, D324E, Q334L, K347KR, T377Q, T386TA, K390R, A400L, V435A, K451R, R461RK	B
Venturi (1999)	GV-30	Vent30B	AF169100	AZT	None	T215D	A98G	R83K, K103X, K122E, D123E, I167X, D177E, I178M, T200A, R211K	B
Bacheler (2000)	LB3-P92	P92-0		NRTI	None	M41L, L210W, T215D		V35M, T39A, E40D, S68G, K122E, T139M, Q174E	B
	LB3-P94	P94-0		NRTI	None	M41L, T215D		V60I, R83K, R211K	B
	LB4-P108	P108-0		AZT, 3TC	None	M41L, M184V, L210W, T215D		T7P, V60I, S68G, Q207E, R211K	B
Miller (2000)	MV-137	MV-137wk04		ABC	None	T215D		I50S, D123E, S162C, D177DE, R211K	B
	MV-751	MV-751wk24		ABC	None	K70R, L74V, M184V, T215D		K49R, V60I, K122E, I135T, A158AT, E169EK, G196R, R211K	B
Venturi (2000)	V2000-22	V2000-22P	AF158785	AZT, DDI	None	M41L, T215D		V60I, D123E, I135T	B
Bacheler (2001)	DMP003-94	03-94242B	AF349369	NRTI	None	M41L, T215D		V60I, R83K, R211K, A272P, I293V, G333E, Q334Y, M357T, K390R	B
Gonzales (2001)	CA4058	CA9323	AY031053	NRTI	None	L210W, T215D		V35M, R83K, V118I, I202V, R211K	B
	CA4345	CA10543	AY031208	AZT, D4T, 3TC	None	M41L, L74LV, M184MV, T215D		K20R, E44D, S68SG, V90VI, V118I, A158AP, N265ND, A272P, E291DV, V292I, E300EQ	B
Ait-Khaled (2002)	MAK-1858	1858161	AJ425943	AZT, 3TC	None	M184V, T215D		K20R, D121Y, K122E, I135T, S162C, D177E, G196E, E203V, Q207E	B
Venturi (2002)	GV-12	GV-12.1	AF517264	D4T, 3TC	None	M41L, D67N, T69D, L210W, T215D		E44D, V106I, V118I, K122E, D123E, I135IT, Q207EK, H208HY, R211K	B
	GV-41	GV-41.1	AF517293	D4T, 3TC	None	M41L, T215D		V60I, D123E, I135T, Q197L, K223KT	B
Gonzales (2003)	CA8009	CA20119	AF514261	AZT, DDC, 3TC, DDI	None	D67N, T69D, M184V, L210W, T215D		E6EK, K20R, V60I, V118I, K122E, I135V, E169K, K173E, Q174QR, D177E, T200A, Q207E, R211K, A272P, K275R, T286A, A299AG	B
Kuritzkes (2004)	KDR_pat130	A0158	AY527975	D4T, 3TC	None	M184V, T215D		S68N, I135T, T200A, Q207G	B
		A0157	AY527974	D4T, 3TC	None	M184V, T215D		S68N, I135IT, T200A, Q207G	B
Montes (2004)	MB_patFRAI	02_FRA716	AJ577892	AZT, 3TC, DDI, D4T	None	M41L, M184V, L210W, T215D		K43R, R83K, V90I, V118I, I135V, K166R, I202V	B
Gallant (2005)	JEG25	JEG25_w12	DQ199598	ABC, TDF, 3TC	None	M41L, K65R, M184V, L210W, T215D		V60I, S68G, K122E, I135T, D177E, G196E, I202IV, R211K, V245T, D250E, A272P, K277R, E297A	B
Rhee (2005)	CA1263	CA5015	AY800818	AZT, DDI, D4T, 3TC	None	M184V, T215D		I142V, S162C, E203K, Q207E, V245I	B
		CA5017	AY800819	AZT, DDI, D4T, 3TC	None	M184V, T215D		I142V, S162C, Q207E, V245I	B
	CA1496	CA21138	AY800990	AZT, 3TC, D4T, DDI	None	M41L, T215D		L34LF, D123E, S162C, D177E, Q207E, A272P, K277R, R284K, T286A, I293IV	B
	CA14410	CA38239	AY802337	TDF, 3TC, DDI	None	M41L, K65R, M184V, T215D		V60I, S68G, D123E, I202V, Q207QR, R211A, K259KR, I293V, E297A	B
	CA16425	CA39011	AY802511	ABC, AZT, 3TC	None	T215D		K32N, V35IT, K101Q, D123E, I135R, I142AV, S162C, E169AT, K173E, P176PS, D177DE, I178ILM, I202IMV, A272P, T286TA	B
Riddler (2008)	RG13005	RG13005w118		AZT, 3TC	None	A62AV, M184V, T215D		E6ED, V60I, R83K, E138Q, N175H, V179L, I202V, Q207K, R211K, K275Q, T286A, I293V, T296S, E297K, V317A, I329V, Q334E, A355S, T369A, K385R	B
Rhee (2009)	CA14185	CA34309	FJ983346	AZT, D4T, 3TC, DDC	None	M184V, T215D, K219KR		K20R, I135V, S162C, Q174H, V179T, T200A, Q207E, V245K	B

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