<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation L210F
Rx RTI-naive
IncludeMixtures No
References 61
Patients 140
Isolates 140
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Pellegrin (1999)IP-13IP13-B NoneNone  R83K, K122E, E138A, S162A, Q174E, V189VI, I202V, L210FB
Vergne (2000)LV713GUELV713GUEAJ287049NoneNone  K122E, D177E, G196E, L210F, A272P, K277R, T286A, E297K, I326V, V365I, A376T, V381I, T403MB
Perno (2001)PCF_Pat182PCF231AF376524NoneNone  T7P, K49R, I50V, A98S, D123E, I142T, K173KT, L210F, R211K, A272P, K281R, E297KB
Kaye (2002)38009380090AY042769NoneNone  E44G, K104KN, V111L, D123E, I135L, I142L, S162C, S163C, D177E, I178M, G196E, L210FB
Machado (2002)206cdpol206AF373726NoneNone  E29G, V60I, D121Y, K122E, L210FB
Shafer (2003)A384_35243524aEF548225NoneNone  V60I, A98S, K122E, D123N, D177E, L210F, R211K, V245KB
 A384_30983098aEF548266NoneNone  R83K, I135IT, E169D, G196E, T200IV, L210FB
 A384_06020602aEF548268NoneNone V108VIV60VI, R83K, V90I, D121DY, K122KE, D123DE, P176PS, D177DE, G196E, T200TA, L210F, R211KB
 A384_06120612aEF548269NoneNone  R83K, V90I, D121Y, K122E, P176S, G196E, L210F, R211KB
 A384_32583258aEF548508NoneNoneT215DV108IKK82KR, H96HN, A98AP, K122Q, K166R, D177E, I202V, L210F, V245TB
 A384_36073607aEF548767NoneNone  I37X, R83K, H96HN, K122E, G196E, T200A, L210F, V245VMB
 A384_36033603aEF548786NoneNone  I37X, D123E, T200A, I202V, Q207N, L210F, R211K, D218DE, F227FS, V245EB
 A384_36343634aEF548796NoneNone  I37X, R83K, V118I, K122P, I178L, T200I, L210F, R211RK, F214LB
 A384_05600560aEF548836NoneNone  K102R, I135T, K173R, V189I, G196E, L210FB
 A384_14931493aEF548872NoneNone  E79ED, R83K, G196E, L210FB
 A384_03740374aEF548908NoneNone V179DV60I, R83K, K122E, D123N, I135L, Q197QK, T200EK, L210FB
Gulick (2004)RG341RG341w1 NoneNone K103KTK49R, R83K, K122E, I202V, L210F, R211KB
 RG478RG478w0 NoneNone  S48E, I135V, S162C, Q207E, L210F, R211K, V245IMB
 RG489RG489w0 NoneNone  K122E, I178M, V179VG, L210F, R211KB
Kuritzkes (2004)KDR_pat31A0028AY527845NoneNone  K102R, D123E, E169D, G196E, L210F, R211RKB
 KDR_pat218A0292AY528109NoneNone  V106VI, D123E, T200AE, L210FB
Yerly (2004)161GE02_161AY562464NoneNone K103NR83K, D123E, R172K, D177G, I202V, L210F, R211QB
Babic (2006)DB_SI7655-04SI7655-04AJ971113NoneNone  V35VI, V60I, A98AS, K122E, D123N, T139K, I142V, T200I, Q207E, L210F, R211K, A272S, E297AB
 DB_SI4314-03SI4314-03AJ971114NoneNone  V60I, K122E, D123N, T139K, I142V, T200I, Q207N, L210F, R211K, A272S, E297AB
 DB_SI6439-02SI6439-02AJ971116NoneNone  V35I, K122E, D123N, T139K, I142V, T200I, Q207D, L210F, R211K, A272S, E297AB
 DB_SI4736-03SI4736-03AJ971117NoneNone  V60I, K122E, D123N, T139K, I142V, T200I, Q207D, L210F, R211K, A272S, E297A, I329RB
 DB_SI6663-03SI6663-03AJ971140NoneNone  V60I, K122E, D123N, T139K, I142V, T200I, Q207A, L210F, R211K, A272S, E297AB
 DB_SI8504-04SI8504-04AJ971287NoneNone  A98S, K166R, L210F, R211K, V245EB
Jayaraman (2006)2-00-05432-00-0543 NoneNone  T39A, R83K, G99X, D123E, I178IM, L210FB
 2-00-06542-00-0654 NoneNone  D123E, S162C, D177E, T200A, L210F, E224DB
Lama (2006)Pt38163816 NoneNone  D121H, K122E, I135T, K173R, G196E, L210F, F214L, A272P, V292I, I293V, E297K, K311R, Q334LB
Lindstrom (2006)SIIDC0275SIIDC0275 NoneNone  V35M, R83K, D123E, E169D, K173KN, Q174K, T200A, Q207A, L210F, R211K, E248QB
Rodrigues (2006)BR04RS139BR04RS139DQ070627NoneNone  V35I, I135T, T200A, L210F, R211KB
Santos (2006)B112B112DQ190965NoneNone  K20R, A98S, I135L, Q197E, T200A, L210F, R211QB
Brumme (2007)1244RT_1244EF369378NoneNone  D123E, I135T, S162C, G196E, T200A, Q207E, L210FB
 1388PRRT_1388EF368698NoneNone  V35VI, K122P, K173E, D177E, I178IM, T200TA, Q207E, L210F, A272P, K390RB
 1505PRRT_1505EF368815NoneNone  K122E, G196E, L210F, R211RKNS, T286TA, A288AS, I293V, E297A, I326IV, Q334QL, M357T, A376T, K390R, E399DB
 1798PRRT_1798EF369108NoneNone  A98S, K122E, L210F, F214L, I293V, E297V, A327V, M357T, V365I, K390RB
 1809PRRT_1809EF369119NoneNoneK70KQ, T215D I50V, V60I, A98S, I135T, E169D, G196E, T200A, L210F, V292I, I293V, E297R, I326V, R356RK, K390RB
Dilernia (2007)F398F398EF120263NoneNone  E6D, K122E, F130L, I135T, K166R, K173KQ, Q207E, L210F, R211K, D250X, A272P, I274X, Q334L, K347KQ, M357T, K385RB
Gatanaga (2007)A04-201016-1A04-201016-1AB640071NoneNone V179DI5IV, K20R, D123E, I135T, K166R, G196E, I202V, L210F, R211K, V245M, A272PB
 C04-51110131-1C04-51110131-1AB640231NoneNone  V35L, R83K, D123E, S162N, E169D, D177E, G196E, E204K, Q207E, L210F, R211KB
 C04-51110230-1C04-51110230-1AB640329NoneNone  K13N, V35I, A98S, I135T, Q174L, Q207E, L210F, R211KB
 C03-5555-5435-1C03-5555-5435-1AB640377NoneNone  I135L, S162C, I195M, G196E, L210F, R211GB
 C04-5555-6201-1C04-5555-6201-1AB640440NoneNone  A98S, K102Q, I135T, K166R, L210F, R211KB
 C04-5555-6380-1C04-5555-6380-1AB640461NoneNone  V35I, K122Q, I135L, S162C, D177E, E194Q, G196E, L210FB
 C04-2066220-1C04-2066220-1AB640488NoneNone  V35I, D76DN, R78RK, K122Q, R125K, I135L, S162C, R172K, D177E, E194Q, G196E, L210FB
Parker (2007)RW0543RW0543AY701367NoneNoneM41LV179DT39S, V60I, I142T, K166R, D177K, T200A, L210F, R211KB
 RW0546RW0546AY701389NoneNoneM41LV179DT39S, I142T, S162SC, K166R, D177K, T200A, L210F, R211KB
Vicenti (2007)415457716REF376665NoneNone  E6D, D123DE, I135T, I142T, D177E, I178M, I180V, L210FB
 455462304REF376933NoneNoneT215C V106I, V118I, K122E, I135T, T139K, F171Y, I202V, L210F, R211K, F214LB
von Wyl (2007)455933490EF449804NoneNone  R83K, K122E, D123E, E138A, K173Q, L210F, R211KB
Chang (2008)TW3641TW3641EU164891NoneNoneT215D E6D, S68G, K103R, I135V, T200TA, Q207E, L210F, R211K, F214LB
 TW10507aTW10507a NoneNone  V35I, T39X, R83K, I135V, K166R, E204Q, Q207E, L210F, R211KB
 TW5129aTW5129a NoneNone  K11KT, T39A, S68G, I135V, G196E, T200A, E204K, Q207E, L210FB
Ferreira (2008)46BR06PR46EU340734NoneNone  V35M, S48T, A98S, D123E, I135T, S162C, T200A, Q207N, L210F, R211K, L228HB
Holguin (2008)SP44-333546SP44-333546EU255417NoneNone  V35VI, K49R, I50V, R83K, D123E, I135T, I167X, D177E, G196E, L210F, R211K, A272P, K277KR, L283I, I293V, E297A, I329VB
Lloyd (2008)TX09003HN_TX090EU312828NoneNone  V35M, Y56YN, K101Q, K103R, D123E, I135K, S162C, Q174E, T200I, L210F, V245M, A272T, T286A, I293V, E297P, E312AB
 TX20003HN_TX200EU312930NoneNone  V35M, K101Q, K103R, D123E, I135K, S162C, Q174E, T200M, L210F, V245M, A272T, T286A, I293V, E297P, E312ATB
Palacios (2008)1256112561 NoneNone  V60I, D123E, I142V, S162A, Q207E, L210FB
Sirivichayakul (2008)NBC-20NBC-20RTJQ364404NoneNone  R83K, D123E, I142T, K166R, G196E, L210F, W252CB
Avi (2009)M66M66FJ154047NoneNone  K101Q, K102R, I135M, E138A, S162C, T200A, L210FB
Brumme (2009)P4527P4527GQ372085NoneNone  D17DE, K122E, I142V, S162C, G196E, T200A, L210F, V245E, K277R, L283I, I293V, K390R, A400T, E404D, W410WR, V435E, A437V, D460N, R461K, H483Y, S519SN, Q524E, I556IV, V559IB
Cuevas (2009)P1681P1681.1EU822743NoneNone  E6D, I142T, S162C, K173Q, T200A, Q207A, L210F, R211KB
 P1703P1703.1EU822751NoneNone  S48T, K49R, K103R, K122E, D123E, I135T, E169D, I178M, G196E, T200A, L210F, R211KB
 P1734P1734.1EU822762NoneNone  S48T, K49R, I135T, E169D, I178M, G196E, T200A, L210F, R211KB
Fujisaki (2009)655655AB442316NoneNoneT215DE V35I, S68G, D123E, I135L, S162C, D177E, G196E, Q197QK, L210F, R211KB
Lee (2009)S07033S07033EU715208NoneNone  E6D, V60I, R83K, K166R, K173KE, Q174R, D177E, I202V, Q207E, L210F, R211K, V245E, A272P, E312V, D324E, Q334LB
Luo (2009)sz.65804HBsz.658FJ375022NoneNone V179EK11R, I135V, S162N, T200A, L210F, R211K, K277R, Q278E, L283I, P294S, Q334LB
Nadai (2009)TRI00945TRI00945EU439734NoneNone  V35T, V60I, A98S, K122P, I135V, K173Q, T200A, Q207E, L210F, R211KB
 TR02914TR02914EU439739NoneNone  V8I, A98S, K122E, I178M, T200A, Q207G, L210F, R211KB
Smith (2009)PI18US2001PI18 NoneNone  E6D, D123E, I135T, T165I, L210F, V245M, K277R, I293VB
 CR102US2006CR102 NoneNone  E6D, K43KR, S68N, K122KE, D123DE, I135T, Q207QR, L210F, V245M, I257IL, K277R, Q278QH, I293VB
 CR121US2006CR121 NoneNone  E28A, V35I, A98S, K101R, D123DE, I135LV, T200A, L210F, E248D, D250E, A272S, K281R, T286A, A288AS, I293V, P294PST, E297KB
Vercauteren (2009)pt2127509818155GQ398897NoneNoneM184ML V35VI, V60I, A98AS, K122E, D123N, T139K, I142V, T200I, Q207E, L210F, R211K, A272S, E297AB
 pt15873838112166GQ399437NoneNone  K30Q, K32G, A33C, L34T, V35L, E36N, I37F, A98S, K166R, L210F, R211K, V245EB
 pt10726795753306GQ399952NoneNone  E6D, A98S, D123E, G196E, E203K, L210F, R211K, V245D, E248D, A272P, V292I, I293V, E297KB
 pt6928962601113GQ400332NoneNoneT215D V60I, S68G, I135T, I180V, L210F, T286A, K311R, I326VB
Brennan (2010)Pat061ARC-A177JN697318NoneNone  V35I, R83K, I135T, K173N, T200V, L210F, R211K, K238R, V245E, E248Q, A272S, I293V, H315YB
Descamps (2010)289odyssee289odysseeHQ718122NoneNone  V35M, E40D, R83K, K122P, S162N, T165I, D177E, G196E, L210F, R211KB
 453odyssee453odysseeHQ718286NoneNone  K20R, K122E, I135T, Q174H, G196E, T200A, L210F, R211K, F214L, T286P, I293V, E297K, V317A, S322T, Q334DB
Ragonnet-Cronin (2010)PHAC_347PHAC_347HM468845NoneNone G190AA98S, K122E, L210F, F214L, A272S, I293V, E297AB
 PHAC_545PHAC_545HM469043NoneNone  V35I, R83K, I135T, S162C, Q207G, L210F, R211K, V245M, A272P, I293V, E297AB
Aulicino (2011)3407-G3333407-G333HQ158226NoneNone  V35I, I135L, L210F, R211KB
Chibo (2011)S31S31JF895218NoneNone  E6D, D121DN, G196E, E203K, R206RK, Q207D, L210F, V245KB
 S60S60JF895247NoneNone  K11S, V35T, T39TA, E40ED, V60I, H96HP, K122E, D123N, I135T, I202V, E203EG, R206RG, L210F, R211KB
 S102S102JF895289NoneNone  K20R, I50V, D123E, K166T, K173R, D177E, T200A, L210F, V245KB
El Annaz (2011)47464746HQ393346NoneNone  S48E, D123E, S162A, T200A, L210FB
Ferreira (2011)BRMT2701BRMT2701HQ638721NoneNone  K20R, K101Q, D123E, L210F, R211Q, L228QB
 BRMT2835BRMT2835HQ638729NoneNone  V106I, D123E, L210F, R211K, E224DB
Kao (2011)Pat04337245HQ657997NoneNone  E6EK, I31IV, K122E, I135V, N175Y, G196E, L210F, W239L, V245G, I293V, I326VB
Sanabani (2011)BR1084BR1084JN692466NoneNone  K49R, I135T, D177H, L210F, R211K, F214L, V245I, I293V, P321S, D324P, Q334Y, K347R, V365I, T386I, A400T, T403I, G490E, A554NB
Truong (2011)0500141405001414JX073502NoneNone  I37X, D177E, L210F, F214LB
 0500031705000317JX073547NoneNone  K122P, K166R, L210F, R211KB
Avila-Rios (2012)M500FD1IUBM500FD1IUBKC169265NoneNone  S48T, V60VI, D121H, K122E, I135T, E138A, T200E, I202V, L210F, R211RK, A272P, V276I, L283I, A288AT, I293V, E297Q, L301I, V317A, S322T, L325IB
 M500MD7LUCM500MD7LUCKC169266NoneNone  S48T, D121H, K122E, I135T, E138A, T200A, I202V, L210F, F214FL, A272P, V276I, K281R, L283I, I293V, E297Q, L301I, K311R, V317A, S322T, L325IB
 O000MD3NTXO000MD3NTXKC169431NoneNone  V35X, K102R, K104R, D123DE, I135IV, D177DE, Q207N, L210F, R211K, A272S, I293V, E312T, I326TB
 P2UVF97TJTP2UVF97TJTKC169569NoneNone V108VIV35M, T39TA, K64KR, V118VI, K122KPQT, D123E, I142V, Q174R, D177E, I178IV, L210F, F214L, V245M, K259KR, K281KR, E291ED, E297A, I329L, Q334EB
 E000FG0SKCE000FG0SKCKC168512NoneNone  E6ED, V35I, T39A, K122P, I135T, I142V, D177E, T200A, I202V, L210F, R211K, I293V, P294T, I326VB
 E200M7ALSJE200M7ALSJKC168697NoneNone  K20R, V60I, A98S, K122P, I135V, D177E, L210F, A272P, V276VI, K277R, I293V, E298G, S322A, Q334NB
 C000MG_TRDC000MG_TRDKC168191NoneNone  V60I, R83K, L120LI, K122P, D177DE, I178IL, T200TA, L210F, R211K, A272P, K277R, I293V, E297A, Q334LB
da Silveira (2012)BRMS22BRMS22JF342279NoneNone  V35T, K122E, I135T, L210F, F214FL, P243TB
Delwart (2012)476-7173-1476-7173-1JN214956NoneNone  K102R, K122E, I178M, L210F, R211K, V245M, D250E, I293VB
 478-1600-6478-1600-6JN215084NoneNone  E53D, K82R, I142T, T165I, E169D, D177E, I178L, L210F, R211K, V292I, I293VB
Frange (2012)972104JR972104JRJQ292205NoneNone  K122E, D123S, I135T, Q207A, L210F, R211K, V245KB
 751610WBY751610WBYJQ292659NoneNone  K122E, T200A, E204D, L210F, R211KB
Ragonnet-Cronin (2012)A05_051A05_051JX014658NoneNone  E6D, D123E, I135T, E194D, L210F, V245I, K277R, I293VB
 A05_070A05_070JX014673NoneNone  E6D, D123E, I135T, L210F, V245M, K277R, I293VB
 A05_078A05_078JX014677NoneNone  A98S, D123E, D177E, L210F, F214L, I293V, E297AB
 A10_052A10_052JX014699NoneNone  E6D, K102Q, D123E, S162C, D177E, Q207E, L210F, R211K, A272P, V276I, K277R, L283I, I293V, E297A, A304EB
 A10_126A10_126JX014727NoneNone  V35M, T39A, A98S, Q207N, L210F, R211K, A272S, T286A, A288AS, I293VB
 A10_234A10_234JX014777NoneNone  E6D, V8VI, V35VI, K122KE, D123E, I135T, G196E, L210F, V245IM, I293VB
 A10_417A10_417JX014841NoneNone  E6D, R83K, D123E, I135IT, I178M, G196E, L210F, K277R, I293VB
 B07_086B07_086JX014888NoneNone  E6D, K64KR, D123E, L210F, M230MV, V245VM, K277KR, I293IVB
 B07_182B07_182JX014920NoneNone  A98S, K102KQ, K103KR, I135V, K173E, T200A, L210F, R211K, V276I, L283I, T286A, I293VB
 F09_013F09_013JX015096NoneNone  E6D, D123E, I135T, L210F, V245M, K277R, I293VB
Ragonnet-Cronin (2012)PHAC08_084PHAC08_084JQ674820NoneNone  V35M, A98S, K122E, I135R, K173KQ, D177DE, I178L, I202V, L210F, R211T, F214L, V292VI, I293V, E297AB
 PHAC08_151PHAC08_151JQ675103NoneNone  V35L, A98S, K122KE, Q174K, I178L, Q207H, L210F, I293V, P294A, E297AB
 PHAC08_236PHAC08_236JQ675150NoneNone G190AT39A, R83K, D123E, S162SHNR, V179I, L210F, V245VEKM, A272P, K275R, K277R, I293V, E297AB
 PHAC09_002PHAC09_002JQ675195NoneNone  D123E, G196E, L210F, W212WG, A272P, K277R, I293V, E297AB
Alencar (2013)RJ2-0056RJ2-0056JQ238103NoneNone  E6D, K20R, H96L, A98Q, K102KR, I135T, L210FB
 RJ2-0057RJ2-0057JQ238104NoneNone  E6D, K20R, I135T, L210F, L228XB
Brooks (2013)CAN2013-052CAN13-052KF727886NoneNone  V35T, E36D, D123E, I135T, G152GR, D177E, G196E, T200A, E204K, Q207E, L210FB
Frentz (2013)EHR-56225EHR-56225JX300476NoneNone  T7I, T27S, V60I, K122E, D123N, T139K, I142V, S162A, E169D, Q174N, T200I, Q207N, L210F, R211KB
 EHR-67345EHR-67345JX300672NoneNone  V60I, K104N, K122E, D123N, T139K, I142V, S162A, Q174K, T200M, Q207D, L210F, R211K, V245EB
 EHR-69685EHR-69685JX300710NoneNone  V35E, V60I, K122E, D123N, T139K, I142V, T200I, Q207D, L210F, R211KB
 EHR-92377EHR-92377JX301083NoneNone  V35I, A98S, I135T, K166R, L210F, R211K, V245EB
Hawke (2013)9077538 H9077538 HKC238253NoneNone  E6ED, V8VI, K11KR, V35I, K122E, I135T, I202V, L210FB
Heipertz (2013)306501_RT306501_RTJX863962NoneNone K103NE6D, K122E, T200E, L210F, R211K, T286A, I293V, I329L, G335S, Y342F, T377V, K390R, A400T, T403A, V435AB
Kiertiburanakul (2013)R73002R73002KC810571NoneNone  A98S, G196E, L210F, V245EB
 R73191R73191KC810718NoneNone  E6D, K166R, K173E, G196E, Q207QH, L210F, R211RKB
 R75014R75014KC962547NoneNone  V35VI, T39A, V111I, D123DE, I135T, T165TS, K166KR, G196E, Q207E, L210F, R211K, A272G, K277R, Q278E, T286TA, I293V, E297R, I326V, Q334LB
Lunar (2013)14963-1014963-10JX028316NoneNone  V35E, V60I, A98S, K122E, D123DN, T139K, I142V, T200I, Q207E, L210F, R211KB
 10159-0610159-06JX028399NoneNone  V60I, K104N, K122E, D123N, T139K, I142V, S162A, Q174K, T200M, Q207D, L210F, R211KB
 7820-077820-07JX028373NoneNone  T7I, T27S, V60I, K122E, D123N, T139K, I142V, S162A, E169D, Q174N, T200I, Q207N, L210F, R211KB
 9296-069296-06JX028405NoneNone  V35I, A98S, I135T, K166R, L210F, R211KB
 8902-068902-06JX028395NoneNone  V35E, V60I, K122E, D123N, T139K, I142V, T200I, Q207D, L210F, R211KB
 7672-097672-09JX028349NoneNone  K11N, K20R, V35E, V60I, A98S, D123E, T139K, I142V, D177E, T200I, Q207K, L210F, R211KB
Tramuto (2013)CV1347_122CV1347_122HQ667703NoneNone G190AK49R, K101A, K103KR, K122E, S162A, K173KR, V179I, G196E, L210F, R211RK, V245M, S251N, A272P, K277R, E297KQ, E300Q, Q334EB
Zeng (2013)cdbc59cdbc59KC352131NoneNone  V35K, T39D, S48T, V60I, H96P, D121Y, K122E, I135R, E204A, L210FB