<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation L210F
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 19
Patients 28
Isolates 35
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hammer (1997)ACTG320_1818 AZTNoneM41ML, D67N, K70R, T215Y, K219Q G196E, L210F, K277R, I293V, P294T, E297K, S322T, Q334E, A355AE, K366KR, A376T, K390R, A400T, K454R, D460N, L491LFB
 ACTG320_361361 DDC, AZTNoneD67NT, K70R, T215F, K219E E6D, T39TP, T69N, K102Q, S162C, I202V, L210F, R211K, L228H, K277R, T286A, P294T, E297K, Y342F, M357I, R358K, A376V, K390R, A400T, T403TM, N447S, L452I, T470A, H483CB
Murphy (1999)ACTG347_0068068_RT_w21 AZT, 3TCNoneM184V V35T, K122E, K166R, I202V, Q207E, L210F, R211KB
Pellegrin (1999)IP-13IP13-M6 D4T, DDINone  I31V, R83K, K122E, E138EA, S162A, K173KN, Q174QE, V189I, I202V, L210F, P243PHLRB
Falloon (2000)JF01JF01-(-)1wAF227707AZT, DDI, DDC, D4T, 3TCNoneM41L, D67N, T215Y E53D, L210F, V245EB
  JF01-8wAF227708AZT, DDI, DDC, D4T, 3TC, ABCNoneM41L, D67N, K70KR, T215Y E53D, L210F, V245EB
Albrecht (2001)ACTG364_904904 DDI, AZT, 3TCNoneM41L, D67N, T215Y V118VI, K122E, I135V, S162C, G196E, L210F, R211Q, V245T, I293VB
Gonzales (2001)CA597CA1121AY030411AZT, 3TCNone  D121H, K122E, D123E, S162C, L210F, R211QB
 CA4497CA10983AY031337AZT, 3TC, DDC, D4TNoneA62AV, V75LS, M184V K20KR, V35IT, K122E, I135T, K166R, L210F, R211K, A272P, K277R, L283I, I293VB
 CA4504CA10993AY031343DDC, AZT, 3TC, D4T, DDINoneM41L, D67N, K70R, T215F R72RG, E169D, D177E, Q207E, L210F, R211K, M230MV, A272P, I293VB
Perez (2001)EP-1875EP-1875AF320518NRTINone  V60I, I135T, Y144G, K173K*EQ, T200A, Q207E, L210F, P243SB
Tural (2002)880810880810 3TC, D4TNoneM184V K65E, K122E, S162C, E169D, L210F, R211KB
Shafer (2003)A384_30983098bEF548267D4T, DDINoneD67N R83K, I135T, E169D, G196E, T200V, L210FB
Kuritzkes (2004)KDR_pat31A0029AY527846D4TNone  K102R, D123E, E169D, G196E, L210F, R211RKB
  A0032AY527849D4T, 3TCNoneK70R, M184V K102R, D123E, E169D, G196E, L210F, R211RKB
 KDR_pat218A0293AY528110D4TNone  V106VI, D123E, K166KR, T200AE, L210FB
  A0294AY528111D4T, 3TCNoneM184V, T215NY V106VI, D123E, A158AS, T200A, L210FB
Machado (2004)cs129cs129AY313413AZT, DDINoneM41L, D67N, T215Y D123E, I178L, V179I, G196E, I202V, L210F, R211KB
Montes (2004)MB_patSEG02_SEGS703AJ578158ABC, AZT, 3TC, D4TNone  E6D, K49R, I135T, I195L, Q207E, L210F, R211KB
 MB_patDEP01_DEP716AJ577877AZT, DDI, 3TC, D4TNoneM41L, M184V, T215Y K122E, D123N, I135L, S162C, I195L, L210FB
Rhee (2005)SWC-0835P835-823 D4T, 3TCNoneM184V I31IL, R83RS, F87FL, D123E, I167IM, L210F, R211KB
 CA8095CA20250AY801953D4T, DDINoneD67N E6D, V35I, R83K, I135T, E169D, G196E, T200V, L210F, K277R, E297KB
  CA24660AY801954D4T, DDINone  E6D, K20KR, V35I, R83K, I135IT, E169D, G196E, T200V, L210F, K277R, E297KB
 CA8356CA21064AY801974AZT, 3TC, D4T, DDINoneD67DN, K70R, K219Q E6D, V35T, K64KN, A98S, T200I, L210F, R211T, L228R, Q278QH, T286A, E297KB
  CA24248AY801975AZT, 3TC, D4T, DDINoneD67DANT, K70R, K219Q E6D, V35T, K64N, A98S, T200I, L210F, R211T, L228HR, T286A, E297KB
 CA14205CA34336AY802269AZT, 3TC, D4TNoneM41ML, M184V, N348I K122P, I142IV, S162SN, L210F, R211K, K277R, E291D, A327V, I341IF, M357T, E370G, K390R, E404D, V435A, L452S, D460N, R461K, L469I, L491P, Q509H, S519N, Q524EB
  CA41367AY802270AZT, 3TC, D4TNoneM41ML, M184V K122P, I142IV, S162SN, L210F, R211K, K277R, E291EDB
 CA14219CA34357AY802271AZT, 3TCNoneM41L, D67N, T69D, M184V, T215Y K122E, D123DN, I135T, T200A, E203EDV, Q207E, H208Y, L210F, R211K, H221HY, P243S, V245E, A272S, T286A, I293V, E297K, A304E, E312Q, A360V, A371V, A376T, T386I, K390R, A400T, T470P, K527N, A554SB
 CA14449CA42758AY802343AZT, 3TC, ABCNoneD67N, K70R, M184V, K219Q K11KRT, T39TS, T69N, K122P, D123S, L210F, V245KB
Lama (2006)Pt32273227 NRTINoneM184V E6D, S48T, K101KQ, K166R, D177E, I178M, L210F, V245M, A272P, K277R, T286TA, K311KR, V317VA, I326VB
Santos (2006)019019PR_RTAY275727AZT, 3TCNone  V179I, G196E, T200A, I202V, E204G, L210FB
Rosen-Zvi (2008)5200p52-1 AZT, DDC, D4T, DDI, ABC, 3TCNoneD67N, K70R, V75T, K219Q V35I, K43Q, K64Y, K102KR, K103R, V118I, L210F, F214L, D218DE, L228H, K277R, T286A, A288T, I293VB
Rhee (2009)CA14205CA84222FJ983348AZT, 3TC, D4TNoneM184V K11KR, K122P, I142V, I178IM, L210F, R211K, K277R, E291DB
von Wyl (2010)47988974798897GQ848141AZT, DDI, 3TCNoneM184V V35I, R83K, K166R, I195T, G196E, L210F, K277R, T286A, E297K, V317A, S322T, G333GE, A376V, T386A, K390R, A400TB
Melo (2012)0614SV0614SVJF804809NRTINone  D123E, I135T, F171Y, D177E, G196E, I202V, L210F, A272P, M357T, V365I, S379G, T386I, T403V, F440Y, L452Q, S468T, H483Y, G490E, Q547R, A554TB