<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation M184V
Rx RTI-naive
IncludeMixtures No
References 73
Patients 174
Isolates 178
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Gonzales (2001)CA4425CA10636AY031279NoneNoneM184V E29D, V35T, V60I, R83K, G196E, T200TA, I202V, V245Q, A272P, K277RB
Perno (2001)PCF_Pat23PCF3776AF376699NoneNoneM184V K20R, K102Q, K122R, D123E, I135T, S162C, R211K, I293V, E297KB
Brindeiro (2003)BRC1537BRC1537AY213530NoneNoneM184V E6D, K49R, P119L, K122E, I135T, E169D, G196E, T200I, Q207K, R211AB
Gulick (2004)RG44RG44w0 NoneNoneM184V I37IFLV, K102Q, K122E, I135V, S162C, D177DE, T200A, Q207E, R211K, V245IMB
Yerly (2004)167GE98_167AY562471NoneNoneM184VK101E, G190AK49R, E53D, K122E, I135T, L168LPS, E169D, T200AB
Bernardin (2005)10581058-08AY331294NoneNoneM184V V35A, T39A, R83K, K122R, D123E, I135V, D177E, R211K, S251T, K277R, Q278H, K390R, A400S, E404D, Q524E, A534T, Q547KB
  1058-11AY331295NoneNoneM184V V35A, T39A, R83K, K122R, D123E, I135V, D177E, R211K, S251T, K277R, Q278H, K390R, A400S, E404D, Q524E, A534T, Q547KB
Escoto-Delgadillo (2005)18GDLEVV-RT_18GU291865NoneNoneV75A, M184VK103NK64R, F77S, V90F, P119PS, D123E, I135T, K166R, T200A, Q207D, R211RKB
Vazquez de Parga (2005)RU01009RU01009EU345724NoneNoneM184V V35I, A98S, K122Q, I135L, R172RK, D177E, I178M, E204A, Q207E, E248EK, T286A, E297AB
Jayaraman (2006)2-00-06342-00-0634 NoneNoneM184V S162C, T200AB
 2-01-01352-01-0135 NoneNoneM184V A98S, T139K, S162C, G196E, Q207E, R211K, F214L, L228Q, V245EB
Lama (2006)Pt40434043 NoneNoneM184VK101E, K103NT27S, E28K, T39S, D121Y, K122E, D177E, E203K, R211K, V245E, I293V, E297T, V317A, I329VB
Saad (2006)MDS_02UAKV17702UAKV177DQ055305NoneNoneM184V K32N, V35I, A98S, D123E, I135R, T200IB
Santos (2006)PA178PA178DQ343977NoneNoneM184VK103NA98S, I195L, T200AB
 PA227PA227DQ343995NoneNoneM184V K20R, I135T, Q174H, R211KB
 057RT057RTAY275790NoneNoneM184V D123E, S162C, K166R, D177N, T200A, L210S, F214LB
 B150RTB150RTDQ190952NoneNoneM184V V35I, R83K, I135T, Q197E, I202VB
 B025RTB025RTDQ190993NoneNoneM184V K82R, K122E, I142V, R211KB
 B042RTB042RTDQ190997NoneNoneM184V K122E, I135T, K173T, I178M, T200A, Q207N, R211KB
 DB104RTDB104RTDQ191037NoneNoneM184V K49R, V60I, K122E, I135L, D177E, W239X, E248QB
 PA136PA136DQ343966NoneNoneM184V I50V, A114V, K122E, D123E, I135T, T200A, I202VB
Valle-Bahena (2006)RT-54PROT-RT-54DQ150721NoneNoneM184V D123E, S162Q, D177E, A272P, I293V, P294S, W337M, G359S, A371V, K390R, A400T, V435LB
Zarandia (2006)MZ_03GEMZ01503GEMZ015DQ205272NoneNoneM184V V35I, K122Q, I135T, D177G, E194K, Q207EB
Brumme (2007)1086RT_1086EF369220NoneNoneM184V V35I, R83K, K122R, I135T, D177E, I178M, T200E, Q207H, R211KB
 1379PRRT_1379EF368689NoneNoneM184V I135L, T139TS, S162C, K173S, I178L, T200A, Q207K, R211M, A272P, V276I, K277R, L283I, I293V, E300ED, V317A, S322T, K390R, K395R, E399DB
Gatanaga (2007)C03-5555-5061-1C03-5555-5061-1AB640342NoneNoneM184V T7P, K20R, V35T, A98S, K122E, I178M, T200A, Q207E, P225SB
 C04-5555-5926-1C04-5555-5926-1AB640406NoneNoneM184V K32KR, V35I, I50IV, K122KE, I135L, S162C, T200TI, R211RKB
Gonsalez (2007)90HIV_90GU288716NoneNoneM184VK103N, P225HE6D, K11R, K101Q, I135T, I178M, T200I, R211K, L228N, V245MB
Holguin (2007)566846566846EF583181NoneNoneM184VK101KAET, K103KN, V106VAK49R, K102KR, I135L, K166R, E169D, I202V, R211K, F214L, V245L, A272P, K277R, T286A, I293V, K311R, G333E, Q334SB
 598842598842EF583228NoneNoneM184VV106M, V179DV35I, R83K, K122E, I178L, R211K, V245M, A272P, I293V, E297A, K311R, G333DB
Rios (2007)CH26MR_CH26EF193913NoneNoneM184V K122E, S134SI, K166R, R172RK, D177E, R211K, D250E, K277RB
Sanchez Onoro (2007)598842598842 NoneNoneM184VV106M, V179DV35I, R83K, K122E, I178L, R211K, V245M, A272P, I293V, E297A, K311R, G333DB
Sucupira (2007)BRR_03_99BRR_03_99DQ903001NoneNoneM184V S48T, K49R, K122E, I135T, S162CB
Chang (2008)TW8145TW8145DQ640278NoneNoneM184V V35L, K166KR, I178IM, Q207E, F214LB
 TW6335TW6335EU164874NoneNoneM184VV106A, G190GA, F227LV35M, S68SG, K122E, I178L, T200A, I202IV, Q207E, F214FLB
 TW8189TW8189EU164878NoneNoneM184VG190AT27TP, E28A, K122E, I135T, K166R, K173KE, F214L, V245IM, L246VB
 TW9570TW9570EU164898NoneNoneM184VV179EV35M, K43N, I135T, A158S, S162C, K166R, D177E, I178M, T200AB
 TW8023TW8023EU164912NoneNoneM184VV179DV35L, V60I, R83K, K103R, I135L, K173E, Q207EB
 TW1409aTW1409a NoneNoneM184VK103N, V108IV35L, R83K, K122E, I135L, Q207E, R211KB
Holguin (2008)05SP24-27995805SP24-279958EU255327NoneNoneM184V I135T, R211RK, F214FL, V292I, I293V, I326IVB
 SP48-276330SP48-276330EU255351NoneNoneM184V A98S, D123E, I142V, A158S, I202IM, R211KB
 SP53-290843SP53-290843EU255356NoneNoneM184VV106A, V179E, F227LV35I, R83K, K102R, I135T, G196E, T200I, Q207E, T286A, I293V, E297K, P313A, V317AB
 SP67-267814SP67-267814EU255370NoneNoneM184VA98AEGV, K103N, P225HK20KR, V35LPQR, K122E, I135L, S162C, T200A, V245K, I293V, I329V, Q336XB
 SP51-328859SP51-328859EU255424NoneNoneM184VK101E, G190AI37IM, K49KR, I142IV, Q207EG, R211K, F214L, K277R, E297EK, I326V, I329VB
 SP21-0240626SP21-0240626EU342754NoneNoneM184V V35T, T39A, D123E, S162C, I178L, G196E, T200I, E204EK, R211K, A272P, T286A, A288S, E297K, D324EB
Lloyd (2008)CR04003HN_CR040EU312649NoneNoneM184VK103N, V108VIV60I, A98S, I135T, Q174E, I202V, R211M, V245E, A272P, I293VB
 CR04203HN_CR042EU312651NoneNoneM184VK103N, V108IK20R, I135T, S162C, Q174E, Q207R, F214L, H221Y, V245M, K249R, A272S, K277R, Q278E, I293V, E298A, E312KB
 CR09003HN_CR090EU312676NoneNoneM184VK103N, V108I, G190AK101Q, D123E, I135K, Q174K, T200I, R211S, V245M, A272T, K277R, T286A, I293VB
 CR09403HN_CR094EU312679NoneNoneM184VK103NK20R, V35I, D123E, I135L, Q174E, D177E, Q197R, R211K, V245M, S251R, K277R, T286A, V292I, I293V, E297AB
 CR16403HN_CR164EU312719NoneNoneM184VY181CV35I, D86E, D121Y, K122E, I135T, I142T, T165M, I178L, I195T, T200TA, F214FL, V245VM, A272P, V276I, L283I, I293V, E312TB
 CR00603HN_CR006EU312722NoneNoneM184VK103NV60I, A98S, I135T, Q174E, I202V, R211M, V245E, A272P, I293VB
 CR00903HN_CR009EU312723NoneNoneM184VK103N, P225HV60I, K101Q, I135T, I178M, T200A, V245Q, A272P, T286A, I293VB
 TX17003HN_TX170EU312908NoneNoneM184VY181CV35VA, D123E, I135R, A158AT, K173R, I202V, R211K, F214L, D250E, A272P, K277R, I293V, P294S, E297RB
Riddler (2008)60381535D_bsHM056607NoneNoneM184V K20R, K122A, I142T, K166KR, K173Q, I178L, V179VI, R211K, A272P, G273R, K275R, K277R, Q278H, T296TS, E297K, I329L, A376V, K390R, A400T, V417I, V435I, R461K, S519N, A554TB
Brown (2009)CAS_1069_16_38764CAS_1069_16_38764FJ030648NoneNoneM184V R83K, I135T, S162Y, R211GB
de Sa-Filho (2009)5504255042PgrGQ294604NoneNoneM184VV108IK102Q, I135T, S162CB
Dumans (2009)202_05202_05FJ405102NoneNoneM184V K20R, K122E, I135T, R199S, T200R, R211K, V245KB
Smith (2009)PI253US2000PI253 NoneNoneM184V E6D, T39A, D123E, I142V, S162C, R211Q, V245T, K275KQ, K277KR, V292I, I293VB
 PI322US2002PI322 NoneNoneM184V E6D, R211A, V245K, G273GR, T286A, I293VB
 PI328US2003PI328 NoneNoneM184V P4PL, K20R, R83K, V90I, K102KQ, I135V, S162CY, G196E, R211GB
 CR178US2006CR178 NoneNoneM184VK103NE28K, D123E, I135T, S162C, D177E, T200A, I202V, Y232H, V245E, I293V, P294QB
 CR207US2006CR207 NoneNoneM184VK103N, G190GA, P225PHV35I, S48E, K82KR, R83K, V90VI, K101KQ, K102Q, T200TA, R211K, A272AP, K281KR, R284K, I293V, P294PTB
 CR234US2006CR234 NoneNoneM184V A98S, D123E, I135IV, I142IT, Q174H, D177E, R211KQ, R284K, T286A, T296S, E297KB
 CR242US2006CR242 NoneNoneM184V K102R, T139K, D177E, I178M, V179I, R211K, F214FL, H235HR, V245E, T286A, A288AV, E291ED, I293IM, E297K, A304EB
Thomson (2009)SP_B_004RU_SP_B_004FJ009782NoneNoneM184V D123E, I142V, S162A, K166KR, D177E, R211K, F214L, V245T, A272P, K277R, T286TA, A288S, I293V, E297KB
Vercauteren (2009)pt15563993935960GQ399468NoneNoneM184V I50V, K122E, I142V, T200A, F214L, V245TB
 pt8787935314489GQ400146NoneNoneM184VK103N, K238TE28A, V35T, V60I, K122E, I135V, S162C, F214L, V245K, A272P, I293V, E297A, D324E, I326VB
Wang (2009)CR0222XCR0222XFJ469709NoneNoneM184V, N348I V21I, I135L, V245E, E248N, V276I, Q278E, L283I, I293V, E298A, R356K, A376T, K390R, T403M, V417I, E432D, A446S, R461K, K527N, A554SB
 L861PL861PFJ469748NoneNoneM184V V60I, R83K, K102R, I135V, R211K, I244V, D250V, A272P, E297Q, S322T, I329L, A360V, A400T, V435I, D460N, R461K, K465R, V467I, L469I, H483N, L491P, A554SB
Bonura (2010)865_77865_77GU969490NoneNoneM184VK103N, Y188LR83K, K102KR, K122E, R211K, E224D, A272P, I329VB
Brennan (2010)ARC-A240ARC-A240GU565680NoneNoneM184V K20R, I37IS, E44EK, K49R, K122E, D123NS, E138A, I142IV, D177E, V179I, F214L, P243S, I293V, E297EK, D320DNB
 ARC-A242ARC-A242GU565681NoneNoneM184VK103NK11R, R83K, I142V, S162A, D192DN, I202V, L210S, R211K, A272P, K311KR, D324E, I329L, Q334YB
Hattori (2010)C08-6000C182C08-6000C182AB865842NoneNoneM184V K102R, D121Y, K122E, I135V, I142IV, S162C, I195L, T200EK, R211G, V245KB
 C08-504501C08-504501AB864611NoneNoneM184V R83K, K122E, I135T, T200A, I202V, R211KB
 F07-5112093F07-5112093AB866729NoneNoneM184V V35T, T39A, T69TA, D123E, I135K, S162C, K173Q, Q174R, T200A, Q207E, V245NB
 C08-6000C197C08-6000C197AB865850NoneNoneM184VK103N, M230MLE53D, D123E, I135T, S162A, Q174R, D177E, G196E, F214LB
 F08-5112190F08-5112190AB866821NoneNoneM184V E6D, E28EK, K32KE, V35M, T39S, K122KE, I135L, V179VI, I195L, G196GE, T200A, E203ED, Q207QE, R211RK, E248DB
Yebra (2010)32435006SP324350FJ481806NoneNoneM184V K49R, R83K, V90VI, L120S, S134SG, S162X, T165TI, E169D, G196EB
de Felipe (2011)SE94RT_SE94JF338786NoneNoneM184VK101KE, K103KN, Y181CV60I, D123E, I142IV, D177DN, V179I, T200E, E203EK, R211KB
 SE93RT_SE93JF338785NoneNoneM184VL100LI, K101KE, K103N, V108VIK82R, T200V, R211KB
El Annaz (2011)26112611HQ393336NoneNoneM184V K102R, V118I, K122E, Q174E, T200A, Q207E, R211K, F214L, V245EB
Sanabani (2011)BR2018BR2018JN692449NoneNoneM184VK103ND123E, I135M, K166R, V189I, T200A, A272P, K281R, P294T, E297K, V317A, Q334N, Y342F, M357T, A376S, T377I, K390R, T397I, A400T, V435I, D460H, R461K, T470S, H483L, I506L, L517I, K527R, A554TB
Santos (2011)J63J63_PR_RTJN010450NoneNoneM184VK103NV35I, I142V, E169D, G196V, T200K, Q207E, R211KB
Truong (2011)0500109305001093JX073489NoneNoneM184V K49R, D123E, I135T, D177E, R211K, V245TB
Avila-Rios (2012)JFJ0MG0SRLJFJ0MG0SRLKC169131NoneNoneM184VY188LV106I, K122P, S162N, D177N, V189I, Y232H, K249Q, P294T, K311R, Q334EB
 CJ00MB2MQECJ00MB2MQEKC168228NoneNoneM184V V35M, D123E, K173N, Q174K, I178M, Q207E, R211K, A272P, P294Q, E312T, D324DEB
 VJ00MF5IUMVJ00MF5IUMKC169741NoneNoneM184V V35M, R83K, K122P, I135L, I142V, K166R, D177E, G196E, T200A, R211K, A272P, K277R, I293V, E297Q, L301I, D324DE, Q334LB
 J0JYMB5PR5J0JYMB5PR5KC169007NoneNoneV75L, M184VG190SK20R, E53D, V90I, K122P, A272S, I293V, P294S, E297K, D324E, I326LB
De Gascun (2012)IRL15220IRL15220JN622634NoneNoneM184VK103NR83K, V90VI, D123E, T200A, I202V, Q207K, R211KB
 IRL31721IRL31721JN622657NoneNoneM184VK103N, G190GA, P225HV60I, F77FS, Q197K, T200E, E204D, R211KB
Delwart (2012)476-8892-6476-8892-6JN214970NoneNoneM184VP225HV8I, T200A, K277RB
Machado (2012)CUPL1114CUPL1114JX194193NoneNoneM184VY181CK20R, K49R, A98S, D123E, I135T, E169D, D177E, I178L, Q207K, F214LB
 CUPL1119CUPL1119JX194198NoneNoneM184VY188LV35M, A98S, E138A, S162C, G196E, Q207D, R211KB
Melikian (2012)CA75822CA162699 NoneNoneM184VV106M, V179DV35VI, D123E, I135T, F214L, Y232H, I244V, T286A, I293VB
Murillo (2012)1139711397KC412769NoneNoneM184V K20KR, E28EA, V60I, D86E, I142V, S162H, D177E, I178IM, V245MB
 1201312013KC412787NoneNoneM184V V35M, T39A, K82R, R83K, V118I, D123E, I135T, S162G, D177E, R206RG, R211K, F214L, E248DB
Ragonnet-Cronin (2012)A05_063A05_063JX014667NoneNoneM184V E6D, I135IL, S162C, T200I, I274V, K277R, I293V, E297AB
 B07_181B07_181JX014919NoneNoneM184V S68N, I178M, T200A, R211K, V245K, S251I, I293V, E297KB
 D05_004D05_004JX015017NoneNoneM184VK101E, K103N, P225PHV10VL, E28K, V60I, I135T, S162C, T200A, I202V, Q207GR, R211K, L283LI, I293V, E312RB
Ragonnet-Cronin (2012)PHAC07_311PHAC07_311JQ674784NoneNoneM184VK103N, V108II135T, S162C, D192DN, G196E, H221Y, S251SI, K277R, I293V, E297AB
 PHAC09_039PHAC09_039JQ674897NoneNoneM184V V35I, K104R, I135K, K173E, Q207E, V245T, A272P, I274V, K277R, I293VB
Grgic (2013)cro481cro481HE653294NoneNoneM184V I135L, F171Y, D177E, T200IB
Bao (2014)HN-13HN-13KJ193539NoneNoneM184VK103N, Y181CK102Q, K122E, D123N, I135V, T200A, E203D, H221Y, A272P, K277R, Q278EB
Chikata (2014)KI-700KI-700AB874050NoneNoneM184V V35VI, V60I, I135L, I142V, S162C, D177HN, G196E, T200A, R211G, A272P, A288G, I293V, E297A, K311R, D324E, Q334L, E344D, M357I, R358K, K390R, T403M, E404D, R463K, I556VB
Martin (2014)ACU19ACU19KJ869918NoneNoneM184VK101E, G190AD123E, D177E, T200A, Q207E, V245E, I329L, M357T, A376SB
Meixenberger (2014)07-0100307-01003KJ770541NoneNoneM184V K11KR, V35X, A98S, I135T, S162C, T200I, R211A, K277RB
 10-0186510-01865KJ771290NoneNoneM184V V35R, A98S, I135T, S162C, T200I, R211A, K277R, Q278H, T286AB
 98-0024498-00244KJ771849NoneNoneM184V K32E, V35I, K64R, D123E, I135R, D177E, I178M, R211K, A272P, K277RB
 12-0103512-01035KJ771717NoneNoneM184V I135T, I142V, R211KB
 11-0273111-02731KJ771561NoneNoneM184V V35R, A98S, I135T, S162C, T200I, R211A, G213GR, F214L, K277R, Q278H, T286AB
Ross (2014)747747KF262860NoneNoneM184VK103N, V108VIK122KE, D123X, I135IT, N136NK, D177DE, T200A, Q207EB
 866866KF262963NoneNoneM184VK103N, V108VIK122E, D123DGNS, I135IT, T200A, Q207EB
Velasco-de-Castro (2014)05BRRJLTS27505BRRJLTS275KF922060NoneNoneM184VK103NR83K, I135IL, I142T, K166R, R211QB
 05BRRJRS6405BRRJRS64KF922121NoneNoneM184VV108VI, Y181CT27S, K49R, I50V, I135T, D177E, I178V, H221YB
 05BRRJRS2005BRRJRS20KF922082NoneNoneM184VA98G, G190AK20R, K122E, I135T, T200A, E203D, R211K, F214LB
Weng (2014)200936200936 NoneNoneM184V V35I, V60I, K122E, I135L, V245E, A272P, K277R, I293V, E297A, S322A, Q334LB
Carvalho (2015)284284KM206114NoneNoneM184V R83K, K104R, D123E, I142V, K166R, G196E, R211K, V245EB
 9292KM205986NoneNoneM184V T39A, S48T, D123E, Q174K, V179VI, T200TA, Q207E, R211K, V245MB
 129129KM205949NoneNoneM184VV179D, G190AV90VI, K102KR, I135R, S162SC, D177E, V189I, E203EK, R211K, D237DEB
Guimaraes (2015)BRSP892-14BRSP892-14KP115571NoneNoneM184V K32G, A33C, L34T, V35L, E36N, I37F, E40D, K49R, V60I, K103R, V118I, K122P, D123E, N175NY, V179IT, T200A, R211K, F214LB
Moura (2015)BRMA_197BRMA_197KF782732NoneNoneM184V D17E, V35T, D76N, R78K, R83K, K122KE, D123E, I135T, I142V, P176Q, E194ED, G196E, Q197K, I202V, F214LB
Yao (2015)TZ07ZJD1010TZ07ZJD1010KJ614133NoneNoneM184VG190AV35M, I135M, S162D, T200A, K277R, Q278EB
Castley (2016)P060148405P060148405KT228344NoneNoneM184V K104N, K122E, D123S, K173KR, T200AB
 P080186034P080186034KT228481NoneNoneM184VV108I, P225HV35R, S68G, K122AV, D123N, I135T, W153WG, D177EB
 P128114778P128114778KT228835NoneNoneM184VK101KE, Y181C, G190AK122E, D123E, S134SN, I135T, K173Q, D177E, V179I, Q197P, T200K, I202IV, Q207EB
 R040216795R040216795KT229240NoneNoneM184V E89EK, I135T, K154KR, S162A, Q197KRB
Delatorre (2016)07BRRJPG14407BRRJPG144KX273360NoneNoneM184V P4S, D123E, I135V, I142T, S162A, K173R, Q174A, Q207E, R211K, F214L, V245Q, E248D, D250DE, A272P, K277R, T286A, T296N, E297K, E298R, A299S, E300R, Q334EB
Escoto-Delgadillo (2016)GDLEVV012GDLEVV012RTKX253694NoneNoneM184VY181II37F, K122Q, A158S, V245MB
Hattori (2016)C11_111212C11-51111212-1AB865618NoneNoneM184VK103NK20R, K43R, A98S, K122E, I135T, T165IB
 F10_12368F10-5112368-1AB866999NoneNoneM184V I5V, K20R, V35I, K102R, I135T, Q174R, G196E, Q207D, R211K, F214LB
 C12_933818C12-20933818-1AB864479NoneNoneM184V V35T, E40ED, K104KR, V106I, V118I, D121H, K122E, I135T, T165TI, V179VI, G196E, R211AT, F214LB
Hoenigl (2016)V0873245V0873245KU574459NoneNoneM184VK101P, K103SK30Q, K32G, A33C, L34T, V35L, E36N, I37F, V60I, D123E, I135R, I142L, V245EB
Li (2016)CN-103CN-103KU050299NoneNoneM184VV179DI135L, T200A, E203K, Q207E, Q278E, E297AB
 CN-465CN-465KU050661NoneNoneM184VK103NK102R, T139TK, S162C, V189I, T200A, E203EK, Q278E, L283IB
 CN-470CN-470KU050666NoneNoneM184VK103N, Y181CI135V, T200A, F214L, L228H, A272P, K275R, K277R, Q278E, E297A, A327E, E328KB
 CN-474CN-474KU050670NoneNoneM184VV108I, Y181CT7A, S68G, K104R, V106I, D121H, K122E, I135T, E169D, R211S, F214L, H221HY, V245M, V261I, K277R, T286A, A288S, I293V, E297H, E300EKB
 CN-426CN-426KU050622NoneNoneM184VV108I, Y181CL34I, K66X, K82R, V106I, V118I, D121H, K122E, I135T, T139A, K166R, I178M, F214L, H221Y, V245K, A272P, I293V, P294Q, D324E, I329L, G359S, I375V, T386I, A400T, E449D, Q507H, A554SB
 CN-466CN-466KU050662NoneNoneM184VY181CV21I, V106I, I135V, T139R, S162C, T200A, A272P, V276I, K277R, Q278E, L283I, I293VB
 CN-102CN-102KU050298NoneNoneM184V I135L, V179N, T200A, Q207E, K277R, Q278E, E297AB
 CN-101CN-101KU050297NoneNoneM184VE138K, V179D, P225HI135L, S162C, T200A, Q207E, K277R, Q278E, E297AB
Li (2016)31113111KT191984NoneNoneM184V K49R, K102Q, I135V, S162C, E169D, T200A, Q278E, L283I, R284K, Q334L, F346Y, M357R, K366R, T369V, Q373H, I375V, V417T, V435E, D460N, R461K, S468T, L491G, Q524E, A554TB
Panichsillapakit (2016)9tf/201111049tf NoneNoneK70E, M184VV179E, Y188LP14S, K102Q, K104R, I135T, S162A, R211NB
Pouran Yousef (2016)457012-01035KX467123NoneNoneM184V I135T, I142V, R211KB
 252807-01003KX465747NoneNoneM184V K11KR, V35X, A98S, I135T, S162C, T200I, R211AB
  10-01865KX465748NoneNoneM184V V35R, A98S, I135T, S162C, T200I, R211AB
  11-02731KX465749NoneNoneM184V V35R, A98S, I135T, S162C, T200I, R211A, G213GR, F214LB
Zhao (2016)LS4627LS4627KT379375NoneNoneM184V P4T, E6D, V8I, K11R, K20R, V60I, R83K, V90I, D123E, K166R, T200IV, I202V, R211K, A272PB
Hachiya (2017)C14-2093GM4126LC161896LC161896NoneNoneM184V E6D, V35T, D123E, I135L, S162C, G196E, T200I, R211G, A272PB
 F13-5112642LC163370LC163370NoneNoneM184V I5V, K20R, V35I, K102R, I135T, K173D, Q174K, G196E, T200TA, Q207E, R211K, F214LB
Patiño-Galindo (2017)32734134631609163273413463160916MF404926NoneNoneM184VK103N, P225HV35I, K49R, I50V, A98S, I135T, S162C, S163N, Q207E, R211K, A288T, N306GB
 20292176450310112029217645031011MF404756NoneNoneM184VK103N, P225HK20R, A98S, K122E, I135T, T200A, Q207E, I257IV, T286A, E297K, L301M, K311KR, I329L, G333EB
 41999722948246764199972294824676MF404712NoneNoneM184VV108VI, V179DK20R, I31IL, V35VA, K49KR, K101Q, I135IT, A272P, P294Q, S322T, Q334LB
 13985494949599731398549494959973MF404696NoneNoneM184VK103NT27S, I135T, E203D, R211Q, A272P, K277R, P294SB
 20035430206588572003543020658857MF404679NoneNoneM184VK101E, K238NI31L, V90I, L109LW, K122P, R125RT, I142T, S162Y, Q174H, D177E, V189I, Q207G, R211K, F214L, V245M, D250E, K263KR, A272P, I293V, P294S, E298EG, E302EG, K323KE, Q332QH, Q334LB
 21388796058238582138879605823858MF404657NoneNoneM184VK103NV35VL, K43KQ, R83K, S162Y, E169D, Q197K, I202V, A272P, L283I, R284K, I293V, I329L, Q334EB
 21593886699540862159388669954086MF404654NoneNoneM184VV108I, V179DK20R, E28K, K101Q, I135T, A272P, P294Q, S322T, Q334LB
 01881160298618560188116029861856MF404643NoneNoneM184V A98S, D123E, Q197P, L210E, V245Q, T286A, E297KB
 72316664348863947231666434886394MF404638NoneNoneM184VV179DK32R, V35T, T39L, K103E, D177E, Q197P, T200E, I202V, A272P, T286A, A288S, E297T, I326V, G333E, Q334HB
 41274244601791184127424460179118MF404611NoneNoneM184V I5V, K20R, L100F, I142V, T200E, V245E, K277R, I293V, E297A, I326V, G335SB
 13899470579631591389947057963159MF404594NoneNoneM184V A98S, D123E, I135V, D177E, E204A, A272P, K277R, E297Q, E328DB
 24245732628866232424573262886623MF404480NoneNoneM184VK103N, P225HK20R, K64KR, A98S, D121H, K122E, I135T, T200A, I293VB
 23320776368753392332077636875339MF404333NoneNoneM184V R83K, D177E, Q207H, R211K, A272P, T286A, G333EB
 41674562957309824167456295730982MF404283NoneNoneM184V R83K, D123E, G196E, T200I, F214L, K249R, S251I, A272P, K277R, E297RB
 22729742436739722272974243673972MF404264NoneNoneM184VV106VA, G190AV35VM, T39A, R83K, K122E, I142V, E169D, G196E, T200A, I202V, E204D, L228LR, E248D, A272P, K277R, A288S, E297R, S322T, Q334LB
 19749373302485791974937330248579MF404086NoneNoneM184VK103N, P225HV35I, K64R, T69S, R83K, A98S, I135L, T200E, Q207K, I257L, V276I, T286A, I326V, I329LB
 17690439983396191769043998339619MF404060NoneNoneM184V V35I, R83K, K166R, G196E, R211K, K277R, T286A, E297R, G333E, Q334HB
 52504888282312225250488828231222MF404047NoneNoneM184VK103NE40D, K122E, G196E, Q197T, E248N, A272P, I293V, E297A, I326VB
 28020755021156072802075502115607MF404004NoneNoneM184VK103N, P225HD123E, I135T, D177E, R211K, V245M, A272P, I293V, E297V, I326V, Q334DB
 81491222137531368149122213753136MF403887NoneNoneM184V V35I, K82R, R83K, K104R, D123E, T165X, K173KQ, R211K, K219X, V245X, L246X, A272P, K277R, A288AT, I293V, K311KRB
 42835260237527084283526023752708MF403839NoneNoneM184VK103N, P225HV35L, R83K, D123E, D177E, G196E, T200A, E204EK, R211S, L228R, V276I, I293VB
 32311108265720123231110826572012MF403827NoneNoneM184V V35I, D123E, G196E, Q197K, R211K, S251T, K281R, E297K, I326V, I329LB
 16831479637419871683147963741987MF403760NoneNoneK70E, M184VK103N, P225HK20R, V35I, T39TK, E40A, K43E, K82R, A98S, K122E, I135L, T200A, L210F, V245Q, A272P, K277R, T286A, A288S, S322T, G333E, Q334HB
 29364870318621892936487031862189MF403619NoneNoneM184V, K219RK103N, P225HK102KR, I135M, D177E, I178M, T200A, R211K, L228H, A272P, I293V, P294Q, Q334HB
 16666335521950451666633552195045MF403560NoneNoneM184V V35I, D123E, S162C, D177E, V179I, E204EA, R211K, K277R, E297R, E312N, G333EB
 13595319288977151359531928897715MF403532NoneNoneM184VK103NE6D, K20KR, A98S, K101KQ, I135T, E138EQ, I142IV, I195IM, T200X, R211RK, A272AP, K277R, E297EAB
 16637892696341451663789269634145MF403496NoneNoneM184V V35I, I50IV, I135M, K166R, D177G, G196E, V245E, A272P, K277R, L283I, A288S, I293V, Q334NB
 24184494546523532418449454652353MF403465NoneNoneM184VK103NV35T, R83K, K101R, I293VB
 11965462708256161196546270825616MF403437NoneNoneM184VK103N, V179EE6K, K122E, I135V, D177E, I178M, V189I, T200A, Q207N, R211K, I293V, I309L, Q334YB