Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	M184I
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	10
Patients	17
Isolates	27

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Venturi (1999)	GV-14	Vent14W24	AF169069	AZT, DDC	None	M184I		K103KR, D121N, D123E, W153*, G155R, K166R, G196R, I202V	B
Balotta (2000)	CB-5	CB-5	AF186770	DDC, AZT, D4T, 3TC	None	M41L, T69S_SG, K70KR, M184I, L210W, T215Y		S48T, D86DN, T107TP, D110DN, V118I, K122P, I195V, Q197R, T200E	B
Baxter (2000)	GART-G86	GART-86		NRTI, 3TC, D4T	None	M41L, D67N, T69D, M184I, L210W, T215Y		V21I, E44D, V118I, K122E, D123E, S162C, D177E, Q197K, T200A, E203K, H208Y, R211K, K223E, V245K	B
	GART-G108	GART-108		NRTI, 3TC, D4T	None	M41L, D67N, K70R, L74I, M184I, L210W, T215Y, K219Q		K20R, V35L, K122E, A158S, E169D, T200I, R211K, D218E	B
Falloon (2000)	JF10	JF10-(-)1w	AF227723	AZT, DDI, DDC, D4T, 3TC, PFA	None	M41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219R	V108I	V118I, K122E, I178M, G196E, E203K, R211E, F214X	B
		JF10-12w	AF227724	AZT, DDI, DDC, D4T, 3TC, PFA, ABC	None	M41L, D67N, T69D, L74LI, V75T, M184I, L210W, T215C, K219R	V108I	V118I, K122E, I178M, G196E, E203K, R211E	B
Katzenstein (2001)	ACTG302_1893	1893RT_f1		AZT, DDI, 3TC	None	M41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y		V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RI	B
Servais (2001)	JS15	JS96414	AJ401757	AZT, DDI, DDC	None	M41L, D67N, K70R, M184I, L210W, T215Y		T39E, E44D, V118I, D123E, I135T, S162C, G196E, E203D, R211K	B
		JS97051	AJ401764	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, K70R, M184I, L210W, T215Y		T39E, E44D, V118I, D123E, I135T, S162C, G196E, E203D, R211K	B
		JS97359	AJ401785	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, K70R, M184I, L210W, T215Y		T39E, E44D, V118I, I135T, S162C, G196E, R211K	B
		JS97498	AJ401792	AZT, DDI, DDC, 3TC, D4T	None	M41L, D67N, K70R, M184I, L210W, T215Y	G190A	T39E, V118I, I135T, I142V, S162C, G196E, E203D, R211K	B
	JS21	JS97295	AJ401782	AZT, DDI, D4T, 3TC	None	T69S_SS, K70R, M184I, T215Y		K64R, D123E, I142T, Q197E, R211K, F214W, D218H, I244L	B
		JS98025	AJ401795	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		K64R, D123E, Q197E, E203K, R211K, F214W, D218H, I244L	B
		JS98158	AJ401805	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		K64R, V118I, D123E, Q197E, E203K, R211K, F214W, D218H, I244L, S251T	B
		JS98287	AJ401814	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		K64R, V118I, D123E, Q197E, E203K, R211K, F214W, D218H, I244L, E248K	B
		JS98465	AJ401829	AZT, DDI, D4T, 3TC	None	A62V, T69S_SS, K70R, M184I, L210W, T215Y		L34F, S48L, K64R, V118I, D123E, I142T, Q197E, E203K, R211K, F214L, D218H, L228R, I244L	B
	JS24	JS96388	AJ401754	DDC, 3TC	None	M184I		K122E, D123N, D177E, R211K, V245Q	B
Papa (2002)	AP-5	AP-5	AF315743	DDC, AZT, D4T, 3TC	None	M41L, D67N, K70R, M184I, T215F, K219Q		R83K, V90I, K122E, D123E, S162Y, E203D, H208Y, R211K	B
Montes (2004)	MB_patAVO	01_AVO720	AJ577732	DDC, AZT, 3TC, D4T	None	A62V, M184I, L210W, T215S	A98G	R83K, I135V, S162C, T165V, I202V	B
Rhee (2005)	SWC-5729	5729-3376		AZT, 3TC, D4T	None	M41L, A62V, T69S_SS, M184I, L210W, T215Y		V35M, K43E, V118I, K122E, I135T, V245Q	B
		5729-4183		AZT, 3TC, D4T	None	M41L, A62V, T69S_SS, M184I, L210W, T215Y		V35M, K43E, V118I, K122E, I135T, V245Q	B
	CA7848	CA19878	AY801794	AZT, DDI, D4T, 3TC, ABC	None	M41L, D67G, T69D, V75VL, M184I, L210W, T215Y, K219R		K43KN, E44D, V60I, V118I, K122E, D123E, I135T, I142V, G196E, I202X, E203EK, Q207E, H208Y, R211K, H221HY, K223KE, V245K, A272P	B
		CA23659	AY801795	AZT, DDI, D4T, 3TC, ABC	None	M41L, D67G, T69D, M184I, L210W, T215Y, K219R	F227FL	T39TP, K43KN, E44D, S48SP, V60I, V118I, K122E, D123E, I135T, I142V, G196E, E203K, Q207E, H208Y, R211K, K223E, V245K, A272P	B
	CA9700	CA37961	AY802073	D4T, 3TC	None	M41L, D67N, M184I, L210W, T215Y, K219R		E6ED, K43Q, E44D, V90I, K104R, V118I, G196E, E203K, Q207E, H208Y, R211K, K223E, V292I, I293V	B
	CA9831	CA24186	AY802137	AZT, 3TC	None	F77L, F116Y, Q151M, M184I		V35I, V90I, K122E, Q207E, R211K, A272P, K277R, V292I	B
	CA21096	CA48506	AY802582	D4T, 3TC, ABC, AZT, TDF	None	M184I		D123E, K166R, T200I, Q207E, K277R, I293V	B
Melikian (2012)	CA14602	CA35008	GQ207006	D4T, 3TC, AZT, TDF, DDI	None	M184I		V35VI, R83K, V90I, K122E, S162Y, K173E, R211RK, A272P, K277R, E297X	B

Reverse Transcriptase Inhibitors

Database

Resources

Team