<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation Q151M
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 34
Patients 69
Isolates 90
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP26JIDP26W88AF021308AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M, K219E T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245MB
 JIDP25JIDP25W104AF021296AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219E V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211KB
 CA478CA899AF021299AZT, DDINoneF77L, F116Y, Q151M V35I, R83K, A158S, R211K, V245EB
Ruiz (1996)JCS-C13C13BZ99306AZT, DDINoneK65R, V75I, F77L, F116Y, Q151M V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
  C13W24Z99307AZT, DDI, 3TCNoneK65R, V75I, F77L, F116Y, Q151M, M184V V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
Hammer (1997)ACTG320_546546 AZT, DDINoneF77FL, F116FY, Q151M, K219KE K49R, E53D, L205LF, R211K, A272P, K277R, I293V, E297R, L301I, I329IV, G333E, Q334H, I375V, T377TI, E404D, S468P, T470AB
Cabana (1999)Cab-kK24AF102364DDC, AZT, D4T, 3TCNoneQ151M, M184V T69N, K122E, I135T, S163C, D177N, G196E, I202VB
  K35AF102365DDC, AZT, D4T, 3TCNoneT69D, Y115F, Q151M, M184V K122E, I135T, S163C, D177N, G196E, I202VB
 Cab-lL0AF102366AZT, 3TC, DDINoneK65R, K70R, V75I, F77L, F116Y, Q151M T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211GB
  L39AF102367AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228QB
  L47AF102368AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228KB
Lawrence (1999)JL-Pt11JL-11-pre AZT, DDC, D4T, 3TCNoneD67N, K70S, F116Y, Q151M, M184V, T215Y T58S, F77V, D121H, K122E, I135V, D177E, K277RB
  JL-11-post AZT, DDC, D4T, 3TC, DDINoneD67N, K70S, V75I, F116Y, Q151M, T215Y T58S, F77V, D121H, K122E, I135V, D177E, Q242XB
Pellegrin (1999)IP-8IP8-M12 D4T, DDINoneQ151M V35I, K122E, I135T, S162C, T200I, R211KB
 IP-36IP36-M12 D4T, DDINoneF77L, F116Y, Q151M S3ST, K20R, D123E, I142V, I178L, Q197L, Q207EB
Zolopa (1999)CA626CA3200AF088111AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V I31X, S68N, Q207E, F214L, T286AB
Albrecht (2000)ACTG303_1212RT_bl AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302XB
  12RT_f1 AZT, DDI, 3TCNoneA62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297AB
 ACTG303_13491349RT_bl AZT, DDINoneM41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245MB
  1349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
 ACTG303_19341934RT_bl AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279XB
  1934RT_f1 AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297KB
Balotta (2000)CB-1CB-1AF186766DDC, AZT, 3TC, D4TNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219Q W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214LB
 CB-2CB-2AF186767AZT, DDI, 3TC, DDC, D4TNoneK65R, K70R, V75I, F77L, F116Y, Q151M V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211KB
Baxter (2000)GART-NG43GART-43 NRTI, 3TC, D4TNoneF116Y, Q151M, M184V S48T, K122E, R211K, E248D, T296S, E297KB
 GART-NG65GART-65 NRTI, D4T, DDINoneF116Y, Q151M V35I, R83K, G196EB
 GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
Coakley (2000)EC30EC30F D4T, DDINoneQ151M V60I, I142V, P243R, T286A, I293V, M357T, A376T, A400S, E404D, E432D, A446S, D460N, L491P, S519NB
 EC31EC31FAY047466D4T, DDINoneQ151M S68G, K122E, S162C, D177N, V245E, K277R, I293V, E344D, P345Q, K390R, A400T, F416Y, R461K, S519N, I522V, A554TB
 EC34EC3428w D4T, DDINoneQ151M K13N, K22N, K122E, A158S, I178M, R211G, A272P, T286A, I329V, T377Q, K390R, D460N, R461K, V466T, S468TB
  EC3452w D4T, DDINoneF116Y, Q151MV108IV60I, K122E, A158S, I178M, R211G, A272P, T286A, I329V, Q367P, T377Q, K390R, D460N, R461K, V466T, S468T, L486S, S519NB
  EC3480w D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329VB
Miller (2000)MV-168MV-168wk48 ABC, AZT, 3TCNoneK65R, V75VIL, F77L, Y115F, Q151M, M184V V35I, S68G, K122E, I135T, G196E, E204DB
Shulman (2000)CA624CA9919AY802614DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297KB
Albrecht (2001)ACTG364_12081208 DDI, AZTNoneA62V, K70N, V75I, F77L, F116Y, Q151M E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277RB
Eshleman (2001)A021AF357625AF357625AZT, DDINoneV75I, F77L, F116Y, Q151M S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297KB
Gonzales (2001)CA624CA1189AY030418DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*B
 CA1166CA2649AY030474AZT, DDC, D4T, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297DB
 CA1317CA3303AY030517AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297KB
 CA1408CA3777AY030553DDI, AZT, DDC, D4T, 3TCNoneD67N, Q151M, M184V K20R, K104KN, I135T, Q145QP, T200A, R211K, T286A, A288T, I293V, E297KB
 CA1467CA3912AY030602AZT, 3TC, DDC, D4TNoneM41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215YV108IR83K, D123E, K166R, D177E, I202V, A272P, I293VB
 CA1523CA4364AY030642D4T, 3TC, DDINoneF116Y, Q151M S68G, K122E, D123E, S162C, R172K, D177E, T200A, R211S, F214L, D250DE, K277R, A288SB
 CA2316CA8409AY030861D4T, 3TC, AZTNoneF116Y, Q151M, M184V T27S, V35X, E40EG, K49R, S68G, R83K, K122E, T165I, I202V, F214LB
 CA3889CA9081AY030894AZT, D4T, 3TCNoneM41L, D67N, K70R, Q151M, M184V, T215F, K219Q K20R, T69N, V90I, I135V, S162A, D177E, G196E, E203DB
 CA4159CA9921AY031136AZT, 3TC, D4TNoneM41ML, V75A, Q151M, M184V S68SG, D121H, K122E, K173Q, D177E, I178L, G196E, T200A, F214FL, T215X, V245M, E248D, D250A, A272P, E291D, I293VB
 CA4477CA10957AY031319D4T, 3TCNoneQ151M, M184V S68G, K122E, T200A, Q207E, F214FL, K277R, R284K, I293V, E297A, A304G, I329L, Q334N, R358RK, T369S, E370ED, I375IV, K390R, K395KR, V435A, D460N, L491EV, S519N, K527Q, A554ATB
 CA5047CA12324AY031617AZT, 3TC, D4TNoneM41L, D67N, K70R, Q151M, M184V, T215F, K219E V35I, T39A, R83K, K104R, G112A, T200I, I202IT, H208Y, R211K, L228HB
 CA5433CA13168AY031985D4T, 3TCNoneV75T, Q151M, M184V S68G, I142V, S162C, E203D, R211K, F214L, Y232YF, E233EQ, D237X, T240TPB
Brindeiro (2002)TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Clevenbergh (2002)CP0402CP0402AF519434NRTI, D4T, DDINoneD67N, F77FL, F116Y, Q151M K122E, I135M, S162A, Q197E, V245VEB
 CP1902CP1902AF519424NRTI, D4T, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151MY181CT69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245TB
Romano (2002)MZ-pt38pt38-t0AF493373AZT, DDI, D4T, 3TC, ABCNoneK65R, V75I, F77L, F116Y, Q151M S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214LB
Tural (2002)880219880219 AZT, DDC, DDI, D4T, 3TCNoneM41L, D67N, K70R, F116Y, Q151M, T215F, K219Q K20R, V60I, T69N, V90I, S162H, R172K, H208Y, R211KB
 880814880814 AZT, D4T, DDI, 3TCNoneM41L, K65R, V75I, F116Y, Q151M K49R, I50V, V60I, S68G, T69I, K122E, I135T, I142M, T165I, D177E, F214L, V245MB
Gonzales (2003)CA626CA1193AF513998AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V S68N, Q207E, F214L, T286AB
 CA635CA12321AF514001AZT, DDC, 3TC, D4T, DDINoneD67N, K70R, Q151M, M184V, T215F, K219Q V118I, K122E, D123E, I135T, V179VI, Q207EK, F214L, T286A, E297KB
 CA1317CA12527AF514050AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288SB
Gonzales (2003)CA1408CA8382AY305908DDI, AZT, DDC, D4T, 3TCNoneD67N, K70E, F116Y, Q151M, M184V K20R, I31IL, K49K*, V60I, I135T, E138ED, T200A, R211K, F214FLB
Gonzales (2003)CA1506CA24407AF514090AZT, DDCNoneQ151M V35X, T39A, T69X, K102Q, V111L, A158AS, S162A, T165I, I167IV, G196K, L228H, S251N, K277R, L283LI, I293V, E297AB
Gonzales (2003)CA1625CA16446AF514110AZT, 3TC, D4T, DDINoneF116Y, Q151M K22R, V60I, K122E, D123E, I135V, I142V, T200A, I202V, F214FL, V245M, K277R, Q278E, T286A, I293V, E297TB
Gonzales (2003)CA4007CA20207AF514172D4T, DDI, ABC, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293VB
Gonzales (2003)CA5242CA23663AY305921AZT, 3TC, D4T, DDINoneF116Y, Q151M, N348IV179DV35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554SB
Gonzales (2003)CA6434CA15945AY032387AZT, 3TC, NRTI, D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293VB
 CA7052CA17358AF514250AZT, D4T, DDINoneA62V, K65KR, V75I, F77L, Q151M A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304GB
Roge (2003)cw8cw8-F1AY222068ABC, D4T, DDINoneK70E, Q151M Q91QP, D113E, E138D, S162C, Q197H, R211K, H221YB
  cw8-F2AY222069ABC, D4T, DDINoneK70E, Q151M N54NK, N57Y, S68SG, D113K, S162C, Q197H, R211K, H221Y, I244KB
Saah (2003)AS-42AS-42 AZT, D4T, DDINoneF77L, F116Y, Q151M V35T, V90I, D123E, I142V, D177EB
Dumans (2004)180180AY390156AZT, DDINoneV75I, Y115F, F116Y, Q151M, K219Q S68G, D177E, R211KB
 197197AY390154AZT, DDI, D4T, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219QE138KK49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214LB
 208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Kuritzkes (2004)KDR_pat72A0081AY527898D4TNoneQ151M M41MI, K49R, K122E, I142V, T165I, E169D, Q174K, I178L, T200A, I202V, Q207D, R211KB
 KDR_pat94A0115AY527932D4T, 3TCNoneD67N, F77L, F116FY, Q151M, M184V I135V, G196E, Q207K, R211AB
Machado (2004)cs157cs157AY313424AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I202V, F214LB
Mo (2005)91249124_d1 NRTINoneM41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQB
 82568256_d1 NRTINoneM41ML, A62AV, F116FY, Q151M, M184V K20KR, V60I, K64KR, S68SR, V118VI, I142V, F214FL, E248EDKN, D250DN, T286A, I293VB
Non-B Workgroup (2005)TH_146TH_146AY605559AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219EY188YDE28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245RB
Rhee (2005)CA1317CA7990AY800863AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277RB
  CA9386AY800864AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250EB
 CA1506CA34254AY801008AZT, DDCNoneQ151M V35VA, T39A, T69X, K102Q, V111L, A158AS, S162A, T165I, I167IV, G196K, L228H, S251N, K277R, L283LI, I293V, E297AB
 CA1625CA13140AY801069AZT, 3TC, D4T, DDINoneD67DN, Q151M K22R, K122E, D123E, I135V, I142V, T200A, I202V, V245M, K277R, Q278E, T286A, I293V, E297TB
 SWC-6100P6100-1220 DDC, NRTI, D4T, 3TCNoneT69D, F116Y, Q151M, M184V V118I, K122E, A158S, I202V, R211K, F214LB
 CA5242CA16447AY801521AZT, 3TC, D4T, DDINoneQ151MV179DV35I, V118I, K122E, I135T, I142V, T200A, F214L, K277R, I293X, L301LVB
 CA5433CA34379AY801578D4T, 3TCNoneV75T, Q151M, M184V, K219E I5IV, K11KR, K20KR, A33V, S68G, V111I, I142V, S162Y, E203D, R211RK, F214L, V245E, D250DE, V292I, I293VB
 CA7884CA19929AY801812AZT, D4T, DDINoneF77FL, Q151M, N348I K22KR, R83RK, K166R, T200A, F214L, A272P, K277R, Q278QE, T286A, I293V, P294S, E297A, G333E, Q334H, I341F, K366R, A376AT, T386TI, A400T, T470A, H483Y, E516D, S519N, Q520N, K527N, K530R, A554SB
 CA9831CA24186AY802137AZT, 3TCNoneF77L, F116Y, Q151M, M184I V35I, V90I, K122E, Q207E, R211K, A272P, K277R, V292IB
 CA9933CA24557AY802197D4T, DDINoneV75I, F77L, F116Y, Q151MV108VIK20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554SB
 CA14191CA34315AY8022603TC, D4TNoneA62AV, K70N, V75T, Q151M, M184V K11KT, V35VAIT, T39A, S68G, A98S, D123N, E169D, D177E, I178L, T200A, Q207E, R211K, F214L, V245E, A272P, K277R, T286A, E297A, Q334L, M357T, E370D, A376T, T386TI, A400T, V435A, D460N, R461K, K512QB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
Rosen-Zvi (2008)5503p55-1 AZT, DDI, DDCNoneA62V, V75I, F77L, Q151M K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328DB
von Wyl (2010)48147394814739GQ848144AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377LB