Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	Q151M
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	34
Patients	69
Isolates	91

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP26	JIDP26W88	AF021308	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M, K219E		T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245M	B
	JIDP25	JIDP25W104	AF021296	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E		V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K	B
	CA478	CA899	AF021299	AZT, DDI	None	F77L, F116Y, Q151M		V35I, R83K, A158S, R211K, V245E	B
Ruiz (1996)	JCS-C13	C13B	Z99306	AZT, DDI	None	K65R, V75I, F77L, F116Y, Q151M		V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250E	B
		C13W24	Z99307	AZT, DDI, 3TC	None	K65R, V75I, F77L, F116Y, Q151M, M184V		V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250E	B
Hammer (1997)	ACTG320_546	546		AZT, DDI	None	F77FL, F116FY, Q151M, K219KE		K49R, E53D, L205LF, R211K, A272P, K277R, I293V, E297R, L301I, I329IV, G333E, Q334H, I375V, T377TI, E404D, S468P, T470A	B
Cabana (1999)	Cab-k	K24	AF102364	DDC, AZT, D4T, 3TC	None	Q151M, M184V		T69N, K122E, I135T, S163C, D177N, G196E, I202V	B
		K35	AF102365	DDC, AZT, D4T, 3TC	None	T69D, Y115F, Q151M, M184V		K122E, I135T, S163C, D177N, G196E, I202V	B
	Cab-l	L0	AF102366	AZT, 3TC, DDI	None	K65R, K70R, V75I, F77L, F116Y, Q151M		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211G	B
		L39	AF102367	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228Q	B
		L47	AF102368	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q		K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228K	B
Lawrence (1999)	JL-Pt11	JL-11-pre		AZT, DDC, D4T, 3TC	None	D67N, K70S, F116Y, Q151M, M184V, T215Y		T58S, F77V, D121H, K122E, I135V, D177E, K277R	B
		JL-11-post		AZT, DDC, D4T, 3TC, DDI	None	D67N, K70S, V75I, F116Y, Q151M, T215Y		T58S, F77V, D121H, K122E, I135V, D177E, Q242X	B
Pellegrin (1999)	IP-8	IP8-M12		D4T, DDI	None	Q151M		V35I, K122E, I135T, S162C, T200I, R211K	B
	IP-36	IP36-M12		D4T, DDI	None	F77L, F116Y, Q151M		S3ST, K20R, D123E, I142V, I178L, Q197L, Q207E	B
Zolopa (1999)	CA626	CA3200	AF088111	AZT, DDI, D4T, 3TC	None	D67G, K70G, F77L, F116Y, Q151M, M184V		I31X, S68N, Q207E, F214L, T286A	B
Albrecht (2000)	ACTG303_12	12RT_bl		AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302X	B
		12RT_f1		AZT, DDI, 3TC	None	A62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V		T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297A	B
	ACTG303_1349	1349RT_bl		AZT, DDI	None	M41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245M	B
		1349RT_f1		AZT, DDI, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293V	B
	ACTG303_1934	1934RT_bl		AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279X	B
		1934RT_f1		AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297K	B
Balotta (2000)	CB-1	CB-1	AF186766	DDC, AZT, 3TC, D4T	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q		W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214L	B
	CB-2	CB-2	AF186767	AZT, DDI, 3TC, DDC, D4T	None	K65R, K70R, V75I, F77L, F116Y, Q151M		V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211K	B
Baxter (2000)	GART-NG43	GART-43		NRTI, 3TC, D4T	None	F116Y, Q151M, M184V		S48T, K122E, R211K, E248D, T296S, E297K	B
	GART-NG65	GART-65		NRTI, D4T, DDI	None	F116Y, Q151M		V35I, R83K, G196E	B
	GART-G87	GART-87		NRTI, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234X	B
Coakley (2000)	EC30	EC30F		D4T, DDI	None	Q151M		V60I, I142V, P243R, T286A, I293V, M357T, A376T, A400S, E404D, E432D, A446S, D460N, L491P, S519N	B
	EC31	EC31F	AY047466	D4T, DDI	None	Q151M		S68G, K122E, S162C, D177N, V245E, K277R, I293V, E344D, P345Q, K390R, A400T, F416Y, R461K, S519N, I522V, A554T	B
	EC34	EC3428w		D4T, DDI	None	Q151M		K13N, K22N, K122E, A158S, I178M, R211G, A272P, T286A, I329V, T377Q, K390R, D460N, R461K, V466T, S468T	B
		EC3452w		D4T, DDI	None	F116Y, Q151M	V108I	V60I, K122E, A158S, I178M, R211G, A272P, T286A, I329V, Q367P, T377Q, K390R, D460N, R461K, V466T, S468T, L486S, S519N	B
		EC3480w		D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329V	B
Miller (2000)	MV-168	MV-168wk48		ABC, AZT, 3TC	None	K65R, V75VIL, F77L, Y115F, Q151M, M184V		V35I, S68G, K122E, I135T, G196E, E204D	B
Shulman (2000)	CA624	CA9919	AY802614	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297K	B
Albrecht (2001)	ACTG364_1208	1208		DDI, AZT	None	A62V, K70N, V75I, F77L, F116Y, Q151M		E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277R	B
Eshleman (2001)	A021	AF357625	AF357625	AZT, DDI	None	V75I, F77L, F116Y, Q151M		S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297K	B
Gonzales (2001)	CA624	CA1189	AY030418	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV		S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*	B
	CA1166	CA2649	AY030474	AZT, DDC, D4T, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE		E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297D	B
	CA1317	CA3303	AY030517	AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297K	B
	CA1408	CA3777	AY030553	DDI, AZT, DDC, D4T, 3TC	None	D67N, Q151M, M184V		K20R, K104KN, I135T, Q145QP, T200A, R211K, T286A, A288T, I293V, E297K	B
	CA1467	CA3912	AY030602	AZT, 3TC, DDC, D4T	None	M41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215Y	V108I	R83K, D123E, K166R, D177E, I202V, A272P, I293V	B
	CA1523	CA4364	AY030642	D4T, 3TC, DDI	None	F116Y, Q151M		S68G, K122E, D123E, S162C, R172K, D177E, T200A, R211S, F214L, D250DE, K277R, A288S	B
	CA2316	CA8409	AY030861	D4T, 3TC, AZT	None	F116Y, Q151M, M184V		T27S, V35X, E40EG, K49R, S68G, R83K, K122E, T165I, I202V, F214L	B
	CA3889	CA9081	AY030894	AZT, D4T, 3TC	None	M41L, D67N, K70R, Q151M, M184V, T215F, K219Q		K20R, T69N, V90I, I135V, S162A, D177E, G196E, E203D	B
	CA4159	CA9921	AY031136	AZT, 3TC, D4T	None	M41ML, V75A, Q151M, M184V		S68SG, D121H, K122E, K173Q, D177E, I178L, G196E, T200A, F214FL, T215X, V245M, E248D, D250A, A272P, E291D, I293V	B
	CA4477	CA10957	AY031319	D4T, 3TC	None	Q151M, M184V		S68G, K122E, T200A, Q207E, F214FL, K277R, R284K, I293V, E297A, A304G, I329L, Q334N, R358RK, T369S, E370ED, I375IV, K390R, K395KR, V435A, D460N, L491EV, S519N, K527Q, A554AT	B
	CA5047	CA12324	AY031617	AZT, 3TC, D4T	None	M41L, D67N, K70R, Q151M, M184V, T215F, K219E		V35I, T39A, R83K, K104R, G112A, T200I, I202IT, H208Y, R211K, L228H	B
	CA5433	CA13168	AY031985	D4T, 3TC	None	V75T, Q151M, M184V		S68G, I142V, S162C, E203D, R211K, F214L, Y232YF, E233EQ, D237X, T240TP	B
Brindeiro (2002)	TVGG8	TVGG8	AY145786	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297A	B
Clevenbergh (2002)	CP0402	CP0402	AF519434	D4T, DDI	None	D67N, F77FL, F116Y, Q151M		K122E, I135M, S162A, Q197E, V245VE	B
	CP1902	CP1902	AF519424	D4T, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M	Y181C	T69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245T	B
Romano (2002)	MZ-pt38	pt38-t0	AF493373	AZT, DDI, D4T, 3TC, ABC	None	K65R, V75I, F77L, F116Y, Q151M		S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214L	B
		pt38-t1	AF493412	AZT, DDI, D4T, 3TC, ABC	None	K65R, V75I, F77L, F116Y, Q151M	Y181CF	V35I, S68G, E79D, R83K, V118I, D121Y, K122E, S162C, S163A, I178M, Q197E, T200A, R211AT, F214L	B
Tural (2002)	880219	880219		AZT, DDC, DDI, D4T, 3TC	None	M41L, D67N, K70R, F116Y, Q151M, T215F, K219Q		K20R, V60I, T69N, V90I, S162H, R172K, H208Y, R211K	B
	880814	880814		AZT, D4T, DDI, 3TC	None	M41L, K65R, V75I, F116Y, Q151M		K49R, I50V, V60I, S68G, T69I, K122E, I135T, I142M, T165I, D177E, F214L, V245M	B
Gonzales (2003)	CA626	CA1193	AF513998	AZT, DDI, D4T, 3TC	None	D67G, K70G, F77L, F116Y, Q151M, M184V		S68N, Q207E, F214L, T286A	B
	CA635	CA12321	AF514001	AZT, DDC, 3TC, D4T, DDI	None	D67N, K70R, Q151M, M184V, T215F, K219Q		V118I, K122E, D123E, I135T, V179VI, Q207EK, F214L, T286A, E297K	B
	CA1317	CA12527	AF514050	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288S	B
Gonzales (2003)	CA1408	CA8382	AY305908	DDI, AZT, DDC, D4T, 3TC	None	D67N, K70E, F116Y, Q151M, M184V		K20R, I31IL, K49K*, V60I, I135T, E138ED, T200A, R211K, F214FL	B
Gonzales (2003)	CA1506	CA24407	AF514090	AZT, DDC	None	Q151M		V35X, T39A, T69X, K102Q, V111L, A158AS, S162A, T165I, I167IV, G196K, L228H, S251N, K277R, L283LI, I293V, E297A	B
Gonzales (2003)	CA1625	CA16446	AF514110	AZT, 3TC, D4T, DDI	None	F116Y, Q151M		K22R, V60I, K122E, D123E, I135V, I142V, T200A, I202V, F214FL, V245M, K277R, Q278E, T286A, I293V, E297T	B
Gonzales (2003)	CA4007	CA20207	AF514172	D4T, DDI, ABC, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293V	B
Gonzales (2003)	CA5242	CA23663	AY305921	AZT, 3TC, D4T, DDI	None	F116Y, Q151M, N348I	V179D	V35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554S	B
Gonzales (2003)	CA6434	CA15945	AY032387	AZT, 3TC, NRTI, D4T, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293V	B
	CA7052	CA17358	AF514250	AZT, D4T, DDI	None	A62V, K65KR, V75I, F77L, Q151M		A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A299AG, A304G	B
Roge (2003)	cw8	cw8-F1	AY222068	ABC, D4T, DDI	None	K70E, Q151M		Q91QP, D113E, E138D, S162C, Q197H, R211K, H221Y	B
		cw8-F2	AY222069	ABC, D4T, DDI	None	K70E, Q151M		N54NK, N57Y, S68SG, D113K, S162C, Q197H, R211K, H221Y, I244K	B
Saah (2003)	AS-42	AS-42		AZT, D4T, DDI	None	F77L, F116Y, Q151M		V35T, V90I, D123E, I142V, D177E	B
Dumans (2004)	180	180	AY390156	AZT, DDI	None	V75I, Y115F, F116Y, Q151M, K219Q		S68G, D177E, R211K	B
	197	197	AY390154	AZT, DDI, D4T, 3TC	None	A62V, V75I, F77L, F116Y, Q151M, M184V, K219Q	E138K	K49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214L	B
	208	208	AY390155	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		S68G, D177E	B
Kuritzkes (2004)	KDR_pat72	A0081	AY527898	D4T	None	Q151M		M41MI, K49R, K122E, I142V, T165I, E169D, Q174K, I178L, T200A, I202V, Q207D, R211K	B
	KDR_pat94	A0115	AY527932	D4T, 3TC	None	D67N, F77L, F116FY, Q151M, M184V		I135V, G196E, Q207K, R211A	B
Machado (2004)	cs157	cs157	AY313424	AZT, DDI	None	A62V, V75I, F77L, F116Y, Q151M		K122E, I202V, F214L	B
Mo (2005)	9124	9124_d1		NRTI	None	M41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q		K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQ	B
	8256	8256_d1		NRTI	None	M41ML, A62AV, F116FY, Q151M, M184V		K20KR, V60I, K64KR, S68SR, V118VI, I142V, F214FL, E248EDKN, D250DN, T286A, I293V, M357T, A400S	B
Non-B Workgroup (2005)	TH_146	TH_146	AY605559	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E	Y188YD	E28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245R	B
Rhee (2005)	CA1317	CA7990	AY800863	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277R	B
		CA9386	AY800864	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250E	B
	CA1506	CA34254	AY801008	AZT, DDC	None	Q151M		V35VA, T39A, T69X, K102Q, V111L, A158AS, S162A, T165I, I167IV, G196K, L228H, S251N, K277R, L283LI, I293V, E297A	B
	CA1625	CA13140	AY801069	AZT, 3TC, D4T, DDI	None	D67DN, Q151M		K22R, K122E, D123E, I135V, I142V, T200A, I202V, V245M, K277R, Q278E, T286A, I293V, E297T	B
	SWC-6100	P6100-1220		DDC, NRTI, D4T, 3TC	None	T69D, F116Y, Q151M, M184V		V118I, K122E, A158S, I202V, R211K, F214L	B
	CA5242	CA16447	AY801521	AZT, 3TC, D4T, DDI	None	Q151M	V179D	V35I, V118I, K122E, I135T, I142V, T200A, F214L, K277R, I293X, L301LV	B
	CA5433	CA34379	AY801578	D4T, 3TC	None	V75T, Q151M, M184V, K219E		I5IV, K11KR, K20KR, A33V, S68G, V111I, I142V, S162Y, E203D, R211RK, F214L, V245E, D250DE, V292I, I293V	B
	CA7884	CA19929	AY801812	AZT, D4T, DDI	None	F77FL, Q151M, N348I		K22KR, R83RK, K166R, T200A, F214L, A272P, K277R, Q278QE, T286A, I293V, P294S, E297A, G333E, Q334H, I341F, K366R, A376AT, T386TI, A400T, T470A, H483Y, E516D, S519N, Q520N, K527N, K530R, A554S	B
	CA9831	CA24186	AY802137	AZT, 3TC	None	F77L, F116Y, Q151M, M184I		V35I, V90I, K122E, Q207E, R211K, A272P, K277R, V292I	B
	CA9933	CA24557	AY802197	D4T, DDI	None	V75I, F77L, F116Y, Q151M	V108VI	K20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554S	B
	CA14191	CA34315	AY802260	3TC, D4T	None	A62AV, K70N, V75T, Q151M, M184V		K11KT, V35X, T39A, S68G, A98S, D123N, E169D, D177E, I178L, T200A, Q207E, R211K, F214L, V245E, A272P, K277R, T286A, E297A	B
Villena (2007)	36708	36708-1	EF154391	D4T, 3TC, DDI	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V	Y181C	K20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519N	B
Rosen-Zvi (2008)	55	03p55-1		AZT, DDI, DDC	None	A62V, V75I, F77L, Q151M		K22N, I50S, V189I, R211K, F214L, T286A, I293V, E297A, E328D	B
von Wyl (2010)	4814739	4814739	GQ848144	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377L	B

Reverse Transcriptase Inhibitors

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