<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation F116Y
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 32
Patients 52
Isolates 66
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP26JIDP26W88AF021308AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M, K219E T39A, S68G, A98S, I135V, R172K, Q174H, R211G, F214L, V245MB
 JIDP25JIDP25W104AF021296AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219E V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211KB
 CA478CA899AF021299AZT, DDINoneF77L, F116Y, Q151M V35I, R83K, A158S, R211K, V245EB
Ruiz (1996)JCS-C13C13BZ99306AZT, DDINoneK65R, V75I, F77L, F116Y, Q151M V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
  C13W24Z99307AZT, DDI, 3TCNoneK65R, V75I, F77L, F116Y, Q151M, M184V V35M, T39K, K43E, S68G, T69I, K70X, K102Q, K122E, K166R, T200A, R211G, V245E, D250EB
Cabana (1999)Cab-lL0AF102366AZT, 3TC, DDINoneK65R, K70R, V75I, F77L, F116Y, Q151M T39K, K43E, S68G, T69I, K102Q, K122E, K166R, R211GB
  L39AF102367AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228QB
  L47AF102368AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228KB
Lawrence (1999)JL-Pt11JL-11-pre AZT, DDC, D4T, 3TCNoneD67N, K70S, F116Y, Q151M, M184V, T215Y T58S, F77V, D121H, K122E, I135V, D177E, K277RB
  JL-11-post AZT, DDC, D4T, 3TC, DDINoneD67N, K70S, V75I, F116Y, Q151M, T215Y T58S, F77V, D121H, K122E, I135V, D177E, Q242XB
Pellegrin (1999)IP-36IP36-M12 D4T, DDINoneF77L, F116Y, Q151M S3ST, K20R, D123E, I142V, I178L, Q197L, Q207EB
Zolopa (1999)CA626CA3200AF088111AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V I31X, S68N, Q207E, F214L, T286AB
Albrecht (2000)ACTG303_1212RT_bl AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M V35VI, S68SG, T69A, R83K, K173R, Q174K, V245E, A272P, I293V, E297A, E302XB
  12RT_f1 AZT, DDI, 3TCNoneA62V, K65R, K70R, V75I, F77L, F116Y, Q151M, M184V T7P, V8G, V35VI, S68G, T69A, R83K, D123G, K173R, Q174K, V245E, A272P, I293V, L295T, E297AB
 ACTG303_13491349RT_bl AZT, DDINoneM41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245MB
  1349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
 ACTG303_19341934RT_bl AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279XB
  1934RT_f1 AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297KB
Balotta (2000)CB-1CB-1AF186766DDC, AZT, 3TC, D4TNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219Q W24WG, E40K, K43N, I50IF, E53D, S68G, T107TP, V118I, D121H, K122E, I178L, T200A, I202V, R211T, F214LB
 CB-2CB-2AF186767AZT, DDI, 3TC, DDC, D4TNoneK65R, K70R, V75I, F77L, F116Y, Q151M V35I, S68G, R83K, D123E, K166R, D177E, G196E, R211KB
Baxter (2000)GART-NG43GART-43 NRTI, 3TC, D4TNoneF116Y, Q151M, M184V S48T, K122E, R211K, E248D, T296S, E297KB
 GART-NG65GART-65 NRTI, D4T, DDINoneF116Y, Q151M V35I, R83K, G196EB
 GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
Coakley (2000)EC34EC3452w D4T, DDINoneF116Y, Q151MV108IV60I, K122E, A158S, I178M, R211G, A272P, T286A, I329V, Q367P, T377Q, K390R, D460N, R461K, V466T, S468T, L486S, S519NB
  EC3480w D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I142D, R143W, A158S, I178M, R211G, A272P, T286A, I329VB
Shulman (2000)CA624CA9919AY802614DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297KB
Albrecht (2001)ACTG364_12081208 DDI, AZTNoneA62V, K70N, V75I, F77L, F116Y, Q151M E6D, T58N, S68G, D123E, I135T, S162C, D177E, I202V, Q207E, V245E, K277RB
 ACTG364_33083308 AZT, DDI, 3TCNoneM41L, A62V, D67E, K70R, F116Y, M184MIV, L210W, T215Y V35I, T39TA, T69S, V90I, V118I, K122KE, S162C, E203EK, R211S, L228H, A272P, K277R, E300X, L301X, A304XB
Delgado (2001)ED_V24ED_V24AY016934AZT, 3TCNoneM41L, A62AV, K65R, V75I, F116Y V60I, S68R, D123E, I132IV, Q151X, S162CY, E169D, I178L, Q207EB
Eshleman (2001)A021AF357625AF357625AZT, DDINoneV75I, F77L, F116Y, Q151M S68G, T69I, K122E, D123DN, G196E, F214FL, I257IL, V261I, T286A, E297KB
Gonzales (2001)CA624CA1189AY030418DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*B
 CA1166CA2649AY030474AZT, DDC, D4T, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297DB
 CA1317CA3303AY030517AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297KB
 CA1467CA3912AY030602AZT, 3TC, DDC, D4TNoneM41L, D67N, T69D, V75I, F116Y, Q151M, L210W, T215YV108IR83K, D123E, K166R, D177E, I202V, A272P, I293VB
 CA1523CA4364AY030642D4T, 3TC, DDINoneF116Y, Q151M S68G, K122E, D123E, S162C, R172K, D177E, T200A, R211S, F214L, D250DE, K277R, A288SB
 CA2316CA8409AY030861D4T, 3TC, AZTNoneF116Y, Q151M, M184V T27S, V35X, E40EG, K49R, S68G, R83K, K122E, T165I, I202V, F214LB
Katzenstein (2001)ACTG302_18931893RT_bl AZT, DDINoneD67DE, K70R, F116Y, T215Y V35I, T69S, R83K, S162C, R211RKNS, A272P, K277RB
  1893RT_f1 AZT, DDI, 3TCNoneM41ML, A62V, D67E, K70R, F116Y, M184I, L210W, T215Y V35VI, T69S, R83RK, V90I, V118I, S162C, T165TI, R211S, L228H, A272P, K277R, R284RIB
Servais (2001)JS16JS98324AJ401818DDC, AZTNoneM41L, D67N, F116Y, T215Y V35E, S48T, V118I, K122E, I135T, F214WB
Brindeiro (2002)TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Clevenbergh (2002)CP0402CP0402AF519434D4T, DDINoneD67N, F77FL, F116Y, Q151M K122E, I135M, S162A, Q197E, V245VEB
 CP1902CP1902AF519424D4T, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151MY181CT69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245TB
Romano (2002)MZ-pt38pt38-t0AF493373AZT, DDI, D4T, 3TC, ABCNoneK65R, V75I, F77L, F116Y, Q151M S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214LB
Tural (2002)880219880219 AZT, DDC, DDI, D4T, 3TCNoneM41L, D67N, K70R, F116Y, Q151M, T215F, K219Q K20R, V60I, T69N, V90I, S162H, R172K, H208Y, R211KB
 880814880814 AZT, D4T, DDI, 3TCNoneM41L, K65R, V75I, F116Y, Q151M K49R, I50V, V60I, S68G, T69I, K122E, I135T, I142M, T165I, D177E, F214L, V245MB
Gonzales (2003)CA626CA1193AF513998AZT, DDI, D4T, 3TCNoneD67G, K70G, F77L, F116Y, Q151M, M184V S68N, Q207E, F214L, T286AB
 CA1317CA12527AF514050AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288SB
Gonzales (2003)CA1408CA8382AY305908DDI, AZT, DDC, D4T, 3TCNoneD67N, K70E, F116Y, Q151M, M184V K20R, I31IL, K49K*, V60I, I135T, E138ED, T200A, R211K, F214FLB
Gonzales (2003)CA1625CA16446AF514110AZT, 3TC, D4T, DDINoneF116Y, Q151M K22R, V60I, K122E, D123E, I135V, I142V, T200A, I202V, F214FL, V245M, K277R, Q278E, T286A, I293V, E297TB
Gonzales (2003)CA4007CA20207AF514172D4T, DDI, ABC, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293VB
Gonzales (2003)CA5242CA23663AY305921AZT, 3TC, D4T, DDINoneF116Y, Q151M, N348IV179DV35IL, S68SG, T69TA, V118I, K122E, I135T, I142V, R172RK, T200A, F214L, K277R, I293IV, I326T, R356K, T386I, G436E, V466A, T477A, E492A, K527N, A554SB
Gonzales (2003)CA6434CA15945AY032387AZT, 3TC, NRTI, D4T, DDINoneA62V, V75I, F77L, F116Y, Q151M K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293VB
Saah (2003)AS-42AS-42 AZT, D4T, DDINoneF77L, F116Y, Q151M V35T, V90I, D123E, I142V, D177EB
Dumans (2004)180180AY390156AZT, DDINoneV75I, Y115F, F116Y, Q151M, K219Q S68G, D177E, R211KB
 197197AY390154AZT, DDI, D4T, 3TCNoneA62V, V75I, F77L, F116Y, Q151M, M184V, K219QE138KK49R, I50V, S68G, K101Q, R172K, V179A, I202V, F214LB
 208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Machado (2004)cs157cs157AY313424AZT, DDINoneA62V, V75I, F77L, F116Y, Q151M K122E, I202V, F214LB
Mo (2005)91249124_d1 NRTINoneM41L, D67N, T69DN, K70KR, V75I, F77L, F116Y, Q151M, M184V, T215FV, K219Q K20R, S162D, K166R, G196E, I202V, Q207E, R211RK, A272P, K277KR, A288AS, E297EKQB
Non-B Workgroup (2005)TH_146TH_146AY605559AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219EY188YDE28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245RB
Rhee (2005)CA1317CA7990AY800863AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277RB
  CA9386AY800864AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250EB
 SWC-6100P6100-1220 DDC, NRTI, D4T, 3TCNoneT69D, F116Y, Q151M, M184V V118I, K122E, A158S, I202V, R211K, F214LB
 CA9831CA24186AY802137AZT, 3TCNoneF77L, F116Y, Q151M, M184I V35I, V90I, K122E, Q207E, R211K, A272P, K277R, V292IB
 CA9933CA24557AY802197D4T, DDINoneV75I, F77L, F116Y, Q151MV108VIK20R, V35I, E79ED, R83K, V118I, E203D, F214L, T286A, A288T, E297K, K311KR, S322T, I329L, A376T, K390R, A400T, A437V, E449D, H483HN, K530R, A554SB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
von Wyl (2010)48147394814739GQ848144AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377LB