<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype B
Gene RT
Mutation Y115F
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 20
Patients 36
Isolates 44
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Shafer (1995)JIDP25JIDP25W104AF021296AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219E V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211KB
Cabana (1999)Cab-kK35AF102365DDC, AZT, D4T, 3TCNoneT69D, Y115F, Q151M, M184V K122E, I135T, S163C, D177N, G196E, I202VB
 Cab-lL39AF102367AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228QB
  L47AF102368AZT, 3TC, DDI, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228KB
Albrecht (2000)ACTG303_13491349RT_bl AZT, DDINoneM41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245MB
  1349RT_f1 AZT, DDI, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293VB
 ACTG303_19341934RT_bl AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279XB
  1934RT_f1 AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297KB
Baxter (2000)GART-G87GART-87 NRTI, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234XB
Miller (2000)MV-140MV-140wk16 ABCNoneK65R, Y115F, M184V I50V, R83K, K122E, E169D, D186DN, G196E, T200I, R206RKB
 MV-167MV-167wk48 ABC, AZT, 3TCNoneL74V, Y115F, M184V I31V, K122E, S162C, E169D, R211KB
 MV-168MV-168wk36 ABC, AZT, 3TCNoneL74V, Y115F, M184V V35I, S68G, K122E, I135T, G196E, E204DB
  MV-168wk48 ABC, AZT, 3TCNoneK65R, V75VIL, F77L, Y115F, Q151M, M184V V35I, S68G, K122E, I135T, G196E, E204DB
 MV-198MV-198wk24 ABCNoneL74V, Y115F, M184V D123E, I142X, R143X, Y144XB
 MV-199MV-199wk16 ABCNoneV75I, Y115F, L210LW S162C, T200X, E204DB
Shulman (2000)CA624CA9919AY802614DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297KB
Gonzales (2001) CA1189AY030418DDI, D4T, 3TC, AZTNoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*B
 CA1166CA2649AY030474AZT, DDC, D4T, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297DB
 CA1317CA3303AY030517AZT, DDI, 3TCNoneV75I, F77L, Y115F, F116Y, Q151M, M184V K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297KB
Ait-Khaled (2002)MAK-17511751481AJ425992ABC, AZT, 3TCNoneY115F, M184V R125K, I142V, S162A, D177E, G196EB
Brindeiro (2002)TVGG8TVGG8AY145786AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297AB
Clevenbergh (2002)CP1902CP1902AF519424NRTI, D4T, 3TCNoneA62V, V75I, F77L, Y115F, F116Y, Q151MY181CT69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245TB
Gonzales (2003)CA1317CA12527AF514050AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288SB
 CA4007CA20207AF514172D4T, DDI, ABC, AZT, 3TCNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293VB
 CA6874CA23563AF514248ABC, D4T, 3TCNoneY115F, M184V K49KR, K102R, K122E, I135V, I178V, T200A, R211K, H221Y, V245T, A272AS, V276I, L283I, I293V, E297AB
Dumans (2004)180180AY390156AZT, DDINoneV75I, Y115F, F116Y, Q151M, K219Q S68G, D177E, R211KB
 208208AY390155AZT, DDI, 3TC, D4TNoneK65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E S68G, D177EB
Gulick (2004)RG111RG111w62 ABC, AZT, 3TCNoneY115F, M184V, T215TNSY D123E, R211K, V245EB
 RG219RG219w51 ABC, AZT, 3TCNoneY115F, M184V, T215Y K122E, T139K, K166R, D177E, R211KB
 RG278RG278w67 ABC, AZT, 3TCNoneY115F, M184V V60I, R83K, V90VI, H221HYB
 RG306RG306w37 ABC, AZT, 3TCNoneY115F, M184V I37X, D177E, E203EK, R211K, E224D, L228LHB
 RG31RG31w112 ABC, AZT, 3TCNoneY115F, M184V, T215Y T39TA, V60I, K64R, D123E, I142T, E169D, L228RB
 RG469RG469w100 ABC, AZT, 3TCNoneY115F, M184VK103NT39S, V90VI, K101R, K122E, D123N, I142V, S162A, E169D, Q174K, G196E, Q207E, R211K, L228R, V245QB
Montes (2004)MB_patGUZ01_GUZ714AJ577908ABC, AZT, 3TCNoneD67E, K70R, Y115F, M184V K49R, V90I, D123E, T165I, I202V, E204D, F214LB
 MB_patFRE00_FRE705AJ577893AZT, DDI, DDC, D4T, 3TC, ABCNoneV75T, Y115F, M184V K11R, E53D, V118I, D123E, I135T, S162Y, T200I, R211G, F214LB
 MB_patGUZM01_GUZ814AJ577909ABC, AZT, 3TCNoneD67E, K70R, Y115F, M184V K49R, V90I, D123E, T165I, I202V, E204D, F214LB
 MB_patGUZM J01_GUZ914AJ577910ABC, AZT, 3TCNoneD67E, K70R, Y115F, M184V K49R, V90I, D123E, T165I, I202V, E204D, F214LB
Non-B Workgroup (2005)TH_146TH_146AY605559AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M, K219EY188YDE28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245RB
Rhee (2005)CA1317CA7990AY800863AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277RB
  CA9386AY800864AZT, DDI, 3TC, D4TNoneV75I, F77L, Y115F, F116Y, Q151M, M184V E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250EB
Villena (2007)3670836708-1EF154391D4T, 3TC, DDINoneA62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184VY181CK20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519NB
Rosen-Zvi (2008)803p8-1 AZT, D4T, 3TC, ABC, TDFNoneK65R, K70KEGR, Y115F, M184V V60I, S68SN, T69TN, D121H, K122E, I135T, D177E, R211K, A288S, I293V, E297K, K311R, Q334EB
von Wyl (2010)48147394814739GQ848144AZT, DDINoneV75I, F77L, Y115F, F116Y, Q151M V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377LB
Melikian (2012)CA8340CA79292GQ212723D4T, DDINoneY115F, M184V T69A, V118I, K122KE, I135IV, Q174H, G196E, R211G, F214L, L228H, V245T, A272P, K277R, D324E, A360T, A371V, I375V, A376S, A400T, V435E, R448G, L452V, D460N, T470A, H483Y, Q547R, A554SB