Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	B
Gene	RT
Mutation	Y115F
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	20
Patients	36
Isolates	44

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Shafer (1995)	JIDP25	JIDP25W104	AF021296	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E		V35E, E36K, I37X, S48T, S68G, K122E, I142T, R211K	B
Cabana (1999)	Cab-k	K35	AF102365	DDC, AZT, D4T, 3TC	None	T69D, Y115F, Q151M, M184V		K122E, I135T, S163C, D177N, G196E, I202V	B
	Cab-l	L39	AF102367	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228Q	B
		L47	AF102368	AZT, 3TC, DDI, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219Q		K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228K	B
Albrecht (2000)	ACTG303_1349	1349RT_bl		AZT, DDI	None	M41ML, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20KN, Y56YD, K66KN, S68G, T107P, D123E, S162T, K220KN, V245M	B
		1349RT_f1		AZT, DDI, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		V35I, S68G, D123E, S162T, V245M, K277R, Q278H, I293V	B
	ACTG303_1934	1934RT_bl		AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68SG, N81NI, K122E, E169D, T200A, Q207E, R211K, V245VM, E248DN, A272P, K277R, L279X	B
		1934RT_f1		AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K49R, I50V, S68G, V90I, K122E, E169D, T200A, Q207E, R211K, V245M, E248D, D250DE, A272P, K277R, T286A, A288S, V292I, E297K	B
Baxter (2000)	GART-G87	GART-87		NRTI, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219E		S68G, K122E, Q174K, D177E, T200A, Q207K, R211A, L234X	B
Miller (2000)	MV-140	MV-140wk16		ABC	None	K65R, Y115F, M184V		I50V, R83K, K122E, E169D, D186DN, G196E, T200I, R206RK	B
	MV-167	MV-167wk48		ABC, AZT, 3TC	None	L74V, Y115F, M184V		I31V, K122E, S162C, E169D, R211K	B
	MV-168	MV-168wk36		ABC, AZT, 3TC	None	L74V, Y115F, M184V		V35I, S68G, K122E, I135T, G196E, E204D	B
		MV-168wk48		ABC, AZT, 3TC	None	K65R, V75VIL, F77L, Y115F, Q151M, M184V		V35I, S68G, K122E, I135T, G196E, E204D	B
	MV-198	MV-198wk24		ABC	None	L74V, Y115F, M184V		D123E, I142X, R143X, Y144X	B
	MV-199	MV-199wk16		ABC	None	V75I, Y115F, L210LW		S162C, T200X, E204D	B
Shulman (2000)	CA624	CA9919	AY802614	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, T69K, K122E, K166R, D177E, R211K, K277R, I293V, E297K	B
Gonzales (2001)		CA1189	AY030418	DDI, D4T, 3TC, AZT	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184EV		S68G, T69N, V148VE, K166KR, D177DE, I178M, Y183Y*	B
	CA1166	CA2649	AY030474	AZT, DDC, D4T, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219KE		E6D, V35IM, S68G, K122E, I135T, T200I, I202V, T216TI, V245M, A272P, K275KR, E297D	B
	CA1317	CA3303	AY030517	AZT, DDI, 3TC	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		K46X, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, P243A, V245K, E248D, A272P, K277R, T286A, A288S, V292I, E297K	B
Ait-Khaled (2002)	MAK-1751	1751481	AJ425992	ABC, AZT, 3TC	None	Y115F, M184V		R125K, I142V, S162A, D177E, G196E	B
Brindeiro (2002)	TVGG8	TVGG8	AY145786	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		K20R, S68G, I135T, R172K, D177E, T200A, R211K, V245M, A272P, Q278H, I293V, E297A	B
Clevenbergh (2002)	CP1902	CP1902	AF519424	D4T, 3TC	None	A62V, V75I, F77L, Y115F, F116Y, Q151M	Y181C	T69N, K122E, K173Q, Q174R, I202V, Q207E, R211K, V245T	B
Gonzales (2003)	CA1317	CA12527	AF514050	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40K, K46Q, K49R, I50V, T58N, S68G, K122E, Q174K, T200A, Q207E, R211K, K219T, V245T, E248D, D250E, S251D, A272P, K277R, T286A, A288S	B
	CA4007	CA20207	AF514172	D4T, DDI, ABC, AZT, 3TC	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, M184V		S68G, D121H, K122E, D177E, E203D, E248D, R284K, T286A, A288S, V292I, I293V	B
	CA6874	CA23563	AF514248	ABC, D4T, 3TC	None	Y115F, M184V		K49KR, K102R, K122E, I135V, I178V, T200A, R211K, H221Y, V245T, A272AS, V276I, L283I, I293V, E297A	B
Dumans (2004)	180	180	AY390156	AZT, DDI	None	V75I, Y115F, F116Y, Q151M, K219Q		S68G, D177E, R211K	B
	208	208	AY390155	AZT, DDI, 3TC, D4T	None	K65R, K70R, V75I, F77L, Y115F, F116Y, Q151M, K219E		S68G, D177E	B
Gulick (2004)	RG111	RG111w62		ABC, AZT, 3TC	None	Y115F, M184V, T215TNSY		D123E, R211K, V245E	B
	RG219	RG219w51		ABC, AZT, 3TC	None	Y115F, M184V, T215Y		K122E, T139K, K166R, D177E, R211K	B
	RG278	RG278w67		ABC, AZT, 3TC	None	Y115F, M184V		V60I, R83K, V90VI, H221HY	B
	RG306	RG306w37		ABC, AZT, 3TC	None	Y115F, M184V		I37X, D177E, E203EK, R211K, E224D, L228LH	B
	RG31	RG31w112		ABC, AZT, 3TC	None	Y115F, M184V, T215Y		T39TA, V60I, K64R, D123E, I142T, E169D, L228R	B
	RG469	RG469w100		ABC, AZT, 3TC	None	Y115F, M184V	K103N	T39S, V90VI, K101R, K122E, D123N, I142V, S162A, E169D, Q174K, G196E, Q207E, R211K, L228R, V245Q	B
Montes (2004)	MB_patGUZ	01_GUZ714	AJ577908	ABC, AZT, 3TC	None	D67E, K70R, Y115F, M184V		K49R, V90I, D123E, T165I, I202V, E204D, F214L	B
	MB_patFRE	00_FRE705	AJ577893	AZT, DDI, DDC, D4T, 3TC, ABC	None	V75T, Y115F, M184V		K11R, E53D, V118I, D123E, I135T, S162Y, T200I, R211G, F214L	B
	MB_patGUZM	01_GUZ814	AJ577909	ABC, AZT, 3TC	None	D67E, K70R, Y115F, M184V		K49R, V90I, D123E, T165I, I202V, E204D, F214L	B
	MB_patGUZM J	01_GUZ914	AJ577910	ABC, AZT, 3TC	None	D67E, K70R, Y115F, M184V		K49R, V90I, D123E, T165I, I202V, E204D, F214L	B
Non-B Workgroup (2005)	TH_146	TH_146	AY605559	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M, K219E	Y188YD	E28V, E29R, V35T, T39A, S68G, I135V, S162C, K173I, Q174K, V245R	B
Rhee (2005)	CA1317	CA7990	AY800863	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M		K49R, I50V, S68G, K122E, T200A, E203EQ, Q207E, R211K, K219T, V245T, E248D, D250E, S251X, A272P, K277R	B
		CA9386	AY800864	AZT, DDI, 3TC, D4T	None	V75I, F77L, Y115F, F116Y, Q151M, M184V		E40EK, K46KQ, K49R, I50V, S68G, K122E, E169ED, T200A, Q207E, R211K, K219T, V245T, E248D, D250E	B
Villena (2007)	36708	36708-1	EF154391	D4T, 3TC, DDI	None	A62V, K70G, V75I, F77L, Y115F, F116Y, Q151M, M184V	Y181C	K20R, T39A, S68G, T69A, K101R, D123E, I135T, I167V, D177E, I202V, R211K, I293V, P294T, E297K, I375V, T386I, V435I, E449D, D460N, S468P, L491S, K512T, L517I, S519N	B
Rosen-Zvi (2008)	8	03p8-1		AZT, D4T, 3TC, ABC, TDF	None	K65R, K70KEGR, Y115F, M184V		V60I, S68SN, T69TN, D121H, K122E, I135T, D177E, R211K, A288S, I293V, E297K, K311R, Q334E	B
von Wyl (2010)	4814739	4814739	GQ848144	AZT, DDI	None	V75I, F77L, Y115F, F116Y, Q151M		V35I, S68SG, D123E, I135R, K173KQ, A272P, K281KR, T286P, E297K, K311KR, V317A, Q334R, M357T, T369A, I375V, A376T, T377L	B
Melikian (2012)	CA8340	CA79292	GQ212723	D4T, DDI	None	Y115F, M184V		T69A, V118I, K122KE, I135IV, Q174H, G196E, R211G, F214L, L228H, V245T, A272P, K277R, D324E, A360T, A371V, I375V, A376S, A400T, V435E, R448G, L452V, D460N, T470A, H483Y, Q547R, A554S	B

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