<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation K70R
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 6
Patients 27
Isolates 28
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Carr (1999)SE8538SE8538AF069669AZTNoneK70R V35T, V60I, T69N, K122E, D123S, I135T, A158S, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, V245N, D250E, T286A, E291D, V292I, I293V, P294T, E312A, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, L391V, A400T, T403M, E432D, V435A, D471E, L479V, Q480H, L491S, K512S, S519N, Q524K, K527G, E529D, A534S, A554SA
Gibb (2002)DMG1111_w31 AZT, 3TCNoneM41ML, K70R, M184V, N348NI K11E, K20KR, V35T, V60I, T69N, D121H, K122E, D123S, I135T, I142IV, K173S, Q174K, D177E, V179I, Q197L, Q207A, R211S, V245IM, D250E, A272G, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357KR, G359S, T369AV, A371V, I375V, A376V, T377MA
Vergne (2002)LV04BLV04BAJ313406AZT, D4TNoneK65R, K70R, V75I, F77L, F116Y, Q151M K11T, V35T, T39K, K43E, S68G, D121Y, K122E, D123G, K173S, Q174K, I180V, Q207A, R211S, V245Q, E248D, K277R, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, M357K, G359S, K366R, I375V, T377Q, S379C, K390R, T403M, K431T, E432D, V435AA
Snoeck (2004)BE25BE25AY901287AZTNoneD67N, K70R, K219Q K11T, V35IT, T39X, V60VI, T69TN, K122E, D123N, I135T, E138EA, I142IV, K166R, K173S, I202V, Q207A, R211S, F214L, V245Q, E248D, K277R, T286A, E291D, V292VI, I293V, P294V, E312NA
Non-B Workgroup (2005)TK2029TK2029 AZT, 3TC, D4T, ABCNoneM41L, D67N, K70R, M184V, T215F, K219EA98GV35T, T39A, V60I, S117X, K122E, D123S, I135T, I167V, K173S, Q174K, D177E, V179I, T200A, E203D, Q207A, R211NS, L228H, Q242H, V245T, D250E, T286A, E291D, I293V, P294T, E312DA
 TK3030TK3030 AZT, 3TC, DDINoneM41ML, K70R, T215I, K219Q V35T, T39I, V60I, T69N, D121Y, K122E, I135T, K173S, Q174K, D177E, V179I, Q197E, Q207A, R211N, V245K, D250E, A272T, T286A, I293V, P294T, L295LM, E312DA
  TK3030a AZT, 3TC, DDINoneM41ML, D67DG, K70R, T215TI, K219Q V35T, T39I, V60I, K64KN, T69N, D121Y, K122E, I135T, K173S, Q174K, D177E, V179I, Q197E, Q207A, R211NS, V245K, D250E, A272T, T286A, I293V, P294T, L295LM, E312DA
 TK4006TK4006 AZT, 3TCNoneD67N, K70R, M184V E6D, V35T, S48T, V60I, K122E, D123NS, I135T, K173I, Q174K, D177E, I178L, V179I, Q207A, R211S, P243A, V245E, D250E, E291D, V292I, I293V, P294T, E312D, Q334P, G335DA
 TK5002TK5002 D4T, 3TCNoneD67N, T69D, K70R, M184V, K219QA98GK11T, V35T, E40D, K49R, V60I, K122E, D123S, I135T, S162A, T165I, K173S, D177E, V179I, Q207A, R211S, F214L, D218E, V245Q, A272P, E291D, I293V, P294T, E312D, D324EA
 PL4985392544 ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E S3R, K11S, V35T, T39N, K64KN, K122E, D123N, A158S, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E, A272P, K281KR, E291D, I293V, P294PT, L295M, E297KQ, E312DA
Ndembi (2010)13228D_P113228GQ409549ABC, AZT, 3TCNoneD67N, K70R, M184V, K219Q I5V, E6D, V35T, V60I, S68SR, K122E, D123S, I135T, K173S, Q174K, D177E, Q197E, Q207A, R211N, H221YA
 13240D_P113240GQ409550ABC, AZT, 3TCNoneD67N, K70R, M184V K20R, V21I, V35T, T39A, V60I, K122E, D123N, I135T, F171L, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, F214LA
 13325D_P1rt13325GQ409554ABC, AZT, 3TCNoneK70R, M184V V35T, T39M, K49R, V60I, K122E, D123S, I135T, S162N, K173S, Q174K, D177E, V179I, T200A, Q207EA
 13354D_P113354GQ409556ABC, AZT, 3TCNoneD67N, K70R, M184VK103NP4S, V35T, T39M, K122E, D123N, I135T, S162C, K173S, Q174K, D177E, T200A, Q207E, R211KA
 14411D_P114411GQ409568ABC, AZT, 3TCNoneD67N, K70R, M184V K11T, K20R, V21I, V35T, V90VI, K122E, D123DG, S162A, T165I, K173S, Q174R, D177E, V179I, T200A, I202V, Q207D, R211KA
 14888D_P114888GQ409570ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E I31V, V35T, T39A, E40D, K122E, D123S, K173G, Q174K, V179I, T200A, Q207A, R211S, F214LA
 15460D_P115460GQ409574ABC, AZT, 3TCNoneD67N, K70R, M184V E6N, V35T, T39L, V60I, V118I, K122E, I135T, K173S, Q174K, D177E, V179I, T200K, Q207A, R211S, F214LA
 15710D_P115710GQ409576ABC, AZT, 3TCNoneD67N, K70R, M184V E6S, V35T, V60I, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211SA
 16182D_P116182GQ409582ABC, AZT, 3TC, D4TNoneM41L, D67N, K70R, L74I, M184V, T215F, K219QK103NV21I, V35T, T39K, V60I, V90I, K102Q, K122E, D123G, K173S, D177E, T200A, I202V, Q207EA
 16712D_P116712GQ409588ABC, AZT, 3TCNoneD67N, K70R, M184V, T215Y K11T, K20R, V21I, V35T, T39N, K122E, D123N, I135T, S162H, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, R211SA
 16735D_P116735GQ409589ABC, AZT, 3TC, D4TNoneK65R, K70R, V75I, F116Y, Q151M, M184V V35T, K43R, V60I, S68G, D121H, K122E, K173S, Q174K, D177E, I178M, T200M, Q207E, R211K, F214LA
 17219D_P117219GQ409591ABC, AZT, 3TC, TDFNoneD67N, K70R, M184V, T215TI K11T, K20L, L26M, V35T, K122E, D123S, I135T, T165L, K173A, D177E, I178L, V179I, T200A, I202V, Q207A, R211NA
 DT0971_05_P1971GQ409598ABC, AZT, 3TC, TDFNoneD67N, K70R, M184V E6DN, K11H, V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211SA
 DT2172_05_P12172GQ409603ABC, AZT, 3TCNoneD67N, K70R, M184V E6K, K11Q, K20R, T27S, V35T, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179T, Q207A, R211SA
 DT2829_05_P12829GQ409610ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E V21I, V35T, T69A, K122Q, D123S, E169D, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, R211SA
 DT3516_05_P13516GQ409620ABC, AZT, 3TCNoneD67N, K70R, M184V, T215IE138KK20R, V35T, T39A, E40D, V60I, K122E, D123S, I135T, N136H, K166I, K173S, Q174K, D177E, Q207N, R211K, F214LA
 DT3793_05_P13793GQ409625ABC, AZT, 3TCNoneD67N, K70R, M184V K11T, V21I, V35T, T39R, V60I, K101T, K122E, D123S, G141E, I142S, V148G, G152D, W153R, I159L, F160I, K173S, Q174K, D177E, I202V, Q207A, R211KA
 DT3994_05_P13994GQ409628ABC, AZT, 3TCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E E6D, K11I, V35T, T39K, K43E, K122E, D123S, I135T, S162C, K173T, Q174K, G196E, T200A, Q207A, R211KA