Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	T69S
Rx	RTI-naive
IncludeMixtures	No

References	7
Patients	18
Isolates	18

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	OtherMut	Subtype
Lwembe (2007)	NYU79	79MFEB03		None	None		V35T, T69S, D121H, K122E, I135T, K173A, Q174K, V179I, Q207A, R211S	A
Ndembi (2008)	IAEM078	IAEM078	EU306794	None	None		V35T, K49R, I50V, V60I, T69S, D121H, K122E, D123S, I135T, I142V, T165I, E169D, K173S, Q174K, T200A, Q207A, R211K, F214L	A
Nyombi (2008)	TBK023	TBK023	EU251729	None	None		V35T, V60I, T69S, K122E, D123S, I142V, K173A, Q174K, D177E, V179I, T200A, I202IV, Q207A, R211N, D250E, A272P, E291D, I293V, E312D, Q334L, G335D, P345S, M357R, R358K, G359S, A371V, I375V	A
	TMS119	TMS119	EU251819	None	None		K11T, V35T, I50IV, T69S, V106VI, K122E, D123N, I135T, K173S, D177E, V179I, I202V, Q207A, R211S, V245M, T286A, I293V, P294T, E312NT, V314M, G335D, M357K, G359S, K366KR, A371V, I375V, A376V, T377M	A
Vercauteren (2009)	pt935	7651373154	GQ400089	None	None		E6D, E28K, K32DE, V35T, T39TA, T69S, K122E, D123S, I135T, I142V, S162H, K173S, D177E, V179I, Q207A, R211K, P243A, V245Q, T286A, E291D, V292VI, I293V, E312D, I326V	A
	pt756	8621913674	GQ400268	None	None	K219Q	E36K, I37F, E40D, V60I, T69S, K101R, V118I, K122E, D123N, I135T, I142T, K173LS, Q174K, V179I, T200A, Q207A, R211S, F214L, V245R	A
	pt703	8877010072	GQ400321	None	None	K219Q	K30Q, K32G, A33C, L34T, V35L, E36N, I37F, E40D, E53ED, V60I, T69S, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L	A
Hamers (2011)	CP076302253	CP076302253	HQ993767	None	None		V21I, V35T, T39A, E40D, K49R, V60I, T69S, K122E, I135T, I142V, K173S, Q174K, D177E, V179VI, T200A, Q207E, R211AGST, F214FL, V245E, D250E, T286A, E291D, V292I, I293V	A
	CP076302260	CP076302260	HQ993826	None	None		I5IV, E6EK, V35T, V60I, T69S, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245KQ, D250DE, T286A, E291D, V292VI, I293V, P294T, E312DN, G335D	A
	CP076302293	CP076302293	HQ993841	None	None		K20R, V35T, V60I, T69S, K122E, I135T, E169D, K173S, Q174K, D177E, V179I, G196E, I202V, Q207A, R211S, F214FL, V245I, D250E, A272P, K277R, L283LI, T286A, E291D, V292I, I293V, L295M, E297K, E312D, S322A	A
	CP076301880	CP076301880	HQ995009	None	None		K11A, V35I, T69S, K102Q, K122E, D123S, I135T, I142V, K173S, D177E, V179I, G196K, T200A, Q207A, R211S, V245Q, E248D, E291D, V292VI, I293V, P294PT, E297K	A
	CP076302004	CP076302004	HQ995017	None	None		K32I, V35T, T39K, T69S, K122E, D123N, D177E, Q197QK, Q207E, V245EK, E248D, D250E, K281R, T286A, E291D, I293V, P294T	A
	CP076302062	CP076302062	HQ995025	None	None	A62V	P4S, K20R, V21I, V35I, T39N, T69S, K122E, D123N, I135L, S162C, K173S, Q174K, D177E, V179I, G196E, T200A, I202V, Q207A, R211K, V245Q, E248D, R284K, T286A, E291D, V292I, I293V, P294T, L295M, E297K	A
	CP076303001	CP076303001	HQ995069	None	None		V35T, T69S, K122E, D123N, K173S, Q174K, I178L, T200A, Q207A, R211K, V245Q, A272P, T286A, I293V, P294T	A
	CP076301921	CP076301921	HQ995393	None	None		V35T, V60I, T69S, K122E, I135T, I142V, S162H, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, V245T, D250E, S251R, A272P, K275R, T286A, E291D, V292I, I293V, P294T, E297D	A
	CP076301933	CP076301933	HQ995400	None	None	K70Q	K20R, V35T, T39L, K43R, V60I, T69S, V106I, D121H, K122E, D123S, I135T, I142V, D177E, I178L, T200I, Q207A, R211K, F214L, V245T, S251D, A272AP, T286A, E291D, V292I, I293V, P294T, E297D	A
Fernandez-Garcia (2012)	RUA001	RUA001	JQ292893	None	None	A62V	K11T, V35I, E36D, T39K, T69S, D123N, A158S, K173V, Q174K, D177E, Q207A, R211S, V245T, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E300EK, I326V, E328EK, Q334L, G335D, R356K, M357K, R358G, G359S, E370A, A371V, I375V, K390R, V435I, L452I, D471E, Q480H, L491S, K512R, E516EK, L517I, S519N, Q520K, Q524K, K527E, K530R, A534S, A554Y, K558R	A
Hassan (2012)	RS09000941	RS09000941	HQ441683	None	None		E6D, V35T, E40D, K49R, V60I, K64KR, T69S, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, I178L, V179I, Q207A, R211AT, V245E, E248D, D250E, A272P, K275Q, E291D, I293V, P294IV, E312D	A

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