Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	D67N
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	5
Patients	26
Isolates	26

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Montes (2004)	MB_patBES	00_BES703	AJ577738	AZT, DDI, 3TC, D4T, ABC	None	D67N, K219Q		K11T, V35T, T39A, S48A, K49R, V60I, T69N, K122E, D123S, I135T, K173S, D177E, T200A, Q207A, R211S, F214L	A
Snoeck (2004)	BE25	BE25	AY901287	AZT	None	D67N, K70R, K219Q		K11T, V35IT, T39X, V60VI, T69TN, K122E, D123N, I135T, E138EA, I142IV, K166R, K173S, I202V, Q207A, R211S, F214L, V245Q, E248D, K277R, T286A, E291D, V292VI, I293V, P294V, E312N	A
Non-B Workgroup (2005)	TK2012	TK2012		AZT, 3TC, D4T	None	D67N, M184V, T215F, K219E		V35I, V60I, K122E, D123S, I135T, I142V, K173A, D177E, V179I, T200A, Q207A, R211RS, V245E, A272P, K281R, E291D, I293V, P294T	A
	TK2029	TK2029		AZT, 3TC, D4T, ABC	None	M41L, D67N, K70R, M184V, T215F, K219E	A98G	V35T, T39A, V60I, S117X, K122E, D123S, I135T, I167V, K173S, Q174K, D177E, V179I, T200A, E203D, Q207A, R211NS, L228H, Q242H, V245T, D250E, T286A, E291D, I293V, P294T, E312D	A
	TK4006	TK4006		AZT, 3TC	None	D67N, K70R, M184V		E6D, V35T, S48T, V60I, K122E, D123NS, I135T, K173I, Q174K, D177E, I178L, V179I, Q207A, R211S, P243A, V245E, D250E, E291D, V292I, I293V, P294T, E312D, Q334P, G335D	A
	TK5002	TK5002		D4T, 3TC	None	D67N, T69D, K70R, M184V, K219Q	A98G	K11T, V35T, E40D, K49R, V60I, K122E, D123S, I135T, S162A, T165I, K173S, D177E, V179I, Q207A, R211S, F214L, D218E, V245Q, A272P, E291D, I293V, P294T, E312D, D324E	A
	PL49853	92544		ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E		S3R, K11S, V35T, T39N, K64KN, K122E, D123N, A158S, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E, A272P, K281KR, E291D, I293V, P294PT, L295M, E297KQ, E312D	A
Weber (2005)	F45753	F45753	AY677506	AZT, D4T, 3TC, DDI, ABC	None	M41L, D67N, M184V, L210W, T215Y		K11T, K20R, V21I, V35T, T39S, E44ED, V60I, D121H, K122E, D123S, D177E, V179I, T200A, I202V, Q207A, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, E312D	A
Ndembi (2010)	13228D_P1	13228	GQ409549	ABC, AZT, 3TC	None	D67N, K70R, M184V, K219Q		I5V, E6D, V35T, V60I, S68SR, K122E, D123S, I135T, K173S, Q174K, D177E, Q197E, Q207A, R211N, H221Y	A
	13240D_P1	13240	GQ409550	ABC, AZT, 3TC	None	D67N, K70R, M184V		K20R, V21I, V35T, T39A, V60I, K122E, D123N, I135T, F171L, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, F214L	A
	13354D_P1	13354	GQ409556	ABC, AZT, 3TC	None	D67N, K70R, M184V	K103N	P4S, V35T, T39M, K122E, D123N, I135T, S162C, K173S, Q174K, D177E, T200A, Q207E, R211K	A
	14006D_P1	14006	GQ409562	ABC, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215F	A98G, G190A	E6EK, V35T, E44D, S48E, V60I, K122E, D123N, I135L, K166R, K173S, D177E, V179I, G196E, T200A, E203D, Q207A, R211NS	A
	14411D_P1	14411	GQ409568	ABC, AZT, 3TC	None	D67N, K70R, M184V		K11T, K20R, V21I, V35T, V90VI, K122E, D123DG, S162A, T165I, K173S, Q174R, D177E, V179I, T200A, I202V, Q207D, R211K	A
	14888D_P1	14888	GQ409570	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E		I31V, V35T, T39A, E40D, K122E, D123S, K173G, Q174K, V179I, T200A, Q207A, R211S, F214L	A
	15460D_P1	15460	GQ409574	ABC, AZT, 3TC	None	D67N, K70R, M184V		E6N, V35T, T39L, V60I, V118I, K122E, I135T, K173S, Q174K, D177E, V179I, T200K, Q207A, R211S, F214L	A
	15710D_P1	15710	GQ409576	ABC, AZT, 3TC	None	D67N, K70R, M184V		E6S, V35T, V60I, K122E, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S	A
	15712D_P1	15712	GQ409577	ABC, AZT, 3TC	None	D67N, K70KR, M184V		P4S, K11T, K20R, V35T, D123N, K173A, D177E, I178L, V179I, T200A, I202V, Q207A, R211K	A
	16182D_P1	16182	GQ409582	ABC, AZT, 3TC, D4T	None	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	K103N	V21I, V35T, T39K, V60I, V90I, K102Q, K122E, D123G, K173S, D177E, T200A, I202V, Q207E	A
	16712D_P1	16712	GQ409588	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215Y		K11T, K20R, V21I, V35T, T39N, K122E, D123N, I135T, S162H, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, R211S	A
	17219D_P1	17219	GQ409591	ABC, AZT, 3TC, TDF	None	D67N, K70R, M184V, T215TI		K11T, K20L, L26M, V35T, K122E, D123S, I135T, T165L, K173A, D177E, I178L, V179I, T200A, I202V, Q207A, R211N	A
	DT0971_05_P1	971	GQ409598	ABC, AZT, 3TC, TDF	None	D67N, K70R, M184V		E6DN, K11H, V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, T200A, Q207A, R211S	A
	DT2172_05_P1	2172	GQ409603	ABC, AZT, 3TC	None	D67N, K70R, M184V		E6K, K11Q, K20R, T27S, V35T, V60I, K122E, D123N, I135T, K173S, Q174K, D177E, V179T, Q207A, R211S	A
	DT2829_05_P1	2829	GQ409610	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E		V21I, V35T, T69A, K122Q, D123S, E169D, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, R211S	A
	DT3516_05_P1	3516	GQ409620	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I	E138K	K20R, V35T, T39A, E40D, V60I, K122E, D123S, I135T, N136H, K166I, K173S, Q174K, D177E, Q207N, R211K, F214L	A
	DT3793_05_P1	3793	GQ409625	ABC, AZT, 3TC	None	D67N, K70R, M184V		K11T, V21I, V35T, T39R, V60I, K101T, K122E, D123S, G141E, I142S, V148G, G152D, W153R, I159L, F160I, K173S, Q174K, D177E, I202V, Q207A, R211K	A
	DT3994_05_P1	3994	GQ409628	ABC, AZT, 3TC	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219E		E6D, K11I, V35T, T39K, K43E, K122E, D123S, I135T, S162C, K173T, Q174K, G196E, T200A, Q207A, R211K	A

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