Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	M41L
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	7
Patients	13
Isolates	13

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Yahi (2001)	NY_M29	M29	AY010488	D4T, 3TC	None	M41L, M184V, T215F		V35T, E36A, T39K, K43E, K49KR, E53D, T69S, D121H, K122E, D123S, I142V, S162D, K173S, Q174K, D177E, Q207A	A
Vergne (2003)	VL00SN69HPD	00SN69	AJ583752	D4T, DDI	None	M41L, M184V, T215Y		K11T, V35T, T39A, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178V, V179I, Q197E, Q207A, R211S, F214L, V245K, D250E, A272P, A288S, E291D, I293V, P294T, G335D, R356K, M357R, G359S, V365I, A371V, I375V, A376G, T377L, A400T, T403M, E404D, E432N	A
Non-B Workgroup (2005)	UK2088	UK2088	AY901395	AZT, 3TC	None	M41L, M184V, L210W, T215Y		K11T, K20R, V21I, V35T, T39G, V60I, K122E, D123N, I135T, E138A, I142V, K173S, D177E, V179I, T200A, I202V, Q207A	A
	PL9728	60099	AY901680	D4T, DDI, DDC, AZT	None	M41L, M184V, L210W, T215Y		V35T, K43KE, V118VI, D121H, K122E, I135T, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, V245K, K281R, T286A, E291D, V292I, I293V, E297K, A304E, E312N, D320E, D324E, I329V	A
	TK2029	TK2029		AZT, 3TC, D4T, ABC	None	M41L, D67N, K70R, M184V, T215F, K219E	A98G	V35T, T39A, V60I, S117X, K122E, D123S, I135T, I167V, K173S, Q174K, D177E, V179I, T200A, E203D, Q207A, R211NS, L228H, Q242H, V245T, D250E, T286A, E291D, I293V, P294T, E312D	A
	TK4003	TK4003a		AZT, 3TC	None	M41L, M184V, T215F		V35T, K122E, D123S, I135V, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, T216TR, V245Q, D250E, S251X, A272AP, K275KQ, T286A, E291D, V292I, I293V, E312D	A
Weber (2005)	F45753	F45753	AY677506	AZT, D4T, 3TC, DDI, ABC	None	M41L, D67N, M184V, L210W, T215Y		K11T, K20R, V21I, V35T, T39S, E44ED, V60I, D121H, K122E, D123S, D177E, V179I, T200A, I202V, Q207A, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, E312D	A
Tee (2006)	MYKL1855	04MYKL1855	AY960905	NRTI, D4T, 3TC	None	M41L, M184V, T215Y	Y188L	V35T, T39K, K43E, K122E, D123S, S162C, I202V, V245E	A
Ndembi (2010)	14006D_P1	14006	GQ409562	ABC, AZT, 3TC	None	M41L, D67N, M184V, L210W, T215F	A98G, G190A	E6EK, V35T, E44D, S48E, V60I, K122E, D123N, I135L, K166R, K173S, D177E, V179I, G196E, T200A, E203D, Q207A, R211NS	A
	16182D_P1	16182	GQ409582	ABC, AZT, 3TC, D4T	None	M41L, D67N, K70R, L74I, M184V, T215F, K219Q	K103N	V21I, V35T, T39K, V60I, V90I, K102Q, K122E, D123G, K173S, D177E, T200A, I202V, Q207E	A
	DT3994_05_P1	3994	GQ409628	ABC, AZT, 3TC	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219E		E6D, K11I, V35T, T39K, K43E, K122E, D123S, I135T, S162C, K173T, Q174K, G196E, T200A, Q207A, R211K	A
	DT3340_05_P1	3340	GQ409635	ABC, AZT, 3TC	None	M41L, D67DN, K70KR, M184V, T215F		E6D, V35T, V60I, K122E, D123N, I135T, T139K, I142V, A158E, K173A, Q174K, D177E, T200E, Q207A, R211K	A
von Wyl (2010)	4815086	4815086	GQ848149	D4T, DDI	None	M41L, T215F		K11T, K20R, V35T, T39G, K173S, D177E, V179I, T200A, Q207A, R211K, V245K, T286A, A288AT, E291D, V292I, I293V, P294T, E312D, V317VA, G335D, M357K, G359S, T369TA, A371V, I375V, A376V, T377M, E396D	A

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