<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation M41L
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 8
Patients 22
Isolates 22
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010488D4T, 3TCNoneM41L, M184V, T215F V35T, E36A, T39K, K43E, K49KR, E53D, T69S, D121H, K122E, D123S, I142V, S162D, K173S, Q174K, D177E, Q207AA
Vergne (2003)VL00SN69HPD00SN69AJ583752D4T, DDINoneM41L, M184V, T215Y K11T, V35T, T39A, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178V, V179I, Q197E, Q207A, R211S, F214L, V245K, D250E, A272P, A288S, E291D, I293V, P294T, G335D, R356K, M357R, G359S, V365I, A371V, I375V, A376G, T377L, A400T, T403M, E404D, E432NA
Non-B Workgroup (2005)UK2088UK2088AY901395AZT, 3TCNoneM41L, M184V, L210W, T215Y K11T, K20R, V21I, V35T, T39G, V60I, K122E, D123N, I135T, E138A, I142V, K173S, D177E, V179I, T200A, I202V, Q207AA
 PL972860099AY901680D4T, DDI, DDC, AZTNoneM41L, M184V, L210W, T215Y V35T, K43KE, V118VI, D121H, K122E, I135T, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, V245K, K281R, T286A, E291D, V292I, I293V, E297K, A304E, E312N, D320E, D324E, I329VA
 PL3892365841AY901690DDC, TDF, AZT, D4TNoneM41L, D67DN, T215Y S3ST, V35T, T39N, E44D, V60I, V111VG, D121DN, K122E, D123S, K173A, Q174K, D177E, I178M, G196E, T200A, E204KN, Q207E, R211K, V245Q, P247A, E248D, S251H, A272P, T286A, E291D, V292I, I293V, P294VA
 PL3943966997 AZT, DDI, 3TC, D4TNoneM41L, K70Q, L210W, T215Y K22R, V35T, T39K, K43E, V106I, K173T, Q174KR, D177E, G196E, T200K, I202V, Q207D, R211K, L228H, V245Q, A272P, L283I, T286A, I293V, P294T, E297NA
 TK2029TK2029 AZT, 3TC, D4T, ABCNoneM41L, D67N, K70R, M184V, T215F, K219EA98GV35T, T39A, V60I, S117SAP, K122E, D123S, I135T, I167V, K173S, Q174K, D177E, V179I, T200A, E203D, Q207A, R211NS, L228H, Q242H, V245T, D250E, T286A, E291D, I293V, P294T, E312DA
 TK4003TK4003a AZT, 3TCNoneM41L, M184V, T215F V35T, K122E, D123S, I135V, I142V, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, T216TR, V245Q, D250E, S251SDGN, A272AP, K275KQ, T286A, E291D, V292I, I293V, E312DA
Weber (2005)F45753F45753AY677506AZT, D4T, 3TC, DDI, ABCNoneM41L, D67N, M184V, L210W, T215Y K11T, K20R, V21I, V35T, T39S, E44ED, V60I, D121H, K122E, D123S, D177E, V179I, T200A, I202V, Q207A, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, E312DA
 M92470M92470AY677531AZT, 3TCNoneM41L, M184V, L210LW, T215Y V35IT, T39A, E40D, K122E, D123S, I142V, K173T, T200A, Q207D, V245Q, K277R, K281KR, E291D, I293V, P294TA
Ndembi (2010)14006D_P114006GQ409562ABC, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215FA98G, G190AE6EK, V35T, E44D, S48E, V60I, K122E, D123N, I135L, K166R, K173S, D177E, V179I, G196E, T200A, E203D, Q207A, R211NSA
 16182D_P116182GQ409582ABC, AZT, 3TC, D4TNoneM41L, D67N, K70R, L74I, M184V, T215F, K219QK103NV21I, V35T, T39K, V60I, V90I, K102Q, K122E, D123G, K173S, D177E, T200A, I202V, Q207EA
 DT3994_05_P13994GQ409628ABC, AZT, 3TCNoneM41L, D67N, K70R, M184V, L210W, T215Y, K219E E6D, K11I, V35T, T39K, K43E, K122E, D123S, I135T, S162C, K173T, Q174K, G196E, T200A, Q207A, R211KA
 DT3340_05_P13340GQ409635ABC, AZT, 3TCNoneM41L, D67DN, K70KR, M184V, T215F E6D, V35T, V60I, K122E, D123N, I135T, T139K, I142V, A158E, K173A, Q174K, D177E, T200E, Q207A, R211KA
von Wyl (2010)48150864815086GQ848149D4T, DDINoneM41L, T215F K11T, K20R, V35T, T39G, K173S, D177E, V179I, T200A, Q207A, R211K, V245K, T286A, A288AT, E291D, V292I, I293V, P294T, E312D, V317VA, G335D, M357K, G359S, T369TA, A371V, I375V, A376V, T377M, E396D, A400TA
Sigaloff (2011)HIV100812HIV100812JN132247ABC, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215YK103N, G190AK11T, V35T, T39E, E44D, K102R, V118I, K122E, D123N, I135T, K173L, Q174K, D177E, T200A, E203D, Q207A, R211N, V245Q, D250E, A272P, T286TP, E291D, V292I, I293VA
 HIV100840HIV100840JN132250ABC, AZT, 3TCNoneM41L, D67N, M184V, L210W, T215YG190AI2IV, K11T, K20R, V21I, V35T, T39D, E44D, E53D, V111I, K122E, D123S, I142V, K173S, Q174K, D177E, I178M, V179I, T200A, I202V, E203D, Q207A, H208Y, R211K, H221Y, V245Q, E248D, A272P, T286A, E291DA
Acharya (2014)DGP185DGP185KJ185355TDF, 3TCNoneM41L, D67N, T69D, V75M, M184V, L210W, T215YK101E, Y188LK11E, V35T, V60I, V106I, D121Y, K122E, D123G, T165I, K173T, Q174N, D177E, Q197K, T200A, Q207A, R211S, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
 DGP152DGP152KJ185322TDF, 3TCNoneM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, K103N, P225HK11E, V35T, V60I, D121Y, K122E, D123G, T165I, K173T, Q174N, D177E, Q197K, T200A, Q207A, R211S, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
 DGP122DGP122KJ185292AZT, 3TCNoneM41L, D67N, M184V, L210W, T215FG190AK11E, V35T, V60I, D121H, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, Q197E, T200A, E203D, Q207A, R211S, V245Q, D250E, T286A, E291D, I293VA
 DGP096DGP096KJ185266TDF, 3TCNoneM41L, L74I, M184V, L210W, T215YK103N, V108IK11E, V35T, V60I, D121Y, K122E, D123G, T165I, K173T, Q174N, D177E, Q197K, T200A, Q207A, R211S, V245K, D250E, T286A, E291D, V292I, I293V, P294TA
 DGP088DGP088KJ185258TDF, 3TCNoneM41L, D67N, V75M, M184V, L210W, T215Y, K219EY188L, K238TK11E, V35T, V60I, D121H, K122E, D123S, I135T, S162H, K173S, Q174K, D177E, V179I, Q197K, T200A, I202V, R206K, Q207A, R211S, V245M, D250E, I293V, P294TA