Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	E40D
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	7
Patients	15
Isolates	18

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Eshleman (2002)	115106j	115106j	AF410205	AZT	None			K11KT, V35T, T39A, E40D, K43R, K64R, K122E, D123S, I135R, K173AS, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, A272S, T286TA, E291D, I293V, P294T, L310LI, E312D	A
	130526d	130526d	AF410218	AZT	None			P4H, K11T, V35T, E40D, K43R, I50V, V118I, K122E, D123S, I135R, K173S, D177E, V179I, I202V, Q207A, R211S, F214L, V245K, A272P, V276I, K277R, L282C, L283I, R284RK, T286A, A288T, V292I, I293V, E297A	A
	142181q	142181q	AF410239	AZT	None			E6D, V35T, E40D, V60I, D121H, K122E, D123S, K173S, D177E, V179VI, T200TA, Q207A, R211S, V245Q, D250E, A272AS, K281KR, E291D, I293V, P294T, L295LM, E312D, V317VA	A
	144449s	144449s	AF410242	AZT	None			V35T, E40D, V60I, D121H, K122E, D123E, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, P243S, V245K, E248D, D250E, T286A, E291D, I293V, P294T, E312D	A
	145484o	145484o	AF410245	AZT	None			V35T, E40D, V60I, D121H, K122E, I135T, E138A, I142V, K173A, Q174K, I178M, V179I, T200A, Q207A, R211S, V245K, D250E, T286A, E291D, I293V, P294T, L295M, E312D	A
Gibb (2002)	DMG102	102_w51		ABC, 3TC	None			K11KT, K20R, V35T, T39KQ, E40D, K122E, D123N, E138EA, K173S, T200A, Q207AD, F214L, V245Q, E248D, A272P, T286A, E291ED, V292VI, I293V, P294PST, K311R, G335D, M357K, G359S, T369A, A371V, A376V, T377M, K390R	A
	DMG98	98_w29		AZT, 3TC	None			K11KT, K20R, V35T, T39KQ, E40D, K122E, D123N, E138EA, K173S, T200A, Q207A, F214L, V245Q, E248D, A272P, T286A, E291ED, V292VI, I293V, P294PS, K311R, G335D, M357K, G359S, T369A, A371V, A376V, T377M, K390R	A
Weber (2003)	5W	IRIS5W-48	AY140814	AZT, 3TC	None	M184V		P4T, K11T, V21I, V35T, E40D, K49R, V60I, V90I, K122E, D123S, I135T, K173S, D177E, T200A, Q207A	A
Gallant (2005)	JEG08	JEG08_w12	DQ199581	ABC, TDF, 3TC	None	M184MIV		K11T, K20KR, V35T, E36D, T39R, E40D, V60I, D121H, K122E, D123S, I135T, I142V, S162HY, K173R, D177E, V179I, T200I, Q207A, R211RK, F214L, V245E, D250E, K275Q, T286A, E291D, V292I, I293V, P294T	A
Non-B Workgroup (2005)	IL276	IL276		AZT, 3TC	None			E40D, K43R, K49R, V60I, K122E, D123S, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S	A
	TK3017	TK3017		AZT, 3TC	None	M184V		K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, I202IV, Q207A, R211K, V245Q, T286A, E291D, I293V, E312D, H315HQ	A
		TK3017a		AZT, 3TC	None	M184V		K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, V245Q, T286A, E291D, I293V, E312D	A
		TK3017b		AZT, 3TC	None	M184V		K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, T200TI, I202IV, Q207A, R211K, V245Q, T286A, E291D, I293V, E312D	A
		TK3017c		AZT, 3TC	None	M184V		K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, T200TI, I202IV, Q207AD, R211K, V245Q, T286A, E291D, I293V, E312D, I329IV	A
	TK5002	TK5002		D4T, 3TC	None	D67N, T69D, K70R, M184V, K219Q	A98G	K11T, V35T, E40D, K49R, V60I, K122E, D123S, I135T, S162A, T165I, K173S, D177E, V179I, Q207A, R211S, F214L, D218E, V245Q, A272P, E291D, I293V, P294T, E312D, D324E	A
Laurent (2006)	CK2-75	02CM-75	AM279446	D4T, 3TC	None	M184V		K11T, K20R, V35T, E40D, K49R, I50V, V60I, K122E, D123N, I135T, T165I, K173S, Q174K, V179I, T200A, Q207A, R211S, F214L, V245Q, K275Q, I293V, P294T, G335D, M357K, G359S, K366R, T369A, A371V, I375V, A376V, A400T, E404D, E432D	A
Ndembi (2010)	14888D_P1	14888	GQ409570	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I, K219E		I31V, V35T, T39A, E40D, K122E, D123S, K173G, Q174K, V179I, T200A, Q207A, R211S, F214L	A
	DT3516_05_P1	3516	GQ409620	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215I	E138K	K20R, V35T, T39A, E40D, V60I, K122E, D123S, I135T, N136H, K166I, K173S, Q174K, D177E, Q207N, R211K, F214L	A

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