<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype A
Gene RT
Mutation E40D
Rx >= 1 NRTI
(but no NNRTI)
IncludeMixtures No
References 8
Patients 16
Isolates 19
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2002)115106j115106jAF410205AZTNone  K11KT, V35T, T39A, E40D, K43R, K64R, K122E, D123S, I135R, K173AS, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, A272S, T286TA, E291D, I293V, P294T, L310LI, E312DA
 130526d130526dAF410218AZTNone  P4H, K11T, V35T, E40D, K43R, I50V, V118I, K122E, D123S, I135R, K173S, D177E, V179I, I202V, Q207A, R211S, F214L, V245K, A272P, V276I, K277R, L282C, L283I, R284RK, T286A, A288T, V292I, I293V, E297AA
 142181q142181qAF410239AZTNone  E6D, V35T, E40D, V60I, D121H, K122E, D123S, K173S, D177E, V179VI, T200TA, Q207A, R211S, V245Q, D250E, A272AS, K281KR, E291D, I293V, P294T, L295LM, E312D, V317VAA
 144449s144449sAF410242AZTNone  V35T, E40D, V60I, D121H, K122E, D123E, I135T, K173A, Q174K, D177E, V179I, Q207A, R211S, P243S, V245K, E248D, D250E, T286A, E291D, I293V, P294T, E312DA
 145484o145484oAF410245AZTNone  V35T, E40D, V60I, D121H, K122E, I135T, E138A, I142V, K173A, Q174K, I178M, V179I, T200A, Q207A, R211S, V245K, D250E, T286A, E291D, I293V, P294T, L295M, E312DA
Gibb (2002)DMG102102_w51 ABC, 3TCNone  K11KT, K20R, V35T, T39KQ, E40D, K122E, D123N, E138EA, K173S, T200A, Q207AD, F214L, V245Q, E248D, A272P, T286A, E291ED, V292VI, I293V, P294PST, K311R, G335D, M357K, G359S, T369A, A371V, A376V, T377M, K390RA
 DMG9898_w29 AZT, 3TCNone  K11KT, K20R, V35T, T39KQ, E40D, K122E, D123N, E138EA, K173S, T200A, Q207A, F214L, V245Q, E248D, A272P, T286A, E291ED, V292VI, I293V, P294PS, K311R, G335D, M357K, G359S, T369A, A371V, A376V, T377M, K390RA
Weber (2003)5WIRIS5W-48AY140814AZT, 3TCNoneM184V P4T, K11T, V21I, V35T, E40D, K49R, V60I, V90I, K122E, D123S, I135T, K173S, D177E, T200A, Q207AA
Gallant (2005)JEG08JEG08_w12DQ199581ABC, TDF, 3TCNoneM184MIV K11T, K20KR, V35T, E36D, T39R, E40D, V60I, D121H, K122E, D123S, I135T, I142V, S162HY, K173R, D177E, V179I, T200I, Q207A, R211RK, F214L, V245E, D250E, K275Q, T286A, E291D, V292I, I293V, P294TA
Non-B Workgroup (2005)IL276IL276 AZT, 3TCNone  E40D, K43R, K49R, V60I, K122E, D123S, K173S, Q174K, D177E, V179I, T200A, Q207A, R211SA
 TK3017TK3017 AZT, 3TCNoneM184V K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, I202IV, Q207A, R211K, V245Q, T286A, E291D, I293V, E312D, H315HQA
  TK3017a AZT, 3TCNoneM184V K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, I202V, Q207A, R211K, V245Q, T286A, E291D, I293V, E312DA
  TK3017b AZT, 3TCNoneM184V K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, T200TI, I202IV, Q207A, R211K, V245Q, T286A, E291D, I293V, E312DA
  TK3017c AZT, 3TCNoneM184V K11T, V21I, V35T, T39A, E40D, I135V, K173A, Q174K, D177E, V179I, T200TI, I202IV, Q207AD, R211K, V245Q, T286A, E291D, I293V, E312D, I329IVA
 TK5002TK5002 D4T, 3TCNoneD67N, T69D, K70R, M184V, K219QA98GK11T, V35T, E40D, K49R, V60I, K122E, D123S, I135T, S162A, T165I, K173S, D177E, V179I, Q207A, R211S, F214L, D218E, V245Q, A272P, E291D, I293V, P294T, E312D, D324EA
Laurent (2006)CK2-7502CM-75AM279446D4T, 3TCNoneM184V K11T, K20R, V35T, E40D, K49R, I50V, V60I, K122E, D123N, I135T, T165I, K173S, Q174K, V179I, T200A, Q207A, R211S, F214L, V245Q, K275Q, I293V, P294T, G335D, M357K, G359S, K366R, T369A, A371V, I375V, A376V, A400T, E404D, E432DA
Ndembi (2010)14888D_P114888GQ409570ABC, AZT, 3TCNoneD67N, K70R, M184V, T215I, K219E I31V, V35T, T39A, E40D, K122E, D123S, K173G, Q174K, V179I, T200A, Q207A, R211S, F214LA
 DT3516_05_P13516GQ409620ABC, AZT, 3TCNoneD67N, K70R, M184V, T215IE138KK20R, V35T, T39A, E40D, V60I, K122E, D123S, I135T, N136H, K166I, K173S, Q174K, D177E, Q207N, R211K, F214LA
Mollan (2012)MK105MK105w24 ABC, 3TCNone  V35T, T39A, E40D, V60I, V118VI, K122E, D123N, I135T, K173S, Q174K, D177E, T200A, Q207D, R211RS, F214L, D250E, S251D, T286A, E291D, V292I, I293V, E297RA