Reverse Transcriptase Inhibitors

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Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	T215Y
Rx	>= 1 NRTI (but no NNRTI)
IncludeMixtures	No

References	7
Patients	13
Isolates	13

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Weidle (2001)	PW_UG460	PW_UG460b	AY901269	AZT, 3TC	None	M41ML, M184V, T215Y		V35T, S48T, V60I, V90I, K122E, D123S, I135T, S162F, T165I, K173AT, Q174K, D177E, T200A, Q207A, R211S, V245K, D250E, A272P, T286A, E291D, V292VI, I293V, P294T, E312D, G335D, M357R, G359S, T369A, A371V, I375V, T377M, A400T	A
Yahi (2001)	NY_M25	M25	AY010502	AZT, 3TC, DDI	None	L210W, T215Y		V21I, E28K, K32E, V35T, T39TK, V60VI, K64R, T69S, D121HY, K122E, I135T, I142V, K166K*, E169D, K173A, Q174K, D177E, I178L, V179I, G196E, T200A, E204K, Q207A, R211S	A
	NY_M27	M27	AY010465	AZT, 3TC, DDI	None	D67E, L210W, T215Y	Y181C, G190A	V21I, V35T, T39TA, K101Q, D121H, K122E, K173S, Q174R, D177E, I178M, G196GE, T200TI, Q207N, R211RK, L228H	A
Vergne (2003)	VL00SN69HPD	00SN69	AJ583752	D4T, DDI	None	M41L, M184V, T215Y		K11T, V35T, T39A, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178V, V179I, Q197E, Q207A, R211S, F214L, V245K, D250E, A272P, A288S, E291D, I293V, P294T, G335D, R356K, M357R, G359S, V365I, A371V, I375V, A376G, T377L, A400T, T403M, E404D, E432N	A
Non-B Workgroup (2005)	UK2088	UK2088	AY901395	AZT, 3TC	None	M41L, M184V, L210W, T215Y		K11T, K20R, V21I, V35T, T39G, V60I, K122E, D123N, I135T, E138A, I142V, K173S, D177E, V179I, T200A, I202V, Q207A	A
	PL9728	60099	AY901680	D4T, DDI, DDC, AZT	None	M41L, M184V, L210W, T215Y		V35T, K43KE, V118VI, D121H, K122E, I135T, I142V, K173S, Q174K, D177E, T200A, Q207A, R211K, V245K, K281R, T286A, E291D, V292I, I293V, E297K, A304E, E312N, D320E, D324E, I329V	A
	TK2017	TK2017		AZT, 3TC	None	T215Y		E6K, V21I, V35T, S48T, K49R, V60I, D121H, K122E, I135T, K173L, Q174K, D177E, V179I, Q207A, L210I, R211N, V245K, D250E, T286A, E291D, V292I, I293V, E312N	A
Weber (2005)	F45753	F45753	AY677506	AZT, D4T, 3TC, DDI, ABC	None	M41L, D67N, M184V, L210W, T215Y		K11T, K20R, V21I, V35T, T39S, E44ED, V60I, D121H, K122E, D123S, D177E, V179I, T200A, I202V, Q207A, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, E312D	A
Tee (2006)	MYKL1855	04MYKL1855	AY960905	NRTI, D4T, 3TC	None	M41L, M184V, T215Y	Y188L	V35T, T39K, K43E, K122E, D123S, S162C, I202V, V245E	A
Ndembi (2010)	14493D_P1	14493	GQ409569	ABC, AZT, 3TC	None	M184V, T215Y		K11T, K20R, V21I, V35T, T39K, V60I, K122E, D123N, K173S, Q174K, D177G, I178L, V179I, T200A, I202V, Q207A	A
	16712D_P1	16712	GQ409588	ABC, AZT, 3TC	None	D67N, K70R, M184V, T215Y		K11T, K20R, V21I, V35T, T39N, K122E, D123N, I135T, S162H, K173S, Q174K, D177E, I178L, V179I, T200A, I202V, Q207A, R211S	A
	DT3513_05_P1	3513	GQ409619	ABC, AZT, 3TC	None	M184V, T215Y		E6D, E28A, V35T, T39E, V60I, V118I, K122E, I135T, T139R, I142T, T165I, K173S, Q174K, V179I, T200A, Q207A, R211S, F214L	A
	DT3994_05_P1	3994	GQ409628	ABC, AZT, 3TC	None	M41L, D67N, K70R, M184V, L210W, T215Y, K219E		E6D, K11I, V35T, T39K, K43E, K122E, D123S, I135T, S162C, K173T, Q174K, G196E, T200A, Q207A, R211K	A

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