Reverse Transcriptase Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Reverse Transcriptase Inhibitors

Subtype	A
Gene	RT
Mutation	V118I
Rx	RTI-naive
IncludeMixtures	No

References	29
Patients	49
Isolates	49

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	NRTIs	NNRTIs	NRTIDRMs	NNRTIDRMs	OtherMut	Subtype
Cornelissen (1997)	92UG031	92UG031	AF009398	None	None			E6D, V35T, E40D, V60I, V118I, K122E, D123N, I135T, E138A, I142V, K173S, Q174K, V179I, T200A, Q207G, R211S, F214L, V245E, D250E, S251H, T286A, E291D, V292I, I293V, P294A	A
Becker-Pergola (2000)	171.005	BPG171-005	AF177366	None	None			E6D, V35T, E40D, K43R, V118I, K122E, D123N, I135T, S162G, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, P243S, V245E, A272P, K281R, E291D, I293V, P294T, E312D	A
Konings (2004)	KFA_01CMNYU5203	01U5203	AY534744	None	None			V35T, E40D, S48T, V60I, V118I, K122E, D123N, K173S, I202V, Q207A, R211S, F214L, V245Q, E248D, D250E, S251N, Y271F, A272P, V276I, T286A, E291D, V292I, I293V, P294T, L295M, E297Q, E312D, I326V, G335D, R356K, M357R, G359S, T369V, A371V, I375V, A376S, T386I, K390R, A400L, E432D, V435L, L452S, R461K, V467I, S468T, D471E, Q480H, H483Y, L491S, K512S, L517I, S519N, Q524K, K527E, K530R, A534S	A
Snoeck (2004)	BE65	BE65	AY901498	None	None			K22R, E28EA, V35T, T39E, E40D, K49KR, I50IV, V118I, K122E, D123NS, I135T, K173L, Q174K, D177E, Q207A, R211S, F214L, V245X, E248ED, D250DE, S251SN, K281R, T286A, E291D, V292I, I293V, P294T, E312DN, D320DE, D324E	A
Vessiere (2006)	AV_M5348N	AV_M5348N	DQ297343	None	None		V179D	E6K, K11T, V35T, T39TA, V118I, D121E, K122E, D123S, I142V, K173S, Q174K, I202V, Q207A, R211S, F214L, V245Q, E248D	A
Church (2007)	445-124360B	445	EF612029	None	None			E6N, V8VI, V35T, E40ED, V60I, V118I, K122E, D123S, I135T, K173A, Q174K, V179I, Q207A, R211S, F214L, V245E, D250E, A272P, T286A, E291D, I293V, E312D	A
McNulty (2007)	Cam32	Cam32PL	DQ869193	None	None			E6N, V8I, K11T, V35T, E40D, V118I, D121H, K122E, D123S, I142V, F171Y, K173S, D177E, I202V, Q207A, R211S, F214L	A
Vidal (2007)	U2226	02BU.U2226	AM260240	None	None			I5V, K11T, V35T, E40D, S48T, K104R, V118I, K122E, D123S, S163T, T165I, K173L, Q174K, D177E, V179I, G196S, T200I, Q207A, R211N, F214L, V245K, E248D, A272P, V276I, T286A, E291D, I293V, P294T, E312D, G335D, R356K, M357K, R358K, G359S, A360T, A371V, I375V, A376V, T377M, A400T, T403M, E404N, K431T, E432D, V435A	A
Nyombi (2008)	TMS002	TMS002	EU251783	None	None			K11Q, V35T, T39M, E40D, I50V, V60I, V118I, D121H, K122E, D123S, I135T, K173L, Q174K, D177E, T200A, Q207A, F214L, I244V, A272P, K277R, T286A, I293V, P294T, G335D, M357K, G359S, T369A	A
Somi (2008)	OY-05-514	OY-05-514	JQ616978	None	None			E28K, K32E, V35T, V60I, V118I, K122E, D123S, I135T, S162A, K173S, Q174K, D177E, V179I, T200I, Q207A, R211S, F214L, V245Q, D250E	A
Aghokeng (2009)	CYV085	CYV085	GU191582	None	None			K11R, V35I, T39A, V60I, V118I, D121H, K122E, D123S, I142V, T165I, D177E, V179I, G196GE, Q207A, R211S, F214L, V245Q, V261I, A272V, T286A, E291D, V292I, I293V, P294T, G335D, R356K, M357K, G359S, T369V, A371V, I375V, A376V, K390R, A400T, T403M, W410C	A
	AV_0108	AV_0108	GU191649	None	None			E6D, K11T, K20R, V35T, T39S, R72RG, V118I, D123N, I135T, K166R, K173T, D177E, G196E, Q207N, L210LF, R211K, F214L, V245Q, K275Q, V276I, T286A, I293V, P294T, R307K, I326V, G335D	A
Vercauteren (2009)	pt959	7484273043	GQ400065	None	None			E6N, K11T, K22R, V35T, V118I, K122E, D123N, I135T, I142V, K166KR, K173S, Q174K, I202V, Q207A, R211S, F214L, V245Q, E248D, L283I, E291D, I293V, P294T, L295M, E297Q, E312D, I326V	A
Yaotse (2009)	HT077	06TG.HT077	FM955710	None	None			P4S, K11T, V35T, E36A, T39K, K43E, V106I, V118I, D123N, I142V, S162Y, K173S, Q174K, D177E, I178L, V179I, T200A, Q207E, R211K, F214L, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, A400T, T403M, W410H, E432D	A
Balode (2010)	S2011	S2011	GU945074	None	None			K11T, V35IT, E36D, T39KQ, V118I, K122E, D123S, I142T, A158S, K173L, Q174K, Q207A, R211S, F214L, V245M, E248D	A
Burda (2010)	06LPH19CM	06LPH19CM	GQ344999	None	None			E6K, K11V, L12S, V35T, E40D, K102Q, V118I, K122E, D123N, I135T, T139L, S162A, K173S, V179I	A
Diop-Ndiaye (2010)	114HALD	114HALD	FN599681	None	None		V179D	K22R, E28A, V35T, T39A, V118I, D123N, I135T, I142V, T165I, E169N, K173T, Q174K, T200A, I202V, Q207A, R211K, F214L, V245Q, E248D, K281R, T286A, E291D, I293V, P294T, L295M, E297Q, K311R, Q334D, G335S, M357T, K390R, A400T, E404D	A
Towler (2010)	371850-K	371850-K	HM037863	None	None			K11T, K20R, V21I, V35T, T39K, K43G, K49R, I50V, V60I, V118I, K122E, D123S, K173S, D177E, V179I, T200A, I202V, Q207A, R211S, V245Q, E248D, T286A, E291D, I293V, P294T, E312D, V317VA	A
	385494-T	385494-T	HM037866	None	None			I5V, E6P, V35T, V60I, V118I, K122E, I135IT, I142IV, S162A, K173S, D177E, Q207E, F214L, V245E, D250E, V254I, D256DE, A272P, T286A, E291D, V292I, I293V, L303LM, E312T	A
El Annaz (2011)	291	291	HQ393324	None	None			V35T, E36A, T39K, K43E, K64R, V118I, D121H, K122E, I135T, I142V, S162H, K173T, D177E, V179I, I195L, T200A, Q207A, F214L	A
	10375	10375	HQ393383	None	None			K30KN, V35T, E36EA, T39K, K43E, E53ED, N54NY, V60I, K64R, K102KQ, V118I, D121H, K122E, I135T, I142V, S162H, K173T, Q174QK, D177E, V179I, I195L, G196GE, T200TA, Q207A, F214L, V245Q	A
Fokam (2011)	CIRCB-11689	CIRCB-11689	JQ796138	None	None			E6N, K11T, V35T, T39TI, V118I, D123N, I142V, K173S, I178L, I202V, Q207A, R211RS, F214L, V245Q, E248D, S251T, A272P, V276I, T286A, E291ED, V292I, I293V, P294E, E297Q	A
Hamers (2011)	CP076301533	CP076301533	HQ993577	None	None			V35T, E40ED, V60I, V118I, D121H, K122E, I135IT, S162A, E169D, K173S, Q174K, D177E, T200A, Q207A, R211S, F214L, D250E, A272P, T286A, I293V, P294T, E312D, D324DE	A
	CP076301553	CP076301553	HQ993596	None	None			V35T, E40ED, M41MT, V60I, V118I, D121H, K122E, I135IT, S162AD, E169D, K173S, Q174K, D177E, T200A, Q207A, R211S, F214L, D250E, Y271F, A272S, I274G, K275Q, V276D, K277P, Q278F, T286A, I293V, P294T, E308V, I309F, E312D, D324E, L325I, G333S, Q334R	A
	CP076301581	CP076301581	HQ993620	None	None			E28A, K32Q, V35T, T39K, E40D, I50V, V60I, V118I, K122E, D123S, I135T, A158S, T165I, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245E, T286A, I293V, P294T	A
	CP076302243	CP076302243	HQ993816	None	None			E6D, V35T, E36D, T39TA, V60I, V118I, K122E, D123NS, I135T, Y144YF, Q145X, K173A, Q174K, D177E, V179I, T200A, Q207DE, R211K, F214FL, V245E, D250E, A272S, T286A, E291D, V292I, I293V, P294PT, E312N, S322A	A
	CP076304180	CP076304180	HQ993894	None	None			V35T, T39TIM, K43KR, V60I, V118I, D121H, K122E, I135T, K173LS, Q174K, D177E, I178V, T200A, Q207A, R211S, F214L, V245KM, E248D, D250E, S251SI, E291D, V292I, I293V, P294T, E312N, Q334H, G335D	A
	CP076304265	CP076304265	HQ993953	None	None			E6D, V35T, V60I, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207N, R211S, F214L, V245E, A272P, T286A, E291D, V292I, I293V, E312D	A
	CP076300847	CP076300847	HQ995114	None	None			E6D, K11Q, K20R, V35T, T39A, E40D, V60I, V118I, K122E, D123N, I135T, K173L, Q174K, D177E, V179I, Q207A, R211S, F214L, V245Q, E248D, T286A, E291D, I293V, P294T	A
	CP076302054	CP076302054	HQ995204	None	None			E6D, K11Q, K20R, V35T, T39A, E40D, V60I, V118I, K122E, D123N, I135T, K173L, Q174K, D177E, V179I, Q207A, R211S, F214L, V245Q, E248D, T286A, E291D, I293V, P294T	A
	CP076300715	CP076300715	HQ995317	None	None			K20R, V35T, E40D, V60I, V118I, D121H, K122E, I135T, E138A, K173A, Q174R, D177E, I178V, V179I, Q207A, R211S, V245K, A272P, K277R, T286A, E291D, V292I, I293V, P294T	A
	CP076301897	CP076301897	HQ995376	None	None			V35T, V60I, V118I, K122E, D123N, I135T, E138A, S162A, K173S, Q174K, V179I, T200A, Q207D, R211K, F214L, P243S, V245E, D250E, A272P, T286A, E291D, V292I, I293V	A
	CP076301966	CP076301966	HQ995430	None	None		L234LI	E6K, K11T, V35T, V60I, V118I, K122E, D123G, I135V, I142T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245Q, A272S, K275Q, K281R, T286A, E291D, I293V, P294T	A
	CP076301977	CP076301977	HQ995440	None	None			E6N, V35T, K43R, V60I, V118I, K122E, I135T, E138A, K173S, Q174K, I195K, T200A, Q207E, R211S, F214L, I244V, V245K, D250E, K277T, E291D, I293V, P294T	A
	CP076302036	CP076302036	HQ995460	None	None		G190GR	E6K, K20KR, V35T, E40ED, V60I, I63IV, V118I, K122E, I135T, E138A, S162A, T165X, K173S, Q174K, V179I, I202IV, Q207D, R211S, F214L, V245E, D250E, T286A, E291D, V292I, I293V	A
Kasang (2011)	14497	14497	HM572366	None	None	K219KR		V35T, G45GE, V60I, V118I, D121H, K122E, D123E, I135T, E138A, I142V, K173S, Q174K, V179I, T200A, Q207A, R211S, F214L, V245M, E248Q, D250E, A272T, T286A, E291D, V292I, I293V, P294T, E312D	A
Ndembi (2011)	NTCPS701	NTCPS701	HQ702669	None	None			E6D, K20R, V35T, V60I, V118I, K122E, I135T, F160Y, S163T, T165I, K173A, Q174K, D177E, V179I, Q207A, R211K, F214L	A
	AICPS164	AICPS164	HQ702671	None	None			E6D, V35T, V60I, V118I, K122E, D123N, I135T, K173S, Q174K, D177E, I178V, T200A, Q207A, R211S, F214L	A
Frange (2012)	750733HML	750733HML	JQ292414	None	None			T39L, V60I, K64R, V118I, D121H, K122E, K173S, Q174K, D177E, T200A, Q207A, R211S, F214L	A
	690206LKKF	690206LKKF	JQ292417	None	None			T39A, M41T, K43Q, V60I, V118I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L	A
Hassan (2012)	RS09000870	RS09000870	HQ441615	None	None			K11T, K20R, V21I, V35T, T39K, V118I, K122E, D123N, I135T, K173S, D177E, V179I, G196R, I202V, Q207A, R211K, V245Q, E248MR, I270V, A272P, T286A, E291D, I293V, P294A, L295W, E312D	A
	RS09000945	RS09000945	HQ441687	None	None			K20KR, V35T, V60I, V118I, D121C, K122E, D123S, I135K, S162C, K173L, Q174K, D177E, T200A, Q207S, R211S, V245E, D250E, A272P, T286A, E291D, V292I, I293V, E312D	A
	RS11000310	RS11000310	JQ698392	None	None			E6K, K11T, V35T, E36D, T39A, E40D, V118I, K122E, D123N, I135T, K173A, D177E, V179I, V189I, Q207A, R211K, F214L, V245Q, D250E, V276I, Q278N, T286A, E291D, I293V, P294T, E312D	A
Sigaloff (2012)	KEMGO613	KEMGO613	JN628532	None	None			I2T, E6D, K11E, K20R, V35T, T39I, E40D, E42K, V60I, K104E, V118I, K122E, D123S, Q145W, K173L, Q174K, D177E, V179I, L193I, Q197K, R199G, T200A, Q207D, F214L	A
Ssemwanga (2012)	RCC_TDR_480631	RCC_TDR_480631	JQ266033	None	None			V35T, T39A, E40D, K49R, V60I, V118I, K122R, I135T, Q145C, K173L, Q174K, D177E, V179T, Q207A, R211S, F214L	A
	RCC_TDR_483515	RCC_TDR_483515	JQ266050	None	None			V35T, T39A, E40D, V60I, V118I, I135T, Q145C, K173L, Q174K, D177E, V179T, T200A, Q207A, R211S, F214L	A
Yang (2012)	KN-45	KN-45	JQ616942	None	None			K11Q, V35T, V60I, V118I, D121H, K122E, I135R, K173S, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, V245E, D250E	A
Youngpairoj (2012)	cm8bb	cm8bb	DQ166432	None	None			E6N, V8I, K11T, V35T, E40D, V118I, D121H, K122E, D123S, I142V, F171Y, K173S, D177E, I202V, Q207A, R211S, F214L, V245Q, E248D, K275Q, V276I, R284K, T286A, V292I, I293V, P294T, L295M, E297Q, E312N, S322T, M357K, G359S, T369A, A371V, I375A, K390R, A400L, E432D, V435L	A
Frentz (2013)	EHR-14086	EHR-14086	JX299772	None	None			V35T, E40D, I50V, V118I, K122E, D123DN, I135T, I142IT, T165I, K173S, Q174QR, V179VI, E194ED, T200TA, Q207A, R211S, F214L, V245L	A

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