<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype G
Gene RT
Mutation F227L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 12
Patients 21
Isolates 21
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL3510257431AY901538AZT, DDI, D4T, 3TCNVP, EFVA62AV, K65R, K70R, V75I, F77L, F116Y, Q151MY181C, G190A, F227LV21I, V35T, E40D, K43KR, T58N, S68G, V90I, A98S, T139TA, R172K, K173T, Q174K, D177E, I195K, G196E, T200A, R211S, F214L, H221Y, E224D, V245Q, E248D, D250E, A272P, T286A, A288AT, E291D, V292I, I293V, E297AG
 PL1945480060 Unknown, ABCUnknown, EFVM41L, D67N, L74V, M184V, L210W, T215YK101EQ, K103KN, Y181C, G190A, F227LL34I, V35T, T39L, V60I, A98S, V111VI, K122E, D123NS, K173R, Q174N, D177E, T200A, E203K, Q207ADE, H208HY, R211K, K223E, V245T, D250E, A272P, T286A, E291D, V292I, I293V, E297T, L303LRW, A304E, D324E, I329VG
 PL43995101842 D4T, DDINVPM41ML, D67DN, T215YV106A, F227LV35T, K43R, K49KR, V60I, A98S, K122E, D123S, I135T, P157PA, S162SN, K173I, Q174K, D177E, T200A, R211S, V245Q, E248D, D250E, A272P, T286A, A288G, E291D, V292I, I293V, E297T, D320E, D324E, I329VG
Baxter (2006)48-12731273-30904DQ877793NRTINNRTIM41L, D67N, K70R, L74I, M184V, T215F, K219QK103N, F227LV35T, E42EK, K49KR, V60I, T69N, V90I, K122E, D123S, A158S, E169D, K173R, Q174K, D177E, I178M, G196E, T200A, E203A, Q207E, H208Y, R211K, D218E, L228LH, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, E297A, D324E, I329V, Q334P, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, Q394R, A400VG
Hawkins (2009)Q784ZZQ784FJ931250AZT, D4T, 3TCNVPM41L, M184V, T215YK103N, F227LV35T, V60I, S68G, T107S, L109LI, V118I, D121H, K122E, I135T, K173T, Q174K, D177E, T200A, Q207E, R211K, F214FL, H221Y, V245Q, E248D, A272P, K275Q, V276I, T286A, E291D, V292I, I293V, P294T, E297A, V314VI, I329VG
 R48ZZR48FJ931355AZT, 3TCNVPM41L, D67DN, K70R, M184V, T215F, K219QV106A, G190GA, F227LV35T, V60I, W88C, A98S, K122E, D123G, E138A, I142IV, K173T, Q174R, D177E, I178L, T200A, I202IV, R211K, F214L, H221HY, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, S322T, I329LG
 R252ZZR252FJ931397AZT, 3TCNVPM41L, M184V, T215YV106A, F227LV35T, T39K, K104R, S105Q, L109I, K122E, D123S, S162SCT, K173A, Q174K, D177E, T200A, H208HY, R211EK, V245K, E248D, D250E, A272S, T286A, E291D, V292I, I293V, I329LG
 R270ZZR270FJ931446AZT, 3TCNVPM184VV106A, F227LK20R, V21VI, V35T, T39K, E40D, K49KR, V60I, K122P, K166R, K173I, Q174K, D177E, I178M, T200A, Q207A, R211K, F214L, V245Q, E248D, D250E, S251N, A272P, K277R, Q278H, K281R, T286A, E291D, V292I, I293V, E297T, L301M, I326V, I329VG
Pircher (2013)B1126B1126JX110226D4T, 3TC, AZTNVPM41L, D67N, K70R, M184V, T215YK103N, V106A, P225H, F227LP4PS, K20R, V35T, T39N, E40D, P119PS, K122E, V148G, K173A, Q174K, D177E, I178L, S191SF, T200A, Q207N, R211KG
Rawizza (2013)PJ8430PJ8430KF241500NRTINNRTIM41L, D67DN, K70KR, V75VIM, M184V, T215Y, K219KEV106A, F227LS3C, I5V, V8I, V21I, V35T, V60I, D121H, K122E, I135T, S163T, Q174A, D177E, T200A, I202V, E203A, Q207D, L228R, V245Q, E248D, D250E, S251N, A272AP, T286A, E291D, V292I, I293V, I329VG
Theys (2013)33323332KC219253TDF, 3TCNVPM184VK101E, V106A, E138K, F227LV60I, A98S, K122E, D123S, I135T, I142V, R172K, K173I, Q174K, D177E, T200A, I202V, Q207G, R211SG
 57665766KC219440NRTI, TDFNNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219RV106A, G190A, P225H, F227LE44D, V60I, R72E, A98S, V118I, D121H, K122E, S162D, K173A, Q174K, D177E, I178L, G196E, E203K, Q207D, H208Y, R211K, H221YG
 36443644KC219287NRTI, TDFNNRTIM41L, M184V, T215YF227LK43R, W88WC, A98S, L109I, K122E, K173IR, Q174K, D177E, T200A, E203K, Q207E, H208HY, R211RS, K223E, L228RG
Theys (2013)129127129127 D4T, 3TCNVPM41L, D67N, M184V, T215FYV106A, F227LK20KR, L34I, V35T, T39A, K43R, V60I, A98S, L109I, K122E, D123S, Q174N, V179VI, I195K, G196E, T200A, I202IV, R211S, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297A, A304E, D324E, I329VG
Aghokeng (2014)TG-2-292TG-2-292KC350205NRTINNRTIM184VA98G, V106A, F227LK20R, V35T, V60I, S105I, D121Y, K122E, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245Q, E248D, D250E, A272P, Q278H, K281R, T286A, E291D, V292I, I293V, P294S, E297V, L301M, I329V, Q334L, G335D, F346Y, M357K, R358G, G359S, A360P, V365I, A371V, S379G, T386I, Q394R, A400VG
Konou (2015)H1455H1455KT316115NRTINNRTIK70R, M184VV106A, F227LG15E, K20R, V35T, T39M, K49R, T69S, S105I, D121H, K122E, S162H, K173L, Q174K, D177E, I178L, V179I, Q207A, F214L, L228R, V245QG
Saravanan (2015)CTLA30CTLA30KP993633NRTINNRTIM41L, D67G, T69D, K70KR, M184V, T215FV108I, Y181C, G190A, F227LV35T, T39E, K43Q, E44D, V60I, K101KR, D121Y, K122E, T139R, S162DN, K173T, Q174K, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, W212M, K223EG
Lam (2016)2103100921031009KR868001TDF, FTCEFVK70E, Y115F, M184VK103N, V106A, F227LK20R, V35T, T58S, V60I, K104R, L109I, K122E, D123S, S162N, S163T, K173A, Q174K, D177E, I178IM, T200A, Q207E, H208L, R211K, F214L, L228H, P243A, V245K, E248EK, D250E, V276I, Q278N, T286A, E291D, V292I, I293V, D324E, Q334P, G335EG
Chaplin (2017)NJIH0178NJIH0178MF622729NRTINNRTIM41L, M184V, L210W, T215Y, K219NV106A, F227LV35T, T39K, K43E, E44A, K104KR, S105Q, L109I, K122E, D123S, S162X, K173A, Q174K, D177E, I195IV, T200A, I202IV, E203ED, H208Y, R211K, V245K, E248D, D250EG
 NJIH0177NJIH0177MF622728NRTINNRTIM41L, M184V, T215YV106A, F227LV35T, T39K, K104R, S105Q, L109LI, K122E, D123S, S162X, K173A, Q174K, D177E, I178IV, T200A, H208HY, R211K, V245K, E248D, D250E, A272S, T286A, E291D, V292I, I293V, I329L, Q334P, G335DG
 NJIH0052NJIH0052MF622603NRTINNRTIK65R, D67DN, K70KE, Y115F, M184V, K219KEV106M, V179E, F227LK20R, V35T, V60I, K102Q, D121H, K122E, D123S, I135V, S162C, E169D, K173S, Q174R, D177E, I195L, T200A, Q207E, R211K, V245Q, E248D, D250E, S251IG