<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype G
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 9
Patients 41
Isolates 41
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL3510257431AY901538AZT, DDI, D4T, 3TCNVP, EFVA62AV, K65R, K70R, V75I, F77L, F116Y, Q151MY181C, G190A, F227LV21I, V35T, E40D, K43KR, T58N, S68G, V90I, A98S, T139TA, R172K, K173T, Q174K, D177E, I195K, G196E, T200A, R211S, F214L, H221Y, E224D, V245Q, E248D, D250E, A272P, T286A, A288AT, E291D, V292I, I293V, E297AG
 PL2388257573AY901554D4T, DDINVPK65R, Q151MK103N, Y181CV35T, K43R, V60I, S68G, A98S, K122E, D123S, K166R, K173I, Q174K, D177E, T200A, Q207K, R211S, H221Y, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, E297A, L301M, D320E, D324EG
 PL3713161948AY901575AZT, 3TC, D4TNVPM184MVY181CV35T, E40D, K43R, T69TN, A98S, K122E, D123S, K173I, Q174K, D177DE, T200A, Q207K, R211S, H221Y, V245Q, D250E, A272P, K277NS, T286A, A288T, I293V, E297AG
 PL4703784917 AZT, 3TC, D4TNVPM184VY181CK20R, V35T, K43R, K49KR, A98S, K122E, D123S, I135T, K173T, Q174K, N175NY, D177E, Q207K, R211S, F214L, H221Y, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297A, D320E, D324E, I329V, Q334LG
 PL4715595777 D4T, DDINVPL74LVK103N, Y181CV35T, K43R, V60I, A98S, K122E, D123S, K173I, Q174K, D177E, T200A, Q207E, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293IV, E297A, V317A, D320E, D324E, I329V, Q334LG
 PL4936399208 D4T, DDINVPK65RK103N, Y181CV35T, K43KR, V60I, S68G, A98S, D121HQ, K122E, I135T, K173I, Q174K, D177E, T200A, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297T, K311R, I329VG
 PL4986792554 Unknown, 3TC, DDIUnknown, EFVM184VK103NV35T, E40D, K49R, V60I, A98S, K102GR, K122E, D123S, E169EK, K173I, Q174K, D177E, T200A, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, K275Q, K277R, T286A, E291D, V292I, I293V, E297A, V317VF, D324E, I326VG
 PL5206098324 AZT, 3TCNVPM41L, M184VG190AV35T, V60I, A98S, K122E, D123S, I135V, S162C, Q174N, D177E, T200A, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, I293V, E297A, L301M, D324E, I329VG
 PL5238999114 TDF, DDI, 3TCEFVK65R, M184VK103N, V179EE28K, V35T, K43R, V60I, S68SG, A98S, K102KR, K122E, D123S, I135T, T165I, K173I, Q174K, D177E, T200A, Q207E, H221Y, V245Q, E248D, D250E, A272P, T286A, A288AG, E291ED, V292I, I293IV, E297A, D320E, D324E, I329VG
Baxter (2006)48-22252225-30423DQ877867NRTINNRTID67N, K70R, M184V, K219EK103N, Y181CE28EK, V35T, K43R, K49KR, V60I, T69N, A98S, K122E, D123S, I135T, K173T, Q174K, D177E, T200A, I202IV, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297V, D320E, D324E, I329V, Q334P, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, Q394RG
 48-22382238-30731DQ877877NRTINNRTIK219QG190SV35T, K43R, V60I, A98S, K101Q, K122E, D123S, S162N, K173T, Q174K, D177E, T200A, Q207K, R211S, H221Y, V245Q, E248D, D250E, A272P, T286A, E291A, V292I, I293V, E297A, D320E, D324E, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, K390R, Q394RG
 48-80118011-30506DQ879056NRTINNRTIM41L, D67N, K70R, L74V, M184V, T215Y, K219Q, N348IK101N, V108I, Y181CV8VG, P9PL, K32Q, V35T, T39A, E44D, V60I, V118I, D121H, K122E, I135R, S162DN, K173V, Q174N, D177E, V179VA, T200A, I202V, Q207D, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, P321S, D324E, I329V, Q334L, G335D, P345Q, F346Y, R356K, M357R, R358G, G359S, A371GV, T386V, K390R, Q394R, E399DG
Hawkins (2009)P910ZZP910FJ931179D4T, 3TCNVPM184VK101E, V108I, Y181CK11KT, V35T, T39M, V60I, K104R, D121H, K122E, D123S, E138Q, K173T, Q174K, D177E, T200A, Q207D, H221Y, V245Q, E248D, D250E, A272P, Q278N, T286A, E291D, V292I, I293V, K311R, D324E, I329VG
 P609ZZP609FJ931183D4T, 3TCNVPM184V, T215FK101E, V108I, Y181CV21I, V35T, V60I, K104R, K122E, D123S, I135RT, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, H221Y, V245Q, E248D, D250E, A272S, K277R, T286A, E291D, V292I, I293V, P294QG
 Q191ZZQ191FJ931199D4T, 3TCNVPK70KR, M184VV108I, Y181YC, G190GAV35T, T39N, E40D, V60I, K104R, K122E, D123N, I135IT, K173T, Q174K, D177E, I178M, T200A, E203EK, Q207E, R211K, H221Y, V245Q, E248NS, D250E, A272P, T286A, E291D, V292I, I293V, I329VG
 Q196ZZQ196FJ931203D4T, 3TCNVPV75I, M184V, T215YV108I, Y181CV35T, V60I, L109LI, K122E, D123T, I132L, K173KAET, Q174KR, D177E, I178L, T200A, R211K, H221Y, V245Q, E248N, D250E, A272P, Q278C, T286A, E291D, V292I, I293V, P294T, I329VG
 Q221ZZQ221FJ931216D4T, 3TCNVPV75I, F77L, F116Y, Q151M, M184IY181CV35T, V60I, K122P, D123S, I132L, I135V, T165I, K173T, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, H221Y, L228R, V245Q, E248N, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294TG
 Q407ZZQ407FJ931230D4T, 3TCNVPK65R, T69~, V75I, F77L, Q151M, K219RK103N, Y181VK20R, V35T, T39K, V60I, S68G, R83I, H96L, K101R, V111I, D121Y, K122E, K126N, F171Y, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250E, S251D, A272P, T286A, A288S, E291D, V292I, I293V, E297T, L301MG
 Q784ZZQ784FJ931250AZT, D4T, 3TCNVPM41L, M184V, T215YK103N, F227LV35T, V60I, S68G, T107S, L109LI, V118I, D121H, K122E, I135T, K173T, Q174K, D177E, T200A, Q207E, R211K, F214FL, H221Y, V245Q, E248D, A272P, K275Q, V276I, T286A, E291D, V292I, I293V, P294T, E297A, V314VI, I329VG
 Q822ZZQ822FJ931255D4T, 3TCNVPM41L, K65R, T69~, K219RY181C, G190SL34IV, V35T, T39A, V60I, S68G, W88S, V106VI, V118I, K122E, P157A, T165TI, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250K, I270IV, A272P, T286A, E291D, V292I, I293V, L301W, I329VG
 R71ZZR71FJ931270D4T, 3TCNVPM184VK103N, Y181CV35T, K49KR, V60VI, K122E, D123S, K173KT, Q174R, D177E, I178M, T200A, Q207E, R211K, F214FL, H221Y, V245Q, E248N, D250E, A272P, K277R, T286A, E291D, V292VI, I293V, P294T, D324E, I329V, Q334LG
 Q981ZZQ981FJ931286D4T, 3TCNVPK65R, V75VA, K219EY181C, M230LK20R, V35T, V60I, S68G, K101*Q, K104R, K122E, D123N, P140T, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, F214L, H221Y, L228R, V245Q, E248D, D250E, S251R, A272P, T286A, E291D, V292I, I293V, K311R, I329VG
 Q411ZZQ411FJ931340D4T, 3TCNVPK65R, T69~, K219RK103N, Y181C, G190AK20R, V35T, V60I, D121H, K122E, K173T, Q174K, D177E, T200E, I202V, Q207E, H221Y, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, D324EG
 R150ZZR150FJ931346D4T, 3TCNVPF116Y, Q151M, M184VV108I, Y181CK20K*, V35T, K102R, K104KQ, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, P243Q, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297K, I329VG
 R5ZZR5FJ931365D4T, 3TCEFV, NVPM184MIVK103N, V108VI, Y181CK20KR, V35T, T69S, W88C, K122E, I142V, F171Y, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250E, S251DN, A272P, Q278H, T286A, E291D, V292R, I293V, P294PS, E297T, L301M, I329VG
 R220ZZR220FJ931380AZT, D4T, 3TCNVPM184VK101H, V108I, Y181CK20KR, T27S, V35T, K49R, V60I, S68SG, K122E, D123NS, T139TI, K173A, Q174K, D177E, I178M, T200E, Q207E, R211K, H221Y, L228H, V245Q, E248N, D250E, A272P, T286A, E291D, V292I, I293V, D324DEG
 R250ZZR250FJ931395AZT, 3TCNVPM41L, D67DN, K70KR, M184V, T215FA98G, Y181C, G190AV35T, T39A, E44ED, K49R, V60I, V90VI, I94L, K104R, K122E, D123N, I132V, S162N, F171Y, K173T, Q174N, D177E, I178M, T200A, I202V, Q207E, R211K, F214L, H221Y, V245K, E248D, D250E, S251V, A272P, K277R, T286A, E291D, V292I, I293V, D324E, I329VG
 R358ZZR358FJ931415NRTIEFVY115F, M184VK103N, Y188CK20R, V35A, T39K, E40D, S105T, V106I, V118I, I135T, K173IM, Q174K, D177DE, I178L, T200A, Q207E, L210LQ, R211K, F214L, H221Y, V245Q, E248D, D250E, S251D, A272P, Q278QH, T286A, K287KR, V292I, I293V, E297A, L301M, I329VG
 R237ZZR237FJ931432TDF, AZT, D4T, 3TCEFV, NVPM184V, T215TNSYK101EQ, V108I, Y181C, G190AV21I, V35T, V60I, K122E, D123N, I135T, K173L, Q174R, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, D250E, S251N, A272P, G273N, K275R, K277R, T286A, E291D, V292I, I293VG
El-Khatib (2010)Pat06810ZA_SAVE2429HQ012346D4T, 3TCNVPL74V, M184VK103N, M230L, L234IV21VI, V35T, V60I, V90VI, K122E, I142V, S163T, K173L, Q174K, D177E, I178M, T200A, Q207N, R211K, H221Y, V245Q, E248D, D250E, S251TG
Charpentier (2011)233CP 001 1781 D4T, 3TCNVPL74LV, M184MIVK103N, Y181CV35T, T39N, E40D, K49R, V60VI, K104R, K122E, D123E, T165IL, K173T, Q174K, D177E, I178IM, T200A, Q207DN, R211K, H221Y, V245N, A272AS, K281R, E291D, V292I, I293V, E297EA, E312N, Q334EG
Afonso (2012)ANG30ANG30JN937043NRTINNRTIM41L, M184V, T215FY181CV35T, T39A, T107S, D121Y, K122E, I135V, K173T, Q174K, D177E, T200A, E203D, Q207E, R211K, H221YG
Fourati (2012)91103479110347JQ396016NRTINNRTI  K22K*, V35T, T39E, E40D, V60I, K122E, D123G, Q145QH, S162C, K173R, Q174K, D177E, I195L, G196E, T200A, Q207T, R211K, H221YG
Pircher (2013)B1123B1123JX110223D4T, 3TC, AZTNVPM41L, V75M, M184V, L210W, T215YK103N, V108I, Y181CV35T, K49R, V60I, T107S, L109I, D121DN, K122E, D123S, R125RK, E138G, D177E, I178M, Q182QP, T200E, Q207S, R211K, H221Y, V245Q, D250EG
 B1115B1115JX110216D4T, 3TC, AZTNVPM41L, D67G, M184V, T215FA98G, V108I, Y181C, G190AP4S, E6D, L34I, V35T, T39L, E44D, V60I, S68G, K102Q, K122E, D123S, I135T, S162Y, K173T, Q174N, S191SF, I195L, T200A, E203A, Q207E, R211K, F214L, D218E, K219G, H221Y, V245QG
 B1151B1151JX110247D4T, 3TC, AZTNVPD67DN, K70R, M184V, K219KQV108I, Y188W, F227LV35T, T39A, E40D, V60VI, D121H, K122E, I135T, T139KR, K173T, Q174K, D177E, T200A, Q207E, R211RK, H221Y, V245QG
 B1106B1106JX110208D4T, 3TC, AZTNVPM41L, D67N, M184V, L210W, T215YA98G, Y181CV35T, T39N, E44D, K122E, D123S, I135T, K173R, Q174N, D177E, I178M, T200A, E203K, Q207D, R211K, H221Y, V245T, E248D, D250E, L260VG
 B1155B1155JX110250D4T, 3TC, AZTNVPD67N, K70R, M184V, T215F, K219EK103N, V108VI, Y181CE6D, L34I, V35T, V60I, K64KR, K122P, I135T, S162A, Q174A, D177EG, V179VI, V189VI, G196E, T200A, E203EG, Q207E, R211K, H221Y, V245QG
 B1129B1129JX110231D4T, 3TC, AZTNVPM41ML, M184V, T215TNSYK101H, Y181CK20R, V35T, T39K, K43E, V60I, D121H, K122E, D123S, I135T, L149LV, K166R, Q174E, D177E, E194ED, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250EG
Rawizza (2013)LM4439LM4439KF241483NRTINNRTIK65R, T69~, K219RK103NS, Y181C, G190AK20R, V35T, K46M, V60I, I63L, S68G, V90I, D121H, K122E, K173T, Q174K, D177E, E194EK, G196GR, T200E, I202V, Q207E, H221Y, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, D324EG
 PJ1681PJ1681KF241504NRTINNRTID67G, K70R, M184V, T215F, K219QY188LK20R, V35T, K46Q, S68G, S105T, K122E, D123NS, I135V, S163T, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, H221Y, E224D, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293IV, G333D, Q334NG