<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype G
Gene RT
Mutation Y188L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 8
Patients 35
Isolates 37
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patRAM02_RAM705AJ577980AZT, Unknown, 3TC, D4TUnknown, EFVK70R, M184VK103N, Y188LW24V, P25A, V35T, E40D, K43R, V60I, A98S, K122E, D123S, I135T, E138A, S162A, K173T, Q174K, T200A, Q207E, F214LG
Non-B Workgroup (2005)PL2740255298AY901515D4T, 3TCEFVM184VY188LV35T, K43R, V60I, A98S, K122E, D123S, I135T, K173I, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, D320E, D324EG
 PL1435061920AY901578AZT, 3TC, D4TEFVM184VY188LV35T, K49R, V60I, A98S, V106I, K122E, D123S, I135T, S162A, K173I, Q174K, D177E, T200E, Q207K, R211S, Y232H, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297A, D320EG
 PL3949567131AY901636AZT, 3TCEFVM184VY188LV35T, K43R, V60I, A98S, K102KR, K122E, D123N, I135T, I142V, K173T, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, D324E, I329VG
 TK2013TK2013 AZT, 3TC, D4T, ABC, DDIEFVM41L, L74V, M184V, L210W, T215YY188LV21I, V35T, T39A, S48T, K49R, V60I, V106VI, E169D, K173R, Q174K, D177E, T200E, Q207E, R211K, V245Q, D250E, A272P, E291D, V292I, I293V, E297K, D324EG
  TK2013a AZT, 3TC, D4T, ABC, DDIEFVM41L, L74V, M184V, L210W, T215YV179E, Y188LV21I, V35T, E36D, T39A, S48T, V60I, V106I, V118I, E169D, K173R, Q174K, D177E, T200E, Q207E, R211K, T240TM, V245Q, D250E, A272PS, E291D, V292I, I293V, E297KG
  TK2013b AZT, 3TC, D4T, ABC, DDIEFVM41L, L74V, M184V, L210W, T215YV179E, Y188LV21I, V35T, E36ED, T39A, S48T, V60I, V106I, V118I, E169D, K173R, Q174K, D177E, T200E, E203K, Q207E, R211K, T240TM, V245Q, D250E, A272PS, E291D, V292I, I293V, E297K, D324E, I329VG
 PL1014683346 NoneEFV V179E, Y188LV35T, V60I, A98S, K122E, D123S, I135T, T139I, E169EG, K173I, Q174K, D177E, T200A, R211S, V245Q, E248D, D250E, A272P, V276I, T286A, E291D, V292I, I293V, E297AVG
 PL2133384771 AZT, DDI, 3TC, D4TEFVK65RK103KN, Y188LK20R, V35T, V60I, S68G, A98S, V106VI, K122E, D123S, K126KR, I135T, K173I, Q174K, D177EG, V179VM, T200A, I202V, Q207K, R211NS, F214L, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, L301M, D324E, I329VG
 PL2502257676 Unknown, AZT, DDIUnknown, NVPD67N, K70KR, T215YY188LV35T, E40D, K49R, V60I, A98S, K122E, D123S, I135T, K173I, Q174K, D177G, T200A, Q207K, R211S, V245Q, E248A, D250E, A272P, K277R, T286A, E291D, V292I, I293V, E297A, D320E, D324EG
 PL2750698076 AZT, 3TC, TDF, D4TEFVM41L, D67N, K70R, T215FY, K219KEV179E, Y188LV35K, T39M, K43R, V60I, T69N, A98S, L109LI, K122E, D123S, I135T, K173T, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297AITV, D320E, D324E, I329V, Q334QLG
 PL3704676044 AZT, 3TCEFVM41L, M184V, T215FY188LI5L, E6K, V8Y, V35T, V60I, A98S, K122E, D123S, I135T, K166R, K173I, Q174K, D177E, V189I, R199RK, T200A, Q207K, R211S, E224D, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, D324E, I329V, K331NG
 PL4630287549 D4T, DDINVPM41L, T215FY188LV35T, K49R, V60I, A98S, V106VI, K122E, D123S, K173I, Q174K, D177E, T200A, Q207K, R211S, V245Q, E248A, D250E, A272P, T286A, E291D, V292I, I293V, E297A, I329VG
 PL4689984517 ABC, AZT, 3TCEFVM184VV179E, Y188LV35T, E40D, V60I, K122E, D123S, I135M, K173T, Q174K, T200A, Q207K, R211S, V245Q, E248D, D250E, A272P, T286A, E291ED, V292I, I293IV, E297A, V317VA, D320E, D324E, I329V, K331NG
 PL4812187876 AZT, 3TCEFVM41L, M184V, T215YY188LV21I, V35T, K43R, V60I, A98S, V106VI, K122E, D123S, I135T, K173I, Q174K, D177E, I178L, G196E, T200A, E204D, Q207K, R211S, V245Q, E248D, K249R, D250E, A272P, T286A, E297RG
 PL5133996552 AZT, 3TC, TDFEFVV75M, M184VY188LK13KNT, K32KN, L34LF, V35T, K43R, V60I, V90I, K122E, D123N, I135T, S162H, F171Y, K173T, Q174K, D177E, T200A, R211S, V245Q, E248D, D250E, A272P, T286A, V292I, E297A, V317A, D324EG
Hawkins (2009)P655ZZP655FJ931158D4T, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, Y188LK20R, V35T, T39Q, E40ED, V60VI, L109I, V118VI, K122E, D123N, K166R, F171Y, K173T, Q174E, D177E, I178M, T200A, I202V, E204EK, Q207E, F214L, V245Q, D250E, S251A, A272P, I274V, K277R, Q278H, K281R, T286A, E291D, V292I, I293V, P294T, E297P, L301M, I329VG
 Q208ZZQ208FJ931210D4T, 3TCNVPD67DN, K70KR, M184VY188LV21VI, V35T, T39M, V60I, K104R, K122E, K173T, Q174K, D177E, V189VI, T200A, I202V, Q207E, R211K, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, P294T, K311KR, I329V, Q334LG
 Q222ZZQ222FJ931217D4T, 3TCNVPD67DN, K70KR, M184VA98AG, Y188LV35T, V60I, T69TN, K104R, K122E, D123S, I135V, K173T, Q174K, D177E, I178M, T200A, Q207E, F214FL, V245Q, E248D, D250E, S251D, T286A, A288S, E291D, V292I, I293V, E297K, D324E, I329VG
 Q794ZZQ794FJ931248D4T, 3TCNVPM184VY188LK20KR, V35T, T39TAMV, E40ED, V60I, K103Q, K122E, D123S, I135V, I142T, T165L, K173T, Q174N, D177E, I178M, D192N, G196E, T200A, R211K, F214FL, V245Q, E248D, D250E, A272P, T286A, E291D, I293V, K311R, D324E, I329VG
 Q978ZZQ978FJ931283D4T, 3TCNVPA62V, K70KN, V75T, M184MIY188LV35T, K104R, D121H, K122E, I135V, S162C, T165I, Q174E, D177E, T200A, Q207E, F214FL, H221HY, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, P294PQ, E300Q, K311RG
Knops (2010)Pat09Pat09GU9918703TC, D4T, DDIEFVM41L, T215FK103N, Y188LL34I, V35T, K102Q, V118I, K122E, D123S, G141A, K166R, K173R, D177E, I178M, T200A, Q207E, R211K, F214L, V245Q, E248D, D250E, A272P, V276I, L283I, E291D, I293V, E297EK, E302AG
Kebe (2013)SNA3-066SNA3-066HM002537NRTIEFVM184VY188LV35T, V60I, A98S, V106VI, D121DE, K122E, I135L, K173L, Q174K, D177E, V179I, T200A, Q207E, R211K, F214FL, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, E297A, S322A, D324E, I329VG
Rawizza (2013)PJ1681PJ1681KF241504NRTINNRTID67G, K70R, M184V, T215F, K219QY188LK20R, V35T, K46Q, S68G, S105T, K122E, D123NS, I135V, S163T, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, H221Y, E224D, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293IV, G333D, Q334NG
 PJ4671PJ4671KF241502NRTINNRTID67N, M184V, T215Y, K219EY188LI2V, P4PS, E6EK, V35T, T39K, E40D, V60I, K104R, V118I, K122E, D123N, T165I, K173T, Q174K, D177E, V189I, T200A, E203K, Q207E, H208Y, R211K, F214L, K223E, V245Q, E248N, D250E, S251N, A272P, K275R, Q278N, R284K, T286A, E291D, V292I, I293V, E297K, I329VG
Theys (2013)81308130KC219570TDF, FTCEFVK70E, M184VV179E, Y188LV60I, T69N, A98S, K122E, D123N, I135R, K173I, Q174K, D177E, T200A, Q207A, R211S, F214LG
 26572657KC219188NRTI, TDFNNRTIM41L, D67N, K70R, V75I, T215FY, K219EL100LI, Y188LK43R, V60I, T69N, A98S, K122E, D123S, I135T, K173V, Q174K, D177E, T200A, Q207K, R211SG
 29482948KC219216NRTI, TDFNNRTIV75M, M184VY188LK43R, V60I, V90I, K122E, D123N, I135T, S162H, F171Y, K173T, Q174K, D177E, T200A, R211SG
 713713KC219076NRTI, TDFNNRTIM41L, D67N, K70R, T215FY, K219KEV179E, Y188LK43R, V60I, T69N, A98S, L109LI, K122E, D123S, I135T, K173T, Q174K, D177E, T200A, Q207K, R211SG
 62606260KC219488NRTI, TDFNNRTIM41L, D67N, T215YK103N, Y188LK43N, K49R, V60I, A98S, K122E, D123S, I132V, I135T, E138A, K173T, Q174K, D177E, T200A, Q207K, R211SG
 1038310383KC219759NRTI, TDFNNRTIM184MVK103N, Y188LK43KR, V60I, A98S, S105T, K122E, D123S, I135T, E138A, K173I, Q174K, D177E, T200A, I202V, Q207K, R211SG
 61186118KC219476NRTI, TDFNNRTI V179E, Y188LE40D, K43R, K49R, V60I, K64KR, A98S, K122E, D123N, I135T, S162SDGN, K173T, Q174K, D177E, I195IL, T200A, Q207K, R211SG
 1033110331KC219755NRTI, TDFNNRTI Y188LV60I, A98S, K122E, D123S, I135V, K173I, Q174K, D177E, T200A, R211S, K238RG
 58115811KC219447NRTI, TDFNNRTI Y188LV60I, K122E, D123N, I135V, I142V, K173A, Q174K, D177E, I178M, T200A, Q207K, R211QG
 93819381KC219700NRTI, TDFNNRTIK65RV179E, Y188LV60I, S68G, T69TI, V106I, K122KQ, D123DE, K166KR, K173I, Q174K, D177E, T200A, Q207K, R211SG
 14511451KC219124NRTI, TDFNNRTIM41L, T215FY188LV60I, A98S, K122E, D123S, I135T, K166R, K173I, Q174K, D177E, V189VI, T200A, Q207K, R211SG
Grossman (2014)10431043 RTI, AZT, 3TCRTI, EFVM41ML, L210W, T215CYV179E, Y188LV60I, V106VI, K122E, D123S, I135T, K173T, Q174K, D177E, I178L, T200A, Q207D, R211K, V245QG