<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype G
Gene RT
Mutation E138Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 28
Isolates 28
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL834365230AY901639DDC, AZT, 3TCNVP, EFVL74V, M184VK103N, V179VEV35T, K43R, V60VI, A98S, K122E, D123S, I135T, E138Q, K173I, Q174K, D177E, T200AV, Q207K, R211S, V245Q, E248D, D250E, A272P, K281KR, T286A, E291D, V292I, I293V, E297A, A304E, D320E, D324E, I329V, Q334LG
 PL54239103947 AZT, 3TCNVPM184VK103NV35T, V60I, A98S, K122E, D123R, I135T, E138Q, K173I, Q174K, D177E, T200A, Q207K, R211S, E224ED, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, D320E, D324E, I329VG
Hawkins (2009)P634ZZP634FJ931140D4T, 3TCNVPM41L, M184V, T215FG190AV35T, K49R, V60I, V90I, D121H, K122E, I135T, E138Q, T139TI, S162D, K166KR, K173T, Q174K, D177E, T200A, I202V, Q207E, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, I329VG
 P635ZZP635FJ931141D4T, 3TCNVPM41L, D67N, K70R, V75M, M184V, T215F, K219QA98G, K103N, Y181CI2V, V8VL, K20R, K32I, V35T, T39E, E40ED, V60I, S117A, V118I, K122E, I135R, E138Q, S162Y, K173T, Q174K, N175Y, D177E, T200A, Q207E, R211K, F214L, D218E, L228H, Q242H, V245Q, E248N, A272P, Q278H, K281R, T286A, A288T, E291D, V292I, I293V, P294T, E297A, L301M, I329VG
 P910ZZP910FJ931179D4T, 3TCNVPM184VK101E, V108I, Y181CK11KT, V35T, T39M, V60I, K104R, D121H, K122E, D123S, E138Q, K173T, Q174K, D177E, T200A, Q207D, H221Y, V245Q, E248D, D250E, A272P, Q278N, T286A, E291D, V292I, I293V, K311R, D324E, I329VG
 R131ZZR131FJ931338AZT, 3TCNVPM41L, D67N, K70R, M184V, T215YK103NV35T, V60I, W88C, K102KQR, E138Q, K173T, Q174N, D177E, I178L, G196E, T200A, Q207E, F214FL, K238KR, V245Q, E248D, D250E, A272P, K275Q, E291D, V292I, I293V, E297Q, I329VG
 R26ZZR26FJ931343TDF, AZT, D4T, 3TCNVPK65R, K70KT, M184VK101E, Y181C, G190AV35T, V60I, S68SKNR, K102Q, V111VI, D121H, K122E, D123S, I135V, E138Q, S162A, K173A, Q174K, D177E, T200A, Q207QK, F214FL, V245Q, E248DN, D250DGNS, S251SN, A272P, T286A, E291D, V292I, I293V, P294TG
 R257ZZR257FJ931402AZT, 3TCNVPM41L, M184V, L210LW, T215FA98G, K103NV8VI, V35T, V60I, V90I, K122E, D123S, I135T, E138Q, S162Y, Q174N, D177E, I178L, G196GE, T200A, Q207D, V245Q, E248D, D250E, A272P, V276VI, T286A, E291D, V292I, I293V, D324EG
 R258ZZR258FJ931403AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AK20R, V35T, I50IV, V60I, W88C, K104R, K122E, D123N, E138Q, I142V, K166R, K173T, Q174R, D177E, I178M, T200A, Q207E, R211S, F214L, V245Q, E248D, D250E, S251N, A272P, K277R, K281R, T286A, E291D, V292I, I293V, P321S, D324E, I329VG
 R446ZZR446FJ931456AZT, 3TCNVPM41L, M184V, T215YK103NK20R, V35T, V60I, A98AS, K122E, D123N, E138Q, K173T, Q174K, D177E, I178M, T200A, E203ED, Q207A, R211K, V245Q, E248D, D250E, S251N, A272P, T286A, E291D, V292I, I293V, K311R, V314A, I329VG
Sigaloff (2011)HIV105178HIV105178JN132371D4T, 3TCNVPM184VK103NK20R, V35T, E40A, K43E, V60I, D121H, K122E, I135V, E138Q, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, V245Q, E248N, D250E, A272P, E291D, V292I, I293V, P294T, K311KR, Q334L, G335DG
Fourati (2012)83402898340289JQ396169NRTINNRTIM41L, D67N, L74V, M184V, T215Y, K219NA98G, K103N, Y181C, G190AV35T, T39A, E44D, V60I, K64R, V118I, K122E, D123S, I135T, E138Q, K173R, Q174K, D177E, V179T, T200A, E203G, R206M, Q207E, L210S, R211K, T216M, L228HG
Theys (2013)81908190KC219579NRTI, TDFNNRTIM184VV179EV60I, A98S, K122E, D123NS, E138Q, K173I, Q174K, Q197L, T200A, Q207K, R211S, F214LG
 23982398KC219168NRTI, TDFNNRTIM41L, D67N, L74I, T215YK103NK43KR, V60I, D121Y, K122E, I135V, E138Q, S162C, R172K, K173I, Q174K, D177G, G196E, T200A, Q207K, R211SG
 5555KC219039NRTI, TDFNNRTIM184VK103NK43R, V60I, A98S, K122E, D123G, E138Q, K173L, Q174R, T200A, Q207E, R211S, F214LG
 14251425KC219121NRTI, TDFNNRTID67N, K70R, K219QK103NK49R, V60I, K64H, V90VI, A98S, K122E, D123S, I135T, E138Q, K173I, Q174K, T200A, E203A, Q207K, R211S, H221YG
 89028902KC219620NRTI, TDFNNRTID67N, K70R, K219QK103NV60I, A98S, K122E, D123S, I135T, E138Q, K173I, Q174K, D177E, T200A, Q207K, R211S, F214FLG
Theys (2013)26842684KY386688TDF, 3TCEFVL74LV, M184VK103N, V179EV35T, E40D, V60I, A98S, K122E, D123S, E138Q, K173I, Q174K, Q197L, T200A, Q207K, R211S, F214L, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, E297A, D320E, D324E, I329VG
 103947103947 AZT, 3TCNVPM184VK103NV35T, V60I, A98S, K122E, D123R, I135T, E138Q, K173I, Q174K, D177E, T200A, Q207K, R211S, E224ED, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, E297A, D320E, D324E, I329VG
Aghokeng (2014)TG-1-195TG-1-195KC350216NRTINNRTIK70KR, M184VV108I, V179EK20R, V35T, T39N, E40D, V60I, V90VI, K102KQ, K122I, D123N, I135T, E138Q, K166R, E169ED, Q174E, D177E, T200A, Q207N, D218DE, V245Q, E248D, D250EG
Konou (2015)H1439H1439KT316113NRTINNRTIM41L, M184V, L210W, T215YK103N, K238TV35T, E44D, K104KR, D121Y, K122E, D123E, I135M, E138Q, S162A, K173T, Q174K, D177E, T200A, Q207X, R211E, L228R, V245Q, E248D, D250EG
Lam (2016)2101201321012013KR867741AZT, 3TCNVPM41L, D67DN, K70KR, V75VIM, M184V, T215Y, K219KQK103NK20KR, V35T, K49R, V60I, K122E, D123S, I135M, E138Q, S162A, K173T, Q174K, D177E, I178M, T200A, Q207K, R211AT, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, P294T, D324E, I329V, Q334P, G335DG
Chaplin (2017)NJIH0202NJIH0202MF622753NRTINNRTID67G, K70R, M184V, T215I, K219EV106A, V179EK11Q, K20R, V35T, T39S, K49KR, V60VI, S68G, K104R, D121H, K122E, D123S, E138Q, K166Q, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, I244V, V245Q, E248D, D250E, S251NG
 NJIH0201NJIH0201MF622752NRTINNRTIM184VV106AK11Q, K20R, V35T, T39S, V60VI, S68G, V90I, K104R, D121H, K122E, D123S, E138Q, K166Q, Q174R, D177E, I178L, T200A, Q207E, R211K, F214L, I244V, V245Q, E248D, D250E, S251N, A272P, Q278H, T286A, E291D, V292I, I293V, L301LF, E308G, I309N, V317X, D320X, K323N, A327T, I329LG
 NJIH0200NJIH0200MF622751NRTINNRTID67N, K70KR, M184V, K219QK101E, G190AK20R, V35T, I50IV, V60I, W88C, K104R, K122E, D123N, E138Q, I142V, K166R, K173T, Q174R, D177E, I178M, T200A, Q207E, R211S, F214LG
 NJIH0199NJIH0199MF622750NRTINNRTIM184VG190AK20R, V35T, I50V, W88C, K104R, K122E, D123N, E138Q, I142V, K166R, K173T, Q174R, D177E, I178L, T200A, Q207E, R211S, F214L, V245Q, E248D, D250E, S251N, A272P, K277R, K281R, T286A, E291D, V292I, I293V, P321S, D324E, I329V, Q334L, G335DG
 NJIH0188NJIH0188MF622739NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219QK103N, K238TK20R, V35T, T39N, E40D, V60I, A98S, K104KR, I135T, E138Q, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, L228H, V245Q, E248D, D250E, S251DG
Rhee (2017)45614561_FL TDF, FTCEFVV75M, M184VG190EV21I, V35T, T39A, E40D, V60I, R83K, E89EG, V90G, Q91P, K102KR, K104KR, I135V, E138Q, K173I, Q174K, D177E, G196E, T200A, R211S, Q222RG