<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype F
Gene RT
Mutation Y181C
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 19
Patients 59
Isolates 60
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Brindeiro (2002)TVGG27TVGG27AY145828D4T, DDI, 3TCNVPM41L, D67N, K70S, V75S, T215YV106A, Y181CV35T, E44D, K122E, E169D, K173T, Q174K, I178L, Q197E, T200A, E203K, Q207A, H208Y, R211K, K223Q, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, N306DF
Apetrei (2003)AC_Pat22RO.00.IS.22AY333579AZT, 3TC, D4TNVP Y181CV35P, T39A, E40D, D123E, I135L, S162H, K173A, Q174R, D177E, I195L, T200A, Q207E, R211KF
 AC_Pat23RO.00.IS.23AY333602AZT, 3TCNVPD67N, T69D, K70R, K219QK103N, Y181CV35T, T39A, E40D, V60I, D123E, I135L, S162H, K173A, Q174K, I195L, Q197K, T200A, Q207T, R211K, L228HF
  RO.01.IS.23AY333601AZT, 3TC, DDINVPD67N, T69D, K70R, K219QK103N, Y181CV35T, T39A, E40D, V60I, V90I, D123E, I135L, T139S, S162H, K173A, Q174K, I195L, G196E, Q197K, T200E, E203D, Q207E, R211K, E224D, L228HF
 AC_Pat37RO.01.IS.37AY333540AZT, 3TC, D4TNVPK70RY181CV35T, T39A, E40A, K46Q, K49R, D123E, I135L, S162H, K173A, Q174K, P176Q, D177E, I195L, T200A, Q207T, R211K, H221YF
Dumans (2004)RG008RG008AY390204AZT, 3TC, D4T, DDI, UnknownEFV, UnknownD67N, K70R, M184V, T215F, K219EA98G, Y181CV35T, T39G, K49R, I135V, S162C, E169D, K173A, Q174K, D177E, G196E, T200A, Q207E, R211K, V245Q, P247A, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297A, S322T, I329LF
Montes (2004)MB_patBAR01_BAR714AJ577734AZT, DDI, 3TC, D4T, ABCNVP, EFVT215FK103N, Y181C, G190AV35T, K49R, I135L, S162C, E169D, K173A, Q174K, Q207E, R211K, L228RF
Non-B Workgroup (2005)PL3793363674 AZT, DDI, 3TCNVPM184MV, T215*DEYY181CV21I, V35M, K101Q, S162Y, K166KQ, E169AD, K173A, Q174K, E203EK, Q207E, R211K, L228LH, V245Q, E248D, A272P, K277R, T286TA, E291D, V292I, I293V, E297R, P313T, I326VF
 PL4840688662 D4T, DDI, ABC, AZT, 3TCEFVM41L, D67N, V75M, L210W, T215F, K219WV179VF, Y181C, G190SE28K, K32E, V35T, K49R, P52PS, V60I, K101Q, K122E, I135V, S162C, E169D, K173A, Q174K, D177E, I178L, Q207D, H208HY, R211K, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297ATF
 PL4965792049 TDF, DDI, AZT, 3TCNVPK65RY181CV35T, T39L, E40D, V90VI, D123E, I135IT, S162Y, E169D, K173T, Q174K, Q207D, R211K, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297T, I326V, Q334EF
 PL882265161 AZT, DDI, 3TC, D4T, ABCNVPM41L, D67N, T69D, L74V, L210W, T215Y, K219RV108I, Y181C, K238NT7TA, K20R, V35X, I37IR, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196GE, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237DE, V241M, V245Q, E248D, A272P, L283I, T286A, E291D, V292VI, I293V, E297Q, V317AF
Rodrigues (2005)BR0181201AY643261AZT, 3TC, D4T, DDINVP, EFVD67N, K70KR, V75VL, T215YK101KE, Y181C, G190GAE28K, V35T, D123E, I135T, S162SC, E169A, K173A, Q174K, D177E, G196E, Q207A, R211T, V245Q, D250EF
 BLF_Pat3BR02SP249AY643219AZT, DDI, Unknown, 3TCNVP, UnknownM41L, M184V, L210W, T215YV108I, Y181CL34I, V35T, K49R, I135V, S162C, E169D, K173A, Q174K, T200I, Q207E, R211K, H221Y, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, K311RF
 BLF_Pat4BR02SP265AY643222D4T, DDI, 3TCNVPA62AV, K70NS, V75I, F77L, F116Y, Q151M, M184VK103N, Y181CE6S, K20R, V21VI, V35T, T39A, K64R, S68G, K122E, S162SC, E169D, K173A, Q174K, I178L, G196E, T200A, Q207E, R211K, H221Y, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297V, V317AF
 BLF_Pat6BR03SP164AY643237AZT, Unknown, DDI, 3TC, D4TUnknown, NVPM41L, L210W, T215YA98G, K101HQ, Y181CP4PT, V35I, K43KE, E44D, K49R, V118VI, K122E, I135T, S162C, E169D, K173A, Q174K, E203K, Q207D, R211KT, K223Q, L228R, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297AV, V317A, S322AF
 BLF_Pat18BR03SP130AY643233AZT, 3TC, D4TNVPK70KR, M184V, K219KEA98G, Y181CV35T, V118I, D121H, K122E, E169D, K173A, Q174K, D177E, I178L, V179VI, T200A, Q207E, R211K, F214L, L228LH, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, E297A, I329LF
 BLF_Pat24BR02SP255AY643220AZT, DDI, 3TC, D4TNVPM41L, D67N, L74V, M184V, L210W, T215YK101E, Y181C, G190AV35T, T39PS, K43N, E44D, V118I, K122E, I135V, S162Y, K173T, Q174K, N175Y, T200A, E203K, Q207D, R211K, K223Q, V245Q, E248D, T286A, A288T, V292I, I293V, E297A, Q334EF
 BLF_Pat26BR03SP138AY643234AZT, 3TCNVPD67NS, K70R, M184V, T215F, K219EV108I, Y181CK20KR, V35T, T39R, K43E, T69N, E79D, V90I, D123E, I135L, S162Y, K173T, Q174K, V179I, T200A, Q207E, R211K, V245Q, E248D, D250DE, A272P, R284K, T286TA, E291D, V292VI, I293V, E297V, Q332HF
 BLF_Pat32BR02SP56AY643226AZT, 3TC, D4T, Unknown, DDIUnknown, NVPM41L, D67DN, M184V, L210W, T215YK103KN, Y181CK32I, V35T, T39S, K49R, V118I, K122E, D123E, I135V, K173T, Q174K, I178M, T200TA, Q207E, R211K, V245Q, E248D, A272P, Q278H, T286P, E291D, V292I, I293V, P294T, E297A, S322T, Q334NF
 BLF_Pat33BR03SP36AY643247AZT, 3TC, DDI, D4TNVP, EFVD67N, K70R, M184V, T215F, K219EK101E, V108I, Y181C, G190AE6D, K20R, V35T, T39L, V60I, V90I, I135R, S162H, E169D, K173A, Q174K, V179I, T200R, Q207E, R211K, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294S, E297AF
 BLF_Pat36BR02SP117AY6432083TC, D4TEFV, NVPM41L, D67N, L74IV, M184V, T215YK103N, Y181C, G190AK20R, V35I, T39K, K43E, K49R, V118I, I142V, S162D, E169D, K173A, Q174K, G196E, T200A, E203D, Q207K, H208Y, R211A, H221Y, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297T, I329LF
Baxter (2006)48-10951095-30728DQ880538NRTINNRTI Y181CT39K, K49R, K102Q, K104R, D123E, I135V, K173A, Q174K, Q207A, R211K, V245QF
 48-12061206-30604DQ877750NRTINNRTIM41L, D67N, T69D, L74V, L210W, T215YK103N, Y181CV35T, T39A, E44D, K49R, V60I, V90I, K122E, D123S, S162D, E169A, K173A, Q174K, I178L, Q207E, R211K, D237E, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, E312E*, F346Y, R356K, M357R, G359S, A376S, T377L, K390R, Q394L, E399DF
 48-22512251-30925DQ877885NRTINNRTIM41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219RV108I, Y181C, K238NT7TA, K20R, V35VAIT, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196E, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237E, V241M, V245Q, E248D, A272P, V276VAIT, L283I, T286A, E291D, V292VI, I293V, E297HQ, V314VA, V317A, R356K, G359S, A371T, T377LQ, S379C, K390R, E399DF
 48-32663266-30729DQ878171NRTINNRTID67N, K70R, L74I, M184V, T215F, K219QA98G, K103S, Y181C, G190AP4S, K20KR, V35T, T69N, K122E, D123E, I135L, E138EQ, T165I, I167V, E169EQ, K173A, Q174K, D177E, I178L, V179T, T200A, I202V, E204A, Q207E, R211K, D218E, P243T, V245Q, E248D, D250S, A272P, K275R, T286A, E291D, I293V, E297A, L303M, D324DE, I329V, F346H, R356RK, M357R, G359S, K366R, A371V, S379G, T386I, K390R, E399DF
 48-42864286-30910DQ878509NRTINNRTIM41L, D67N, T69~, L74V, Y115F, F116Y, Q151M, M184V, L210W, T215Y, K219EK101E, V108I, Y181C, G190SV35T, T39A, S48E, V60I, S68G, D123E, R172K, K173A, Q174K, D177E, I178M, G196GE, T200A, Q207A, R211K, H221HY, L228H, P243A, V245Q, E248D, D250S, A272P, K275R, Q278N, T286A, E291D, I293V, E297A, R307RK, D324E, Q334H, G335D, F346H, R356K, M357K, G359S, A371V, I375V, T386I, K390RF
 48-61786178-30731DQ878750NRTINNRTIM41L, D67N, T69D, L74IV, M184V, T215YA98G, V108VIM, Y181C, G190AS3C, K20R, V35T, E44D, K101KQ, D123E, I135V, S162C, I167IV, E169D, R172RK, K173A, Q174K, I178L, Q207E, R211K, D218E, H221HY, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297A, E328D, R356K, G359S, T377L, K390R, Q394L, E399DF
 48-92899289-30930DQ880879NRTINNRTID67N, K70R, T215F, K219QK101E, Y181C, G190ST39L, K49R, V60I, T69TN, S162H, E169D, K173T, Q174K, G196E, Q207E, L228H, V245QF
 48-90949094-30827DQ880717NRTINNRTIM41L, D67DN, L74I, M184V, L210W, T215Y, K219NV108VI, V179D, Y181C, F227LE44D, K103R, V106VI, V111I, K122A, I135T, S162C, M164ML, R172RK, K173A, Q174K, D177EG, I178L, E203D, Q207D, R211K, H221Y, V245QF
 48-91109110-30917DQ880728NRTINNRTID67N, T69D, K70RT, L74V, K219QY181CN57NH, F61FS, V90VI, V118VI, K122E, I135T, I142IT, S162Y, K173T, Q174K, G196GR, T200A, I202IV, E203K, Q207E, R211A, F214L, D218E, L228HKNQ, V245QF
 48-91519151-30826DQ880764NRTINNRTIM41L, L74LI, M184V, L210W, T215YK101KE, V108I, Y181C, G190GAE44D, K49R, V118I, K122E, I135V, S162C, E169A, K173A, Q174K, E203K, Q207E, R211K, H221Y, L228R, V245PF
 48-91379137-30918DQ880753NRTINNRTID67G, K70R, T215F, K219EV179D, Y181CT69N, K103KR, V118I, K122E, S162C, E169D, K173A, Q174K, L187LS, G196E, Q207E, R211K, F214L, L228K, V245AF
Dumans (2009)RENA446RENA446FJ405169AZT, DDI, 3TC, D4T, Unknown, ABCUnknown, EFVD67N, K70R, L74I, V75T, T215F, K219EY181CV35T, T39S, K101Q, D121H, K122E, S162C, K173T, Q174K, I178L, T200A, Q207E, R211K, D218DE, L228LH, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, Q334NF
Hawkins (2009)Q242ZZQ242FJ931229D4T, 3TCNVPM184V, T215YV108I, Y181CI31L, V35I, T69A, V90I, L109I, D123E, I142V, E169D, K173A, Q174K, D177E, I178L, G196V, T200A, I202V, Q207E, R211K, V245Q, D250S, A272P, K275R, Q278Y, T286TA, E291D, I293V, E297AF
Koyalta (2009)74TCHAD-74FJ688204D4T, 3TCNVPM184IK103N, Y181CK49R, V60I, D123E, E169D, K173A, Q174K, D177E, I178M, G196E, Q207E, R211KF
 75TCHAD-75FJ688205D4T, 3TCNVPM184V, T215FV108I, Y181CK49R, V60I, V90I, I135T, S162H, K173T, Q174K, T200A, Q207EF
 85TCHAD-85FJ688209D4T, 3TCNVPM184IK103N, Y181CK49R, V60I, D123E, E169D, K173A, Q174K, D177E, I178M, G196E, Q207E, R211KF
Charpentier (2011)97CP 001 2096 D4T, 3TCNVPM184V, T215TIV108VI, Y181CK20KR, I31IL, V35T, T39L, K49KR, T69TN, I135IT, T139TR, K173T, Q174K, Q207D, R211K, F214FL, H221HY, F227FS, T240TK, P243S, V245Q, D250E, A272P, V276IT, E291D, V292VI, I293V, E297T, V317VA, D324E, L325IF
Charpentier (2011)CR-51CR-51FJ688257AZT, 3TCNNRTID67G, K70R, L74V, M184V, T215CF, K219QY181CV35T, T39M, K46Q, K49R, S68G, S105A, D123E, T139K, K173A, Q174K, N175NY, D177E, I202V, Q207E, R211K, F214L, V245Q, E248D, D250T, A272P, K275R, Q278H, T286A, E291D, V292I, I293V, E297AF
Fokam (2011)CIRCB-10183CIRCB-10183JQ796165D4T, 3TCNVPM184V, K219KNA98G, Y181CV35T, D123E, K173A, Q174KR, D177E, T200TA, Q207A, R211T, V245Q, E248D, D250DE, A272P, K275R, K277R, Q278H, T286A, E291D, I293V, E297P, L310IF
 CIRCB-11096CIRCB-11096JQ796179D4T, 3TCNVPD67DN, M184V, T215FK101E, Y181C, G190AK20R, V35T, T39D, K122E, D123E, E138Q, I142V, E169ED, K173A, Q174K, D177E, I178IL, Q207E, V241VI, P243A, V245Q, E248D, K249KE, A272P, K275R, Q278H, T286A, E291D, I293V, P294T, E297A, L303LM, Q334H, G335D, F346HF
Jones (2012)130299130299JN669482NRTINNRTIM41L, L210W, T215YA98G, Y181CE6D, K20R, L34LV, V35T, K49R, D123E, I135V, S162C, E169D, K173A, Q174K, T200A, Q207D, R211K, V241M, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, D324E, F346Y, R356K, G359S, A360T, T377V, Q394L, E399DF
Kouri (2012)CU772-10CU772-10JQ585416NRTINNRTIK65R, V75I, F116Y, M184VY181CV35T, V60I, S68G, K104R, D123E, I132L, S162C, K173I, Q174K, Q207E, R211K, F214L, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297A, Q334H, G335DF
 CU544-09CU544-09JQ585255NRTINNRTIM41L, L74V, M184V, T215YK101E, Y181C, G190GEV35M, T39K, K43E, D123E, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248D, D250E, A272S, T286A, E291D, V292I, I293V, E297A, V317A, I326VF
 CU737-10CU737-10JQ585413NRTINNRTIM41L, K70KI, L74V, M184V, T215FA98G, V108I, Y181CV35T, E44D, K122P, I135T, Q174E, D177E, G196GE, Q207K, R211T, F214L, V245Q, A272P, K275R, V276I, L283I, T286A, E291D, I293V, E297A, I326IV, Q334Y, G335DF
 CU599-10CU599-10JQ585404NRTINNRTIM41L, D67S, T69S_RG, K70R, F77FL, M184V, T215F, K219EA98G, K101E, V108I, Y181C, G190AE28K, K32E, V35T, V60I, S68G, V106I, L109V, V118I, K122P, D123E, I135V, I159L, D177E, I180IM, Q207E, R211K, F214L, D218E, L228H, V245Q, A272P, V276T, K277R, L283I, T286A, A288T, V292I, I293V, E297AF
Aghokeng (2013)HJ3061HJ3061JX982982NRTINNRTIM184VV106VA, V108VI, Y181CE6EK, V35T, T39L, K49KR, K122KE, D123G, K173L, Q174K, D177E, T200A, I202IV, Q207E, R211K, F214FL, H221HY, P243A, V245Q, E248D, D250S, A272P, K275KR, Q278Y, E291D, I293V, E297P, Q334H, G335D, F346H, R356K, M357R, R358K, G359S, K366R, T386I, K390R, I393IM, A400TF
Pircher (2013)B1131B1131JX110232D4T, 3TC, AZTNVP K103N, Y181CP14T, K20R, V35T, D123E, I135V, S162C, K173I, Q174K, V179VI, T200A, Q207A, R211S, H221Y, V245QF
Theys (2013)1905619056KC219961NRTI, TDFNNRTIK65RV108VI, Y181CE40D, K101R, D123E, I135V, I142IV, S162C, E169D, K173A, Q174K, D177E, T200A, Q207E, R211K, H221YF
 1614616146KC219867NRTI, TDFNNRTIM41L, M184I, T215EA98G, V179D, Y181CK103R, K122E, I135T, S162C, E169A, R172K, K173A, Q174K, T200A, Q207K, R211VF
 14371437KC219123NRTI, TDFNNRTIM41L, D67N, K70KR, L210W, T215F, K219WV108VI, Y181CK43E, K49KR, E53ED, K64Y, T69N, V118VI, D121Y, K122KE, D123DE, I135AT, S162DY, E169D, K173A, Q174K, D177E, Q207E, H208Y, R211K, L228HF
 5539855398KC221702NRTI, TDFNNRTIM41L, M184I, T215EA98G, V179D, Y181CK103R, K122E, I135T, S162C, E169A, R172K, K173A, Q174K, T200A, Q207K, R211VF
 3048630486KC220760NRTI, TDFNNRTID67N, K70R, M184V, T215F, K219QK103N, Y181CI135V, K173T, Q174R, I202V, Q207E, R211KF
 2798227982KC220548NRTI, TDFNNRTIL74LI, M184VY181CK122P, I135L, S162C, E169D, K173S, Q174K, D177E, I178V, S191T, T200A, Q207E, R211K, H221HYF
 28012801KC219204NRTI, TDFNNRTIK65RY181CE40D, V90VI, D123E, I135IT, S162Y, E169D, K173T, Q174K, Q207D, R211KF
 2236922369KC220133NRTI, TDFNNRTIM41L, D67DA, K70KR, M184V, T215TFIS, K219KEV108I, Y181CD123E, I135V, K173I, Q174K, V179I, Q207E, R211A, F214L, H221YF
 1422514225KC219804NRTI, TDFNNRTIM41L, L74LV, M184VK103KN, V108VI, Y181CK122E, T139R, S162C, E169D, K173T, Q174K, T200A, Q207DE, R211K, L228RF
 5174651746KC221477NRTI, TDFNNRTIK65RY181CW88C, K101T, D123E, I135L, S162Y, E169D, R172K, K173A, Q174K, T200A, E203EK, Q207E, K223KQF
 1872218722KC219944NRTI, TDFNNRTIM41L, T69D, L210W, T215YK101E, Y181C, G190AK43M, V118I, K122E, I135V, S162C, E169D, K173T, Q174K, L228RF
Van Zyl (2013)14501215KC422966D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215Y, K219KNK103N, V108I, Y181C, G190GAK20R, V21I, V35T, T39I, E44D, K49KR, V60I, L109I, V118I, K122P, I135T, T165L, K173S, Q174K, N175Y, D177E, T200E, E203K, Q207D, H208Y, R211K, D218DE, H221HY, V245Q, E248DF