<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype F
Gene RT
Mutation V108I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 23
Isolates 23
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Dumans (2004)RES093RES093AY390211AZT, 3TC, DDI, UnknownEFV, UnknownM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IK20KR, V35T, E44D, V118I, K122E, I135L, S162F, E169D, K173A, Q174K, T200A, E203K, Q207E, R211Q, K223E, V245Q, E248DF
Non-B Workgroup (2005)PL882265161 AZT, DDI, 3TC, D4T, ABCNVPM41L, D67N, T69D, L74V, L210W, T215Y, K219RV108I, Y181C, K238NT7TA, K20R, V35X, I37IR, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196GE, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237DE, V241M, V245Q, E248D, A272P, L283I, T286A, E291D, V292VI, I293V, E297Q, V317AF
Rodrigues (2005)BLF_Pat3BR02SP249AY643219AZT, DDI, Unknown, 3TCNVP, UnknownM41L, M184V, L210W, T215YV108I, Y181CL34I, V35T, K49R, I135V, S162C, E169D, K173A, Q174K, T200I, Q207E, R211K, H221Y, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, K311RF
 BLF_Pat17BR02SP88AY643228AZT, DDI, 3TC, D4TNVP, DLVM41L, D67N, K70R, L74I, V75S, M184V, T215Y, K219EA98G, K103N, V108IE6K, K20R, K32R, V35T, T39A, E44D, V118I, K122E, S162Y, E169D, K173A, Q174K, T200A, E203K, Q207E, H208Y, W212WL, K223E, L228H, Q242H, V245Q, E248D, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297T, D324E, Q334EF
 BLF_Pat26BR03SP138AY643234AZT, 3TCNVPD67NS, K70R, M184V, T215F, K219EV108I, Y181CK20KR, V35T, T39R, K43E, T69N, E79D, V90I, D123E, I135L, S162Y, K173T, Q174K, V179I, T200A, Q207E, R211K, V245Q, E248D, D250DE, A272P, R284K, T286TA, E291D, V292VI, I293V, E297V, Q332HF
 BLF_Pat33BR03SP36AY643247AZT, 3TC, DDI, D4TNVP, EFVD67N, K70R, M184V, T215F, K219EK101E, V108I, Y181C, G190AE6D, K20R, V35T, T39L, V60I, V90I, I135R, S162H, E169D, K173A, Q174K, V179I, T200R, Q207E, R211K, L228H, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, P294S, E297AF
 BLF_Pat39BR02SP241AY643218AZT, 3TC, D4TNVPM184VK103N, V108IV35T, T39M, I135V, E169D, K173T, Q174K, E194EG, G196E, T200A, Q207D, R211K, F214L, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, K311R, S322TF
Baxter (2006)48-12711271-30923DQ877792NRTINNRTIM41L, A62V, T69S_SS, V75I, F116Y, L210W, T215YK103N, V108I, Y181YC, K238TP4PS, K20R, V35T, K43Q, E44D, K49KR, K122P, D123E, I135IV, S162CY, E169D, K173A, Q174K, D177E, I178L, E203K, Q207E, R211K, K223Q, L228H, V245Q, E248D, A272P, K277R, Q278N, L283I, T286A, E291D, V292I, I293V, P294T, E297A, Q334L, R356K, G359S, A371V, I375V, T377R, I382V, K390RF
 48-22512251-30925DQ877885NRTINNRTIM41L, D67N, T69D, L74V, M184V, L210W, T215Y, K219RV108I, Y181C, K238NT7TA, K20R, V35VAIT, K43E, E44D, V60I, K101Q, V118I, K122E, I135L, S162Y, K173A, Q174K, I178L, G196E, Q197L, E203K, Q207E, R211A, K223Q, L228H, D237E, V241M, V245Q, E248D, A272P, V276VAIT, L283I, T286A, E291D, V292VI, I293V, E297HQ, V314VA, V317A, R356K, G359S, A371T, T377LQ, S379C, K390R, E399DF
 48-32703270-30703DQ878175NRTINNRTID67N, T69D, K70R, L74I, M184V, T215F, K219Q, N348IV108I, F227LI2V, T27TS, V35T, T39K, K43Q, V60I, D121Y, K122E, I135V, S162C, K173T, Q174K, D177E, V179I, G196E, E203K, Q207A, R211A, K223E, L228H, V245K, E248D, D250DE, S251I, A272P, T286A, E291D, V292VI, I293V, E297D, A327V, I341F, A355G, R356K, G359S, A376S, T377L, T386I, K390R, Q394L, E399DF
 48-42864286-30910DQ878509NRTINNRTIM41L, D67N, T69~, L74V, Y115F, F116Y, Q151M, M184V, L210W, T215Y, K219EK101E, V108I, Y181C, G190SV35T, T39A, S48E, V60I, S68G, D123E, R172K, K173A, Q174K, D177E, I178M, G196GE, T200A, Q207A, R211K, H221HY, L228H, P243A, V245Q, E248D, D250S, A272P, K275R, Q278N, T286A, E291D, I293V, E297A, R307RK, D324E, Q334H, G335D, F346H, R356K, M357K, G359S, A371V, I375V, T386I, K390RF
 48-92669266-30915DQ880860NRTINNRTIM41L, D67N, L74V, M184V, L210W, T215Y, K219RA98G, V108I, F227FLT39M, E44D, V118I, K122E, I135T, I142V, S162Y, E169D, K173A, Q174K, I178IM, E203K, Q207E, H208Y, R211K, K223E, L228H, P243S, V245QF
 48-91499149-30826DQ880762NRTINNRTIM41L, D67G, T69D, V75A, M184V, T215Y, K219RV108IT39A, E44Y, K49R, V111I, S117A, K122E, I135V, S162Y, S163T, E169D, K173T, Q174K, T200A, E203D, Q207E, H208Y, R211K, W212C, H221Y, K223Q, L228R, M230I, E233V, W239CF
 48-91519151-30826DQ880764NRTINNRTIM41L, L74LI, M184V, L210W, T215YK101KE, V108I, Y181C, G190GAE44D, K49R, V118I, K122E, I135V, S162C, E169A, K173A, Q174K, E203K, Q207E, R211K, H221Y, L228R, V245PF
Dumans (2009)192192FJ405073AZT, DDI, DDC, Unknown, D4T, 3TCUnknown, EFVM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IE44D, L109LP, V118I, K122E, D123E, I135L, I142T, E169D, K173A, Q174K, V179I, T200A, Q207E, H208Y, R211K, L228H, V245Q, E248D, A272P, I293V, E297AF
 RENA409RENA409FJ405119AZT, 3TC, D4T, DDIEFVD67N, K70R, K219QK103N, V108IE28K, K32E, V35M, T107S, D123E, S163C, E169D, K173A, Q174K, D177E, Q207E, R211K, H221Y, I244V, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297PF
 RENA626RENA626FJ405172AZT, 3TC, D4T, ABC, DDINVP, DLVM41L, D67N, K70R, L74I, V75S, L210W, T215Y, K219EA98G, K103N, V108IE6K, K20R, K32R, V35T, T39A, E44D, V118I, K122E, E138G, S162Y, E169D, K173A, Q174K, T200A, E203K, Q207E, H208Y, W212M, K223E, F227FY, L228H, Q242H, V245Q, E248D, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297T, D324E, Q334EF
Hawkins (2009)Q242ZZQ242FJ931229D4T, 3TCNVPM184V, T215YV108I, Y181CI31L, V35I, T69A, V90I, L109I, D123E, I142V, E169D, K173A, Q174K, D177E, I178L, G196V, T200A, I202V, Q207E, R211K, V245Q, D250S, A272P, K275R, Q278Y, T286TA, E291D, I293V, E297AF
Koyalta (2009)28TCHAD-28FJ688182D4T, 3TCNVPM184VK103N, V108IK82R, D121H, K122E, S162C, K173S, Q174K, D177E, I178L, T200A, Q207D, R211K, L228QF
 75TCHAD-75FJ688205D4T, 3TCNVPM184V, T215FV108I, Y181CK49R, V60I, V90I, I135T, S162H, K173T, Q174K, T200A, Q207EF
Jones (2012)133405133405JN669522NRTINNRTID67G, K70R, M184V, K219EK103N, V108I, K238TE28G, S68G, T69N, D123E, I135T, I178IM, T200A, Q207N, F214L, V245Q, P247PQ, E248D, A272P, K277R, E291D, I293V, E297T, G333E, Q334H, K390RF
Mollan (2012)MK180MK180w68 ABC, 3TCEFVV75I, M184VK103N, V108IV35T, K64KR, D123E, I132L, S162C, K173A, Q174R, D177E, I178L, T200A, Q207G, R211K, V245Q, E248D, A272P, K275R, K277R, Q278H, T286A, A288T, E291D, V292I, I293VF
Van Zyl (2013)14501215KC422966D4T, 3TCNVPM41L, D67N, V75M, M184V, L210W, T215Y, K219KNK103N, V108I, Y181C, G190GAK20R, V21I, V35T, T39I, E44D, K49KR, V60I, L109I, V118I, K122P, I135T, T165L, K173S, Q174K, N175Y, D177E, T200E, E203K, Q207D, H208Y, R211K, D218DE, H221HY, V245Q, E248DF