<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype F
Gene RT
Mutation K103N
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 63
Isolates 68
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M44M44AY010472AZT, 3TCNVPM41L, M184VK103N, K238NK20R, V35T, T39S, P52PL, V90I, K122E, S162Y, E169D, K173A, Q174K, Q207N, R211K, D237EF
Apetrei (2003)AC_Pat5RO.00.IS.05AY333599AZT, 3TCNVPD67N, T69D, K70R, T215F, K219QK103NV35T, T39A, E40D, D123E, I135L, S162Y, K173I, Q174K, T200E, Q207A, R211KF
 AC_Pat6RO.01.IS.06AY333530AZT, 3TC, D4T, UnknownNVP, UnknownT215CK103NV35T, D123E, I135L, S162Y, K166R, K173T, Q174R, I195L, T200A, Q207T, R211KF
 AC_Pat20RO.00.IS.20AY333576AZT, 3TC, D4TEFV K103NV35T, T39A, E40D, D123E, I135L, S162H, K173A, Q174K, T200A, Q207A, R211KF
  RO.01.IS.20AY333577AZT, 3TC, D4TEFV K103N, P225HV35T, T39A, E40D, D123E, I135L, S162H, K173A, Q174K, T200A, Q207A, R211KF
 AC_Pat23RO.00.IS.23AY333602AZT, 3TCNVPD67N, T69D, K70R, K219QK103N, Y181CV35T, T39A, E40D, V60I, D123E, I135L, S162H, K173A, Q174K, I195L, Q197K, T200A, Q207T, R211K, L228HF
  RO.01.IS.23AY333601AZT, 3TC, DDINVPD67N, T69D, K70R, K219QK103N, Y181CV35T, T39A, E40D, V60I, V90I, D123E, I135L, T139S, S162H, K173A, Q174K, I195L, G196E, Q197K, T200E, E203D, Q207E, R211K, E224D, L228HF
 AC_Pat24RO.00.IS.24AY333607AZT, 3TC, D4TEFV K103NV35T, T39A, E40D, D123E, I135L, S162H, K173A, Q174K, Q207E, R211KF
 AC_Pat25RO.00.IS.25AY333551AZT, 3TC, D4TEFV K103NV35T, T39A, K101Q, D123E, I135L, E138G, S162H, K166Q, Q174R, D177E, I195L, G196K, T200A, Q207A, R211KF
  RO.01.IS.25AY333552AZT, 3TC, D4TEFV K103N, P225HV35T, T39A, W88C, K101Q, D123E, I135L, E138G, S162H, K166Q, Q174R, D177E, I195L, G196K, T200A, Q207A, R211KF
 AC_Pat27RO.00.IS.27AY333608AZT, 3TC, D4TEFVK219QK103NV35T, T39A, E40D, D123E, I135L, S162H, K173A, Q174K, I195L, Q207T, R211KF
  RO.01.IS.27AY333609AZT, 3TC, D4TEFVK219QK103NV35T, T39A, E40D, V60I, D123E, I135L, S162H, K173A, Q174K, D177E, I195L, Q207A, R211KF
 AC_Pat28RO.00.IS.28AY333587AZT, 3TC, D4TEFV K103NV35T, T39A, E40D, V60I, D123E, I135L, S162H, K166R, F171L, K173A, Q174R, I195L, T200A, Q207A, R211KF
 AC_Pat33RO.01.IS.33AY333532AZT, 3TC, D4TNVP K103NV35T, T39A, E40D, D123E, I135L, S162Y, K173T, Q174K, D177E, I178V, I195L, T200A, Q207T, R211KF
 AC_Pat34RO.00.IS.34AY333588AZT, 3TC, D4TEFV K103NV35T, T39A, E40D, D123E, I135L, S162H, K173A, Q174R, I195L, T200A, Q207A, R211KF
 AC_Pat35RO.00.IS.35AY333570AZT, 3TCNVP K103NV35T, T39A, E40D, D123E, I135L, S162H, K173I, Q174K, T200A, Q207A, R211KF
 AC_Pat36RO.00.IS.36AY333568AZT, 3TC, D4TNVPK70RK103NV35T, T39A, E40D, D123E, I135L, S162Y, K173I, Q174K, T200A, Q207E, R211K, Y232HF
 AC_Pat39RO.00.IS.39AY333583AZT, 3TCEFV K103NV35T, T39A, F87L, I135L, S162H, K173T, Q174K, D177G, I195L, T200A, Q207A, R211KF
 AC_Pat40RO.00.IS.40AY333600AZT, 3TCEFVD67N, T69D, K70R, K219QK103N, P225HT39A, I135L, S162Y, K173T, Q174K, I195L, T200A, Q207T, R211KF
 AC_Pat41RO.00.IS.41AY3335903TCEFV K103NV35T, T39A, D123E, I135L, S162H, K173V, Q174K, N175Y, I195L, T200A, Q207E, R211KF
 AC_Pat43RO.00.IS.43AY333584AZT, 3TCEFVK219QK103NV35T, T39A, E40D, D123E, I135L, S162H, K173T, Q174K, I195L, T200A, Q207A, R211KF
 AC_Pat73RO.01.IS.73AY333553NRTI, UnknownNNRTI, UnknownK219RK103N, V106A, P225H, F227LV35T, V60I, S105T, D123E, I135L, S162H, K173T, Q174K, P176A, V189I, I195L, G196E, T200A, I202V, Q207A, R211K, L228RF
Dumans (2004)RES40RES40AY390200AZT, DDI, D4T, 3TC, UnknownEFV, UnknownD67N, K219QK101KE, K103N, K238TI135V, E138A, S162C, E169D, K173T, Q174K, D185X, D186DN, T200A, I202V, Q207E, F214L, V245QF
 RES093RES093AY390211AZT, 3TC, DDI, UnknownEFV, UnknownM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IK20KR, V35T, E44D, V118I, K122E, I135L, S162F, E169D, K173A, Q174K, T200A, E203K, Q207E, R211Q, K223E, V245Q, E248DF
Montes (2004)MB_patBAR01_BAR714AJ577734AZT, DDI, 3TC, D4T, ABCNVP, EFVT215FK103N, Y181C, G190AV35T, K49R, I135L, S162C, E169D, K173A, Q174K, Q207E, R211K, L228RF
Non-B Workgroup (2005)PL2902163632 AZT, 3TC, D4T, DDIEFVT215YL100LI, K101KPQT, K103NV21I, V35R, K49R, D123E, S162C, E169D, K173A, Q174K, Q207E, R211K, V245Q, E248D, A272P, T286A, E291ED, V292I, I293V, E297IV, V317AF
  102123 AZT, 3TC, D4T, DDIEFVM41L, L74V, T215YL100I, K103NV35KR, K43KQ, K102R, D123E, S162SC, E169D, R172RK, K173A, Q174K, E203EK, Q207E, R211K, K223Q, L228R, V245Q, E248D, A272P, T286A, V292I, I293V, E297AVF
Rodrigues (2005)BLF_Pat4BR02SP265AY643222D4T, DDI, 3TCNVPA62AV, K70NS, V75I, F77L, F116Y, Q151M, M184VK103N, Y181CE6S, K20R, V21VI, V35T, T39A, K64R, S68G, K122E, S162SC, E169D, K173A, Q174K, I178L, G196E, T200A, Q207E, R211K, H221Y, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297V, V317AF
 BLF_Pat11BR03SP43AY643248AZT, 3TC, Unknown, D4T, DDIUnknown, EFV, NVPM41L, M184V, T215FK101P, K103NP4T, K20KR, E28K, K32E, V35T, K49R, V60I, I135V, S162C, E169D, K173A, Q174K, T200A, Q207E, R211K, L228H, V245Q, E248D, A272P, T286A, I293V, E297TF
 BLF_Pat17BR02SP88AY643228AZT, DDI, 3TC, D4TNVP, DLVM41L, D67N, K70R, L74I, V75S, M184V, T215Y, K219EA98G, K103N, V108IE6K, K20R, K32R, V35T, T39A, E44D, V118I, K122E, S162Y, E169D, K173A, Q174K, T200A, E203K, Q207E, H208Y, W212WL, K223E, L228H, Q242H, V245Q, E248D, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297T, D324E, Q334EF
 BLF_Pat20BR03SP220AY643241AZT, DDI, 3TC, Unknown, D4TUnknown, EFVM41L, D67N, K70R, V75M, T215F, K219QK103N, V179E, K238TV35T, T39TI, V60I, T69N, K122E, D123S, E138Q, E169D, K173A, Q174K, I178L, T200A, H208Y, R211A, D218DE, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, I329LF
 BLF_Pat31BR03SP35AY6432463TC, D4TEFVM184V, T215YK101P, K103NK20R, E28K, V35T, D123E, E169D, K173A, Q174K, T200A, Q207E, R211K, V245Q, E248N, D250E, A272P, T286V, E291D, V292I, I293V, E297T, V317AF
 BLF_Pat36BR02SP117AY6432083TC, D4TEFV, NVPM41L, D67N, L74IV, M184V, T215YK103N, Y181C, G190AK20R, V35I, T39K, K43E, K49R, V118I, I142V, S162D, E169D, K173A, Q174K, G196E, T200A, E203D, Q207K, H208Y, R211A, H221Y, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297T, I329LF
 BLF_Pat38BR03SP211AY643240AZT, DDI, 3TC, D4TNVPM41L, L74V, M184V, T215FL100I, K103NK20R, V35T, T39S, K122E, E169D, K173A, Q174K, D177DG, T200A, E203K, Q207E, H208Y, R211K, K223E, L228R, V245Q, E248D, A272P, E291D, V292I, I293V, E297A, I326V, I329VF
 BLF_Pat39BR02SP241AY643218AZT, 3TC, D4TNVPM184VK103N, V108IV35T, T39M, I135V, E169D, K173T, Q174K, E194EG, G196E, T200A, Q207D, R211K, F214L, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, K311R, S322TF
 BLF_Pat42BR02SP154AY643211AZT, DDI, 3TC, UnknownEFV, UnknownL74V, T215DL100I, K103NV35T, E169D, K173T, Q174K, T200A, Q207D, R211K, V245Q, E248D, T286A, E291D, V292I, I293V, E297AF
Baxter (2006)48-12061206-30604DQ877750NRTINNRTIM41L, D67N, T69D, L74V, L210W, T215YK103N, Y181CV35T, T39A, E44D, K49R, V60I, V90I, K122E, D123S, S162D, E169A, K173A, Q174K, I178L, Q207E, R211K, D237E, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, E312E*, F346Y, R356K, M357R, G359S, A376S, T377L, K390R, Q394L, E399DF
 48-12711271-30923DQ877792NRTINNRTIM41L, A62V, T69S_SS, V75I, F116Y, L210W, T215YK103N, V108I, Y181YC, K238TP4PS, K20R, V35T, K43Q, E44D, K49KR, K122P, D123E, I135IV, S162CY, E169D, K173A, Q174K, D177E, I178L, E203K, Q207E, R211K, K223Q, L228H, V245Q, E248D, A272P, K277R, Q278N, L283I, T286A, E291D, V292I, I293V, P294T, E297A, Q334L, R356K, G359S, A371V, I375V, T377R, I382V, K390RF
 48-60236023-30403DQ878622NRTINNRTIM41L, D67N, K70R, T215F, K219QK103N, K238KTK20R, V35T, T39N, V60I, T69E, K122P, I135V, E138G, S162C, K173A, Q174K, D177E, I178L, Q207E, R211T, D218DE, K223KT, L228H, V245Q, E248D, A272P, K277R, E291D, V292I, I293V, E297P, R356K, M357I, G359S, T377L, I382V, Q394L, K395R, E399DF
 48-92729272-30922DQ880864NRTINNRTIM41L, V75M, M184V, L210W, T215Y, K219NL100I, K103NT39A, K43E, E44A, K102R, V118VI, D123DE, I135V, K173T, Q174K, D177G, G196E, T200A, E203AV, Q207E, H208Y, R211K, H221HY, L228HR, Q242QH, V245QF
 48-91579157-30924DQ880768NRTINNRTIM184VK103NT39TILS, K49KR, I135T, S162SC, E169ED, K173AE, Q174QK, I178L, Q207QE, R211RK, D237DE, V245QF
 48-90259025-30825DQ880664NRTINNRTIM41L, D67N, K70R, L74V, T215Y, K219EL100I, K103NT39K, K43E, E44A, K49R, D123E, S162C, E169D, P170PS, K173A, Q174K, D177DN, I178L, Q207A, H208Y, R211K, W212WL, D218E, L228H, V245QF
 48-92009200-30911DQ880806NRTINNRTIM184V, T215YK101P, K103NK49R, K64R, K104KR, K122KE, I135V, S162Y, K166KE, K173A, Q174K, D177E, V179VI, T200A, R211K, V245QF
 48-92509250-30908DQ880845NRTINNRTID67N, K70R, L74IV, V75VAIT, M184V, T215F, K219EL100I, K103NT69N, K122E, I135V, E169D, P170L, K173A, Q174K, D177N, G196E, Q207E, R211K, L228H, V245QF
Laurent (2006)CK2-7602CM-76AM279447D4T, 3TCEFVM184V, T215YK103N, M230LV35T, K122E, D123E, A158S, K173A, Q174K, D177E, I178L, Q207E, P243A, V245Q, E248D, D250S, A272P, K275R, L279M, T286A, E291D, I293V, E297A, D324E, P345L, F346H, R356K, M357S, G359S, A371V, T386V, K390R, A400I, K431T, E432DF
Cardoso (2009)3047BRGO3047FJ638429NRTINNRTIM184V, K219RK103N, P225HK20R, V35T, T39L, V60I, K102R, I135V, D177DE, I178M, T200A, Q207E, R211K, F214L, L228HF
 3082BRGO3082FJ638437NRTINNRTIM184VK103NV35T, K49R, D123E, I135T, S162C, E169K, K173E, Q174K, I178L, T200KF
 3127BRGO3127FJ638458NRTINNRTIM184VK103NK101Q, I135L, E138A, T200A, Q207D, R211KF
Dumans (2009)192192FJ405073AZT, DDI, DDC, Unknown, D4T, 3TCUnknown, EFVM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IE44D, L109LP, V118I, K122E, D123E, I135L, I142T, E169D, K173A, Q174K, V179I, T200A, Q207E, H208Y, R211K, L228H, V245Q, E248D, A272P, I293V, E297AF
 RENA409RENA409FJ405119AZT, 3TC, D4T, DDIEFVD67N, K70R, K219QK103N, V108IE28K, K32E, V35M, T107S, D123E, S163C, E169D, K173A, Q174K, D177E, Q207E, R211K, H221Y, I244V, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297PF
 RENA654RENA654FJ405122AZT, DDI, 3TC, D4TEFVM41L, T215FL100I, K103NV35T, K43N, I135V, E169D, K173A, Q174K, I178L, G196E, Q207A, R211K, L228R, P243S, A272P, K277R, T286A, E291D, V292I, I293V, E297AF
 RENA502RENA502FJ405148DDC, AZT, 3TC, D4T, DDIEFVD67N, K70S, L74V, M184V, T215YL100I, K103NE6D, K20R, V35M, K49R, P97PS, K122E, D123E, A129AV, I135T, P150PS, E169A, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, V317AF
 RENA248RENA248FJ405150AZT, DDI, 3TC, D4TNVP, EFVM184VK103NE6D, K20R, K122E, I142A, S162Y, T165K, E169D, K173A, Q174K, T200I, Q207D, R211K, V245Q, E248D, A272P, T286A, V292I, I293V, E297T, V317A, D324EF
 RENA569RENA569FJ405166AZT, DDI, Unknown, 3TC, D4TUnknown, EFV K103N, P225HE28K, K32E, V35T, T39L, E40ED, K49R, D123E, I135T, S162C, E169D, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, V317AF
 RENA626RENA626FJ405172AZT, 3TC, D4T, ABC, DDINVP, DLVM41L, D67N, K70R, L74I, V75S, L210W, T215Y, K219EA98G, K103N, V108IE6K, K20R, K32R, V35T, T39A, E44D, V118I, K122E, E138G, S162Y, E169D, K173A, Q174K, T200A, E203K, Q207E, H208Y, W212M, K223E, F227FY, L228H, Q242H, V245Q, E248D, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297T, D324E, Q334EF
 RENA181RENA181FJ405173AZT, DDI, 3TC, D4TEFVM41ML, T215YL100LI, K101E, K103NK20R, V35T, K49R, V106I, K122E, I135V, E138A, S162C, E169D, Q174K, D177Q, I178L, V179I, Q207D, R211K, L228LR, V245Q, E248D, A272P, K277R, T286A, A288T, E291D, V292I, I293V, E297A, V317AF
 RENA244RENA244FJ405174AZT, DDI, D4T, 3TC, UnknownNVP, EFV, UnknownM41L, D67N, T69D, K70R, V75M, T215F, K219QK103N, G190AE6D, V35T, V60I, V90I, K102N, S117A, D121H, K122E, I135T, S162Y, E169D, P170L, F171Y, Q174K, D177E, G196E, T200A, E203D, Q207E, L228H, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, E297A, V317AF
 RENA166RENA166FJ405176AZT, DDI, 3TC, D4TEFV, NVPT215FK103N, V106MK20R, I135V, S162C, K173A, Q174K, T200A, Q207E, R211K, V245Q, T286V, E291D, V292I, I293V, E297P, V317A, D324E, Q332HF
 RENA576RENA576FJ405182D4T, 3TC, ABC, AZTEFVM184VK101P, K103NV35T, K49R, V60I, D123E, I135V, E169D, K173A, Q174K, T200A, Q207E, R211K, V245Q, D250E, A272P, E291D, V292I, I293V, E297AF
Koyalta (2009)28TCHAD-28FJ688182D4T, 3TCNVPM184VK103N, V108IK82R, D121H, K122E, S162C, K173S, Q174K, D177E, I178L, T200A, Q207D, R211K, L228QF
 74TCHAD-74FJ688204D4T, 3TCNVPM184IK103N, Y181CK49R, V60I, D123E, E169D, K173A, Q174K, D177E, I178M, G196E, Q207E, R211KF
 85TCHAD-85FJ688209D4T, 3TCNVPM184IK103N, Y181CK49R, V60I, D123E, E169D, K173A, Q174K, D177E, I178M, G196E, Q207E, R211KF
Rodrigues (2010)310_07BR07SC310GQ401318AZT, 3TCEFVM184MIK103N, P225HE6N, I31L, V35T, V90VI, K122E, S162C, K173IT, Q174K, Q207E, R211K, V245Q, D250E, A272P, K277Q, T286A, E291D, V292I, I293V, E297AF
 328_07BR07SC328GQ401323AZT, 3TCNVPM184VK103N, V108VIK20KR, V35T, T39L, V90I, I135IT, S162Y, F171Y, K173T, Q174K, E203D, Q207E, R211K, F214L, V245Q, E248D, A272P, T286A, A288T, E291D, V292I, I293V, E297A, V317A, I326V, I329LF
Jones (2012)133405133405JN669522NRTINNRTID67G, K70R, M184V, K219EK103N, V108I, K238TE28G, S68G, T69N, D123E, I135T, I178IM, T200A, Q207N, F214L, V245Q, P247PQ, E248D, A272P, K277R, E291D, I293V, E297T, G333E, Q334H, K390RF
 165415165415JN670100NRTINNRTIM41L, D67N, K70KR, V75M, M184I, L210W, T215Y, K219NK103N, F227L, M230L, L234I, Y318FV35T, T39I, E44D, V60I, V106I, T107S, L109I, V118I, I142IV, S162Y, E169A, K173E, Q174R, T200A, E203D, Q207K, H208Y, R211E, H221Y, K223Q, L228H, V245Q, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297A, S322T, I329V, R356K, G359N, A371V, I375V, T377V, K390R, Q394L, E399DF
 171303171303JN670253NRTINNRTI K103NE6D, K20R, V35T, V106VI, K122KE, I135V, T139TS, S162H, E169D, K173AT, Q174K, T200TA, Q207DE, R211K, F214L, V245Q, E248D, A272P, K275Q, V276I, T286TA, E291D, V292VI, I293V, P294S, E297A, A299AE, L301L*, K311K*, D324DE, R356K, G359S, T377L, Q394LF
 185656185656JN670706NRTINNRTIM41L, D67DN, T215FK103NP4S, E6D, K20R, W24WC, V35R, V106I, D123E, I135T, I142IV, S162Y, E169D, K173AT, Q174K, I178L, T200I, Q207E, R211K, F214L, V245Q, E248D, A272P, K275Q, R284K, T286A, E291D, V292I, I293V, E297V, V317A, R356K, G359S, E370D, T377L, S379C, I382V, Q394L, K395KRF

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