<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation A98G
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 8
Patients 30
Isolates 30
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Baxter (2006)48-14391439-30929DQ877829NRTINNRTIM41L, L74V, L210W, T215YA98G, L100I, K103NV35T, T39K, K43E, E44D, K49R, V60I, K122E, Q174K, D177E, I178M, Q207E, R211K, V245Q, D250E, A272P, L282C, L283I, R284K, T286S, I293V, E297A, G335D, P345Q, F346Y, K347KR, R356K, A360T, T377Q, S379C, K390R, A400TD
Charpentier (2011)CR-47CR-47FJ688253AZT, 3TCNNRTIM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IK20R, V35I, T39A, E44D, V60I, V118I, K122E, I135IMT, I142T, D177E, I178L, E203EK, Q207E, H208HY, R211RK, K223KE, L228LH, V245T, D250E, A272P, K277R, T286A, V292ID
Kouri (2012)CU90-10CU90-10JQ585361NRTINNRTIM41ML, L74IV, M184V, T215FA98GV35T, K49R, V60I, K122E, I135L, E169D, D177E, Q197K, T200S, Q207E, H208Y, R211K, V245T, D250E, A272S, T286A, A288AG, E297A, I326T, I329VD
 CU311-10CU311-10JQ585381NRTINNRTIM41L, L74IV, M184V, T215FA98GV35T, K49R, V60I, K122E, I135L, E169D, D177E, Q197K, T200S, Q207E, H208Y, R211K, V245T, D250E, A272S, T286A, A288G, E297A, I326T, I329VD
Pircher (2013)B1117B1117JX110218D4T, 3TC, AZTNVPM41L, T69D, V75M, M184V, L210W, T215YA98G, Y181CI31L, V35IT, T39A, E44D, V60I, K101Q, V106I, V118I, P119PS, D121C, K122E, S162N, Q174K, D177E, I178V, T200E, K201M, E203K, E204Q, Q207A, R211K, K223T, L228R, V245TD
 B1118B1118JX110219D4T, 3TC, AZTNVPD67N, K70R, M184V, T215F, K219QA98G, V106A, F227LK20R, V35T, T39L, K49R, V60I, I94L, V118I, D121Y, K122E, I135L, E169D, K173R, D177E, I178L, T200E, E204K, Q207E, R211K, F214L, V245T, E248ID
Sigaloff (2013)JCR047_0JCR047_0JX181988NRTINNRTID67G, T69D, K70R, M184V, K219HA98G, V108I, Y181CV35T, K43E, K49R, V60I, I94L, K122E, I135M, S163SC, T165L, R172K, D177E, I178M, T200I, E203R, E204K, Q207E, R211K, E224K, V245K, D250E, A272P, Q278H, L282C, L283I, T286A, A288TD
 JCR024_0JCR024_0JX181986NRTINNRTIM184VA98G, K103N, P225HV35T, E40D, K49R, V60I, D121H, K122E, I135T, S162A, N175H, D177E, I178M, T200M, K201I, Q207E, R211K, F214L, V245T, D250E, A272P, K277RD
 JCR113_0JCR113_0JX182004NRTINNRTIM41L, D67N, V75VL, M184V, L210W, T215YA98G, G190AE6N, K11Q, V35T, E44D, K49R, V60I, I94L, K101Q, V111IM, D121Y, K122E, I135M, T165I, D177E, Q207E, R211K, V245Q, L282C, L283I, K287R, I293VD
 JFP058_0JFP058_0JX182010NRTINNRTID67N, K70R, M184V, K219QA98G, K103N, P225HV35T, E40D, V60I, T69S, K122E, D123N, I135L, D177E, T200I, Q207E, R211K, L228H, V245K, D250E, A272S, L282C, L283I, T286A, I293VD
Meini (2015)111123111123KM438256AZT, 3TC, D4T, ABCNVP, EFVM41L, M184V, L210LW, T215YA98G, Y188LV35T, V60I, V106VI, D121H, K122E, I135IT, D177E, I178L, V179VI, T200I, Q207E, R211KD
 109258109258KM438243D4T, 3TC, DDINVPM41L, L74LI, M184V, L210W, T215FYA98G, G190AK20R, K32R, V35T, T39K, K43KE, V60I, S68SG, V118VI, D121C, K122E, I135ILM, S162SDGN, I178M, V179I, T200A, Q207E, R211K, V245ED
Kekitiinwa (2017)66026_83766026_837KY237949NRTINNRTIM41L, D67N, M184V, L210W, T215YA98GK49R, E53D, V60I, D121Y, K122E, I135V, D177E, I178M, T200I, E203EK, Q207N, R211KD
Kityo (2017)8318683186KY061742NRTINNRTID67DE, M184V, L210W, T215YA98G, Y181CK43E, K49R, V60I, T69S, D121Y, K122E, I135L, D177E, I178IM, V179VI, T200K, Q207E, R211K, H221Y, L228LHD
 8295982959KY061523NRTINNRTIM41L, L74V, M184V, L210W, T215YA98G, K103N, K238TE44ED, P52PL, V60I, V118I, D121H, K122E, I135L, I142V, S162N, D177E, I178IL, G196GE, T200A, E203EK, Q207E, R211KD
 8304183041KY061600NRTINNRTIM41L, L74LI, V75A, M184V, L210W, T215YA98G, K103NK43Q, E44D, K49R, I94L, K102R, V118VI, I135L, D177E, I178IM, G196GE, Q207E, R211K, L228HD
 8347883478KY062032NRTINNRTIM41L, D67N, T69D, M184V, L210W, T215YA98G, Y181CE44D, V60I, V118I, D121C, K122E, I135R, D177E, G196E, T200A, I202V, E203K, Q207E, H208Y, R211K, K223EQ, L228HD
 8305683056KY061615NRTINNRTIM41L, M184V, L210W, T215YA98G, K103N, P225HS48T, V60I, K122E, D177E, I178M, T200A, Q207R, R211E, L228LRD
 8289982899KY061464NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219QA98G, V179DE, Y181CK49R, V60I, K122E, D123N, I135V, I167IV, D177E, T200A, I202V, Q207E, R211K, L228LHD
 8306283062KY061621NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219NA98G, V108VI, Y181CE44D, K49R, V60I, K122E, D123N, A158S, S162CY, E169A, K173E, Q174QR, D177E, I178L, V179VI, G196E, T200M, E203K, Q207E, R211K, H221Y, K238QD
 8330383303KY061858NRTINNRTIM41L, M184V, L210W, T215FA98G, K103N, P225HE44D, V60I, S68G, D121Y, K122E, I142V, D177E, I178IM, T200A, Q207E, R211RK, L228LH, K238RD
 8303983039KY061598NRTINNRTID67N, T69TADN, K70R, M184V, T215FYA98G, K101E, G190A, K238KTK46Q, K49R, V60I, K103KR, D121Y, K122E, I135L, E138A, S162A, E169D, D177E, I178M, T200R, Q207E, R211KD
 8296182961KY061525NRTINNRTID67N, K70R, M184V, T215FV, K219EA98G, K103N, P225HV60I, T69TN, D121DY, K122E, D123DE, I135LM, I142V, T200A, I202IV, Q207G, R211K, E224EAKTD
 8290782907KY061472NRTINNRTIM41L, L74I, M184V, L210W, T215YA98G, K103N, V108I, K238TK49R, V60I, D121HY, K122E, I135M, K173L, Q174K, D177E, V179L, G196E, T200A, E203ED, Q207T, R211N, L228RD
 8340283402KY061956NRTINNRTID67G, K70R, M184V, T215Y, K219EA98G, Y181CK49R, V60I, S68G, K122E, D123N, I135T, D177E, I178M, V179I, I202IV, Q207E, R211K, H235HRD
 8319883198KY061754NRTINNRTID67N, K70R, M184V, T215FI, K219QA98G, G190A, K238TK49R, V60I, D121H, K122E, I142IV, S162DN, D177E, I178M, V179VI, E194D, T200I, Q207E, R211K, F214FL, L228LHD
 8351183511KY062065NRTINNRTIK70E, M184VA98G, K101KE, V108VI, V179VDE, Y181C, G190AV60I, K103KR, D121H, K122E, I135T, I142IV, F171Y, V189VI, T200A, Q207E, L228HD
 8344983449KY062003NRTINNRTIM41L, T69D, M184V, L210W, T215YA98G, V108VI, Y181CK43E, E44A, K49R, V60I, K101Q, V118I, S162N, D177E, T200I, Q207E, R211K, L228RD
 8325983259KY061814NRTINNRTIM41L, V75M, M184V, L210W, T215YA98G, V108I, Y181CK43E, E44A, K49R, V60I, K122E, D123N, S162N, D177E, I178M, V179I, T200A, Q207A, R211K, H221YD
 8304283042KY061601NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K101E, G190AK43KQ, E44D, V60I, I94L, V118I, D121Y, K122E, D123E, D177E, I178M, V179I, T200A, Q207E, R211KD