<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation V90I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 16
Patients 34
Isolates 35
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE227SE227AF388139NoneNVP  V35T, K49R, V60I, V90I, D121Y, K122E, D177E, I178M, I180V, T200A, I202V, Q207D, R211K, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297V, E312RD
Eshleman (2004) SE227_7dAY428680NoneNVP  V35T, K49R, V60I, V90I, D121Y, K122E, D177E, I178M, I180V, T200A, I202V, Q207D, R211K, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297V, E312RD
 ESH_Pat75SE66_7dAY428674NoneNVP  V35T, T39K, V60I, V90I, K122E, D123N, I135T, I142T, I178M, T200I, Q207G, R211K, V245K, D250EQ, A272P, K277R, L282C, L283I, T286A, I293V, I329VD
Weber (2005)C55937C55937AY6775283TC, D4T, AZTNVP K101NV35T, E40D, K49R, V60I, I63IL, V90I, S162A, E204D, Q207E, V241I, V245Q, D250E, A272S, T286A, I329L, G333ED
 01F868601F8686AY677603AZT, 3TCEFV, NVPM184VK101E, G190AK20R, W24WC, V35T, T39M, K49R, V60I, V90I, K122E, D177E, I178M, T200I, Q207E, R211K, V245K, E248D, D250E, A272P, K277R, L282C, L283I, T286A, A288P, I293V, E297K, S322AD
Baxter (2006)48-41654165-30410DQ878398NRTINNRTIM41L, D67N, K70R, T215F, K219QK101E, G190SV35T, K49R, V60I, T69TN, V90I, A98S, V118I, K122E, I135T, E138A, T165I, E169D, R172RK, D177E, I178L, V179X, Q197E, E203A, Q207E, R211K, F214L, L228H, V245T, D250E, A272P, K277R, T286A, E297KR, I329L, G335D, M357MT, G359S, A376T, S379C, T386A, A400TD
Hawkins (2009)R61ZZR61FJ931300TDF, 3TCNVPK65R, M184IK103N, Y181CV35T, T39M, K49R, S68SDGN, V90I, K102R, K122E, T165I, D177E, I178M, Q207E, R211K, F214L, V245T, D250E, A272P, K277R, T286A, E297K, K311R, I329VD
Ndembi (2010)13075D_P113075GQ409548AZT, 3TCNVPM184VV106AV35T, E40D, K49R, T58S, V60I, V90I, D121H, K122E, D177E, I178M, T200M, Q207G, R211KD
Charpentier (2011)160CP0011090 D4T, 3TCNVPK65RK101KE, Y181C, G190AK20KR, V35T, T39TA, E40D, K49R, V60I, T69TA, V90I, D121Y, K122E, D123E, S162A, Q174H, D177E, T200A, E203EK, Q207E, R211K, L228LR, P243H, V245E, D250E, A272S, L283I, I293V, P313TD
Fokam (2011)CIRCB-1519CIRCB-1519JQ796144AZT, 3TCNVPV75M, M184V, T215TSK103NE6K, T7P, P9A, K11Q, V21VI, V35T, K49R, V90I, K122E, D123N, I135T, E138EG, S162N, R172K, D177E, I178L, V179IT, Q182S, T200A, E204K, Q207E, R211K, F214L, D237E, V245K, D250E, A272P, V276VI, K281KR, L283LI, T286A, E297K, K311R, D324DE, Q334E, G335S, T338S, Y339W, R356K, R358K, G359S, A371TD
Afonso (2012)ANG32ANG32JN937045NRTINNRTID67G, K70R, L74I, M184V, T215F, K219QK101E, G190AP4N, I31L, V35T, T39A, E40D, K49R, V60I, S68G, V90I, D121C, K122E, E138G, E169D, D177E, I178L, G196E, T200A, E203D, E204K, Q207D, R211K, F214L, V245T, E248D, K249R, D250KD
Kouri (2012)CU322-11CU322-11JQ585490NRTINNRTIL74V, M184VG190A, F227LV35K, T39A, E40D, K43Q, K49R, V60I, S68G, V90I, K104R, K122E, E169D, V179I, Q207X, R211RK, V245T, A272S, K277R, T286A, E297A, P313Q, I329L, Q334ED
 CU691-09CU691-09JQ585261NRTINNRTIM41L, D67N, K70S, M184V, L210W, T215F, K219QY181CK32Q, V35K, T39A, K49R, V60I, V90I, V111I, V118I, K122E, D123N, I135R, F160Y, Q197K, T200A, I202V, E203K, Q207D, H208Y, R211K, D218E, L228H, V245T, D250E, A272S, T286A, I293V, E297K, L301I, P313Q, I329VD
Reynolds (2012)E0090E0090-1JN652182AZT, 3TCNVPM184MIVV179E, Y181CT7TA, V21I, V35T, T39M, V60I, T69TA, V90I, D121C, K122E, I135T, I142V, D177E, T200A, E203EK, Q207E, R211K, V245Q, D250E, A272P, K277R, L282C, T286A, I293VD
 F0406F0406-1JN652189AZT, 3TCNVPM184VK103DN, P225HV35T, V60I, S68SG, K73KR, V90I, D121Y, K122E, I135M, D177E, I178M, T200I, Q207G, R211K, V241VA, V245K, D250E, W252WR, A272P, L282C, L283I, R284K, I293VD
 F0701F0701-1JN652190AZT, 3TCNVPM184VG190AV35T, K49R, I50T, V60I, V90I, K101Q, K122E, I132V, S162N, D177E, I178M, T200I, Q207E, V245E, D250E, A272P, K277R, L282C, T286A, I293V, E297GD
Kebe (2013)SNA3-144SNA3-144HM002510AZT, 3TCNVPM184VK101KE, Y181C, G190AV35T, K49R, I50IF, V60I, V90I, D121H, K122E, I135T, S162H, T165I, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245T, D250ED
Sigaloff (2013)JCR118_0JCR118_0JX182007NRTINNRTIM184VK103NV35T, T39K, K43E, K49R, V60I, S68G, V90I, D121Y, K122E, D123E, S162D, D177E, I178L, T200Q, E204D, Q207G, R211K, P243S, V245K, D250E, A272P, K275R, K277R, L282C, T286A, I293VD
Saravanan (2015)CTLA466CTLA466KP994069NRTINNRTIL74V, M184VL100I, K103NV35T, K49R, V60I, K82R, V90I, I135IT, I159IL, S162SDGN, K166KQ, D177E, E194D, G196GE, E203K, Q207ED
Kekitiinwa (2017)79377_25479377_254KY237991NRTINNRTI K103NK49KR, V60I, S68SN, V90I, D121DY, K122KE, D177E, I178M, T200TA, Q207ED
 35378_29235378_292KY237843NRTINNRTIK65R, M184MIVV108VI, Y181CI31IL, V35T, E40D, K49R, V60I, V90I, K122E, I135V, S162C, E169K, K173E, D177E, T200M, Q207E, R211K, H221HY, V245K, D250E, L282C, T286V, A288T, I293VD
 79383_17079383_170KY237997NRTINNRTI K101EK49R, V60I, V90I, D121Y, K122E, I135T, E138G, I142V, T200R, Q207E, R211KD
 79386_29279386_292KY238000NRTINNRTIK65R, Y115F, M184VV108I, Y181CK49R, V60I, V90I, K122E, I135V, S162C, E169K, K173E, D177E, T200M, Q207E, R211K, H221YD
Kityo (2017)8343883438KY061992NRTINNRTIK65R, V75M, M184VY181CS68N, V90I, D121H, K122E, S162A, D177N, I178M, V179I, T200M, E203D, Q207E, R211K, H221LD
 8291982919KY061483NRTINNRTIM41ML, V75I, M184V, T215YV106AK49R, V90I, K122E, I132L, D177E, I178L, T200R, Q207E, R211K, P236HD
 8343983439KY061993NRTINNRTIM41L, M184V, T215FK103NK49R, V60I, V90I, A98AS, D121Y, K122E, A158S, S162H, D177E, I178M, T200TIM, Q207E, R211K, K238RD
 8295882958KY061522NRTINNRTIM41L, V75M, M184V, T215YV108IK49R, V60I, V90I, K102R, K103Q, D121HY, K122KE, I135T, E138R, S162N, I178L, T200I, Q207D, R211KD
 8302883028KY061588NRTINNRTIM41L, M184V, T215Y, K219RK103N, P225HK43R, K49R, E53D, V60I, V90I, I135T, S162D, D177DE, I178IM, Q207E, R211K, L228HD
 8356183561KY062115NRTINNRTIK65R, M184IV108I, Y181C, M230LK43N, K49R, V60I, S68G, V90I, D121Y, K122E, R125K, D177E, I178M, G196E, T200R, Q207E, R211KD
 8350783507KY062061NRTINNRTID67N, K70R, M184V, T215F, K219EK101H, V108I, Y181C, P236PLK49R, V60I, K64KR, V90I, K122E, I135IT, S162HN, D177E, G196E, Q207E, R211K, L228LRD
 8316083160KY061716NRTINNRTID67N, K70R, M184V, T215TFIS, K219EY181YC, G190AV60I, K64R, T69TN, V90I, K101Q, I178L, V179I, Q207E, L228QD
 8301183011KY061573NRTINNRTIM41L, D67N, T69D, V75I, M184I, L210W, T215Y, K219RV108I, Y181CK43E, E44D, K49R, V60I, V90I, V118I, D121H, K122E, S162N, T165I, D177E, I178V, V179VI, G196GE, I202V, Q207A, R211RK, H221YD
 6606766067KY061428NRTINNRTIK70E, Y115F, M184VY181CV60I, V90I, K101R, V106VI, K122E, I135V, G196K, T200I, Q207E, R211K, H221Y, L228RD
 8325783257KY061812NRTINNRTID67DN, M184V, L210W, T215YK103NV60I, V90I, K102R, D121H, K122E, D177E, I178M, Q197E, Q207E, R211KD
 8345483454KY062008NRTINNRTIM41L, M184V, T215FV108I, Y181CK43R, V60I, V90I, K122E, I135T, S162C, V179I, T200A, Q207E, R211K, F214L, H221YD