<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation K238R
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 9
Patients 14
Isolates 15
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE676SE676AF388112NoneNVP  V35T, E40D, K49R, V60I, D121Y, K122E, T165TI, D177E, I178M, T200I, Q207E, R211K, K238R, V245E, D250E, V276VI, K277R, K281KR, L282C, L283I, T286A, I293VD
Eshleman (2004) SE676_7dAY428707NoneNVP  V35T, E40D, K49R, V60I, D121Y, K122E, T165TI, D177E, I178M, T200I, Q207E, R211K, K238R, V245E, D250E, V276VI, K277R, K281KR, L282C, L283I, T286A, I293VD
Nyombi (2008)TBK089TBK089EU251772NoneNVP  V35T, E40D, V60I, K122E, D123N, D177E, I178M, T200L, Q207R, R211K, K238R, V245K, D250E, A272P, K277R, L282C, T286A, I293V, K311R, G335D, P345Q, F346Y, R356K, M357VD
Sigaloff (2011)HIV102321HIV102321JN132306AZT, 3TCEFVD67N, K70R, M184V, K219QK103N, P225HV35T, E40D, K49R, V60I, T69N, K101Q, K122E, I135KT, Q174QK, D177E, I178M, Q207E, R211K, L228H, K238R, V245E, D250E, A272P, K277R, L282C, L283I, V292I, I293V, G333E, Q334H, G335DD
Hamers (2012)CP076305797CP076305797JQ480254TDF, FTCEFVM41L, D67N, K70E, V75I, M184VG190QV35T, K43R, V60I, D121Y, K122E, I135T, D177E, I178M, T200A, E204Q, Q207E, R211K, F214L, K238R, V245E, D250E, S251C, A272P, L283I, T286V, I293VD
Kekitiinwa (2017)79391_30379391_303KY238004NRTINNRTIL74V, Y115F, M184VV108VI, Y181CK49R, V60I, K101R, D121HY, K122E, D177E, I178M, V179I, G196GE, T200M, Q207E, R211K, H221Y, K238RD
Kityo (2017)8318383183KY061739NRTINNRTIM41L, M184V, L210W, T215YY181CK43Q, V60I, V111VIM, D121Y, K122E, I135T, S162A, D177E, I178IM, G196GE, T200MR, E203EK, Q207E, R211K, H221Y, K238RD
 8343983439KY061993NRTINNRTIM41L, M184V, T215FK103NK49R, V60I, V90I, A98AS, D121Y, K122E, A158S, S162H, D177E, I178M, T200TIM, Q207E, R211K, K238RD
 8339683396KY061950NRTINNRTI K103NK43KN, S48ST, K49R, V60I, D121H, K122E, I135T, S162C, T165I, D177E, I178V, V179I, G196E, T200L, Q207E, R211K, K238RD
 6609066090KY061442NRTINNRTIM184VY181CK49R, V60I, D121Y, K122E, D123E, S134SN, I135T, D177E, I178L, G196K, T200I, Q207E, R211K, L228R, K238RD
 8293782937KY061501NRTINNRTIM41ML, V75VIM, M184V, T215FA98AG, K101KN, K103N, P225HK49R, V60I, V90VI, D121HY, K122E, I159IV, S162SDGN, Q174K, D177E, I178M, Q197E, Q207E, R211K, K238RD
Rhee (2017)KE02099KE02099KY364326TDF, 3TCNVPK65R, Y115YF, M184VK103KN, Y181CK32KR, V35T, K49Q, S68SN, W88C, K101KR, D123E, T139MR, K166KR, T200I, I202V, Q207E, R211K, K238R, V245E, D250ED
 1054110541_FL TDF, FTCEFV  V35K, T39A, K49R, V60I, D121Y, K122E, T139A, I142V, S162C, T165TA, D177E, I178M, E194N, G196E, Q207G, R211K, K238R, V245Q, D250E, L260I, A272P, L282C, L283I, L303M, D324ED
Svard (2017)1st_1091st_109KX775227AZT, 3TCEFVM41L, T69D, M184V, T215FK101E, V108I, Y181C, G190AV8I, K20R, E28R, K32E, V35T, K49R, V60I, V118I, D121C, K122E, T139TA, S162N, D177E, T200R, Q207E, L228H, K238R, Q242H, V245E, D250ED
 2nd_20232nd_2023KX7752733TC, D4T, TDF, FTCNVPM184V, T215FA98G, K101EV35T, T39A, V60I, S68G, D121Y, K122E, D123E, I135K, S162C, Q174K, D177E, I178M, T200M, Q207E, R211K, K238R, V245ED