<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation P225H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 8
Patients 34
Isolates 34
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Hamkar (2010)3Ir-HIV-DR-03GU724806NRTINNRTIK70R, M184VK103N, P225HK11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 7Ir-HIV-DR-07GU724810NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 11Ir-HIV-DR-11GU724814NRTINNRTIK70R, M184VK103N, P225HV10L, K11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, S251K, A272P, L283I, V292I, I293V, I326XD
 12Ir-HIV-DR-12GU724815NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
Kouri (2012)CU116-10CU116-10JQ585365NRTINNRTID67DN, K70KR, M184V, T215TI, K219KEK103N, P225HV21I, V35T, T39A, E40D, K101Q, K122KE, D177E, I178M, Q207T, V245T, D250E, A272S, T286A, V292I, P313T, V317A, I329VD
Reynolds (2012)C0776C0776-1JN652178AZT, 3TCEFV K103N, P225HE6ED, V8VI, K11S, V35T, T39A, E44ED, V60I, I135T, I142V, P170S, D177E, E194D, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278N, L282C, L283I, I293VD
 G0715G0715-2JN652208AZT, 3TC, TDF, FTCEFVD67N, M184VK103N, P225HE28K, V35T, K49R, V60I, K101Q, K122E, D123A, E169A, D177E, I178L, Q207E, R211K, D250E, A272P, K277R, L282C, L283I, T286A, I293VD
 J0594J0594-2JN652209AZT, 3TC, ABC, DDIEFVM41L, L74LI, M184V, L210W, T215YK103N, P225HV35T, V60I, D121H, K122E, I135L, K173R, D177E, I178M, T200I, Q207E, R211K, P243T, V245E, D250E, A272P, K277R, L282C, L283I, I293V, E297KD
 F0406F0406-1JN652189AZT, 3TCNVPM184VK103DN, P225HV35T, V60I, S68SG, K73KR, V90I, D121Y, K122E, I135M, D177E, I178M, T200I, Q207G, R211K, V241VA, V245K, D250E, W252WR, A272P, L282C, L283I, R284K, I293VD
Sigaloff (2013)MBA036_0MBA036_0JX182014NRTINNRTIM184VK103N, P225H, K238TV35T, V60I, I142V, S162C, D177E, I178M, Q197E, T200K, Q207K, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293VD
 JCR083_0JCR083_0JX181996NRTINNRTID67N, T69D, K70R, M184V, T215F, K219QK103N, P225HE6D, K20R, E28A, V35T, V60I, W88C, I94L, K101Q, V118I, K122E, D123S, I135T, E169D, K173A, Q174K, D177E, I178L, E194D, G196E, T200A, Q207E, F214L, V245K, D250E, K277R, E291D, V292I, I293V, P294TD
 JCR024_0JCR024_0JX181986NRTINNRTIM184VA98G, K103N, P225HV35T, E40D, K49R, V60I, D121H, K122E, I135T, S162A, N175H, D177E, I178M, T200M, K201I, Q207E, R211K, F214L, V245T, D250E, A272P, K277RD
 JFP058_0JFP058_0JX182010NRTINNRTID67N, K70R, M184V, K219QA98G, K103N, P225HV35T, E40D, V60I, T69S, K122E, D123N, I135L, D177E, T200I, Q207E, R211K, L228H, V245K, D250E, A272S, L282C, L283I, T286A, I293VD
Van Zyl (2013)O11611134KC422903D4T, 3TCEFVM184VK103N, P225HK20R, V35T, K49R, V60I, K101Q, K122E, D123S, D177E, I178M, T200L, Q207K, R211K, V245QD
Wallis (2014)4107341073KM458594NRTINNRTIV75I, M184VK103N, P225HV35I, K49R, V60I, D121Y, K122E, I132L, D177E, T200A, Q207E, R211KD
Kekitiinwa (2017)79359_41779359_417KY237986NRTINNRTIL74V, Y115F, M184VK103N, P225HV60I, D121DY, K122E, I135L, E138G, D177E, T200L, Q207E, R211KD
Kityo (2017)8305683056KY061615NRTINNRTIM41L, M184V, L210W, T215YA98G, K103N, P225HS48T, V60I, K122E, D177E, I178M, T200A, Q207R, R211E, L228LRD
 8302883028KY061588NRTINNRTIM41L, M184V, T215Y, K219RK103N, P225HK43R, K49R, E53D, V60I, V90I, I135T, S162D, D177DE, I178IM, Q207E, R211K, L228HD
 8329583295KY061850NRTINNRTIM184VK103N, P225HI47L, K49R, I50V, V60I, D121H, K122E, I135IT, D177E, I178M, Q207E, R211KD
 8302183021KY061581NRTINNRTIM41L, D67DE, L74LI, V75VIM, M184V, L210W, T215YK103N, P225H, K238TE44D, V60I, S68SG, V118VI, D121Y, K122E, I135T, I142V, D177E, I178M, G196GE, T200AE, E203K, Q207E, R211K, K223E, L228RD
 8330383303KY061858NRTINNRTIM41L, M184V, L210W, T215FA98G, K103N, P225HE44D, V60I, S68G, D121Y, K122E, I142V, D177E, I178IM, T200A, Q207E, R211RK, L228LH, K238RD
 8296182961KY061525NRTINNRTID67N, K70R, M184V, T215FV, K219EA98G, K103N, P225HV60I, T69TN, D121DY, K122E, D123DE, I135LM, I142V, T200A, I202IV, Q207G, R211K, E224EAKTD
 8299982999KY061561NRTINNRTIM184VK103N, P225H, K238TV60I, K101KQ, D121Y, K122E, D177E, I178M, T200I, Q207G, R211KD
 8315583155KY061711NRTINNRTIM184V, T215YA98AG, K103N, V108I, Y181C, P225H, F227FLE44D, K49KR, V90VI, T200I, Q207E, R211KD
 8342883428KY061982NRTINNRTID67N, K70R, M184V, T215I, K219EQK103N, V108VI, P225HV60I, K102KR, K122E, I135L, D177E, I178M, T200I, Q207E, R211KD
 8329483294KY061849NRTINNRTI K103N, P225H, P236PLK49R, V60I, S162C, T165I, D177E, I178M, Q207E, R211KD
 8347483474KY062028NRTINNRTIM184VK103N, P225HK49R, V60I, R83RK, K122E, I135M, E138EQ, S162C, D177E, I178L, V179IL, V189VI, Q207E, R211KD
 8296582965KY061529NRTINNRTID67N, K70R, L74I, M184V, T215I, K219QK103N, V108I, P225HK43E, K46Q, V60I, K122E, I135L, D177E, I178M, T200K, Q207E, R211KD
 8290282902KY061467NRTINNRTIK70E, M184V, K219RK103N, P225H, K238TK49R, V60I, D121Y, K122E, D123G, D177E, I178M, T200IM, Q207GR, H208HL, R211K, L228RD
 8293782937KY061501NRTINNRTIM41ML, V75VIM, M184V, T215FA98AG, K101KN, K103N, P225HK49R, V60I, V90VI, D121HY, K122E, I159IV, S162SDGN, Q174K, D177E, I178M, Q197E, Q207E, R211K, K238RD
 8301683016KY061577NRTINNRTIM184VK103N, Y181C, P225HP59PS, V60I, S68G, K122E, D123N, I135T, E169ED, P170PL, D177E, I178L, G196K, Q207E, R211K, H221YD
 8293882938KY061502NRTINNRTIM184VK103N, P225HK49R, S68N, D121Y, K122E, R125K, T165L, D177E, I178M, V179I, G196E, T200I, Q207E, R211KD
 8292282922KY061486NRTINNRTID67N, K70R, M184V, T215TI, K219QK103N, P225HK49R, V60I, K64R, I135T, D177E, I178M, Q207E, R211KD
 8349383493KY062047NRTINNRTIM184V, T215TNSYK103N, P225HK49R, V60I, K101G, K122KE, D177E, I178M, V179I, T200LR, Q207E, R211KD