<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation G190A
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 17
Patients 38
Isolates 43
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Richard (2004)RNJCR17RNJCR17AY556802AZT, 3TC, D4TNVP G190AE28K, K32E, A33P, V35T, V60I, E79D, D121Y, K122E, I178M, T200ID
 RNJCR34RNJCR34AY556801AZT, DDI, ABC, 3TC, D4TEFVM41L, D67NK101P, G190AP4T, E28K, K32E, V35T, V60I, D121H, K122E, I135T, S163I, Q174P, D177E, I178M, T200RD
Non-B Workgroup (2005)UK1446UK1446AY901337AZT, 3TCNVPM184VG190AV8I, V35T, K49R, V60I, K122E, I135L, I142V, D177E, I178M, T200I, E203K, Q207E, R211KD
 UK1972UK1972AY901372AZT, DDI, 3TC, D4TNVPM41L, D67N, M184V, T215YG190AK32I, L34I, V35T, T39A, K49R, K104KR, S117A, S162CY, S163ST, D177E, I178F, T200R, Q207E, H208Y, R211K, W212R, H221YD
 TK1028TK1028 AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
  TK1028a AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
 TK2025TK2025 D4T, 3TC, ABCNVPL74V, M184VK101E, Y181C, G190AK32R, V35M, E42EG, K43N, V60I, K122E, I135T, D177E, T200I, Q207E, R211K, V245EK, D250E, A272P, L282C, R284K, T286A, I293V, E297AD
  TK2025a D4T, 3TC, ABC, DDC, DDINVP, EFVM41L, L74VK101E, Y181C, G190AK32R, V35R, K43N, V60I, V118I, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, P321PQD
Rhee (2005)ASRU017ASRU017AY901227DDC, AZT, 3TC, D4T, DDINVPM41L, T69S_S, T215YY181C, G190AV35T, K49R, V60I, D121C, K122E, I132X, I135T, D177E, I178M, L205X, Q207E, R211KD
Weber (2005)M94371M94371AY677521AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV60I, K122E, D177E, I178L, V179I, T200I, Q207E, R211K, V245Q, E248N, D250E, A272P, L282C, R284K, E291A, I293VD
 01F868601F8686AY677603AZT, 3TCEFV, NVPM184VK101E, G190AK20R, W24WC, V35T, T39M, K49R, V60I, V90I, K122E, D177E, I178M, T200I, Q207E, R211K, V245K, E248D, D250E, A272P, K277R, L282C, L283I, T286A, A288P, I293V, E297K, S322AD
Baxter (2006)48-14291429-30424DQ877819NRTINNRTIM41L, D67N, M184V, T215F, K219QG190AT7P, K20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, Q278H, L282C, T286A, I293V, E297R, G335D, P345Q, F346Y, N348P, R356K, M357T, A360T, T377R, K390R, E399DD
Lwembe (2007)NYU3636MAPR03 RTI, ABC, 3TC, DDI, AZT, D4TRTI, EFVT215FK103N, G190AV35T, E40D, K49R, V60I, K122E, D177E, T200R, Q207ED
  36MFEB04 RTI, ABC, 3TC, DDI, AZT, D4TRTI, EFVT215FK103N, G190AV35T, E40D, K49R, V60I, K122E, I135T, D177E, T200R, Q207ED
  36MAUG04 RTI, ABC, 3TC, DDI, AZT, D4TRTI, EFVT215FK103N, G190AV35T, E40D, K49R, V60I, K122E, I135T, D177E, T200R, Q207ED
Church (2008)391100H391100HEU380747NoneNVP G190AV35T, T39L, V60I, D121Y, K122E, D177E, I178M, Q197K, Q207G, R211K, V245K, D250E, S251N, A272P, V276T, K277R, L282C, L283I, T286A, I293VD
Hawkins (2009)R348ZZR348FJ931375AZT, 3TCNVPD67DN, K70R, M184V, K219QK101E, G190AP4T, E6KQ, E28K, K32E, V35T, T39L, V60I, V118I, K122E, I135T, I142T, D177E, I178LV, T200A, Q207E, R211K, F214L, V245K, D250E, T286A, V292I, E297R, I329VD
Ndembi (2010)13025D_P113025GQ409547AZT, 3TCNVPD67G, M184VG190A, M230LV35T, T39K, S48T, I50V, V60I, E79V, K102Q, K122E, D177E, I178M, T200I, E203G, Q207E, R211KD
 13327D_P113327GQ409555AZT, 3TCNVPM184VG190AV35T, K122E, I135M, I142T, I178M, Q207E, R211KD
 14188D_P114188GQ409564AZT, 3TCNVPM184V, T215NG190A, M230LV21I, V35T, E44D, V60I, K122E, D123E, D177E, I178M, G196E, T200I, Q207G, R211KD
 DT5712_04_P15712GQ409630AZT, 3TCNVPM184VK101E, G190AV35T, T39R, K43E, K49R, V60I, I142M, R143K, N147Q, K166R, I167M, E169D, D177E, T200I, Q207E, R211KD
Towler (2010)8505503-GHM037899D4T, 3TCNVPM184VK103S, G190AK11S, K20KR, V35T, T39K, V60I, K122E, D123S, I135T, D177E, I178M, G196K, T200A, Q207E, V245K, D250E, A272P, T286A, T296SD
Aulicino (2011)ARN272RLDARN272RLDFJ525856NRTINNRTIM41L, D67N, T69D, K70R, L74V, M184V, L210W, T215Y, K219HA98G, K101E, V108I, Y181C, G190AS3C, K20R, E28A, V35T, T39E, E44D, V60I, V90I, L109I, K122E, I135V, I142V, S162N, I167V, V179I, T200A, E203K, Q207E, H208Y, R211KD
Charpentier (2011)160CP 001 1090 D4T, 3TCNVPK65RK101KE, Y181C, G190AK20KR, V35T, T39TA, E40D, K49R, V60I, T69TA, V90I, D121Y, K122E, D123E, S162A, Q174H, D177E, T200A, E203EK, Q207E, R211K, L228LR, P243H, V245E, D250E, A272S, L283I, I293V, P313TD
Afonso (2012)ANG32ANG32JN937045NRTINNRTID67G, K70R, L74I, M184V, T215F, K219QK101E, G190AP4N, I31L, V35T, T39A, E40D, K49R, V60I, S68G, V90I, D121C, K122E, E138G, E169D, D177E, I178L, G196E, T200A, E203D, E204K, Q207D, R211K, F214L, V245T, E248D, K249R, D250KD
Kouri (2012)CU322-11CU322-11JQ585490NRTINNRTIL74V, M184VG190A, F227LV35K, T39A, E40D, K43Q, K49R, V60I, S68G, V90I, K104R, K122E, E169D, V179I, Q207X, R211RK, V245T, A272S, K277R, T286A, E297A, P313Q, I329L, Q334ED
 CU845-09CU845-09JQ585267NRTINNRTIM41L, V75VL, M184V, T215YA98AG, K101E, G190AV35T, V60I, K104KR, F116I, D121Y, K122E, I135T, P157PL, S162C, D177E, I178L, V179I, T200A, E204A, Q207E, R211K, V245A, D250E, A272P, T286A, E297R, L301I, V317T, I329V, G335D, E344DD
 CU749-09CU749-09JQ585263NRTINNRTIM41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219NK101E, Y181C, G190AV35T, V111I, D121Y, K122E, I135T, N137H, S162Y, D177E, I178L, V179VI, T200A, E204A, Q207E, R211K, V245T, D250E, A272S, K277R, T286A, E297K, P313S, V317A, I329V, G335DD
 CU194-11CU194-11JQ585494NRTINNRTIM41L, L210RW, T215S, K219KNY181YC, G190AV8I, V35T, T39A, K43N, E44D, V60I, S68G, A98S, V111VI, K122E, I135AT, E169D, K173KE, D177E, V179IS, G196GE, T200A, E203D, Q207E, D237E, V245T, A272S, T286V, I293V, E297K, P313Q, Y319YN, I329V, G335ED
 CU54-11CU54-11JQ585475NRTINNRTIM184VG190AV35T, K49R, V60I, K122E, I135IT, Q151QH, K166R, E169D, D177E, G196E, Q197K, T200A, Q207E, V245T, D250E, A272S, K277R, T286A, E297K, S322SA, I329V, G335DD
Reynolds (2012)B0715B0715-1JN652173AZT, 3TCNVPM184VK101E, G190AV21VI, E28K, K32E, V35T, T39TK, V60I, K82R, K122A, I135T, D177E, T200I, Q207E, R211K, F214L, V245K, D250E, A272P, K275R, L282C, I293V, E297AD
  B0715-2JN652205AZT, 3TC, TDF, FTCNVPM184VK101E, G190AV21I, E28K, K32E, V35T, T39K, V60I, K82R, K122A, I135T, D177E, T200I, Q207E, R211K, F214L, V245K, D250E, A272P, K275R, L282C, I293V, E297AD
 B0717B0717-1JN652174AZT, 3TCNVPM184VK101KE, G190AE6K, V35T, K43R, K49R, V60I, K122E, I135T, S162C, D177E, I178M, T200L, Q207E, R211K, V245EK, D250E, S251C, A272P, K277R, L282C, L283I, I293VD
 F0701F0701-1JN652190AZT, 3TCNVPM184VG190AV35T, K49R, I50T, V60I, V90I, K101Q, K122E, I132V, S162N, D177E, I178M, T200I, Q207E, V245E, D250E, A272P, K277R, L282C, T286A, I293V, E297GD
Kebe (2013)SNA3-144SNA3-144HM002510AZT, 3TCNVPM184VK101KE, Y181C, G190AV35T, K49R, I50IF, V60I, V90I, D121H, K122E, I135T, S162H, T165I, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245T, D250ED
Sigaloff (2013)JCR111_0JCR111_0JX182003NRTINNRTIM184V, T215FK101E, G190AE28R, V35T, K49R, V60I, A98S, K122E, I135T, I142V, D177E, V179I, Q207E, R211K, V245Q, D250E, K277R, L282C, E297AD
 JCR092_0JCR092_0JX181997NRTINNRTID67N, K70R, M184V, K219QK101E, G190AV35T, T39A, E40D, V60I, K122E, D123S, I135T, E138A, I202V, Q207A, R211S, F214L, V245M, D250E, A272P, K277R, K281R, L282C, L283I, T286A, I293VD
 MBA093_0MBA093_0JX182025NRTINNRTIM41L, T69D, M184V, L210W, T215YK101H, Y181C, G190AE28A, V35T, E44D, K49R, V60I, K122E, I135T, T139R, T165I, D177E, T200I, Q207E, R211K, L228R, V245K, D250E, A272P, K275R, L282C, L283I, T286A, V292I, I293V, G316ED
 MBA049_0MBA049_0JX182019NRTINNRTID67DN, K70KR, M184VK101E, G190AV35T, T39A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, Q278H, L282C, I293V, E297QD
 MBA043_0MBA043_0JX182016NRTINNRTID67N, K70R, M184V, T215F, K219EK101E, G190AV35T, T39L, D121Y, K122E, D177E, I178V, E204Q, Q207E, V245K, D250E, A272P, I274L, K275R, Q278N, T286AD
 MBA031_0MBA031_0JX182013NRTINNRTID67N, K70R, M184V, T215F, K219EK101E, G190AV35T, T39L, D121Y, K122E, D177E, I178V, E204Q, Q207E, V245K, D250E, A272P, I274L, K275R, Q278N, T286AD
 JCR113_0JCR113_0JX182004NRTINNRTIM41L, D67N, V75VL, M184V, L210W, T215YA98G, G190AE6N, K11Q, V35T, E44D, K49R, V60I, I94L, K101Q, V111IM, D121Y, K122E, I135M, T165I, D177E, Q207E, R211K, V245Q, L282C, L283I, K287R, I293VD
 JCR022_0JCR022_0JX181985NRTINNRTIM184VG190AV35T, T39L, V60I, D121Y, K122E, I135V, D177E, I178M, V179I, Q197K, T200A, Q207G, R211K, D237E, V245K, D250E, S251N, A272P, I274V, V276T, K277R, L282C, L283V, T286A, E297AD