<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation Y188L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 15
Isolates 16
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK2001TK2001 D4T, 3TC, AZT, DDI, ABCEFV, NVPM41L, D67G, K70R, L74I, M184V, T215F, K219QL100I, Y188LK20R, V35T, K49KR, E53Q, V60I, T69N, D123E, I135V, K166R, D177E, T200I, Q207E, R211K, D218E, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V, G316G*RD
  TK2001a D4T, 3TC, AZT, DDI, ABC, TDFEFV, NVPM41L, D67G, K70R, L74I, T215F, K219QL100I, Y188LK20R, V35T, E53EQ, V60I, S68SG, T69IN, D123E, I135V, Q161QH, S163X, K166R, D177E, V179VI, T200I, Q207E, R211K, D218E, L228H, Q242QH, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, A288AT, I293VD
Baxter (2006)12-22582258-30721DQ880135NRTINNRTIM41L, D67E, T69S_VG, L74V, M184VK101H, Y181CF, Y188LV60I, D121Y, K122E, T139K, D177E, I178L, V189I, T200AV, Q207E, R211K, H221Y, T240A, V245KD
 48-50525052-30515DQ878573NRTINNRTIM41L, D67N, T69D, V75M, L210W, T215YY188LP4S, K20R, V35T, T39R, K43E, E44D, V60I, K64H, L109I, V118I, I135V, T139V, S162D, K166R, K173A, D177E, Q207E, R211K, D218E, E224ED, V245Q, E248D, D250E, S251N, A272P, K277R, L283I, A288T, I293V, E297K, G333E, Q334H, G335NS, G359S, A371V, T377M, K390RD
Fokam (2011)CIRCB-8995CIRCB-8995JQ796156D4T, 3TCNVPM184VY188LV8I, K13KR, V35T, V60VI, K103KE, D121H, K122E, I135T, T139A, D177DE, I178V, Q207E, R211RK, F214L, V245DEKN, E248EK, D250E, A272P, T286A, E297K, I329V, G335ED
Sigaloff (2011)HIV101882HIV101882JN132286AZT, 3TCNVPM41L, M184V, T215FY188LV35T, T39N, V60I, K122E, D123NS, E138A, V179I, T200A, Q207G, R211K, V245K, A272P, L282C, L283I, T286A, V292I, I293VD
Hamers (2012)CP076304862CP076304862JQ480243AZT, 3TCNVPM184VY188LV35T, S48T, K49R, V60I, K104N, K122E, I135V, T139A, S162A, D177E, I178M, T200I, Q207E, R211K, D237N, V245K, D250E, A272P, K275R, K277R, L282C, L283I, I293VD
Kouri (2012)CU373-10CU373-10JQ585388NRTINNRTIM41L, D67N, F116Y, Q151M, M184V, T215FK101E, Y188LE28K, K32E, V35T, T39AS, K49R, V60I, V111I, K122E, E169D, P170L, K173Q, D177G, G196E, Q197K, Q207E, H208F, R211K, I244V, V245T, D250E, A272S, A288S, E297K, P313Q, I329V, Q334N, G335DD
 CU1960-09CU1960-09JQ585327NRTINNRTIM41ML, D67DN, M184V, L210W, T215YY188LV35T, T39TA, K49R, V60I, K82KR, K122E, E169D, D177E, I178L, G196GE, Q197K, Q207E, V245K, D250E, A272P, K275R, K277R, T286A, E297K, P313K, D324E, I329V, G335DD
Sigaloff (2013)JCR101_0JCR101_0JX182000NRTINNRTIM184VY188LV35T, T39M, V60I, V106VI, I135V, D177E, Q207E, R211K, F214FL, V245K, D250E, A272P, K277R, L282C, V292I, E297AD
Meini (2015)111123111123KM438256AZT, 3TC, D4T, ABCNVP, EFVM41L, M184V, L210LW, T215YA98G, Y188LV35T, V60I, V106VI, D121H, K122E, I135IT, D177E, I178L, V179VI, T200I, Q207E, R211KD
Kityo (2017)8345183451KY062005NRTINNRTIM41L, M184V, L210W, T215YY188LK49R, V60I, K102KE, K104N, K122E, I135V, T139TA, S162A, D177EG, I178M, T200L, Q207E, R211K, D218DE, D237ND
 8291882918KY061482NRTINNRTID67N, K70R, M184V, K219QV179E, Y188LK49R, V60I, K64NY, T69TN, V106I, D121Y, K122E, P133PL, P170PL, D177E, T200R, E203K, Q207E, R211K, L228HD
 8327883278KY061833NRTINNRTIM184VY188LK49R, V60I, K122E, I135T, S162SN, D177E, I178M, L193LF, G196E, Q207E, R211KD
Rhee (2017)NE006875NE006875KY190984TDF, FTCEFVM184VY188LV35T, E40D, K49R, V60I, D121Y, K122E, K173T, D177E, Q207A, R211KD
 17141714_FL TDF, 3TCEFVK70E, M184VY188LV35I, K49R, V60I, V90VI, V106I, D121Y, K122E, I135IT, S162A, D177E, I178M, V179I, T200I, Q207E, R211K, V245K, D250E, S251N, A272P, K281R, T286A, E291D, I293IV, P294T, E297K, K311RD