<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation Y181C
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 30
Patients 139
Isolates 143
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Snoeck (2004)BE40BE40AY901297AZT, DDC, D4T, 3TC, DDINVPK70R, M184VV108I, Y181CV35T, K49R, V60I, T69N, K122E, D177E, Q207E, P243T, V245K, D250ED
Non-B Workgroup (2005)TK2014TK2014 AZT, DDC, 3TC, DDI, D4T, ABCNVP, EFVM41L, L74V, V75M, M184V, L210W, T215Y, K219NK103N, Y181CA33AP, V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, S163SN, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297TD
 TK2016TK2016 AZT, DDI, 3TC, D4TNVPM184VY181CV35T, S48A, K49R, V60I, D121Y, K122E, S163SN, T165TA, D177E, I178M, T200I, I202V, Q207G, R211K, V245E, D250E, A272P, K277R, L282C, T286A, I293V, K323QD
 TK2025TK2025 D4T, 3TC, ABCNVPL74V, M184VK101E, Y181C, G190AK32R, V35M, E42EG, K43N, V60I, K122E, I135T, D177E, T200I, Q207E, R211K, V245EK, D250E, A272P, L282C, R284K, T286A, I293V, E297AD
  TK2025a D4T, 3TC, ABC, DDC, DDINVP, EFVM41L, L74VK101E, Y181C, G190AK32R, V35R, K43N, V60I, V118I, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, P321PQD
 TK3006TK3006a AZT, 3TC, D4TNVP Y181CT27S, V35T, P52PL, V60I, D121Y, K122E, I135T, T139TI, D177E, T200I, Q207E, R211K, F214L, H221HY, V245E, D250E, A272P, K277R, L282C, L283I, R284K, L303LRD
Rhee (2005)ASRU017ASRU017AY901227DDC, AZT, 3TC, D4T, DDINVPM41L, T69S_S, T215YY181C, G190AV35T, K49R, V60I, D121C, K122E, I132X, I135T, D177E, I178M, L205X, Q207E, R211KD
Weber (2005)F43587F43587AY677532AZT, DDI, ABCNVPD67N, K70RY181CK20R, V35T, T39A, K49R, V60I, D121Y, K122E, I135T, T165I, D177E, I178V, G196E, T200A, E204K, Q207E, R211K, F214FL, V245Q, D250E, S251H, T286A, I293V, E297EAD
Baxter (2006)48-42664266-30612DQ878498NRTINNRTIM41L, D67N, L74V, V75M, L210W, T215S, K219NY181CM16T, V35T, E36D, T39R, K43E, V60I, K101KR, D121H, K122E, I135T, A158AT, S162CY, D177E, I178M, V189VI, Q197K, T200A, I202V, Q207E, R211K, V245T, D250E, A272P, K277R, T286A, I293IV, E297K, A304E, P345Q, F346Y, R356RK, R358K, E370G, T377H, S379C, K390R, A400TD
Lwembe (2007)NYU9090FAPR03 NoneNVP Y181CK32I, V35T, K49R, V60I, D121Y, K122E, I135R, S162C, D177E, T200I, Q207G, R211KD
von Wyl (2007)801797997EF449958NRTINNRTIM184VY181CK20R, V35T, K49R, V60I, D121Y, K122E, D123E, I135V, T139V, T165TAIV, E169D, D177E, I178L, G196E, T200A, E204K, Q207E, R211K, F214L, H221YD
Church (2008)378519C378519CEU380742NoneNVP Y181CV60I, S68SN, D121Y, K122E, I135T, S162A, K173S, Q174K, D177E, I178M, T200A, Q207A, R211S, V245T, E248D, D250G, A272P, L282C, T286A, I293VD
 389271-L389271-LEU380745NoneNVP Y181CV35T, T39S, V60I, D121Y, K122E, I142V, K166R, D177E, I178M, Q207E, R211K, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297A, D324ED
 403272F403272FEU380754NoneNVP Y181CV35T, E36A, T39E, E40D, K49R, V60I, D121Y, K122E, E169D, D177E, I178M, G196E, T200I, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293VD
 414210P414210PEU380758NoneNVP Y181CS3R, V21I, V35T, E40D, K49R, V60I, K104R, D121Y, K122E, Q174L, D177E, I178V, T200I, Q207G, R211K, V245T, A272S, I274V, L282C, T286A, I293V, A327VD
 476731T476731TEU380768NoneNVP Y181CV35T, E36D, T39K, V60I, D121Y, K122E, I135T, T165I, D177E, T200I, Q207E, R211K, V245K, P247E, D250E, A272P, K275R, K277R, Q278N, L282C, L283I, I293V, I329VD
Hawkins (2009)R61ZZR61FJ931300TDF, 3TCNVPK65R, M184IK103N, Y181CV35T, T39M, K49R, S68SDGN, V90I, K102R, K122E, T165I, D177E, I178M, Q207E, R211K, F214L, V245T, D250E, A272P, K277R, T286A, E297K, K311R, I329VD
 Q967ZZQ967FJ931372D4T, 3TCNVPD67N, K70R, M184V, K219QY181CL34I, V35T, T39M, V60I, D123E, I135T, D177E, I178V, Q207K, R211K, F214L, H221Y, V245K, D250E, A272P, K277R, T286A, E297K, K311R, I329VD
Burda (2010)07BDHS4007BDHS40GQ344972D4T, 3TCNVPM184V, N348IY181CV35T, T39A, E40D, K49R, V60I, V106I, I135T, S162C, R172K, N175H, D177E, I178L, Q197R, T200E, K201I, E204K, Q207E, F214L, H221Y, V245K, A272P, T286A, I293V, E297K, Q334E, G335S, T338S, Y339W, R356K, K374Q, T377R, K390R, A400T, T403M, V435ID
Ndembi (2010)15845D_P115845GQ409579AZT, 3TCNVPM184VV108I, Y181C, G190GAP4T, V35T, K49R, V60I, D121Y, K122E, I135T, D177E, T200A, E204K, Q207E, R211K, F214L, H221YD
 DT3952_05_P13952GQ409627AZT, 3TCNVPD67DG, M184VY181CI31L, V35T, T39I, E40D, V60I, D121Y, K122E, S162A, D177E, Q207E, R211K, L228LRD
 16535D_P116535GQ409634AZT, 3TC, D4TNVPM184VK103N, Y181CP14PS, K20R, V35T, T39V, K49R, V60I, T69N, K122E, S162H, E169A, D177E, I178M, Q207E, R211KD
Towler (2010)12434747-MHM037890D4T, 3TCNVPM184V, T215SYY181CV35IT, K49R, V60I, D121Y, K122E, D123G, T139R, D177E, I178M, T200K, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V, L310ID
  518577-JHM037902D4T, 3TCNVPM41L, M184V, L210W, T215YY181CV35I, T39TA, K43E, K49R, V60I, D121Y, K122E, D123G, T139R, D177E, I178M, T200K, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V, L310ID
Aulicino (2011)ARN272RLDARN272RLDFJ525856NRTINNRTIM41L, D67N, T69D, K70R, L74V, M184V, L210W, T215Y, K219HA98G, K101E, V108I, Y181C, G190AS3C, K20R, E28A, V35T, T39E, E44D, V60I, V90I, L109I, K122E, I135V, I142V, S162N, I167V, V179I, T200A, E203K, Q207E, H208Y, R211KD
Charpentier (2011)160CP0011090 D4T, 3TCNVPK65RK101KE, Y181C, G190AK20KR, V35T, T39TA, E40D, K49R, V60I, T69TA, V90I, D121Y, K122E, D123E, S162A, Q174H, D177E, T200A, E203EK, Q207E, R211K, L228LR, P243H, V245E, D250E, A272S, L283I, I293V, P313TD
 220CP001040 D4T, 3TCNVPF77FL, M184VY181CV35T, E40D, K49KR, V60VA, F87FL, V90VA, K101KR, K122KE, D123NT, Q174QK, P176PT, V179VI, G196E, T200A, Q207E, L228LR, D237E, V245K, A272P, I274IV, K275R, Q278HY, K281R, E291D, V292I, I293V, E297EK, I329IVD
Kouri (2012)CU1484-09CU1484-09JQ585298NRTINNRTIL74LS, M184V, T215Y, K219EY181CK11R, V35T, K49R, V60I, K64E, K122E, D123N, F130C, Q161L, E169D, T200A, I202V, R206RS, Q207E, F214L, L228H, P243T, V245S, D250E, A272P, K277R, T286A, I329VD
 CU691-09CU691-09JQ585261NRTINNRTIM41L, D67N, K70S, M184V, L210W, T215F, K219QY181CK32Q, V35K, T39A, K49R, V60I, V90I, V111I, V118I, K122E, D123N, I135R, F160Y, Q197K, T200A, I202V, E203K, Q207D, H208Y, R211K, D218E, L228H, V245T, D250E, A272S, T286A, I293V, E297K, L301I, P313Q, I329VD
 CU25-10CU25-10JQ585358NRTINNRTIM41L, D67N, M184V, L210W, T215YK101E, Y181C, G190SE28EG, V35M, K43N, E44D, V106I, V111I, V118I, K122E, D123N, I135T, N136ND, Q174R, D177E, I178M, V189I, T200A, I202V, Q207D, H208Y, V245T, D250E, A272S, T286A, I293V, E297K, P313T, V317A, I329V, Q334DD
 CU749-09CU749-09JQ585263NRTINNRTIM41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219NK101E, Y181C, G190AV35T, V111I, D121Y, K122E, I135T, N137H, S162Y, D177E, I178L, V179VI, T200A, E204A, Q207E, R211K, V245T, D250E, A272S, K277R, T286A, E297K, P313S, V317A, I329V, G335DD
 CU1270-09CU1270-09JQ585285NRTINNRTID67N, K70R, K219QY181C, G190GAV8VAIT, K20R, V35T, T39A, E40D, K49R, V60I, T69TN, K101KQ, V106I, K122E, I135R, E169D, D177E, T200TA, I202V, Q207E, R211K, F214L, H221Y, V245Q, D250E, A272P, T286A, K311R, I329V, G335DD
 CU1483-09CU1483-09JQ585297NRTINNRTID67N, K70R, M184V, T215Y, K219EK103N, Y181C, F227LV35T, T39TA, V60I, T69N, K122E, D123E, E169D, Q174QH, D177E, T200A, I202V, Q207E, L228H, P243T, V245S, D250E, A272P, C280CY, T286A, E305D, E308D, I329V, G335DD
 CU1708-09CU1708-09JQ585308NRTINNRTIM184VV108VI, Y181CV8I, V35T, T39A, E40D, K49R, N54ND, V60I, S68G, I135V, Q161QL, E169D, D177E, Q207E, H221Y, V245T, A272P, K277R, T286A, V292I, E297A, K311R, E312G, P313Q, I329V, G335ED
 CU1959-09CU1959-09JQ585326NRTINNRTIM184V, T215FY181CV21I, V35T, T39A, E40D, K49R, V60I, S68G, I135V, Q174R, D177E, V179I, Q207E, V245T, A272S, K277R, T286A, A288AS, I293V, E297A, K311R, E312G, P313Q, I329V, G335ED
 CU949-09CU949-09JQ585268NRTINNRTIM184VY181CV35T, E40D, V60I, L109W, G112S, F116S, K122P, D123E, I142T, R143T, N147D, E169D, D177E, T200A, Q207E, V245K, D250E, W266WR, K277R, T286A, P294T, I329V, Q334H, G335DD
Reynolds (2012)D0761D0761-1JN652181D4T, 3TCNVPM184IVY181CK13KR, G18GD, V35T, K49R, V60I, D121Y, K122E, D177E, I178M, V179A, T200M, Q207E, R211K, V245I, E248D, D250E, A272P, K277R, L282C, L283I, T286V, I293VD
 E0090E0090-1JN652182AZT, 3TCNVPM184MIVV179E, Y181CT7TA, V21I, V35T, T39M, V60I, T69TA, V90I, D121C, K122E, I135T, I142V, D177E, T200A, E203EK, Q207E, R211K, V245Q, D250E, A272P, K277R, L282C, T286A, I293VD
 E0580E0580-1JN652183AZT, 3TCNVPK65KR, M184VK101KEQ, V108I, Y181CI31IL, L34LI, V35T, E40D, K49R, V60I, D121H, K122E, E169D, D177E, I178M, G196E, T200I, E204EK, Q207D, R211K, V245K, D250E, K277R, L282C, L283I, T286I, A288S, I293V, E297AD
  E0580-2JN652206AZT, 3TC, TDF, DDINVPM184VV108I, Y181CL34I, V35T, E40D, K49R, V60I, K101Q, D121H, K122E, E169D, D177E, I178L, G196E, T200I, E204K, Q207D, R211K, H221Y, V245K, D250E, T253TA, K277R, L282C, L283I, T286I, A288S, I293V, E297AD
 F0703F0703-1JN652191D4T, 3TCNVPM184VY181CV35T, K49R, V60I, K82KR, D121H, K122E, D123E, I135T, D177E, T200I, Q207G, R211K, V245K, D250E, A272P, L282C, T286V, I293V, E297QD
 F0785F0785-1JN652193AZT, 3TCEFVD67DN, K70KR, M184VV179D, Y181CV35T, T39TILS, E40ED, K49R, V60I, K103R, K122KE, I135R, D177E, T200I, E203K, Q207E, R211EK, P243S, V245K, E248D, A272P, K275R, L282C, L283I, A288G, I293VD
 G0772G0772-1JN652195D4T, 3TCNVPM184VY181CV35T, T39LS, K49R, S68G, T69N, D86E, D121Y, K122E, I135T, S162SC, V179I, T200I, Q207X, R211K, H221Y, V245N, D250E, A272P, K277R, L282C, T286A, A288TD
 J0303J0303-1JN652198AZT, 3TCNVPD67DG, M184V, L210LW, T215FYY181CV35T, I47IL, S48T, K49R, V60I, S68SG, K122E, D123GS, I135IT, T165L, D177E, I178L, V179VI, Q207E, R211K, V245E, D250E, A272P, K277R, Q278QH, L282CD
 J0700J0700-1JN652200ABC, 3TC, AZTNVPM184VV108VI, Y181CV35T, E40ED, K49R, V60I, K122E, D123NS, T165L, D177E, I178V, Q207E, R211K, L228R, V245N, D250E, L282C, T286A, I293V, E297KD
 J7221J7221-1JN652201AZT, 3TCNVPM184VY181CI31L, V35T, K49R, V60I, T69N, K122E, D177E, I178M, Q207E, R211K, L228R, V245K, D250E, A272S, L282C, T286A, I293V, E297AD
 B0708B0708-1JN652172NRTI, AZT, 3TCNNRTI, NVP, EFVK65RK103N, Y181C, M230LV35T, E40D, K49R, V60I, K122E, D123N, I159V, E169D, I178L, T200A, I202V, Q207E, R211K, K238R, V245K, A272S, L282C, L283I, I293VD
Aghokeng (2013)HJ3116HJ3116JX982985NRTINNRTIM41L, M184V, L210W, T215FK103N, V108I, Y181CK20R, K49R, V60I, K102N, V118I, I135T, R172K, D177E, I178L, V179I, Q182S, T200A, E203D, E204K, Q207E, R211K, F214L, H221Y, L228R, V245T, A272S, L283I, T286A, I293V, E297K, R307K, V317A, I329V, Q334E, Y339W, I341V, R356K, G359S, A371V, I375V, T377I, K390R, A400T, T403MD
 HJ3051HJ3051JX982983NRTINNRTIM184V, N348IY181CK20KR, V35T, K49R, V60I, D123E, I135T, T139TAIV, R172K, D177E, I178L, G196E, E204K, Q207E, F214L, H221Y, V241I, V245K, A272P, T286A, A288S, E297K, I329V, G335N, T338S, Y339W, G359GS, A376C, K390R, A400TD
Inzaule (2013)317317JQ914102AZT, 3TCNVPM184VY181CE6D, V21VI, V35T, T39L, E40D, K49R, V60I, K64R, K102KQ, D121Y, K122E, I135R, D177E, T200I, E203K, Q207E, R211KD
  317JQ914083AZT, 3TCNVPK70KR, M184VY181CE6D, V21VI, V35T, T39L, E40D, K49R, V60I, K64KR, D121Y, K122E, I135R, D177E, V179VI, T200I, E203K, Q207E, R211KD
Kebe (2013)SNA3-144SNA3-144HM002510AZT, 3TCNVPM184VK101KE, Y181C, G190AV35T, K49R, I50IF, V60I, V90I, D121H, K122E, I135T, S162H, T165I, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245T, D250ED
Pircher (2013)B1117B1117JX110218D4T, 3TC, AZTNVPM41L, T69D, V75M, M184V, L210W, T215YA98G, Y181CI31L, V35IT, T39A, E44D, V60I, K101Q, V106I, V118I, P119PS, D121C, K122E, S162N, Q174K, D177E, I178V, T200E, K201M, E203K, E204Q, Q207A, R211K, K223T, L228R, V245TD
 B1142B1142JX110241D4T, 3TC, AZTNVPM184VV108VI, Y181CK32R, V35T, E36ED, K49R, V60I, V118I, D121C, K122E, I135T, K166R, E169D, D177E, I178L, V179I, T200I, E204K, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250ED
Sigaloff (2013)MBA093_0MBA093_0JX182025NRTINNRTIM41L, T69D, M184V, L210W, T215YK101H, Y181C, G190AE28A, V35T, E44D, K49R, V60I, K122E, I135T, T139R, T165I, D177E, T200I, Q207E, R211K, L228R, V245K, D250E, A272P, K275R, L282C, L283I, T286A, V292I, I293V, G316ED
 JCR011_0JCR011_0JX181983NRTINNRTIM41L, M184V, L210W, T215YY181CE6D, V35T, E44D, V60I, V111I, K122E, I135L, K166R, D177E, I178M, V179I, E203K, Q207D, H208Y, R211K, H221Y, V245Q, D250E, A272P, K277R, L282C, E297AD
 JCR047_0JCR047_0JX181988NRTINNRTID67G, T69D, K70R, M184V, K219HA98G, V108I, Y181CV35T, K43E, K49R, V60I, I94L, K122E, I135M, S163SC, T165L, R172K, D177E, I178M, T200I, E203R, E204K, Q207E, R211K, E224K, V245K, D250E, A272P, Q278H, L282C, L283I, T286A, A288TD
 JCR099_0JCR099_0JX181999NRTINNRTIK65R, Y115FY181CP4T, E28K, V35T, E40ED, V60I, R72K, V118I, I135T, I142V, A158S, K173E, D177E, Q207E, R211K, F214L, P243K, V245E, D250E, A272S, K275R, L282C, I293VD
 JCR077_0JCR077_0JX181994NRTINNRTIM41L, T69D, K70KR, M184V, L210W, T215FK101E, Y181C, K238TV35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293VD
 JCR073_0JCR073_0JX181993NRTINNRTIT69D, K70R, M184VY181CV21I, V35T, T39S, K49R, V60I, D121Y, K122E, I135M, I142V, S162N, K166R, D177E, I178M, T200A, Q207E, R211K, L228R, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297AD
Wallis (2014)4151441514KM458601NRTINNRTIK65R, K219RK103N, Y181CK20R, E28A, V35T, K43E, V60I, S68G, T69X, V90I, D121H, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, H221Y, L228RD
 4108241082KM458607NRTINNRTIA62AV, K70KN, V75T, M184VK101E, Y181C, G190AV35I, K49R, T69TN, D121CY, K122E, E169D, T200M, Q207E, R211KD
Meeme (2015)ML2572ML2572HM596828NRTINNRTID67N, M184VK101E, Y181C, G190AE28K, K32E, V35T, K49R, V60I, V118I, K122E, D123N, D177E, I178M, T200A, Q207E, L210X, R211K, T215X, D218VD
 ML1935ML1935HM596843NRTINNRTIM184VY181CE6K, V35T, E40D, K49R, V60I, P97R, K122E, D177E, I178M, T200A, Q207E, R211N, W212V, F214ID
Meini (2015)109274109274KM438251AZT, 3TC, D4T, DDINVPM41L, T69D, L210W, T215YY181CK32E, V35T, E44D, K49R, V60I, V118I, D121Y, K122E, R172RK, D177E, I178M, E203K, Q207E, R211K, K223T, L228R, V245ND
Boillot (2016)MAK13MAK13KT315965D4T, 3TCEFVM184V, T215TSK103N, Y181CE6D, V35M, K49R, V60I, K122P, I135T, S162SN, D177E, T200E, K201T, E204R, Q207E, R211K, V245QD
Brooks (2016)2102A2102AKU900896TDF, 3TCEFVK70E, M184VY181CV35T, K49R, V60I, A98S, K122E, D123S, I135T, D177E, I178M, E203EK, Q207E, R211K, L228LRD
 2103A2103AKU900900TDF, 3TCNVPK65R, M184V, K219KEK103N, Y181CE6D, V35T, K49R, V60I, S68SG, I135T, D177E, V179VI, G196E, T200I, Q207GD
Inzaule (2016)1.03171.0317HM164119AZT, 3TCNVPM184IY181CE6D, V35T, T39L, E40D, K49R, V60I, K64R, D121Y, K122E, I135R, D177E, T200I, Q207E, R211K, V245I, D250E, L282C, L283I, T286A, I293VD
Ndahimana (2016)14151415KU922858TDF, 3TCNVPA62AV, K65R, M184VK103N, Y181CT39R, K46KQ, I47IL, K49R, D121H, K122E, I135T, E169D, D177E, T200L, Q207E, R211K, V245QD
 14201420KU922857TDF, 3TCNVPK65R, M184VK103N, Y181CT39M, E44EQ, K46Q, I47IL, K49R, V60I, D121Y, K122E, S162SDGN, E169K, K173E, D177E, V179I, G196E, T200A, I202IV, Q207A, R211K, V245QD
Kekitiinwa (2017)83615_101483615_1014KY238030NRTINNRTIK65R, D67N, M184V, K219EV179D, Y181CK49R, V60I, K102Q, K103R, K122E, D123N, I135V, N175NH, D177E, T200I, E204Q, Q207E, R211KD
 65530_90765530_907KY237890NRTINNRTIL74V, Y115F, M184VY181C, G190AK49R, V60I, E138T, S162C, V179I, T200L, E203K, Q207D, R211K, H221YD
 42202_95742202_957KY237859NRTINNRTIL74V, V75I, Y115F, M184VY181C, G190AK49R, V60I, T69N, D121Y, K122E, D123DE, K126Q, I132L, S162C, D177DE, I178M, V179I, T200A, Q207E, F214L, H221YD
 65741_30065741_300KY237909NRTINNRTIK65R, Y115F, M184VV106A, Y181CV60I, S68G, T69N, K122E, I142V, D177E, G196E, T200I, I202IV, E203Q, Q207D, R211K, F214L, H221HY, E224EDD
 28241_30028241_300KY237816NRTINNRTIK65R, Y115FV106A, Y181CV35T, V60I, T69N, D121Y, K122E, I142V, D177E, I178M, G196E, T200I, E203Q, Q207D, R211K, V245K, D250E, A272P, L282C, L283I, T286A, I293VD
 28702_26328702_263KY237831NRTINNRTIL74V, Y115F, M184VV108I, Y181CV35T, E40D, K49R, D121Y, K122E, D177E, I178L, T200I, E204K, Q207E, R211K, F214L, V245K, D250E, I257L, A272P, K277R, L282C, T286A, I293VD
 65490_29365490_293KY237876NRTINNRTIM184VK101KE, Y181CK49R, V60I, D121Y, K122E, T131S, P133PL, I135R, E169D, D177E, I178L, T200I, Q207E, R211K, F214L, H221YD
 65740_25365740_253KY237908NRTINNRTIK70KR, L74V, Y115F, M184VY181CK49R, V60I, D177E, Q207E, R211KT, H221YD
 65539_113665539_1136KY237895NRTINNRTIM184V, T215TAY181CK49R, V60I, V90VI, K102KR, K122E, D123S, I135T, T165L, K166R, D177E, I178IM, V179VI, T200IR, Q207E, R211KD
 28179_30928179_309KY237807NRTINNRTIL74V, Y115F, M184VY181CE29EG, V35T, T39TA, E40D, K49R, V60I, V90VI, K101R, K122E, I135MT, T165TI, K173S, Q174K, D177E, V179I, E194N, G196E, T200I, Q207D, R211K, H221Y, V245E, D250E, A272P, L282C, L283I, R284K, V292ID
 35378_29235378_292KY237843NRTINNRTIK65R, M184MIVV108VI, Y181CI31IL, V35T, E40D, K49R, V60I, V90I, K122E, I135V, S162C, E169K, K173E, D177E, T200M, Q207E, R211K, H221HY, V245K, D250E, L282C, T286V, A288T, I293VD
 79391_30379391_303KY238004NRTINNRTIL74V, Y115F, M184VV108VI, Y181CK49R, V60I, K101R, D121HY, K122E, D177E, I178M, V179I, G196GE, T200M, Q207E, R211K, H221Y, K238RD
 79386_29279386_292KY238000NRTINNRTIK65R, Y115F, M184VV108I, Y181CK49R, V60I, V90I, K122E, I135V, S162C, E169K, K173E, D177E, T200M, Q207E, R211K, H221YD
 65484_44565484_445KY237870NRTINNRTIL74V, Y115F, M184V, K219QK101E, Y181C, G190SV60I, V106I, E169ED, K173KR, D177E, G196E, T200A, Q207E, R211K, F214L, L228RD
 42205_113842205_1138KY237862NRTINNRTIL74V, Y115F, M184VY181C, G190AV60I, D121H, K122E, I142V, D177E, I178M, V179VIM, T200K, Q207E, R211K, H221YD
Kityo (2017)8318683186KY061742NRTINNRTID67DE, M184V, L210W, T215YA98G, Y181CK43E, K49R, V60I, T69S, D121Y, K122E, I135L, D177E, I178IM, V179VI, T200K, Q207E, R211K, H221Y, L228LHD
 8341683416KY061970NRTINNRTIK65R, Y115F, M184V, K219EY181C, G190AV60I, S68K, V106VI, D123E, E169D, D177E, I178V, V179I, T200M, I202V, Q207E, R211KD
 8347883478KY062032NRTINNRTIM41L, D67N, T69D, M184V, L210W, T215YA98G, Y181CE44D, V60I, V118I, D121C, K122E, I135R, D177E, G196E, T200A, I202V, E203K, Q207E, H208Y, R211K, K223EQ, L228HD
 8343883438KY061992NRTINNRTIK65R, V75M, M184VY181CS68N, V90I, D121H, K122E, S162A, D177N, I178M, V179I, T200M, E203D, Q207E, R211K, H221LD
 8318383183KY061739NRTINNRTIM41L, M184V, L210W, T215YY181CK43Q, V60I, V111VIM, D121Y, K122E, I135T, S162A, D177E, I178IM, G196GE, T200MR, E203EK, Q207E, R211K, H221Y, K238RD
 8325483254KY061809NRTINNRTID67N, K70R, M184V, T215F, K219EY181CK49R, V60I, D121Y, K122E, I135V, T139A, D177E, I178M, Q207E, R211K, D218ED
 8326383263KY061818NRTINNRTIA62V, D67KK101KE, Y181CK49R, K66E, S68G, T69F, W88WS, D121HY, K122E, Q174QR, D177E, I178M, V179I, E203K, Q207E, K219GD
 8348583485KY062039NRTINNRTIK65R, Y115YF, M184VL100I, K103N, Y181CK49R, S68SDGN, K122KE, K173A, Q174K, D177E, T200I, Q207E, R211K, L228HD
 8339783397KY061951NRTINNRTIM41L, D67N, T69TADN, V75M, M184V, L210W, T215Y, K219NV108I, Y181CK43E, E44EA, K49R, E53EG, V60I, V118I, D121Y, K122E, D123E, S162D, D177E, I178M, V179I, G196E, T200A, E203EK, Q207E, H208HY, R211K, D218E, L228HD
 8356183561KY062115NRTINNRTIK65R, M184IV108I, Y181C, M230LK43N, K49R, V60I, S68G, V90I, D121Y, K122E, R125K, D177E, I178M, G196E, T200R, Q207E, R211KD
 6589865898KY061394NRTINNRTID67N, K70R, M184V, K219QY181CK49R, V60I, T69TN, D177E, I178M, T200V, E203K, Q207E, R211K, D218E, L228HD
 8289982899KY061464NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219QA98G, V179DE, Y181CK49R, V60I, K122E, D123N, I135V, I167IV, D177E, T200A, I202V, Q207E, R211K, L228LHD
 8306283062KY061621NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219NA98G, V108VI, Y181CE44D, K49R, V60I, K122E, D123N, A158S, S162CY, E169A, K173E, Q174QR, D177E, I178L, V179VI, G196E, T200M, E203K, Q207E, R211K, H221Y, K238QD
 8339883398KY061952NRTINNRTID67N, K70R, M184V, T215F, K219EV108VI, Y181CG45GR, K49R, V60I, K122E, D123DN, I135IT, T200L, Q207E, R211K, D218DED
 8315983159KY061715NRTINNRTIM41L, M184V, T215FY181CV60I, D121Y, K122E, I135R, D177E, I178M, G196K, Q197E, T200I, Q207E, L228LRD
 8305083050KY061609NRTINNRTIM41L, M184V, L210LW, T215FYY181CS48T, K49R, V60I, D121H, K122E, I135V, Q145M, D177E, T200I, Q207E, R211KD
 8307683076KY061634NRTINNRTID67N, K70R, M184V, T215I, K219EY181CK49R, V60I, I135T, D177E, I178M, T200A, Q207T, R211KD
 8350783507KY062061NRTINNRTID67N, K70R, M184V, T215F, K219EK101H, V108I, Y181C, P236PLK49R, V60I, K64KR, V90I, K122E, I135IT, S162HN, D177E, G196E, Q207E, R211K, L228LRD
 8328083280KY061835NRTINNRTIM184V, T215F, K219RWY181CK49R, V60I, D121Y, K122E, T139R, D177E, I178M, T200R, Q207E, R211KD
 8351483514KY062068NRTINNRTID67N, K70R, M184V, T215F, K219EK103N, Y181C, P236PLK49KR, P55PS, V60I, T69N, L92LM, D121Y, K122E, I135T, D177E, T200A, I202IV, Q207E, R211K, L228LHD
 6597165971KY061398NRTINNRTIM41L, D67N, K70R, V75VIM, M184V, T215F, K219EV108I, Y181CV60I, T69PS, D86DE, K102Q, I135T, I167V, K173KR, Q174QR, D177E, I178L, T200A, Q207E, R211K, D218E, L228HD
 8342283422KY061976NRTINNRTIK70GR, M184V, K219EK103N, V108I, Y181C, G190AK49R, V60I, K101KR, Q145V, D177E, I178M, T200I, E204K, Q207E, R211K, L228RD
 8345283452KY062006NRTINNRTIM41L, D67G, K70R, V75M, M184V, T215F, K219QK103N, V108I, Y181C, G190AK43E, K49R, V60I, T69N, K82KR, R83K, D121H, K122E, I135R, T165L, I167IV, E169D, P170L, D177E, T200KM, I202V, Q207E, R211K, L228HD
 8329883298KY061853NRTINNRTIM41L, D67DG, K70R, L74I, M184V, L210LW, T215F, K219QY181CK43KE, K49R, V60I, K64HN, T69N, D121Y, K122E, D123DE, S162D, D177E, I178M, V179I, I202V, Q207E, R211K, D218E, L228RD
 8355483554KY062108NRTINNRTIK65R, M184VV108I, Y181CV60I, S68N, V90VI, D121H, K122E, I132V, S162A, D177E, Q207E, R211K, H221YD
 8340283402KY061956NRTINNRTID67G, K70R, M184V, T215Y, K219EA98G, Y181CK49R, V60I, S68G, K122E, D123N, I135T, D177E, I178M, V179I, I202IV, Q207E, R211K, H235HRD
 8295082950KY061514NRTINNRTIM41L, L74I, M184V, L210W, T215Y, K219NY181CK43E, K49R, V60I, S68G, D121H, K122E, D123E, D177E, I178M, E194D, G196GE, T200I, E203EK, Q207E, R211K, K223KE, L228HD
 8315583155KY061711NRTINNRTIM184V, T215YA98AG, K103N, V108I, Y181C, P225H, F227FLE44D, K49KR, V90VI, T200I, Q207E, R211KD
 8318483184KY061740NRTINNRTIM41L, M184V, L210W, T215YV108I, Y181CK43Q, E44EAD, K49R, V60I, A98AS, K102KR, D123E, S162D, D177E, I178L, G196E, E203K, Q207E, R211K, H221Y, L228RD
 8292982929KY061493NRTINNRTIM184V, L210LW, T215YV108I, Y181CK49R, V60I, S68SG, K122E, I135T, G196R, T200I, Q207EG, R211K, H221YD
 8328283282KY061837NRTINNRTID67G, T69G, K70R, T215F, K219EK101E, V179VF, Y181C, G190AK43E, V60I, D121H, K122E, I135T, F171Y, D177E, G196E, T200E, E203V, Q207A, R211K, L228RD
 8301183011KY061573NRTINNRTIM41L, D67N, T69D, V75I, M184I, L210W, T215Y, K219RV108I, Y181CK43E, E44D, K49R, V60I, V90I, V118I, D121H, K122E, S162N, T165I, D177E, I178V, V179VI, G196GE, I202V, Q207A, R211RK, H221YD
 8317983179KY061735NRTINNRTID67N, K70R, M184V, K219QY181CK46Q, K49R, V60I, T69TN, D121Y, K122E, I135R, D177E, I178M, T200I, E203K, Q207E, R211K, H221HYD
 8355783557KY062111NRTINNRTIK65R, M184MIVK101E, Y181C, G190A, P225PH, K238KTK46KQ, K49R, V60I, V90VI, K122E, D123DEG, I135IT, D177E, I178IM, V179VI, Q207E, R211KD
 6606766067KY061428NRTINNRTIK70E, Y115F, M184VY181CV60I, V90I, K101R, V106VI, K122E, I135V, G196K, T200I, Q207E, R211K, H221Y, L228RD
 8327683276KY061831NRTINNRTIM41L, D67DN, V75VIM, M184V, L210*W, T215YY181CK43Q, E44ED, K49R, V60I, I94IL, V111VI, D121HY, K122E, I135T, T139R, S162SN, E169D, V179I, T200A, Q207E, R211K, E224DD
 8351183511KY062065NRTINNRTIK70E, M184VA98G, K101KE, V108VI, V179VDE, Y181C, G190AV60I, K103KR, D121H, K122E, I135T, I142IV, F171Y, V189VI, T200A, Q207E, L228HD
 8330283302KY061857NRTINNRTIM41L, M184V, T215YY181CK49R, V60I, D121Y, K122E, R125K, T139K, I142V, E169D, D177E, T200I, Q207E, R211KD
 6604966049KY061416NRTINNRTIK70R, M184V, T215F, K219EA98AG, K101E, Y181C, G190SK49R, T69N, K122E, D123S, I135T, D177E, I178M, T200E, I202V, E203K, Q207E, R211K, L228RD
 6606066060KY061423NRTINNRTIM41L, D67G, T69G, K70R, M184V, T215F, K219EK103N, V108VI, Y181C, G190AK122E, I142V, D177E, I178M, V179VI, E194ED, T200R, Q207N, R211K, L228HD
 8344983449KY062003NRTINNRTIM41L, T69D, M184V, L210W, T215YA98G, V108VI, Y181CK43E, E44A, K49R, V60I, K101Q, V118I, S162N, D177E, T200I, Q207E, R211K, L228RD
 8301683016KY061577NRTINNRTIM184VK103N, Y181C, P225HP59PS, V60I, S68G, K122E, D123N, I135T, E169ED, P170PL, D177E, I178L, G196K, Q207E, R211K, H221YD
 8325983259KY061814NRTINNRTIM41L, V75M, M184V, L210W, T215YA98G, V108I, Y181CK43E, E44A, K49R, V60I, K122E, D123N, S162N, D177E, I178M, V179I, T200A, Q207A, R211K, H221YD
 8313783137KY061694NRTINNRTIM41L, D67N, M184V, L210W, T215Y, K219NV108I, Y181C, F227LE44D, V60I, L109I, V111VIM, D121Y, K122E, Q174E, V179VI, I195IM, G196E, T200TAEK, I202V, E203K, Q207E, H208Y, R211K, D218E, H221YD
 2865828658KY061391NRTINNRTIM41L, K70R, M184V, T215F, K219WK101E, Y181C, G190AV35I, K43KE, V60I, T69N, K102Q, V118I, D121Y, K122E, I135T, D177E, T200A, I202V, E204K, Q207E, H208HY, L210LS, R211RG, L228HR, V245K, D250E, A272P, T286A, I293VD
 8319383193KY061749NRTINNRTIK70R, M184VY181CK49R, V60I, T69N, D121Y, K122E, I135T, T139R, I142V, E169D, Q174R, D177E, I178V, V179VI, T200M, Q207E, R211K, F214LD
 8304483044KY061603NRTINNRTIK70KR, M184V, T215TFISV108VI, Y181CK49R, S68SG, I135T, S162DN, I178L, V179I, T200A, E203D, E204S, Q207E, F214FL, H221HYD
 8354683546KY062100NRTINNRTIK65R, M184VY181C, G190AK49R, E53ED, V60I, S68N, V106I, D121Y, K122E, S162D, Q174K, D177E, I178L, V179I, T200M, Q207E, R211KD
 8340783407KY061961NRTINNRTIM41L, V75M, M184V, L210W, T215YY181C, P236PLK43KQ, E44ED, K49R, V60I, V111I, D121H, K122E, I135T, I142T, S162D, T165K, E169D, D177E, I178M, V179I, G196E, T200A, E203V, Q207AE, H208Y, R211K, L228RD
 8342583425KY061979NRTINNRTIT69D, K70R, M184V, K219QY181CI47L, K49R, V60I, K122E, D123N, I135T, D177E, I178M, V179VI, T200IR, E203K, Q207E, R211K, L228HD
 8345483454KY062008NRTINNRTIM41L, M184V, T215FV108I, Y181CK43R, V60I, V90I, K122E, I135T, S162C, V179I, T200A, Q207E, R211K, F214L, H221YD
 8290882908KY061473NRTINNRTID67A, K70R, M184V, T215F, K219EK101E, Y181C, G190AK49R, V60I, T69N, D121Y, K122E, S162SN, D177E, V179I, G196GE, Q207E, R211K, L228HD
 8351883518KY062072NRTINNRTIM41L, D67DN, T215YA98AG, Y181C, G190AV60I, T69TA, V90VI, K122E, S163C, D177E, I178IM, Q207E, R211K, H221HYD
 8343383433KY061987NRTINNRTIK70E, M184VK101KE, K103KN, Y181CK49R, V60I, D177E, I178L, Q207E, R211K, L228RD
 8341183411KY061965NRTINNRTIM41L, D67N, K70R, V75L, M184V, T215F, K219QV108I, Y181CP59PS, V60I, T69N, K122KE, D123DN, T139R, G196GE, T200I, Q207E, R211K, F214L, D218DH, H221YD
 8314483144KY061701NRTINNRTIM41L, T69D, K70R, M184V, T215FY, K219QV108VI, Y181CK49R, V60I, D121Y, K122E, I135T, D177E, T200I, Q207E, R211K, L228RD
 8351083510KY062064NRTINNRTIM184V, K219RV108I, Y181CV60I, D121H, K122E, I142V, D177E, I178IM, V179VI, T200I, Q207E, R211K, F214L, H221Y, L228HD