<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation Y181C
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 21
Patients 56
Isolates 60
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Snoeck (2004)BE40BE40AY901297AZT, DDC, D4T, 3TC, DDINVPK70R, M184VV108I, Y181CV35T, K49R, V60I, T69N, K122E, D177E, Q207E, P243T, V245K, D250ED
Non-B Workgroup (2005)TK2014TK2014 AZT, DDC, 3TC, DDI, D4T, ABCNVP, EFVM41L, L74V, V75M, M184V, L210W, T215Y, K219NK103N, Y181CA33AP, V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, S163SN, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297TD
 TK2016TK2016 AZT, DDI, 3TC, D4TNVPM184VY181CV35T, S48A, K49R, V60I, D121Y, K122E, S163SN, T165TA, D177E, I178M, T200I, I202V, Q207G, R211K, V245E, D250E, A272P, K277R, L282C, T286A, I293V, K323QD
 TK2025TK2025 D4T, 3TC, ABCNVPL74V, M184VK101E, Y181C, G190AK32R, V35M, E42EG, K43N, V60I, K122E, I135T, D177E, T200I, Q207E, R211K, V245EK, D250E, A272P, L282C, R284K, T286A, I293V, E297AD
  TK2025a D4T, 3TC, ABC, DDC, DDINVP, EFVM41L, L74VK101E, Y181C, G190AK32R, V35R, K43N, V60I, V118I, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, P321PQD
 TK3006TK3006a AZT, 3TC, D4TNVP Y181CT27S, V35T, P52PL, V60I, D121Y, K122E, I135T, T139TI, D177E, T200I, Q207E, R211K, F214L, H221HY, V245E, D250E, A272P, K277R, L282C, L283I, R284K, L303LRD
Rhee (2005)ASRU017ASRU017AY901227DDC, AZT, 3TC, D4T, DDINVPM41L, T69S_S, T215YY181C, G190AV35T, K49R, V60I, D121C, K122E, I132X, I135T, D177E, I178M, L205X, Q207E, R211KD
Weber (2005)F43587F43587AY677532AZT, DDI, ABCNVPD67N, K70RY181CK20R, V35T, T39A, K49R, V60I, D121Y, K122E, I135T, T165I, D177E, I178V, G196E, T200A, E204K, Q207E, R211K, F214FL, V245Q, D250E, S251H, T286A, I293V, E297EAD
Baxter (2006)48-42664266-30612DQ878498NRTINNRTIM41L, D67N, L74V, V75M, L210W, T215S, K219NY181CM16T, V35T, E36D, T39R, K43E, V60I, K101KR, D121H, K122E, I135T, A158AT, S162CY, D177E, I178M, V189VI, Q197K, T200A, I202V, Q207E, R211K, V245T, D250E, A272P, K277R, T286A, I293IV, E297K, A304E, P345Q, F346Y, R356RK, R358K, E370G, T377H, S379C, K390RD
Lwembe (2007)NYU9090FAPR03 NoneNVP Y181CK32I, V35T, K49R, V60I, D121Y, K122E, I135R, S162C, D177E, T200I, Q207G, R211KD
von Wyl (2007)801797997EF449958NRTINNRTIM184VY181CK20R, V35T, K49R, V60I, D121Y, K122E, D123E, I135V, T139V, T165TAIV, E169D, D177E, I178L, G196E, T200A, E204K, Q207E, R211K, F214L, H221YD
Church (2008)378519C378519CEU380742NoneNVP Y181CV60I, S68SN, D121Y, K122E, I135T, S162A, K173S, Q174K, D177E, I178M, T200A, Q207A, R211S, V245T, E248D, D250G, A272P, L282C, T286A, I293VD
 389271-L389271-LEU380745NoneNVP Y181CV35T, T39S, V60I, D121Y, K122E, I142V, K166R, D177E, I178M, Q207E, R211K, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297A, D324ED
 403272F403272FEU380754NoneNVP Y181CV35T, E36A, T39E, E40D, K49R, V60I, D121Y, K122E, E169D, D177E, I178M, G196E, T200I, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293VD
 414210P414210PEU380758NoneNVP Y181CS3R, V21I, V35T, E40D, K49R, V60I, K104R, D121Y, K122E, Q174L, D177E, I178V, T200I, Q207G, R211K, V245T, A272S, I274V, L282C, T286A, I293V, A327VD
 476731T476731TEU380768NoneNVP Y181CV35T, E36D, T39K, V60I, D121Y, K122E, I135T, T165I, D177E, T200I, Q207E, R211K, V245K, P247E, D250E, A272P, K275R, K277R, Q278N, L282C, L283I, I293V, I329VD
Hawkins (2009)R61ZZR61FJ931300TDF, 3TCNVPK65R, M184IK103N, Y181CV35T, T39M, K49R, S68SDGN, V90I, K102R, K122E, T165I, D177E, I178M, Q207E, R211K, F214L, V245T, D250E, A272P, K277R, T286A, E297K, K311R, I329VD
 Q967ZZQ967FJ931372D4T, 3TCNVPD67N, K70R, M184V, K219QY181CL34I, V35T, T39M, V60I, D123E, I135T, D177E, I178V, Q207K, R211K, F214L, H221Y, V245K, D250E, A272P, K277R, T286A, E297K, K311R, I329VD
Burda (2010)07BDHS4007BDHS40GQ344972D4T, 3TCNVPM184V, N348IY181CV35T, T39A, E40D, K49R, V60I, V106I, I135T, S162C, R172K, N175H, D177E, I178L, Q197R, T200E, K201I, E204K, Q207E, F214L, H221Y, V245K, A272P, T286A, I293V, E297K, Q334E, G335S, T338S, Y339W, R356K, K374Q, T377R, K390R, A400T, T403M, V435ID
Ndembi (2010)15845D_P115845GQ409579AZT, 3TCNVPM184VV108I, Y181C, G190GAP4T, V35T, K49R, V60I, D121Y, K122E, I135T, D177E, T200A, E204K, Q207E, R211K, F214L, H221YD
 DT3952_05_P13952GQ409627AZT, 3TCNVPD67DG, M184VY181CI31L, V35T, T39I, E40D, V60I, D121Y, K122E, S162A, D177E, Q207E, R211K, L228LRD
 16535D_P116535GQ409634AZT, 3TC, D4TNVPM184VK103N, Y181CP14PS, K20R, V35T, T39V, K49R, V60I, T69N, K122E, S162H, E169A, D177E, I178M, Q207E, R211KD
Towler (2010)12434747-MHM037890D4T, 3TCNVPM184V, T215SYY181CV35IT, K49R, V60I, D121Y, K122E, D123G, T139R, D177E, I178M, T200K, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V, L310ID
  518577-JHM037902D4T, 3TCNVPM41L, M184V, L210W, T215YY181CV35I, T39TA, K43E, K49R, V60I, D121Y, K122E, D123G, T139R, D177E, I178M, T200K, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, I293V, L310ID
Aulicino (2011)ARN272RLDARN272RLDFJ525856NRTINNRTIM41L, D67N, T69D, K70R, L74V, M184V, L210W, T215Y, K219HA98G, K101E, V108I, Y181C, G190AS3C, K20R, E28A, V35T, T39E, E44D, V60I, V90I, L109I, K122E, I135V, I142V, S162N, I167V, V179I, T200A, E203K, Q207E, H208Y, R211KD
Charpentier (2011)160CP 001 1090 D4T, 3TCNVPK65RK101KE, Y181C, G190AK20KR, V35T, T39TA, E40D, K49R, V60I, T69TA, V90I, D121Y, K122E, D123E, S162A, Q174H, D177E, T200A, E203EK, Q207E, R211K, L228LR, P243H, V245E, D250E, A272S, L283I, I293V, P313TD
 220CP 001 040 D4T, 3TCNVPF77FL, M184VY181CV35T, E40D, K49KR, V60VA, F87FL, V90VA, K101KR, K122KE, D123NT, Q174QK, P176PT, V179VI, G196E, T200A, Q207E, L228LR, D237E, V245K, A272P, I274IV, K275R, Q278HY, K281R, E291D, V292I, I293V, E297EK, I329IVD
Kouri (2012)CU1484-09CU1484-09JQ585298NRTINNRTIL74LS, M184V, T215Y, K219EY181CK11R, V35T, K49R, V60I, K64E, K122E, D123N, F130C, Q161L, E169D, T200A, I202V, R206RS, Q207E, F214L, L228H, P243T, V245S, D250E, A272P, K277R, T286A, I329VD
 CU691-09CU691-09JQ585261NRTINNRTIM41L, D67N, K70S, M184V, L210W, T215F, K219QY181CK32Q, V35K, T39A, K49R, V60I, V90I, V111I, V118I, K122E, D123N, I135R, F160Y, Q197K, T200A, I202V, E203K, Q207D, H208Y, R211K, D218E, L228H, V245T, D250E, A272S, T286A, I293V, E297K, L301I, P313Q, I329VD
 CU25-10CU25-10JQ585358NRTINNRTIM41L, D67N, M184V, L210W, T215YK101E, Y181C, G190SE28EG, V35M, K43N, E44D, V106I, V111I, V118I, K122E, D123N, I135T, N136ND, Q174R, D177E, I178M, V189I, T200A, I202V, Q207D, H208Y, V245T, D250E, A272S, T286A, I293V, E297K, P313T, V317A, I329V, Q334DD
 CU749-09CU749-09JQ585263NRTINNRTIM41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219NK101E, Y181C, G190AV35T, V111I, D121Y, K122E, I135T, N137H, S162Y, D177E, I178L, V179VI, T200A, E204A, Q207E, R211K, V245T, D250E, A272S, K277R, T286A, E297K, P313S, V317A, I329V, G335DD
 CU1270-09CU1270-09JQ585285NRTINNRTID67N, K70R, K219QY181C, G190GAV8VAIT, K20R, V35T, T39A, E40D, K49R, V60I, T69TN, K101KQ, V106I, K122E, I135R, E169D, D177E, T200TA, I202V, Q207E, R211K, F214L, H221Y, V245Q, D250E, A272P, T286A, K311R, I329V, G335DD
 CU1483-09CU1483-09JQ585297NRTINNRTID67N, K70R, M184V, T215Y, K219EK103N, Y181C, F227LV35T, T39TA, V60I, T69N, K122E, D123E, E169D, Q174QH, D177E, T200A, I202V, Q207E, L228H, P243T, V245S, D250E, A272P, C280CY, T286A, E305D, E308D, I329V, G335DD
 CU1708-09CU1708-09JQ585308NRTINNRTIM184VV108VI, Y181CV8I, V35T, T39A, E40D, K49R, N54ND, V60I, S68G, I135V, Q161QL, E169D, D177E, Q207E, H221Y, V245T, A272P, K277R, T286A, V292I, E297A, K311R, E312G, P313Q, I329V, G335ED
 CU1959-09CU1959-09JQ585326NRTINNRTIM184V, T215FY181CV21I, V35T, T39A, E40D, K49R, V60I, S68G, I135V, Q174R, D177E, V179I, Q207E, V245T, A272S, K277R, T286A, A288AS, I293V, E297A, K311R, E312G, P313Q, I329V, G335ED
 CU949-09CU949-09JQ585268NRTINNRTIM184VY181CV35T, E40D, V60I, L109W, G112S, F116S, K122P, D123E, I142T, R143T, N147D, E169D, D177E, T200A, Q207E, V245K, D250E, W266WR, K277R, T286A, P294T, I329V, Q334H, G335DD
Reynolds (2012)D0761D0761-1JN652181D4T, 3TCNVPM184IVY181CK13KR, G18GD, V35T, K49R, V60I, D121Y, K122E, D177E, I178M, V179A, T200M, Q207E, R211K, V245I, E248D, D250E, A272P, K277R, L282C, L283I, T286V, I293VD
 E0090E0090-1JN652182AZT, 3TCNVPM184MIVV179E, Y181CT7TA, V21I, V35T, T39M, V60I, T69TA, V90I, D121C, K122E, I135T, I142V, D177E, T200A, E203EK, Q207E, R211K, V245Q, D250E, A272P, K277R, L282C, T286A, I293VD
 E0580E0580-1JN652183AZT, 3TCNVPK65KR, M184VK101KEQ, V108I, Y181CI31IL, L34LI, V35T, E40D, K49R, V60I, D121H, K122E, E169D, D177E, I178M, G196E, T200I, E204EK, Q207D, R211K, V245K, D250E, K277R, L282C, L283I, T286I, A288S, I293V, E297AD
  E0580-2JN652206AZT, 3TC, TDF, DDINVPM184VV108I, Y181CL34I, V35T, E40D, K49R, V60I, K101Q, D121H, K122E, E169D, D177E, I178L, G196E, T200I, E204K, Q207D, R211K, H221Y, V245K, D250E, T253TA, K277R, L282C, L283I, T286I, A288S, I293V, E297AD
 F0703F0703-1JN652191D4T, 3TCNVPM184VY181CV35T, K49R, V60I, K82KR, D121H, K122E, D123E, I135T, D177E, T200I, Q207G, R211K, V245K, D250E, A272P, L282C, T286V, I293V, E297QD
 F0785F0785-1JN652193AZT, 3TCEFVD67DN, K70KR, M184VV179D, Y181CV35T, T39TILS, E40ED, K49R, V60I, K103R, K122KE, I135R, D177E, T200I, E203K, Q207E, R211EK, P243S, V245K, E248D, A272P, K275R, L282C, L283I, A288G, I293VD
 G0772G0772-1JN652195D4T, 3TCNVPM184VY181CV35T, T39LS, K49R, S68G, T69N, D86E, D121Y, K122E, I135T, S162SC, V179I, T200I, Q207X, R211K, H221Y, V245N, D250E, A272P, K277R, L282C, T286A, A288TD
 J0303J0303-1JN652198AZT, 3TCNVPD67DG, M184V, L210LW, T215FYY181CV35T, I47IL, S48T, K49R, V60I, S68SG, K122E, D123GS, I135IT, T165L, D177E, I178L, V179VI, Q207E, R211K, V245E, D250E, A272P, K277R, Q278QH, L282CD
 J0700J0700-1JN652200ABC, 3TC, AZTNVPM184VV108VI, Y181CV35T, E40ED, K49R, V60I, K122E, D123NS, T165L, D177E, I178V, Q207E, R211K, L228R, V245N, D250E, L282C, T286A, I293V, E297KD
 J7221J7221-1JN652201AZT, 3TCNVPM184VY181CI31L, V35T, K49R, V60I, T69N, K122E, D177E, I178M, Q207E, R211K, L228R, V245K, D250E, A272S, L282C, T286A, I293V, E297AD
 B0708B0708-1JN652172NRTI, AZT, 3TCNNRTI, NVP, EFVK65RK103N, Y181C, M230LV35T, E40D, K49R, V60I, K122E, D123N, I159V, E169D, I178L, T200A, I202V, Q207E, R211K, K238R, V245K, A272S, L282C, L283I, I293VD
Aghokeng (2013)HJ3116HJ3116JX982985NRTINNRTIM41L, M184V, L210W, T215FK103N, V108I, Y181CK20R, K49R, V60I, K102N, V118I, I135T, R172K, D177E, I178L, V179I, Q182S, T200A, E203D, E204K, Q207E, R211K, F214L, H221Y, L228R, V245T, A272S, L283I, T286A, I293V, E297K, R307K, V317A, I329V, Q334E, Y339W, I341V, R356K, G359S, A371V, I375V, T377I, K390R, A400T, T403MD
 HJ3051HJ3051JX982983NRTINNRTIM184V, N348IY181CK20KR, V35T, K49R, V60I, D123E, I135T, T139TAIV, R172K, D177E, I178L, G196E, E204K, Q207E, F214L, H221Y, V241I, V245K, A272P, T286A, A288S, E297K, I329V, G335N, T338S, Y339W, G359GS, A376C, K390R, A400TD
Inzaule (2013)317317JQ914102AZT, 3TCNVPM184VY181CE6D, V21VI, V35T, T39L, E40D, K49R, V60I, K64R, K102KQ, D121Y, K122E, I135R, D177E, T200I, E203K, Q207E, R211KD
  317JQ914083AZT, 3TCNVPK70KR, M184VY181CE6D, V21VI, V35T, T39L, E40D, K49R, V60I, K64KR, D121Y, K122E, I135R, D177E, V179VI, T200I, E203K, Q207E, R211KD
Kebe (2013)SNA3-144SNA3-144HM002510AZT, 3TCNVPM184VK101KE, Y181C, G190AV35T, K49R, I50IF, V60I, V90I, D121H, K122E, I135T, S162H, T165I, K173T, Q174K, D177E, I178L, T200A, Q207E, R211K, F214L, V245T, D250ED
Pircher (2013)B1117B1117JX110218D4T, 3TC, AZTNVPM41L, T69D, V75M, M184V, L210W, T215YA98G, Y181CI31L, V35IT, T39A, E44D, V60I, K101Q, V106I, V118I, P119PS, D121C, K122E, S162N, Q174K, D177E, I178V, T200E, K201M, E203K, E204Q, Q207A, R211K, K223T, L228R, V245TD
 B1142B1142JX110241D4T, 3TC, AZTNVPM184VV108VI, Y181CK32R, V35T, E36ED, K49R, V60I, V118I, D121C, K122E, I135T, K166R, E169D, D177E, I178L, V179I, T200I, E204K, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250ED
Sigaloff (2013)MBA093_0MBA093_0JX182025NRTINNRTIM41L, T69D, M184V, L210W, T215YK101H, Y181C, G190AE28A, V35T, E44D, K49R, V60I, K122E, I135T, T139R, T165I, D177E, T200I, Q207E, R211K, L228R, V245K, D250E, A272P, K275R, L282C, L283I, T286A, V292I, I293V, G316ED
 JCR011_0JCR011_0JX181983NRTINNRTIM41L, M184V, L210W, T215YY181CE6D, V35T, E44D, V60I, V111I, K122E, I135L, K166R, D177E, I178M, V179I, E203K, Q207D, H208Y, R211K, H221Y, V245Q, D250E, A272P, K277R, L282C, E297AD
 JCR047_0JCR047_0JX181988NRTINNRTID67G, T69D, K70R, M184V, K219HA98G, V108I, Y181CV35T, K43E, K49R, V60I, I94L, K122E, I135M, S163SC, T165L, R172K, D177E, I178M, T200I, E203R, E204K, Q207E, R211K, E224K, V245K, D250E, A272P, Q278H, L282C, L283I, T286A, A288TD
 JCR099_0JCR099_0JX181999NRTINNRTIK65R, Y115FY181CP4T, E28K, V35T, E40ED, V60I, R72K, V118I, I135T, I142V, A158S, K173E, D177E, Q207E, R211K, F214L, P243K, V245E, D250E, A272S, K275R, L282C, I293VD
 JCR077_0JCR077_0JX181994NRTINNRTIM41L, T69D, K70KR, M184V, L210W, T215FK101E, Y181C, K238TV35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293VD
 JCR073_0JCR073_0JX181993NRTINNRTIT69D, K70R, M184VY181CV21I, V35T, T39S, K49R, V60I, D121Y, K122E, I135M, I142V, S162N, K166R, D177E, I178M, T200A, Q207E, R211K, L228R, V245K, D250E, A272P, K277R, L282C, T286A, I293V, E297AD