<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation V179I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 18
Patients 40
Isolates 41
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE851SE851AF388165NoneNVP  K32I, V35T, T39R, K49R, V60I, D121Y, K122E, I135R, N175H, I178M, V179I, T200I, Q207A, R211K, I244V, V245K, D250E, A272P, K277R, L282C, L283I, T286A, I293VD
Eshleman (2004)ESH_Pat62ESH849AY435375NoneNVP  E28K, V35T, E40D, K49R, V60I, D121Y, K122E, D177E, I178M, V179I, T200I, Q207G, R211K, P243T, V245K, D250E, A272S, K277R, L282C, L283I, T286A, I293VD
 ESH_Pat122ESH874AY435387NoneNVP  V35A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, T200I, Q207E, V245K, D250E, L282C, T286A, V292I, I293V, E297A, S322LD
Non-B Workgroup (2005)TK1028TK1028 AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
  TK1028a AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
 TK2014TK2014 AZT, DDC, 3TC, DDI, D4T, ABCNVP, EFVM41L, L74V, V75M, M184V, L210W, T215Y, K219NK103N, Y181CA33AP, V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, S163SN, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297TD
Weber (2005)M94371M94371AY677521AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV60I, K122E, D177E, I178L, V179I, T200I, Q207E, R211K, V245Q, E248N, D250E, A272P, L282C, R284K, E291A, I293VD
Baxter (2006)48-14291429-30424DQ877819NRTINNRTIM41L, D67N, M184V, T215F, K219QG190AT7P, K20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, Q278H, L282C, T286A, I293V, E297R, G335D, P345Q, F346Y, N348P, R356K, M357T, A360T, T377R, K390R, E399DD
Ojesina (2007)NVJ437NVJ437EF394319NoneNVP  V35T, V60I, D121H, K122E, I135T, D177E, I178V, V179I, T200A, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, E297K, I329V, G335D, R356K, M357S, Q373H, T377Q, S379C, K390R, E399G, V417I, K431E, E432DD
Church (2008)361159H361159HEU380728NoneNVP  P4S, K11R, V35T, D123S, I135T, E138A, K173S, D177E, V179I, Q207A, R211S, V245K, D250E, A272P, K277R, L282C, T286A, I293VD
Nyombi (2008)TMS311TMS311EU251861NoneNVP Y181YC, G190GAE29ED, V35T, T39M, V60I, D121Y, K122E, K173S, Q174K, D177E, I178L, V179I, Q207E, R211K, V245K, A272Q, K275Q, K277R, L282C, L283I, T286A, I293V, P294S, E297K, G335D, E344D, P345Q, F346Y, K347KR, R356K, G359SD
Germanaud (2010)55055505 AZT, 3TCNVPM184VK103NK22N, V35T, V60I, K122E, I135L, E138A, K173N, Q174K, D177E, I178M, V179I, T200A, Q207A, R211KD
Hamkar (2010)3Ir-HIV-DR-03GU724806NRTINNRTIK70R, M184VK103N, P225HK11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 7Ir-HIV-DR-07GU724810NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 11Ir-HIV-DR-11GU724814NRTINNRTIK70R, M184VK103N, P225HV10L, K11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, S251K, A272P, L283I, V292I, I293V, I326XD
 12Ir-HIV-DR-12GU724815NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 24Ir-HIV-DR-24GU724827NRTINNRTI  K11R, V35T, T39A, V60I, D121Y, K122E, S162N, D177E, V179I, Q207A, R211K, W239X, D250E, A272P, L283I, V292I, I293V, I326XD
 28Ir-HIV-DR-28GU724831NRTINNRTI  K11R, V35T, T39I, V60I, D113DG, D121Y, K122E, T165I, V179I, G196K, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 31Ir-HIV-DR-31GU724834NRTINNRTI  K11R, V35T, V60I, D121Y, K122E, D177E, V179I, T200R, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 34Ir-HIV-DR-34GU724837NRTINNRTI  K11R, V35T, V60I, D121Y, K122E, D123E, T165I, D177E, V179I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 35Ir-HIV-DR-35GU724838NRTINNRTI  K11R, V35T, V60I, D121Y, K122E, D177E, V179I, T200R, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326X, K331N, Q332AD
Aulicino (2011)ARN272RLDARN272RLDFJ525856NRTINNRTIM41L, D67N, T69D, K70R, L74V, M184V, L210W, T215Y, K219HA98G, K101E, V108I, Y181C, G190AS3C, K20R, E28A, V35T, T39E, E44D, V60I, V90I, L109I, K122E, I135V, I142V, S162N, I167V, V179I, T200A, E203K, Q207E, H208Y, R211KD
Afonso (2012)ANG56ANG56JN937069NRTINNRTI  V35T, T39A, E40D, E42K, G45E, K49R, V60I, D121Y, K122E, D123E, R125K, I135R, E169D, D177E, I178L, V179I, D192N, G196E, R199K, T200I, I202V, E204K, Q207E, R211K, F214L, D237N, V245T, D250ED
Fourati (2012)90212509021250JQ395579NRTINNRTI  V35T, K49R, I135T, R172K, D177E, I178L, V179I, Q182S, I195IT, I202V, E204N, Q207E, R211K, F214LD
 93410459341045JQ395619NRTINNRTI  K22*, V35T, K49R, I135T, R172K, D177E, I178L, V179I, Q182S, I202V, E204N, Q207E, R211K, F214LD
Kouri (2012)CU322-11CU322-11JQ585490NRTINNRTIL74V, M184VG190A, F227LV35K, T39A, E40D, K43Q, K49R, V60I, S68G, V90I, K104R, K122E, E169D, V179I, Q207X, R211RK, V245T, A272S, K277R, T286A, E297A, P313Q, I329L, Q334ED
 CU1673-09CU1673-09JQ585307NRTINNRTIM184MVK103NL12F, V35IMT, E40D, V60I, Q161QR, S162C, D177E, I178L, V179I, T200S, I202IV, Q207E, R211K, V245T, K249KQ, D250E, A272P, K277KR, T286AP, V292VI, I293IV, P294PT, E297R, L301I, P313AS, V317A, I329V, G335DD
 CU845-09CU845-09JQ585267NRTINNRTIM41L, V75VL, M184V, T215YA98AG, K101E, G190AV35T, V60I, K104KR, F116I, D121Y, K122E, I135T, P157PL, S162C, D177E, I178L, V179I, T200A, E204A, Q207E, R211K, V245A, D250E, A272P, T286A, E297R, L301I, V317T, I329V, G335D, E344DD
 CU1497-09CU1497-09JQ585299NRTINNRTIM184V, T215Y I5T, K11R, G15V, K20I, K22R, Q23L, V35T, K46N, K49R, N54Y, V60I, K122E, D123N, S162D, D177E, I178M, V179I, T200A, E203D, Q207N, D237E, V245Q, D250E, A272P, T286A, I293V, I326VD
 CU1959-09CU1959-09JQ585326NRTINNRTIM184V, T215FY181CV21I, V35T, T39A, E40D, K49R, V60I, S68G, I135V, Q174R, D177E, V179I, Q207E, V245T, A272S, K277R, T286A, A288AS, I293V, E297A, K311R, E312G, P313Q, I329V, G335ED
 CU2043-09CU2043-09JQ585337NRTINNRTID67N, M184V, K219QK101EV35T, N54NS, V60I, K122E, K166R, D177E, V179I, I202V, Q207E, V245Q, E248D, D250E, T286A, I329IVD
Reynolds (2012)C0717C0717-1JN652177AZT, 3TCEFVM184VK101E, G190SK13KN, K32R, V35I, E40D, K49KR, T58TS, V60I, D121Y, K122E, D177E, I178M, V179I, E204K, Q207E, R211K, V245Q, I257L, A272P, K277R, L282C, T286A, V292I, I293VD
 G0772G0772-1JN652195D4T, 3TCNVPM184VY181CV35T, T39LS, K49R, S68G, T69N, D86E, D121Y, K122E, I135T, S162SC, V179I, T200I, Q207X, R211K, H221Y, V245N, D250E, A272P, K277R, L282C, T286A, A288TD
Aghokeng (2013)HJ3116HJ3116JX982985NRTINNRTIM41L, M184V, L210W, T215FK103N, V108I, Y181CK20R, K49R, V60I, K102N, V118I, I135T, R172K, D177E, I178L, V179I, Q182S, T200A, E203D, E204K, Q207E, R211K, F214L, H221Y, L228R, V245T, A272S, L283I, T286A, I293V, E297K, R307K, V317A, I329V, Q334E, Y339W, I341V, R356K, G359S, A371V, I375V, T377I, K390R, A400T, T403MD
Pircher (2013)B1142B1142JX110241D4T, 3TC, AZTNVPM184VV108VI, Y181CK32R, V35T, E36ED, K49R, V60I, V118I, D121C, K122E, I135T, K166R, E169D, D177E, I178L, V179I, T200I, E204K, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250ED
 B1144B1144JX110177D4T, 3TC, AZTNVP  V35T, K49R, I50V, V60I, K173Q, D177E, V179I, Q207ED
Sigaloff (2013)JCR111_0JCR111_0JX182003NRTINNRTIM184V, T215FK101E, G190AE28R, V35T, K49R, V60I, A98S, K122E, I135T, I142V, D177E, V179I, Q207E, R211K, V245Q, D250E, K277R, L282C, E297AD
 MBA049_0MBA049_0JX182019NRTINNRTID67DN, K70KR, M184VK101E, G190AV35T, T39A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, Q278H, L282C, I293V, E297QD
 JCR011_0JCR011_0JX181983NRTINNRTIM41L, M184V, L210W, T215YY181CE6D, V35T, E44D, V60I, V111I, K122E, I135L, K166R, D177E, I178M, V179I, E203K, Q207D, H208Y, R211K, H221Y, V245Q, D250E, A272P, K277R, L282C, E297AD
 JCR077_0JCR077_0JX181994NRTINNRTIM41L, T69D, K70KR, M184V, L210W, T215FK101E, Y181C, K238TV35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293VD
 JCR022_0JCR022_0JX181985NRTINNRTIM184VG190AV35T, T39L, V60I, D121Y, K122E, I135V, D177E, I178M, V179I, Q197K, T200A, Q207G, R211K, D237E, V245K, D250E, S251N, A272P, I274V, V276T, K277R, L282C, L283V, T286A, E297AD