<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation V179I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 21
Patients 60
Isolates 61
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE851SE851AF388165NoneNVP  K32I, V35T, T39R, K49R, V60I, D121Y, K122E, I135R, N175H, I178M, V179I, T200I, Q207A, R211K, I244V, V245K, D250E, A272P, K277R, L282C, L283I, T286A, I293VD
Eshleman (2004)ESH_Pat62ESH849AY435375NoneNVP  E28K, V35T, E40D, K49R, V60I, D121Y, K122E, D177E, I178M, V179I, T200I, Q207G, R211K, P243T, V245K, D250E, A272S, K277R, L282C, L283I, T286A, I293VD
 ESH_Pat122ESH874AY435387NoneNVP  V35A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, T200I, Q207E, V245K, D250E, L282C, T286A, V292I, I293V, E297A, S322LD
Non-B Workgroup (2005)TK1028TK1028 AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
  TK1028a AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
 TK2014TK2014 AZT, DDC, 3TC, DDI, D4T, ABCNVP, EFVM41L, L74V, V75M, M184V, L210W, T215Y, K219NK103N, Y181CA33AP, V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, S163SN, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297TD
Weber (2005)M94371M94371AY677521AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV60I, K122E, D177E, I178L, V179I, T200I, Q207E, R211K, V245Q, E248N, D250E, A272P, L282C, R284K, E291A, I293VD
Baxter (2006)48-14291429-30424DQ877819NRTINNRTIM41L, D67N, M184V, T215F, K219QG190AT7P, K20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, Q278H, L282C, T286A, I293V, E297R, G335D, P345Q, F346Y, N348P, R356K, M357T, A360T, T377R, K390R, E399D, A400TD
Lwembe (2007)NYU7979MFEB04 AZT, 3TCNVPV75M, M184VK101E, G190AE28A, V35T, T39A, E40D, T69S, R83G, D121H, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211SD
Ojesina (2007)NVJ437NVJ437EF394319NoneNVP  V35T, V60I, D121H, K122E, I135T, D177E, I178V, V179I, T200A, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, E297K, I329V, G335D, R356K, M357S, Q373H, T377Q, S379C, K390R, E399G, V417I, K431E, E432DD
Nyombi (2008)TMS311TMS311EU251861NoneNVP Y181YC, G190GAE29ED, V35T, T39M, V60I, D121Y, K122E, K173S, Q174K, D177E, I178L, V179I, Q207E, R211K, V245K, A272Q, K275Q, K277R, L282C, L283I, T286A, I293V, P294S, E297K, G335D, E344D, P345Q, F346Y, K347KR, R356K, G359SD
Afonso (2012)ANG56ANG56JN937069NRTINNRTI  V35T, T39A, E40D, E42K, G45E, K49R, V60I, D121Y, K122E, D123E, R125K, I135R, E169D, D177E, I178L, V179I, D192N, G196E, R199K, T200I, I202V, E204K, Q207E, R211K, F214L, D237N, V245T, D250ED
Fourati (2012)90212509021250JQ395579NRTINNRTI  V35T, K49R, I135T, R172K, D177E, I178L, V179I, Q182S, I195IT, I202V, E204N, Q207E, R211K, F214LD
 93410459341045JQ395619NRTINNRTI  K22*, V35T, K49R, I135T, R172K, D177E, I178L, V179I, Q182S, I202V, E204N, Q207E, R211K, F214LD
Kouri (2012)CU322-11CU322-11JQ585490NRTINNRTIL74V, M184VG190A, F227LV35K, T39A, E40D, K43Q, K49R, V60I, S68G, V90I, K104R, K122E, E169D, V179I, Q207X, R211RK, V245T, A272S, K277R, T286A, E297A, P313Q, I329L, Q334ED
 CU1673-09CU1673-09JQ585307NRTINNRTIM184MVK103NL12F, V35IMT, E40D, V60I, Q161QR, S162C, D177E, I178L, V179I, T200S, I202IV, Q207E, R211K, V245T, K249KQ, D250E, A272P, K277KR, T286AP, V292VI, I293IV, P294PT, E297R, L301I, P313AS, V317A, I329V, G335DD
 CU845-09CU845-09JQ585267NRTINNRTIM41L, V75VL, M184V, T215YA98AG, K101E, G190AV35T, V60I, K104KR, F116I, D121Y, K122E, I135T, P157PL, S162C, D177E, I178L, V179I, T200A, E204A, Q207E, R211K, V245A, D250E, A272P, T286A, E297R, L301I, V317T, I329V, G335D, E344DD
 CU1497-09CU1497-09JQ585299NRTINNRTIM184V, T215Y I5T, K11R, G15V, K20I, K22R, Q23L, V35T, K46N, K49R, N54Y, V60I, K122E, D123N, S162D, D177E, I178M, V179I, T200A, E203D, Q207N, D237E, V245Q, D250E, A272P, T286A, I293V, I326VD
 CU1959-09CU1959-09JQ585326NRTINNRTIM184V, T215FY181CV21I, V35T, T39A, E40D, K49R, V60I, S68G, I135V, Q174R, D177E, V179I, Q207E, V245T, A272S, K277R, T286A, A288AS, I293V, E297A, K311R, E312G, P313Q, I329V, G335ED
 CU2043-09CU2043-09JQ585337NRTINNRTID67N, M184V, K219QK101EV35T, N54NS, V60I, K122E, K166R, D177E, V179I, I202V, Q207E, V245Q, E248D, D250E, T286A, I329IVD
Reynolds (2012)C0717C0717-1JN652177AZT, 3TCEFVM184VK101E, G190SK13KN, K32R, V35I, E40D, K49KR, T58TS, V60I, D121Y, K122E, D177E, I178M, V179I, E204K, Q207E, R211K, V245Q, I257L, A272P, K277R, L282C, T286A, V292I, I293VD
 G0772G0772-1JN652195D4T, 3TCNVPM184VY181CV35T, T39LS, K49R, S68G, T69N, D86E, D121Y, K122E, I135T, S162SC, V179I, T200I, Q207X, R211K, H221Y, V245N, D250E, A272P, K277R, L282C, T286A, A288TD
Aghokeng (2013)HJ3116HJ3116JX982985NRTINNRTIM41L, M184V, L210W, T215FK103N, V108I, Y181CK20R, K49R, V60I, K102N, V118I, I135T, R172K, D177E, I178L, V179I, Q182S, T200A, E203D, E204K, Q207E, R211K, F214L, H221Y, L228R, V245T, A272S, L283I, T286A, I293V, E297K, R307K, V317A, I329V, Q334E, Y339W, I341V, R356K, G359S, A371V, I375V, T377I, K390R, A400T, T403MD
Pircher (2013)B1142B1142JX110241D4T, 3TC, AZTNVPM184VV108VI, Y181CK32R, V35T, E36ED, K49R, V60I, V118I, D121C, K122E, I135T, K166R, E169D, D177E, I178L, V179I, T200I, E204K, Q207E, R211K, F214L, H221Y, V245Q, E248N, D250ED
 B1144B1144JX110177D4T, 3TC, AZTNVP  V35T, K49R, I50V, V60I, K173Q, D177E, V179I, Q207ED
Sigaloff (2013)JCR111_0JCR111_0JX182003NRTINNRTIM184V, T215FK101E, G190AE28R, V35T, K49R, V60I, A98S, K122E, I135T, I142V, D177E, V179I, Q207E, R211K, V245Q, D250E, K277R, L282C, E297AD
 MBA049_0MBA049_0JX182019NRTINNRTID67DN, K70KR, M184VK101E, G190AV35T, T39A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, Q278H, L282C, I293V, E297QD
 JCR011_0JCR011_0JX181983NRTINNRTIM41L, M184V, L210W, T215YY181CE6D, V35T, E44D, V60I, V111I, K122E, I135L, K166R, D177E, I178M, V179I, E203K, Q207D, H208Y, R211K, H221Y, V245Q, D250E, A272P, K277R, L282C, E297AD
 JCR077_0JCR077_0JX181994NRTINNRTIM41L, T69D, K70KR, M184V, L210W, T215FK101E, Y181C, K238TV35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293VD
 JCR022_0JCR022_0JX181985NRTINNRTIM184VG190AV35T, T39L, V60I, D121Y, K122E, I135V, D177E, I178M, V179I, Q197K, T200A, Q207G, R211K, D237E, V245K, D250E, S251N, A272P, I274V, V276T, K277R, L282C, L283V, T286A, E297AD
Aghokeng (2014)CM-1-290CM-1-290KC350180NRTINNRTI  P4PH, E6EK, K20R, V35T, T39N, E40D, K49R, V60I, K101Q, D123E, I135T, E138A, S162C, R172K, K173Q, I178L, V179I, Q182S, T200A, K201R, E204K, Q207E, R211K, F214L, V245T, D250ED
Meini (2015)118152118152KM438310AZT, 3TC, DDI, D4TNVPK65R, F116Y, Q151M, M184VY181IK20R, W24R, V35T, T39K, K49R, V60I, S68K, D121Y, K122E, E138A, V179I, Q207E, R211K, F214LD
 109258109258KM438243D4T, 3TC, DDINVPM41L, L74LI, M184V, L210W, T215FYA98G, G190AK20R, K32R, V35T, T39K, K43KE, V60I, S68SG, V118VI, D121C, K122E, I135ILM, S162SDGN, I178M, V179I, T200A, Q207E, R211K, V245ED
Boillot (2016)MAT06MAT06KT315973D4T, 3TCEFVV75I K11R, V35T, T39A, K49R, V60I, D123E, I132L, P133T, S162H, E169D, D177E, I178M, V179I, T200A, Q207E, R211M, I244V, V245ND
 BEN14BEN14KT315952D4T, 3TCEFV  P4PT, E6A, K20KR, V35T, K49R, V60I, D121Y, K122E, A158S, S162Q, D177E, I178V, V179I, I202V, E204R, Q207E, V245KD
Brooks (2016)2116A2116AKU900897TDF, 3TCNVPK65R, M184VK101P, K103NV35T, E40D, K49R, V60I, S68N, K122E, K166R, D177A, V179I, G196E, I202V, Q207E, R211KD
Kekitiinwa (2017)65530_90765530_907KY237890NRTINNRTIL74V, Y115F, M184VY181C, G190AK49R, V60I, E138T, S162C, V179I, T200L, E203K, Q207D, R211K, H221YD
 65752_48465752_484KY237914NRTINNRTIY115F, M184V K49R, V60I, D121H, K122E, I135R, D177E, I178M, V179I, Q207E, R211K, H221HYD
 28179_30928179_309KY237807NRTINNRTIL74V, Y115F, M184VY181CE29EG, V35T, T39TA, E40D, K49R, V60I, V90VI, K101R, K122E, I135MT, T165TI, K173S, Q174K, D177E, V179I, E194N, G196E, T200I, Q207D, R211K, H221Y, V245E, D250E, A272P, L282C, L283I, R284K, V292ID
 79391_30379391_303KY238004NRTINNRTIL74V, Y115F, M184VV108VI, Y181CK49R, V60I, K101R, D121HY, K122E, D177E, I178M, V179I, G196GE, T200M, Q207E, R211K, H221Y, K238RD
Kityo (2017)8352083520KY062074NRTINNRTID67N, K70R, M184V, T215F, K219QK101E, G190AK49R, V60I, T69N, E138A, S162D, E169K, K173E, V179I, T200I, Q207G, R211KD
 8326383263KY061818NRTINNRTIA62V, D67KK101KE, Y181CK49R, K66E, S68G, T69F, W88WS, D121HY, K122E, Q174QR, D177E, I178M, V179I, E203K, Q207E, K219GD
 8319083190KY061746NRTINNRTIM41L, M184V, L210W, T215YV108I, G190AE44D, A98AS, V118VI, K122E, E138Q, D177E, I178M, V179I, T200I, Q207E, R211KD
 8339783397KY061951NRTINNRTIM41L, D67N, T69TADN, V75M, M184V, L210W, T215Y, K219NV108I, Y181CK43E, E44EA, K49R, E53EG, V60I, V118I, D121Y, K122E, D123E, S162D, D177E, I178M, V179I, G196E, T200A, E203EK, Q207E, H208HY, R211K, D218E, L228HD
 8340083400KY061954NRTINNRTIK65R, Y115YF, M184V, K219KEY181C, G190AK49R, V60I, S68G, V90I, D121Y, K122E, I135IM, S162N, D177E, I178V, V179I, T200IL, I202V, Q207E, R211KD
 8339683396KY061950NRTINNRTI K103NK43KN, S48ST, K49R, V60I, D121H, K122E, I135T, S162C, T165I, D177E, I178V, V179I, G196E, T200L, Q207E, R211K, K238RD
 8296382963KY061527NRTINNRTI A98AG, K103N, V108VI, Y181YCK49R, V60I, V90VI, K102KQ, K122KE, I135T, R172K, D177E, I178M, V179I, T200R, Q207E, R211K, H221HYD
 8329883298KY061853NRTINNRTIM41L, D67DG, K70R, L74I, M184V, L210LW, T215F, K219QY181CK43KE, K49R, V60I, K64HN, T69N, D121Y, K122E, D123DE, S162D, D177E, I178M, V179I, I202V, Q207E, R211K, D218E, L228RD
 8354483544KY062098NRTINNRTIM184VK101E, K103KN, V108IK49R, V60I, K122E, D123E, I135V, E138G, T139TA, D177E, I178M, V179I, Q207E, R211KD
 8340283402KY061956NRTINNRTID67G, K70R, M184V, T215Y, K219EA98G, Y181CK49R, V60I, S68G, K122E, D123N, I135T, D177E, I178M, V179I, I202IV, Q207E, R211K, H235HRD
 8351983519KY062073NRTINNRTIM41L, D67DN, M184V, L210W, T215YK101E, G190AK49R, V60I, E138G, S162SC, T165L, E169D, D177E, I178IL, V179I, Q207E, R211KD
 8330483304KY061859NRTINNRTIM41L, D67N, T69D, V75M, M184V, L210W, T215YK101E, V108I, G190AE44D, K49R, V60I, V106I, V118I, D121Y, K122E, D177E, V179I, V189I, Q207E, R211KD
 8340383403KY061957NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EA98AG, K101E, G190AK43KN, V60I, I94IL, D121H, K122E, D177E, I178L, V179I, E194D, T200M, E203A, Q207E, R211KD
 8354683546KY062100NRTINNRTIK65R, M184VY181C, G190AK49R, E53ED, V60I, S68N, V106I, D121Y, K122E, S162D, Q174K, D177E, I178L, V179I, T200M, Q207E, R211KD
 8340783407KY061961NRTINNRTIM41L, V75M, M184V, L210W, T215YY181C, P236PLK43KQ, E44ED, K49R, V60I, V111I, D121H, K122E, I135T, I142T, S162D, T165K, E169D, D177E, I178M, V179I, G196E, T200A, E203V, Q207AE, H208Y, R211K, L228RD
 8304283042KY061601NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K101E, G190AK43KQ, E44D, V60I, I94L, V118I, D121Y, K122E, D123E, D177E, I178M, V179I, T200A, Q207E, R211KD
 6608166081KY061434NRTINNRTID67N, K70R, M184V, T215N, K219EQA98AG, K101E, G190ASK43A, K49R, V60I, D121H, K122E, I135T, E138A, T139V, E169D, D177E, V179I, T200M, I202V, Q207E, R211KD
 8354183541KY062095NRTINNRTIM184V, T215YG190AI47L, K49R, V60I, V90VI, K122KE, S162D, E169D, D177E, V179I, Q207E, R211KD
 8293882938KY061502NRTINNRTIM184VK103N, P225HK49R, S68N, D121Y, K122E, R125K, T165L, D177E, I178M, V179I, G196E, T200I, Q207E, R211KD
 8290882908KY061473NRTINNRTID67A, K70R, M184V, T215F, K219EK101E, Y181C, G190AK49R, V60I, T69N, D121Y, K122E, S162SN, D177E, V179I, G196GE, Q207E, R211K, L228HD
 8349383493KY062047NRTINNRTIM184V, T215TNSYK103N, P225HK49R, V60I, K101G, K122KE, D177E, I178M, V179I, T200LR, Q207E, R211KD