<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation V179I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 12
Patients 23
Isolates 24
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2001)SE851SE851AF388165NoneNVP  K32I, V35T, T39R, K49R, V60I, D121Y, K122E, I135R, N175H, I178M, V179I, T200I, Q207A, R211K, I244V, V245K, D250E, A272P, K277R, L282C, L283I, T286A, I293VD
Eshleman (2004)ESH_Pat62ESH849AY435375NoneNVP  E28K, V35T, E40D, K49R, V60I, D121Y, K122E, D177E, I178M, V179I, T200I, Q207G, R211K, P243T, V245K, D250E, A272S, K277R, L282C, L283I, T286A, I293VD
 ESH_Pat122ESH874AY435387NoneNVP  V35A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, T200I, Q207E, V245K, D250E, L282C, T286A, V292I, I293V, E297A, S322LD
Non-B Workgroup (2005)TK1028TK1028 AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
  TK1028a AZT, 3TC, ABC, D4TNVPM41L, D67N, K70R, T215F, K219QG190AK20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, K275T, Q278H, L282C, T286A, I293V, E297RD
 TK2014TK2014 AZT, DDC, 3TC, DDI, D4T, ABCNVP, EFVM41L, L74V, V75M, M184V, L210W, T215Y, K219NK103N, Y181CA33AP, V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, S163SN, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297TD
Weber (2005)M94371M94371AY677521AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV60I, K122E, D177E, I178L, V179I, T200I, Q207E, R211K, V245Q, E248N, D250E, A272P, L282C, R284K, E291A, I293VD
Baxter (2006)48-14291429-30424DQ877819NRTINNRTIM41L, D67N, M184V, T215F, K219QG190AT7P, K20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, Q278H, L282C, T286A, I293V, E297R, G335D, P345Q, F346Y, N348P, R356K, M357T, A360T, T377R, K390R, E399DD
Ojesina (2007)NVJ437NVJ437EF394319NoneNVP  V35T, V60I, D121H, K122E, I135T, D177E, I178V, V179I, T200A, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, E297K, I329V, G335D, R356K, M357S, Q373H, T377Q, S379C, K390R, E399G, V417I, K431E, E432DD
Church (2008)361159H361159HEU380728NoneNVP  P4S, K11R, V35T, D123S, I135T, E138A, K173S, D177E, V179I, Q207A, R211S, V245K, D250E, A272P, K277R, L282C, T286A, I293VD
Nyombi (2008)TMS311TMS311EU251861NoneNVP Y181YC, G190GAE29ED, V35T, T39M, V60I, D121Y, K122E, K173S, Q174K, D177E, I178L, V179I, Q207E, R211K, V245K, A272Q, K275Q, K277R, L282C, L283I, T286A, I293V, P294S, E297K, G335D, E344D, P345Q, F346Y, K347KR, R356K, G359SD
Germanaud (2010)55055505 AZT, 3TCNVPM184VK103NK22N, V35T, V60I, K122E, I135L, E138A, K173N, Q174K, D177E, I178M, V179I, T200A, Q207A, R211KD
Hamkar (2010)3Ir-HIV-DR-03GU724806NRTINNRTIK70R, M184VK103N, P225HK11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 7Ir-HIV-DR-07GU724810NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 11Ir-HIV-DR-11GU724814NRTINNRTIK70R, M184VK103N, P225HV10L, K11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, S251K, A272P, L283I, V292I, I293V, I326XD
 12Ir-HIV-DR-12GU724815NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 24Ir-HIV-DR-24GU724827NRTINNRTI  K11R, V35T, T39A, V60I, D121Y, K122E, S162N, D177E, V179I, Q207A, R211K, W239X, D250E, A272P, L283I, V292I, I293V, I326XD
 28Ir-HIV-DR-28GU724831NRTINNRTI  K11R, V35T, T39I, V60I, D113DG, D121Y, K122E, T165I, V179I, G196K, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 31Ir-HIV-DR-31GU724834NRTINNRTI  K11R, V35T, V60I, D121Y, K122E, D177E, V179I, T200R, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 34Ir-HIV-DR-34GU724837NRTINNRTI  K11R, V35T, V60I, D121Y, K122E, D123E, T165I, D177E, V179I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 35Ir-HIV-DR-35GU724838NRTINNRTI  K11R, V35T, V60I, D121Y, K122E, D177E, V179I, T200R, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326X, K331N, Q332AD
Aulicino (2011)ARN272RLDARN272RLDFJ525856NRTINNRTIM41L, D67N, T69D, K70R, L74V, M184V, L210W, T215Y, K219HA98G, K101E, V108I, Y181C, G190AS3C, K20R, E28A, V35T, T39E, E44D, V60I, V90I, L109I, K122E, I135V, I142V, S162N, I167V, V179I, T200A, E203K, Q207E, H208Y, R211KD
Reynolds (2012)C0717C0717-1JN652177AZT, 3TCEFVM184VK101E, G190SK13KN, K32R, V35I, E40D, K49KR, T58TS, V60I, D121Y, K122E, D177E, I178M, V179I, E204K, Q207E, R211K, V245Q, I257L, A272P, K277R, L282C, T286A, V292I, I293VD
 G0772G0772-1JN652195D4T, 3TCNVPM184VY181CV35T, T39LS, K49R, S68G, T69N, D86E, D121Y, K122E, I135T, S162SC, V179I, T200I, Q207X, R211K, H221Y, V245N, D250E, A272P, K277R, L282C, T286A, A288TD