<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation E138A
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 12
Patients 18
Isolates 18
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Eshleman (2004)ESH_Pat96ESH647AY435325NoneNVP  V35T, S48T, K49R, V60I, K122E, D123N, E138A, K166KR, D177E, I178M, T200I, Q207EG, R211K, F214FL, V245K, A272P, K277R, L282C, L283I, T286A, I293VD
 ESH_Pat160ESH450AY435270NoneNVP K101KE, K103KN, G190GAV35T, T39M, V60I, D121Y, K122E, E138A, I142AV, K166R, D177E, I178IM, T200X, Q207G, R211K, L228LH, V245K, D250E, A272P, K275N, K277R, L282C, L283I, I293V, L310ID
Baxter (2006)48-30563056-30318DQ877968NRTINNRTIM41L, M184V, L210W, T215YK101KEK32R, V35T, T39K, K43E, V60I, V118I, D121Y, K122E, I135IV, E138A, S162A, D177E, I178M, E204EK, Q207E, V241I, V245Q, D250E, A272P, K277R, T286A, G333E, R358K, G359S, A371V, T377Q, S379C, K390R, A400TD
 48-41654165-30410DQ878398NRTINNRTIM41L, D67N, K70R, T215F, K219QK101E, G190SV35T, K49R, V60I, T69TN, V90I, A98S, V118I, K122E, I135T, E138A, T165I, E169D, R172RK, D177E, I178L, V179X, Q197E, E203A, Q207E, R211K, F214L, L228H, V245T, D250E, A272P, K277R, T286A, E297KR, I329L, G335D, M357MT, G359S, A376T, S379C, T386A, A400TD
Church (2008)361159H361159HEU380728NoneNVP  P4S, K11R, V35T, D123S, I135T, E138A, K173S, D177E, V179I, Q207A, R211S, V245K, D250E, A272P, K277R, L282C, T286A, I293VD
Nyombi (2008)TMS036TMS036EU251805NoneNVP  V35T, E40D, V60I, E138A, Q174K, I178L, V189I, T200I, I202V, Q207E, R211K, F214L, V245T, D250E, A272P, V276I, L282C, L283I, T286A, V292I, I293V, K311R, G335D, P345Q, F346Y, R356K, M357T, A376T, T377Q, S379AD
Germanaud (2010)55055505 AZT, 3TCNVPM184VK103NK22N, V35T, V60I, K122E, I135L, E138A, K173N, Q174K, D177E, I178M, V179I, T200A, Q207A, R211KD
Pircher (2013)B1145B1145JX110243D4T, 3TC, AZTNVPM41ML, T69DN, K70KR, M184V, T215TNSYK101E, V108I, F227L, M230LV35T, V60I, K122E, D123N, E138A, D177E, I178M, T200E, I202IV, Q207K, R211A, H221Y, L228LH, V245KD
Sigaloff (2013)JCR092_0JCR092_0JX181997NRTINNRTID67N, K70R, M184V, K219QK101E, G190AV35T, T39A, E40D, V60I, K122E, D123S, I135T, E138A, I202V, Q207A, R211S, F214L, V245M, D250E, A272P, K277R, K281R, L282C, L283I, T286A, I293VD
Aghokeng (2014)CM-1-290CM-1-290KC350180NRTINNRTI  P4PH, E6EK, K20R, V35T, T39N, E40D, K49R, V60I, K101Q, D123E, I135T, E138A, S162C, R172K, K173Q, I178L, V179I, Q182S, T200A, K201R, E204K, Q207E, R211K, F214L, V245T, D250ED
Wallis (2014)4123041230KM458598NRTINNRTIV75VA, M184VK101KE, G190SV35T, E40AD, K43KE, K49R, T58S, V60I, V118VA, K122E, D123G, E138A, Q197E, T200R, Q207E, R211RKD
Meini (2015)118152118152KM438310AZT, 3TC, DDI, D4TNVPK65R, F116Y, Q151M, M184VY181IK20R, W24R, V35T, T39K, K49R, V60I, S68K, D121Y, K122E, E138A, V179I, Q207E, R211K, F214LD
Kekitiinwa (2017)28267_46728267_467KY237823NRTINNRTIM184V V35M, V60I, D121Y, K122E, D123E, E138A, T165I, D177E, I178M, Q207D, R211K, I244V, V245K, D250E, S251N, A272P, K277R, L282C, L283I, T286A, I293VD
Kityo (2017)8352083520KY062074NRTINNRTID67N, K70R, M184V, T215F, K219QK101E, G190AK49R, V60I, T69N, E138A, S162D, E169K, K173E, V179I, T200I, Q207G, R211KD
 8308783087KY061645NRTINNRTIM41L, D67N, K70R, V75M, M184V, T215F, K219EK101E, G190CV60I, D121H, K122E, I135T, E138A, K166KR, I178LM, T200A, Q207E, L228LHD
 8303983039KY061598NRTINNRTID67N, T69TADN, K70R, M184V, T215FYA98G, K101E, G190A, K238KTK46Q, K49R, V60I, K103KR, D121Y, K122E, I135L, E138A, S162A, E169D, D177E, I178M, T200R, Q207E, R211KD
 8308683086KY061644NRTINNRTIM41L, M184V, T215YK101E, K103N, G190AK49R, V60I, S105T, D121Y, K122E, D123G, E138A, D177G, T200A, Q207D, R211KD
 6608166081KY061434NRTINNRTID67N, K70R, M184V, T215N, K219EQA98AG, K101E, G190ASK43A, K49R, V60I, D121H, K122E, I135T, E138A, T139V, E169D, D177E, V179I, T200M, I202V, Q207E, R211KD