<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation V108I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 50
Isolates 51
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Snoeck (2004)BE40BE40AY901297AZT, DDC, D4T, 3TC, DDINVPK70R, M184VV108I, Y181CV35T, K49R, V60I, T69N, K122E, D177E, Q207E, P243T, V245K, D250ED
Non-B Workgroup (2005)UK1979UK1979AY9013703TC, D4T, AZTNVPM184VK103N, V108IV35T, V60I, D121H, K122E, I135R, D177E, E203K, Q207ED
Ndembi (2010)15845D_P115845GQ409579AZT, 3TCNVPM184VV108I, Y181C, G190GAP4T, V35T, K49R, V60I, D121Y, K122E, I135T, D177E, T200A, E204K, Q207E, R211K, F214L, H221YD
Charpentier (2011)CR-47CR-47FJ688253AZT, 3TCNNRTIM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IK20R, V35I, T39A, E44D, V60I, V118I, K122E, I135IMT, I142T, D177E, I178L, E203EK, Q207E, H208HY, R211RK, K223KE, L228LH, V245T, D250E, A272P, K277R, T286A, V292ID
Kouri (2012)CU645-09CU645-09JQ585259NRTINNRTID67DN, M184V, L210LW, T215Y, N348NIK103N, V108I, M230MLV8I, P19PS, V35T, T39A, V60I, E79D, K122E, D123T, T139TR, I142T, E169D, D177E, I178M, T200K, E204D, Q207E, R211K, V245S, D250E, A272P, T286A, G335DD
Reynolds (2012)E0580E0580-1JN652183AZT, 3TCNVPK65KR, M184VK101KEQ, V108I, Y181CI31IL, L34LI, V35T, E40D, K49R, V60I, D121H, K122E, E169D, D177E, I178M, G196E, T200I, E204EK, Q207D, R211K, V245K, D250E, K277R, L282C, L283I, T286I, A288S, I293V, E297AD
  E0580-2JN652206AZT, 3TC, TDF, DDINVPM184VV108I, Y181CL34I, V35T, E40D, K49R, V60I, K101Q, D121H, K122E, E169D, D177E, I178L, G196E, T200I, E204K, Q207D, R211K, H221Y, V245K, D250E, T253TA, K277R, L282C, L283I, T286I, A288S, I293V, E297AD
Aghokeng (2013)HJ3116HJ3116JX982985NRTINNRTIM41L, M184V, L210W, T215FK103N, V108I, Y181CK20R, K49R, V60I, K102N, V118I, I135T, R172K, D177E, I178L, V179I, Q182S, T200A, E203D, E204K, Q207E, R211K, F214L, H221Y, L228R, V245T, A272S, L283I, T286A, I293V, E297K, R307K, V317A, I329V, Q334E, Y339W, I341V, R356K, G359S, A371V, I375V, T377I, K390R, A400T, T403MD
Sigaloff (2013)JCR047_0JCR047_0JX181988NRTINNRTID67G, T69D, K70R, M184V, K219HA98G, V108I, Y181CV35T, K43E, K49R, V60I, I94L, K122E, I135M, S163SC, T165L, R172K, D177E, I178M, T200I, E203R, E204K, Q207E, R211K, E224K, V245K, D250E, A272P, Q278H, L282C, L283I, T286A, A288TD
Theys (2013)131238131238 D4T, 3TCEFVM184VK103N, V108IE6A, K11Q, K20R, V35T, V60I, D121Y, K122E, I135V, I142T, T165I, E169D, D177E, I178L, G196E, T200A, E204K, Q207E, R211K, F214L, P243T, V245T, D250E, A272P, K281R, T286TA, E297K, I329L, G333D, Q334RD
Kekitiinwa (2017)65537_38965537_389KY237893NRTINNRTIL74V, Y115F, M184VL100I, K103N, V108IK49R, V60I, D121HY, K122E, I142V, S163T, T165I, D177E, I178M, T200TA, Q207E, R211K, H221Y, L228QD
 28702_26328702_263KY237831NRTINNRTIL74V, Y115F, M184VV108I, Y181CV35T, E40D, K49R, D121Y, K122E, D177E, I178L, T200I, E204K, Q207E, R211K, F214L, V245K, D250E, I257L, A272P, K277R, L282C, T286A, I293VD
 35369_25335369_253KY237841NRTINNRTID67N, K70R, L74I, Y115F, M184V, T215F, K219QV108IV35T, K49R, V60I, K64N, D177E, I202V, Q207E, R211K, H221Y, V245K, D250E, L282C, T286A, I293VD
 79386_29279386_292KY238000NRTINNRTIK65R, Y115F, M184VV108I, Y181CK49R, V60I, V90I, K122E, I135V, S162C, E169K, K173E, D177E, T200M, Q207E, R211K, H221YD
Kityo (2017)8295882958KY061522NRTINNRTIM41L, V75M, M184V, T215YV108IK49R, V60I, V90I, K102R, K103Q, D121HY, K122KE, I135T, E138R, S162N, I178L, T200I, Q207D, R211KD
 8357083570KY062124NRTINNRTIM184VV108I, G190AK43E, V60I, K102Q, D121Y, K122E, I135T, K173KN, V179VI, E203A, Q207E, R211K, H221YD
 8319083190KY061746NRTINNRTIM41L, M184V, L210W, T215YV108I, G190AE44D, A98AS, V118VI, K122E, E138Q, D177E, I178M, V179I, T200I, Q207E, R211KD
 8343083430KY061984NRTINNRTIM41L, D67N, T69D, V75M, M184V, T215YK103N, V108IK49R, V60I, D121H, K122E, I135T, T165L, K173KE, D177E, G196GE, T200I, Q207E, R211KD
 8339783397KY061951NRTINNRTIM41L, D67N, T69TADN, V75M, M184V, L210W, T215Y, K219NV108I, Y181CK43E, E44EA, K49R, E53EG, V60I, V118I, D121Y, K122E, D123E, S162D, D177E, I178M, V179I, G196E, T200A, E203EK, Q207E, H208HY, R211K, D218E, L228HD
 8356183561KY062115NRTINNRTIK65R, M184IV108I, Y181C, M230LK43N, K49R, V60I, S68G, V90I, D121Y, K122E, R125K, D177E, I178M, G196E, T200R, Q207E, R211KD
 8314783147KY061703NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108IP59PS, V60I, R78R*, E79ED, K101Q, D121Y, K122E, D123G, S162C, D177E, I178L, T200I, Q207D, R211K, L228HD
 6603566035KY061405NRTINNRTIM41L, M184V, L210LW, T215FYK103N, V108IV60I, K101KQ, D121H, K122E, I135T, D177E, T200TA, Q207E, R211KD
 8323283232KY061787NRTINNRTIM41L, T69D, M184V, L210W, T215YK103N, V108I, M230L, L234IK43E, S48T, K49R, V60I, D177E, I195L, Q207E, R211K, H221Y, L228HD
 2836328363KY061374NRTINNRTIM41L, T69D, M184V, L210W, T215YK103N, V108I, M230L, L234IV35T, E36D, T39R, K43E, S48T, K49R, V60I, D177E, I195L, Q207E, R211K, H221Y, L228H, V245K, D250E, A272P, L282C, L283I, R284K, I293VD
 8350783507KY062061NRTINNRTID67N, K70R, M184V, T215F, K219EK101H, V108I, Y181C, P236PLK49R, V60I, K64KR, V90I, K122E, I135IT, S162HN, D177E, G196E, Q207E, R211K, L228LRD
 8295382953KY061517NRTINNRTIM41L, L74I, M184V, L210W, T215Y, K219KRK103N, V108IK43N, E44D, S48ST, V60I, V118I, D121Y, K122E, I135L, S162ST, K166KR, D177E, I178M, G196E, T200TA, E203K, Q207DE, R211K, K223Q, L228HD
 8290782907KY061472NRTINNRTIM41L, L74I, M184V, L210W, T215YA98G, K103N, V108I, K238TK49R, V60I, D121HY, K122E, I135M, K173L, Q174K, D177E, V179L, G196E, T200A, E203ED, Q207T, R211N, L228RD
 8292882928KY061492NRTINNRTID67N, K70R, M184V, T215F, K219EK103N, V108I, K238TV60I, T69TN, K122E, D123N, E169D, D177E, I178M, T200M, E204K, Q207E, H208HY, R211K, D218ED
 6597165971KY061398NRTINNRTIM41L, D67N, K70R, V75VIM, M184V, T215F, K219EV108I, Y181CV60I, T69PS, D86DE, K102Q, I135T, I167V, K173KR, Q174QR, D177E, I178L, T200A, Q207E, R211K, D218E, L228HD
 8342283422KY061976NRTINNRTIK70GR, M184V, K219EK103N, V108I, Y181C, G190AK49R, V60I, K101KR, Q145V, D177E, I178M, T200I, E204K, Q207E, R211K, L228RD
 8345283452KY062006NRTINNRTIM41L, D67G, K70R, V75M, M184V, T215F, K219QK103N, V108I, Y181C, G190AK43E, K49R, V60I, T69N, K82KR, R83K, D121H, K122E, I135R, T165L, I167IV, E169D, P170L, D177E, T200KM, I202V, Q207E, R211K, L228HD
 8355483554KY062108NRTINNRTIK65R, M184VV108I, Y181CV60I, S68N, V90VI, D121H, K122E, I132V, S162A, D177E, Q207E, R211K, H221YD
 8354483544KY062098NRTINNRTIM184VK101E, K103KN, V108IK49R, V60I, K122E, D123E, I135V, E138G, T139TA, D177E, I178M, V179I, Q207E, R211KD
 8315583155KY061711NRTINNRTIM184V, T215YA98AG, K103N, V108I, Y181C, P225H, F227FLE44D, K49KR, V90VI, T200I, Q207E, R211KD
 8318483184KY061740NRTINNRTIM41L, M184V, L210W, T215YV108I, Y181CK43Q, E44EAD, K49R, V60I, A98AS, K102KR, D123E, S162D, D177E, I178L, G196E, E203K, Q207E, R211K, H221Y, L228RD
 8292982929KY061493NRTINNRTIM184V, L210LW, T215YV108I, Y181CK49R, V60I, S68SG, K122E, I135T, G196R, T200I, Q207EG, R211K, H221YD
 8330483304KY061859NRTINNRTIM41L, D67N, T69D, V75M, M184V, L210W, T215YK101E, V108I, G190AE44D, K49R, V60I, V106I, V118I, D121Y, K122E, D177E, V179I, V189I, Q207E, R211KD
 8296582965KY061529NRTINNRTID67N, K70R, L74I, M184V, T215I, K219QK103N, V108I, P225HK43E, K46Q, V60I, K122E, I135L, D177E, I178M, T200K, Q207E, R211KD
 8301183011KY061573NRTINNRTIM41L, D67N, T69D, V75I, M184I, L210W, T215Y, K219RV108I, Y181CK43E, E44D, K49R, V60I, V90I, V118I, D121H, K122E, S162N, T165I, D177E, I178V, V179VI, G196GE, I202V, Q207A, R211RK, H221YD
 8330083300KY061855NRTINNRTID67N, K70R, M184V, K219QK103N, V108IK49R, V60I, D121Y, K122E, D123E, A158S, D177E, T200I, Q207E, R211K, K223T, L228HD
 8348783487KY062041NRTINNRTIM41L, M184V, L210W, T215YK103N, V108IK43KQ, V60I, V118VI, K122E, I135T, T139M, I142T, D177E, I178M, T200TI, Q207E, R211KD
 8341283412KY061966NRTINNRTIM41L, D67N, K70R, V75M, M184V, L210W, T215Y, K219EK103N, V108I, G190AV60I, D121C, K122E, I135IT, S162SC, D177E, I178IL, T200M, Q207G, R211K, G231GCD
 8293082930KY061494NRTINNRTID67G, M184VK103N, V108IK49R, V60I, S68G, K102Q, T165L, E169D, T200A, Q207E, R211K, P236PHD
 8327183271KY061826NRTINNRTIM41L, D67N, M184V, L210W, T215YK103N, V108IK43E, E44A, K49R, V60I, V118I, K122E, T139K, E169D, D177E, I178M, T200I, Q207E, R211KD
 8325983259KY061814NRTINNRTIM41L, V75M, M184V, L210W, T215YA98G, V108I, Y181CK43E, E44A, K49R, V60I, K122E, D123N, S162N, D177E, I178M, V179I, T200A, Q207A, R211K, H221YD
 8313783137KY061694NRTINNRTIM41L, D67N, M184V, L210W, T215Y, K219NV108I, Y181C, F227LE44D, V60I, L109I, V111VIM, D121Y, K122E, Q174E, V179VI, I195IM, G196E, T200TAEK, I202V, E203K, Q207E, H208Y, R211K, D218E, H221YD
 8289582895KY061460NRTINNRTIM41L, D67N, T69D, K70R, V75M, M184V, L210W, T215YK103N, V108IE44D, K49R, E53D, V60I, V118VI, D121HY, K122E, I135T, D177E, I178M, V189I, T200IR, Q207E, R211K, K223QD
 8345483454KY062008NRTINNRTIM41L, M184V, T215FV108I, Y181CK43R, V60I, V90I, K122E, I135T, S162C, V179I, T200A, Q207E, R211K, F214L, H221YD
 8341183411KY061965NRTINNRTIM41L, D67N, K70R, V75L, M184V, T215F, K219QV108I, Y181CP59PS, V60I, T69N, K122KE, D123DN, T139R, G196GE, T200I, Q207E, R211K, F214L, D218DH, H221YD
 8351083510KY062064NRTINNRTIM184V, K219RV108I, Y181CV60I, D121H, K122E, I142V, D177E, I178IM, V179VI, T200I, Q207E, R211K, F214L, H221Y, L228HD
 6609166091KY061443NRTINNRTIM184VK103N, V108IK43KQ, K49R, I50V, V60I, A98S, V118VA, D121C, K122E, I135T, K173T, Q174K, D177E, I178ILM, T200A, Q207E, R211KD