<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation K103N
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 49
Isolates 59
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Richard (2004)RN_Pat9RNJLT08DAY556788AZT, 3TCEFVD67N, M184VK103NV35T, T39K, K43E, K49R, V60I, L92V, G93R, D121Y, K122E, I135T, I178M, T200AD
 RNJCR10RNJCR10AY556782AZT, 3TCEFVM41L, M184VK103NK20R, V35T, T39A, V60I, K122E, I135M, K166R, D177E, I178M, T200ID
 RNJCR55RNJCR55AY556784AZT, 3TC, D4T, DDI, ABCEFVL74V, M184VK103NE6D, K11H, K20R, V35T, T39D, V60I, D177E, I178M, T200AD
 RNJCR26RNJCR26AY556785AZT, 3TCNVPM184VK103NE6D, I31L, V35T, K43R, K49R, V60I, D121Y, K122E, S162C, D177E, I178MD
Non-B Workgroup (2005)UK1979UK1979AY9013703TC, D4T, AZTNVPM184VK103N, V108IV35T, V60I, D121H, K122E, I135R, D177E, E203K, Q207ED
 UK4834UK4834 AZT, 3TCEFVM184VK103NV35T, K49R, V60I, K122E, D123E, I135T, T165L, D177E, I178M, T200I, I202V, Q207E, R211KD
 UK4684UK4684AY901814AZT, 3TCEFVM184VK103NV35T, T39K, K43D, D121Y, K122E, D123E, I135T, S162A, D177E, I178M, T200M, Q207E, R211KD
 UK4902UK4902AY901831AZT, 3TCNVP K103NV35T, T39L, K49R, V60I, D121Y, K122E, I135T, I142M, T165I, T200I, Q207E, R211KD
 TK1003TK1003a AZT, 3TC, ABCEFV K103NV35T, T39LS, K49R, V60I, D121H, K122E, T200I, Q207G, R211K, P243S, V245K, A272P, K277R, L282C, L283I, I293VD
 TK1009TK1009 AZT, DDI, 3TC, D4T, ABCEFVM41L, T215FLL100LI, K103NL34I, V35T, T39M, S48T, V60I, L109LI, K122E, I142V, Q207E, R211K, L228H, V245Q, D250E, A272S, K277R, L282C, L283I, T286A, I293V, I326M, A327EQ, Q332P, G335DD
 TK1014TK1014 AZT, DDI, 3TC, D4T, ABCEFVD67N, K70R, K219HK103N, K238TP14PS, V35T, T39A, K43KE, V60I, V118VG, D121Y, K122E, D123E, I142IV, A158AS, D177E, I178M, T200R, E203K, Q207E, R211K, V245R, D250E, A272P, K275R, Q278H, L282C, T286A, I293V, E297EKD
 TK2005TK2005 D4T, 3TC, ABC, DDIEFVD67N, T69D, K70KR, L74V, M184V, K219QL100I, K103NV35T, K49R, V60I, K102E, D121DY, K122KE, I135T, T139K, S162Y, D177E, V189I, I202V, Q207E, R211K, T215X, L228H, V245K, D250E, T253N, A272P, K277R, L282C, L283I, T286A, A288T, I293V, E297KD
  TK2005b D4T, 3TC, ABC, DDI, TDF, AZTEFVD67DN, T69D, K70R, L74V, T215CY, K219QL100I, K103NV35T, K49R, V60I, K102E, K122KE, I135T, T139TK, I159IV, S162Y, D177E, V189VI, I202V, Q207E, R211K, L228H, V245K, D250E, T253TN, A272P, K277R, L282C, L283I, T286A, A288AT, I293V, E297KD
 TK2014TK2014 AZT, DDC, 3TC, DDI, D4T, ABCNVP, EFVM41L, L74V, V75M, M184V, L210W, T215Y, K219NK103N, Y181CA33AP, V35T, K49R, V60I, S68G, T69TI, D121Y, K122E, I135M, S162D, S163SN, D177E, I178L, V179I, Q207E, R211K, P243S, V245K, A272P, L282C, T286A, A288T, I293V, E297TD
 TK3003TK3003 AZT, 3TCNVPM184VK103NV35T, K49R, V60I, K102R, I135T, Q174R, D177E, I178M, T200M, Q207E, R211K, F214FL, L228LH, V245K, D250E, A272P, L282CD
 TK4015TK4016a AZT, 3TC, TDFEFVM184V, L210W, T215CK103NI31R, V35I, K49R, V60I, K101Q, K122E, D123S, I135L, D177E, I178M, T200A, Q207E, V245K, D250E, A272P, L282C, L283I, T286A, I293V, D324E, Q334RD
 TK4016TK4016a AZT, 3TCEFVM184V, L210W, T215CK103NI31R, V35I, K49R, V60I, K101Q, K122E, D123S, I135L, D177E, I178M, T200A, Q207E, V245K, D250E, A272P, L282C, L283I, T286A, I293V, D324E, Q334RD
 TK5003TK5003 AZT, 3TCNVPM184VK103NV35T, T39R, K43E, K49R, V60I, D121Y, K122E, D123E, I135IT, E169D, D177E, I178L, Q207G, R211K, V245K, D250E, A272P, K275R, K277R, Q278H, L282C, L283I, T286A, I293V, V317LD
Weber (2005)M85579M85579AY677595D4T, DDIEFV K103N, P225PHV35T, V60I, D121H, K122E, E138EG, D177E, I178M, V189VI, T200X, Q207EG, R211K, P243PS, V245K, D250E, A272P, K277R, L282C, L283I, T286A, I293V, I326VD
 F69976F69976AY714462D4T, 3TC, Unknown, ABCUnknown, EFV K103NV35T, V60I, K122E, I135T, I142T, E169D, R172K, D177E, I178L, Q197E, T200IM, E204K, Q207E, R211K, F214L, V245T, E248X, K249KR, D250DE, S251I, A272P, T286TA, I293V, I329VD
Baxter (2006)48-12251225-30417DQ877757NRTINNRTIM41L, D67N, T69D, L210W, T215CYK103N, V179VDV35T, K43E, K49R, V60I, K102Q, V118I, D121C, K122E, E169D, D177E, I178L, V189VIM, Q207E, R211K, P243S, V245K, D250E, A272P, I293V, Q334D, G335S, M357T, G359S, V365I, T369V, S379G, T386I, K390RD
 48-12501250-31215DQ877775NRTINNRTID67N, T69TADN, T215C, K219QK103NP4T, V35T, V60I, K104KN, V118I, D121H, K122E, I135T, Q174R, D177E, I178L, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, A288T, E297A, I329L, G335D, R356K, G359NS, V365I, A376S, T386I, K390RD
  1250-40809DQ877774NRTINNRTID67N, T69D, T215C, K219QK103NP4T, V35T, V60I, K101KQ, V118I, D121H, K122E, I135T, Q174R, D177E, I178L, Q207E, R211K, F214L, V245T, D250E, A272P, T286A, A288T, E297A, I329L, G335D, R356K, G359S, V365I, T369TA, A376S, S379SC, T386I, K390RD
 48-14321432-30818DQ877822NRTINNRTID67N, K70R, M184V, K219HK103N, K238TP14LS, V35T, T39A, K43E, V60I, F87FL, D121Y, K122E, D123E, D177E, I178M, T200R, E203K, Q207DE, R211K, V245R, D250E, A272P, K275R, Q278H, L282C, T286A, I293V, E297K, G335D, P345Q, F346Y, R356K, M357S, A360T, A371V, I375V, T377H, S379C, K390RD
 48-14391439-30929DQ877829NRTINNRTIM41L, L74V, L210W, T215YA98G, L100I, K103NV35T, T39K, K43E, E44D, K49R, V60I, K122E, Q174K, D177E, I178M, Q207E, R211K, V245Q, D250E, A272P, L282C, L283I, R284K, T286S, I293V, E297A, G335D, P345Q, F346Y, K347KR, R356K, A360T, T377Q, S379C, K390RD
Lwembe (2007)NYU3636MMAY02 RTI, ABC, 3TC, DDI, AZTRTI, EFV K103NV35T, E40D, K49R, V60I, K122E, D177E, I178M, T200I, Q207ED
  36MAUG02 RTI, ABC, 3TC, DDI, AZTRTI, EFVM184VK103NV35T, E40D, K49R, V60I, K122E, I135M, D177E, T200M, Q207ED
  36MAPR03 RTI, ABC, 3TC, DDI, AZT, D4TRTI, EFVT215FK103N, G190AV35T, E40D, K49R, V60I, K122E, D177E, T200R, Q207ED
  36MFEB04 RTI, ABC, 3TC, DDI, AZT, D4TRTI, EFVT215FK103N, G190AV35T, E40D, K49R, V60I, K122E, I135T, D177E, T200R, Q207ED
  36MAUG04 RTI, ABC, 3TC, DDI, AZT, D4TRTI, EFVT215FK103N, G190AV35T, E40D, K49R, V60I, K122E, I135T, D177E, T200R, Q207ED
 NYU7070MSEP02 NoneNVP K103NK32N, V35M, T39A, K49R, V60I, I135R, S162C, T200I, Q207E, R211KD
  70MJUN03 NoneNVP K103NK32E, V35M, T39S, K49R, V60I, I135R, S162C, T200I, Q207E, R211KD
  70MDEC03 AZT, 3TCNVPM184VK103NK32N, V35M, T39A, K49R, V60I, I135R, S162C, T200I, Q207E, R211KD
 NYU9090FMAR04 AZT, 3TCNVPM184VK103NK32I, V35T, K49R, V60I, D121Y, K122E, I135T, T139K, S162C, D177E, T200I, Q207G, R211KD
von Wyl (2007)1574818282EF449875NRTINNRTIM184VK103NV35T, T39Q, V60I, K122E, D123G, I135T, K173E, D177E, G196E, Q207ED
Church (2008)359642T359642TEU380727NoneNVP K103NV21I, V35T, V60I, K122E, D123S, S162A, D177E, I178M, Q207E, R211K, V245Q, E248N, T286A, A288S, E291D, V292I, I293V, D320E, D324ED
Hawkins (2009)P650ZZP650FJ931154D4T, 3TCNVPM184VK103NE28K, K32E, V35T, K49R, V60I, K122E, I135T, E169D, K173A, Q174K, D177E, I178L, G196E, T200A, E204Q, Q207E, L210M, R211K, F214L, V245K, D250E, A272P, T286A, I293V, Q334ED
 R61ZZR61FJ931300TDF, 3TCNVPK65R, M184IK103N, Y181CV35T, T39M, K49R, S68SDGN, V90I, K102R, K122E, T165I, D177E, I178M, Q207E, R211K, F214L, V245T, D250E, A272P, K277R, T286A, E297K, K311R, I329VD
Steegen (2009)BV123BV123-2EU8721393TC, D4TNVPM184VK103NV35T, T39A, E40D, K122E, D123N, D177E, T200I, Q207E, R211KD
Germanaud (2010)55055505 AZT, 3TCNVPM184VK103NK22N, V35T, V60I, K122E, I135L, E138A, K173N, Q174K, D177E, I178M, V179I, T200A, Q207A, R211KD
Hamkar (2010)3Ir-HIV-DR-03GU724806NRTINNRTIK70R, M184VK103N, P225HK11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 7Ir-HIV-DR-07GU724810NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
 11Ir-HIV-DR-11GU724814NRTINNRTIK70R, M184VK103N, P225HV10L, K11R, V35T, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, S251K, A272P, L283I, V292I, I293V, I326XD
 12Ir-HIV-DR-12GU724815NRTINNRTIK70R, M184VK103N, P225HK11R, V35R, K49R, V60I, I135T, S162C, D177E, I178L, V179I, T200I, Q207A, R211K, D250E, A272P, L283I, V292I, I293V, I326XD
Ndembi (2010)14318D_P114318GQ409566AZT, 3TCNVPM184VK103NV35T, T39R, K49R, V60I, D121Y, K122E, I135T, S162D, I178M, T200I, Q207E, R211KD
 DT2626_05_P12626GQ409607AZT, 3TCNVPM41L, M184V, T215YK103NP4Q, V35T, K43R, V60I, D121Y, K122E, I135IT, D177E, I178M, Q207E, R211K, L228RD
 DT2781_05_P12781GQ409608AZT, 3TCNVPM184VK103NK22R, V35T, V60I, D121C, K122E, I142M, D177E, I178M, T200A, Q207E, R211KD
 16535D_P116535GQ409634AZT, 3TC, D4TNVPM184VK103N, Y181CP14PS, K20R, V35T, T39V, K49R, V60I, T69N, K122E, S162H, E169A, D177E, I178M, Q207E, R211KD
Aghokeng (2011)SK9016-M18SK9016-M18HQ864355D4T, 3TCNVPM184VK103N, Y181YC, M230MLV35T, T39L, K49KR, V60I, D121H, K122E, D123E, I135T, Q207E, H221HY, V241VM, V245K, D250E, A272P, K277KR, T286A, A288T, E297KD
Fokam (2011)CIRCB-1519CIRCB-1519JQ796144AZT, 3TCNVPV75M, M184V, T215TSK103NE6K, T7P, P9A, K11Q, V21VI, V35T, K49R, V90I, K122E, D123N, I135T, E138EG, S162N, R172K, D177E, I178L, V179IT, Q182S, T200A, E204K, Q207E, R211K, F214L, D237E, V245K, D250E, A272P, V276VI, K281KR, L283LI, T286A, E297K, K311R, D324DE, Q334E, G335S, T338S, Y339W, R356K, R358K, G359S, A371TD
Reynolds (2012)C0776C0776-1JN652178AZT, 3TCEFV K103N, P225HE6ED, V8VI, K11S, V35T, T39A, E44ED, V60I, I135T, I142V, P170S, D177E, E194D, Q207E, R211K, V245K, D250E, A272P, K275R, K277R, Q278N, L282C, L283I, I293VD
 D0397D0397-1JN652179AZT, 3TCNVPM41L, M184IK103NP4K, V8I, V35I, G45E, V60I, S68G, D121H, K122E, I135T, D177E, I178L, T200I, Q207E, R211K, V245E, A272Q, V276I, L282C, L283I, T286A, I293VD
 D0710D0710-1JN652180AZT, 3TCNVPM41ML, M184V, T215YK103NK11KE, V35T, K49R, V60I, D121Y, K122E, D123P, S162D, D177E, I178M, T200M, Q207E, R211K, V245EK, D250E, A272P, T286A, I293V, E297QRD
 G0715G0715-1JN652194AZT, 3TCEFVM184VK103NV35T, K49R, V60I, K101Q, K122KE, D123A, E169D, D177E, I178M, Q207E, R211K, D250E, A272P, K277R, L282C, L283I, R284RG, T286A, I293VD
  G0715-2JN652208AZT, 3TC, TDF, FTCEFVD67N, M184VK103N, P225HE28K, V35T, K49R, V60I, K101Q, K122E, D123A, E169A, D177E, I178L, Q207E, R211K, D250E, A272P, K277R, L282C, L283I, T286A, I293VD
 J0594J0594-1JN652199AZT, 3TCEFVM184VK103N, P225PHV35T, V60I, D121H, K122E, I135ILM, K173R, D177E, I178M, T200I, Q207E, R211K, T215X, P243T, V245E, D250E, A272P, K277R, L282C, L283I, I293V, E297KD
  J0594-2JN652209AZT, 3TC, ABC, DDIEFVM41L, L74LI, M184V, L210W, T215YK103N, P225HV35T, V60I, D121H, K122E, I135L, K173R, D177E, I178M, T200I, Q207E, R211K, P243T, V245E, D250E, A272P, K277R, L282C, L283I, I293V, E297KD
 A0260A0260-1JN652169AZT, 3TCNVP K103NV35T, T39TA, K49R, V60I, D121C, K122E, I142T, D177E, I178M, T200R, Q207E, R211K, P243A, V245N, A272P, K277R, L282C, L283I, T286TA, I293VD
 B0708B0708-1JN652172NRTI, AZT, 3TCNNRTI, NVP, EFVK65RK103N, Y181C, M230LV35T, E40D, K49R, V60I, K122E, D123N, I159V, E169D, I178L, T200A, I202V, Q207E, R211K, K238R, V245K, A272S, L282C, L283I, I293VD

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