<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation K101E
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 23
Patients 51
Isolates 53
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK2025TK2025 D4T, 3TC, ABCNVPL74V, M184VK101E, Y181C, G190AK32R, V35M, E42EG, K43N, V60I, K122E, I135T, D177E, T200I, Q207E, R211K, V245EK, D250E, A272P, L282C, R284K, T286A, I293V, E297AD
  TK2025a D4T, 3TC, ABC, DDC, DDINVP, EFVM41L, L74VK101E, Y181C, G190AK32R, V35R, K43N, V60I, V118I, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, P321PQD
Weber (2005)M94371M94371AY677521AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV60I, K122E, D177E, I178L, V179I, T200I, Q207E, R211K, V245Q, E248N, D250E, A272P, L282C, R284K, E291A, I293VD
 01F868601F8686AY677603AZT, 3TCEFV, NVPM184VK101E, G190AK20R, W24WC, V35T, T39M, K49R, V60I, V90I, K122E, D177E, I178M, T200I, Q207E, R211K, V245K, E248D, D250E, A272P, K277R, L282C, L283I, T286A, A288P, I293V, E297K, S322AD
Baxter (2006)48-41654165-30410DQ878398NRTINNRTIM41L, D67N, K70R, T215F, K219QK101E, G190SV35T, K49R, V60I, T69TN, V90I, A98S, V118I, K122E, I135T, E138A, T165I, E169D, R172RK, D177E, I178L, V179X, Q197E, E203A, Q207E, R211K, F214L, L228H, V245T, D250E, A272P, K277R, T286A, E297KR, I329L, G335D, M357MT, G359S, A376T, S379C, T386A, A400TD
Lwembe (2007)NYU7979MFEB04 AZT, 3TCNVPV75M, M184VK101E, G190AE28A, V35T, T39A, E40D, T69S, R83G, D121H, K122E, I135T, K173S, Q174K, D177E, I178V, V179I, T200A, Q207A, R211SD
Church (2008)393395X393395XEU380748NoneNVP K101EV35T, K49R, V60I, D121H, K122E, D177E, I178M, T200I, Q207E, R211K, V245K, D250E, A272P, V276I, K277R, L282C, L283I, T286A, I293V, E297K, D324DND
Hawkins (2009)R348ZZR348FJ931375AZT, 3TCNVPD67DN, K70R, M184V, K219QK101E, G190AP4T, E6KQ, E28K, K32E, V35T, T39L, V60I, V118I, K122E, I135T, I142T, D177E, I178LV, T200A, Q207E, R211K, F214L, V245K, D250E, T286A, V292I, E297R, I329VD
Ndembi (2010)DT5712_04_P15712GQ409630AZT, 3TCNVPM184VK101E, G190AV35T, T39R, K43E, K49R, V60I, I142M, R143K, N147Q, K166R, I167M, E169D, D177E, T200I, Q207E, R211KD
Sigaloff (2011)HIV101849HIV101849JN132282AZT, 3TCNVPM41L, D67N, K70R, M184V, T215F, K219QK101E, G190A, K238NV35T, V60I, A98S, K122E, D123N, I135V, E138A, I142T, S162C, D177E, I178M, V179I, T200R, Q207E, R211K, L228H, V245E, D250E, A272P, K277R, L282C, L283I, T286A, I293V, E297AD
Afonso (2012)ANG32ANG32JN937045NRTINNRTID67G, K70R, L74I, M184V, T215F, K219QK101E, G190AP4N, I31L, V35T, T39A, E40D, K49R, V60I, S68G, V90I, D121C, K122E, E138G, E169D, D177E, I178L, G196E, T200A, E203D, E204K, Q207D, R211K, F214L, V245T, E248D, K249R, D250KD
Hamers (2012)CP076304778CP076304778JQ480235AZT, 3TCNVPM184VK101E, E138KQV35T, E40D, K49R, V60I, K122E, I135T, I142T, T165K, E169ED, D177E, I178M, V179I, G196K, T200I, I202V, Q207E, R211K, V245Q, A272P, K277R, L282C, T286A, A288G, I293VD
Kouri (2012)CU373-10CU373-10JQ585388NRTINNRTIM41L, D67N, F116Y, Q151M, M184V, T215FK101E, Y188LE28K, K32E, V35T, T39AS, K49R, V60I, V111I, K122E, E169D, P170L, K173Q, D177G, G196E, Q197K, Q207E, H208F, R211K, I244V, V245T, D250E, A272S, A288S, E297K, P313Q, I329V, Q334N, G335DD
 CU845-09CU845-09JQ585267NRTINNRTIM41L, V75VL, M184V, T215YA98AG, K101E, G190AV35T, V60I, K104KR, F116I, D121Y, K122E, I135T, P157PL, S162C, D177E, I178L, V179I, T200A, E204A, Q207E, R211K, V245A, D250E, A272P, T286A, E297R, L301I, V317T, I329V, G335D, E344DD
 CU25-10CU25-10JQ585358NRTINNRTIM41L, D67N, M184V, L210W, T215YK101E, Y181C, G190SE28EG, V35M, K43N, E44D, V106I, V111I, V118I, K122E, D123N, I135T, N136ND, Q174R, D177E, I178M, V189I, T200A, I202V, Q207D, H208Y, V245T, D250E, A272S, T286A, I293V, E297K, P313T, V317A, I329V, Q334DD
 CU749-09CU749-09JQ585263NRTINNRTIM41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219NK101E, Y181C, G190AV35T, V111I, D121Y, K122E, I135T, N137H, S162Y, D177E, I178L, V179VI, T200A, E204A, Q207E, R211K, V245T, D250E, A272S, K277R, T286A, E297K, P313S, V317A, I329V, G335DD
 CU2043-09CU2043-09JQ585337NRTINNRTID67N, M184V, K219QK101EV35T, N54NS, V60I, K122E, K166R, D177E, V179I, I202V, Q207E, V245Q, E248D, D250E, T286A, I329IVD
Reynolds (2012)B0715B0715-1JN652173AZT, 3TCNVPM184VK101E, G190AV21VI, E28K, K32E, V35T, T39TK, V60I, K82R, K122A, I135T, D177E, T200I, Q207E, R211K, F214L, V245K, D250E, A272P, K275R, L282C, I293V, E297AD
  B0715-2JN652205AZT, 3TC, TDF, FTCNVPM184VK101E, G190AV21I, E28K, K32E, V35T, T39K, V60I, K82R, K122A, I135T, D177E, T200I, Q207E, R211K, F214L, V245K, D250E, A272P, K275R, L282C, I293V, E297AD
 C0717C0717-1JN652177AZT, 3TCEFVM184VK101E, G190SK13KN, K32R, V35I, E40D, K49KR, T58TS, V60I, D121Y, K122E, D177E, I178M, V179I, E204K, Q207E, R211K, V245Q, I257L, A272P, K277R, L282C, T286A, V292I, I293VD
Sigaloff (2013)JCR111_0JCR111_0JX182003NRTINNRTIM184V, T215FK101E, G190AE28R, V35T, K49R, V60I, A98S, K122E, I135T, I142V, D177E, V179I, Q207E, R211K, V245Q, D250E, K277R, L282C, E297AD
 MBA049_0MBA049_0JX182019NRTINNRTID67DN, K70KR, M184VK101E, G190AV35T, T39A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, Q278H, L282C, I293V, E297QD
 JCR077_0JCR077_0JX181994NRTINNRTIM41L, T69D, K70KR, M184V, L210W, T215FK101E, Y181C, K238TV35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293VD
Kaleebu (2015)MSK-0089UGA-MSK-0089-2012 TDF, 3TCNVPK70EQ, M184MIVA98AG, K101E, Y181C, G190AV35T, K43KR, V60I, V90I, D121H, K122E, I135T, I142V, Q174QK, D177E, I178L, T200L, E203EK, Q207E, R211K, L228LR, V245K, D250E, A272P, L282C, T286V, I293V, E297AD
Meeme (2015)ML2572ML2572HM596828NRTINNRTID67N, M184VK101E, Y181C, G190AE28K, K32E, V35T, K49R, V60I, V118I, K122E, D123N, D177E, I178M, T200A, Q207E, L210X, R211K, T215X, D218VD
Meini (2015)112225112225KM438266AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV35T, T39L, V60I, S68SN, D121Y, K122E, I135T, D177E, I178M, T200I, Q207K, R211I, V245TD
 109261109261KM438245D4T, 3TC, DDINVPD67DN, K70KR, M184VK101E, G190AE6EK, V35T, K49R, V60VI, K122E, I135T, E169Q, D177E, I178M, Q207E, R211KD
Brooks (2016)2164A2164AKU900898TDF, 3TCNVPK65R, M184VK101E, Y181CFGV, G190GAV21I, V35T, E36EG, T39A, E40D, K49R, V60I, S68G, I135K, I142L, K173KE, D177E, I178M, V179VI, T200A, Q207K, R211KD
Inzaule (2016)1.0079.3.71.0079.3.7KR138541NRTINNRTIM184VK101E, G190AE6T, E28A, V35T, V60I, D121F, K122E, D177E, I178M, E203Q, Q207E, R211K, V245K, D250E, I257L, A272S, L282C, A288T, I293V, D324E, I329LD
Chaplin (2017)NJIH0256NJIH0256MF622807NRTINNRTIK70KR, M184V, T215F, K219QK101E, Y181C, G190AT7A, V21VI, E28EK, V35T, V60I, T69TN, K122E, D123DN, I135T, D177E, I178V, E204K, Q207D, R211K, F214L, L228R, V245H, D250ED
Kekitiinwa (2017)28229_27828229_278KY237813NRTINNRTIL74V, M184VK101E, G190SV35T, V60I, T69S, D121Y, K122E, D177E, I178M, T200M, R206K, Q207E, R211K, P243A, V245Q, D250E, A272P, L282C, L283I, T286A, I293VD
 65488_27865488_278KY237874NRTINNRTIT69GS, L74V, Y115F, M184VK101E, Y181YC, G190SV60I, D121H, K122E, I142IV, Q174QR, D177E, I178M, G196E, T200M, E204EK, R206RK, Q207E, R211KD
Kityo (2017)8305383053KY061612NRTINNRTIM41L, L74I, M184V, L210W, T215YK101E, G190AE44D, V60I, K122E, D123N, I135R, D177E, I178M, T200I, E203K, Q207DE, R211K, K223KED
 8352083520KY062074NRTINNRTID67N, K70R, M184V, T215F, K219QK101E, G190AK49R, V60I, T69N, E138A, S162D, E169K, K173E, V179I, T200I, Q207G, R211KD
 8348483484KY062038NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215YK101E, G190AK49R, V60I, I94L, V118I, D121Y, K122E, A158S, S162D, E169D, D177E, I178IM, V179VI, T200I, Q207E, H208Y, R211KD
 8292082920KY061484NRTINNRTIM41L, D67N, M184V, L210W, T215YK101E, G190SK43KQ, K49R, V60I, V90VI, V118I, K122E, I135T, D177E, I178M, T200IK, Q207E, R211KD
 8303983039KY061598NRTINNRTID67N, T69TADN, K70R, M184V, T215FYA98G, K101E, G190A, K238KTK46Q, K49R, V60I, K103KR, D121Y, K122E, I135L, E138A, S162A, E169D, D177E, I178M, T200R, Q207E, R211KD
 8354483544KY062098NRTINNRTIM184VK101E, K103KN, V108IK49R, V60I, K122E, D123E, I135V, E138G, T139TA, D177E, I178M, V179I, Q207E, R211KD
 8351983519KY062073NRTINNRTIM41L, D67DN, M184V, L210W, T215YK101E, G190AK49R, V60I, E138G, S162SC, T165L, E169D, D177E, I178IL, V179I, Q207E, R211KD
 8330483304KY061859NRTINNRTIM41L, D67N, T69D, V75M, M184V, L210W, T215YK101E, V108I, G190AE44D, K49R, V60I, V106I, V118I, D121Y, K122E, D177E, V179I, V189I, Q207E, R211KD
 8355783557KY062111NRTINNRTIK65R, M184MIVK101E, Y181C, G190A, P225PH, K238KTK46KQ, K49R, V60I, V90VI, K122E, D123DEG, I135IT, D177E, I178IM, V179VI, Q207E, R211KD
 8300283002KY061564NRTINNRTID67N, K70R, M184V, K219KHNQK101E, K238TK43E, K49R, P52PL, V60I, I94L, P97PL, A98S, D121H, K122E, I135T, E169D, D177E, I178M, T200R, E203K, Q207ED
 8340383403KY061957NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EA98AG, K101E, G190AK43KN, V60I, I94IL, D121H, K122E, D177E, I178L, V179I, E194D, T200M, E203A, Q207E, R211KD
 2865828658KY061391NRTINNRTIM41L, K70R, M184V, T215F, K219WK101E, Y181C, G190AV35I, K43KE, V60I, T69N, K102Q, V118I, D121Y, K122E, I135T, D177E, T200A, I202V, E204K, Q207E, H208HY, L210LS, R211RG, L228HR, V245K, D250E, A272P, T286A, I293VD
 8328583285KY061840NRTINNRTIM41L, M184V, L210LW, T215FYA98AG, K101E, G190AK43KQ, E44ED, V60I, V118VI, D121H, K122E, D177E, R211KD
 8304283042KY061601NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K101E, G190AK43KQ, E44D, V60I, I94L, V118I, D121Y, K122E, D123E, D177E, I178M, V179I, T200A, Q207E, R211KD
 6608166081KY061434NRTINNRTID67N, K70R, M184V, T215N, K219EQA98AG, K101E, G190ASK43A, K49R, V60I, D121H, K122E, I135T, E138A, T139V, E169D, D177E, V179I, T200M, I202V, Q207E, R211KD
 8290882908KY061473NRTINNRTID67A, K70R, M184V, T215F, K219EK101E, Y181C, G190AK49R, V60I, T69N, D121Y, K122E, S162SN, D177E, V179I, G196GE, Q207E, R211K, L228HD
 8308583085KY061643NRTINNRTIM41L, K70R, L74LI, M184V, T215F, K219QK101E, K103NK49R, V60I, T69S, D121Y, K122E, I135T, I142IV, D177E, V179L, G196GDE, T200R, Q207E, R211K, D218E, L228RD
Rhee (2017)829829KY353422TDF, 3TCNVPK65R, L74LI, Y115F, M184VK101E, Y181C, G190AV35T, K49R, V60I, S68SG, K103KR, K122E, D123N, I135T, T139V, D177E, I178M, T200M, E204Q, Q207G, R211KD
Svard (2017)1st_1091st_109KX775227AZT, 3TCEFVM41L, T69D, M184V, T215FK101E, V108I, Y181C, G190AV8I, K20R, E28R, K32E, V35T, K49R, V60I, V118I, D121C, K122E, T139TA, S162N, D177E, T200R, Q207E, L228H, K238R, Q242H, V245E, D250ED
 2nd_20232nd_2023KX7752733TC, D4T, TDF, FTCNVPM184V, T215FA98G, K101EV35T, T39A, V60I, S68G, D121Y, K122E, D123E, I135K, S162C, Q174K, D177E, I178M, T200M, Q207E, R211K, K238R, V245ED
 2nd_20332nd_2033KX7752783TC, D4T, TDF, FTCNVPM184V, L210W, T215Y, K219KQK101E, G190AE28R, K32E, V35T, K49R, V60I, A98S, D121Y, K122E, D123E, S162D, E169D, D177E, I178IM, V179I, T200K, Q207E, R211K, P243S, V245K, D250ED