<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype D
Gene RT
Mutation K101E
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 13
Patients 24
Isolates 26
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TK2025TK2025 D4T, 3TC, ABCNVPL74V, M184VK101E, Y181C, G190AK32R, V35M, E42EG, K43N, V60I, K122E, I135T, D177E, T200I, Q207E, R211K, V245EK, D250E, A272P, L282C, R284K, T286A, I293V, E297AD
  TK2025a D4T, 3TC, ABC, DDC, DDINVP, EFVM41L, L74VK101E, Y181C, G190AK32R, V35R, K43N, V60I, V118I, K122E, I135T, D177E, T200I, Q207E, R211K, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, P321PQD
Weber (2005)M94371M94371AY677521AZT, 3TCNVPD67N, K70R, M184V, K219QK101E, G190AV60I, K122E, D177E, I178L, V179I, T200I, Q207E, R211K, V245Q, E248N, D250E, A272P, L282C, R284K, E291A, I293VD
 01F868601F8686AY677603AZT, 3TCEFV, NVPM184VK101E, G190AK20R, W24WC, V35T, T39M, K49R, V60I, V90I, K122E, D177E, I178M, T200I, Q207E, R211K, V245K, E248D, D250E, A272P, K277R, L282C, L283I, T286A, A288P, I293V, E297K, S322AD
Baxter (2006)48-41654165-30410DQ878398NRTINNRTIM41L, D67N, K70R, T215F, K219QK101E, G190SV35T, K49R, V60I, T69TN, V90I, A98S, V118I, K122E, I135T, E138A, T165I, E169D, R172RK, D177E, I178L, V179X, Q197E, E203A, Q207E, R211K, F214L, L228H, V245T, D250E, A272P, K277R, T286A, E297KR, I329L, G335D, M357MT, G359S, A376T, S379C, T386A, A400TD
Church (2008)393395X393395XEU380748NoneNVP K101EV35T, K49R, V60I, D121H, K122E, D177E, I178M, T200I, Q207E, R211K, V245K, D250E, A272P, V276I, K277R, L282C, L283I, T286A, I293V, E297K, D324DND
Hawkins (2009)R348ZZR348FJ931375AZT, 3TCNVPD67DN, K70R, M184V, K219QK101E, G190AP4T, E6KQ, E28K, K32E, V35T, T39L, V60I, V118I, K122E, I135T, I142T, D177E, I178LV, T200A, Q207E, R211K, F214L, V245K, D250E, T286A, V292I, E297R, I329VD
Ndembi (2010)DT5712_04_P15712GQ409630AZT, 3TCNVPM184VK101E, G190AV35T, T39R, K43E, K49R, V60I, I142M, R143K, N147Q, K166R, I167M, E169D, D177E, T200I, Q207E, R211KD
Aulicino (2011)ARN272RLDARN272RLDFJ525856NRTINNRTIM41L, D67N, T69D, K70R, L74V, M184V, L210W, T215Y, K219HA98G, K101E, V108I, Y181C, G190AS3C, K20R, E28A, V35T, T39E, E44D, V60I, V90I, L109I, K122E, I135V, I142V, S162N, I167V, V179I, T200A, E203K, Q207E, H208Y, R211KD
Afonso (2012)ANG32ANG32JN937045NRTINNRTID67G, K70R, L74I, M184V, T215F, K219QK101E, G190AP4N, I31L, V35T, T39A, E40D, K49R, V60I, S68G, V90I, D121C, K122E, E138G, E169D, D177E, I178L, G196E, T200A, E203D, E204K, Q207D, R211K, F214L, V245T, E248D, K249R, D250KD
Kouri (2012)CU373-10CU373-10JQ585388NRTINNRTIM41L, D67N, F116Y, Q151M, M184V, T215FK101E, Y188LE28K, K32E, V35T, T39AS, K49R, V60I, V111I, K122E, E169D, P170L, K173Q, D177G, G196E, Q197K, Q207E, H208F, R211K, I244V, V245T, D250E, A272S, A288S, E297K, P313Q, I329V, Q334N, G335DD
 CU845-09CU845-09JQ585267NRTINNRTIM41L, V75VL, M184V, T215YA98AG, K101E, G190AV35T, V60I, K104KR, F116I, D121Y, K122E, I135T, P157PL, S162C, D177E, I178L, V179I, T200A, E204A, Q207E, R211K, V245A, D250E, A272P, T286A, E297R, L301I, V317T, I329V, G335D, E344DD
 CU25-10CU25-10JQ585358NRTINNRTIM41L, D67N, M184V, L210W, T215YK101E, Y181C, G190SE28EG, V35M, K43N, E44D, V106I, V111I, V118I, K122E, D123N, I135T, N136ND, Q174R, D177E, I178M, V189I, T200A, I202V, Q207D, H208Y, V245T, D250E, A272S, T286A, I293V, E297K, P313T, V317A, I329V, Q334DD
 CU749-09CU749-09JQ585263NRTINNRTIM41L, D67N, L74I, V75T, M184V, L210W, T215Y, K219NK101E, Y181C, G190AV35T, V111I, D121Y, K122E, I135T, N137H, S162Y, D177E, I178L, V179VI, T200A, E204A, Q207E, R211K, V245T, D250E, A272S, K277R, T286A, E297K, P313S, V317A, I329V, G335DD
 CU2043-09CU2043-09JQ585337NRTINNRTID67N, M184V, K219QK101EV35T, N54NS, V60I, K122E, K166R, D177E, V179I, I202V, Q207E, V245Q, E248D, D250E, T286A, I329IVD
Reynolds (2012)B0715B0715-1JN652173AZT, 3TCNVPM184VK101E, G190AV21VI, E28K, K32E, V35T, T39TK, V60I, K82R, K122A, I135T, D177E, T200I, Q207E, R211K, F214L, V245K, D250E, A272P, K275R, L282C, I293V, E297AD
  B0715-2JN652205AZT, 3TC, TDF, FTCNVPM184VK101E, G190AV21I, E28K, K32E, V35T, T39K, V60I, K82R, K122A, I135T, D177E, T200I, Q207E, R211K, F214L, V245K, D250E, A272P, K275R, L282C, I293V, E297AD
 C0717C0717-1JN652177AZT, 3TCEFVM184VK101E, G190SK13KN, K32R, V35I, E40D, K49KR, T58TS, V60I, D121Y, K122E, D177E, I178M, V179I, E204K, Q207E, R211K, V245Q, I257L, A272P, K277R, L282C, T286A, V292I, I293VD
Pircher (2013)B1145B1145JX110243D4T, 3TC, AZTNVPM41ML, T69DN, K70KR, M184V, T215TNSYK101E, V108I, F227L, M230LV35T, V60I, K122E, D123N, E138A, D177E, I178M, T200E, I202IV, Q207K, R211A, H221Y, L228LH, V245KD
Sigaloff (2013)JCR111_0JCR111_0JX182003NRTINNRTIM184V, T215FK101E, G190AE28R, V35T, K49R, V60I, A98S, K122E, I135T, I142V, D177E, V179I, Q207E, R211K, V245Q, D250E, K277R, L282C, E297AD
 JCR092_0JCR092_0JX181997NRTINNRTID67N, K70R, M184V, K219QK101E, G190AV35T, T39A, E40D, V60I, K122E, D123S, I135T, E138A, I202V, Q207A, R211S, F214L, V245M, D250E, A272P, K277R, K281R, L282C, L283I, T286A, I293VD
 MBA049_0MBA049_0JX182019NRTINNRTID67DN, K70KR, M184VK101E, G190AV35T, T39A, V60I, D121Y, K122E, I135T, D177E, I178M, V179I, Q207E, R211K, F214L, V245E, D250E, A272P, K277R, Q278H, L282C, I293V, E297QD
 MBA043_0MBA043_0JX182016NRTINNRTID67N, K70R, M184V, T215F, K219EK101E, G190AV35T, T39L, D121Y, K122E, D177E, I178V, E204Q, Q207E, V245K, D250E, A272P, I274L, K275R, Q278N, T286AD
 MBA031_0MBA031_0JX182013NRTINNRTID67N, K70R, M184V, T215F, K219EK101E, G190AV35T, T39L, D121Y, K122E, D177E, I178V, E204Q, Q207E, V245K, D250E, A272P, I274L, K275R, Q278N, T286AD
 JCR077_0JCR077_0JX181994NRTINNRTIM41L, T69D, K70KR, M184V, L210W, T215FK101E, Y181C, K238TV35T, V60I, V118VI, D121Y, K122E, I135R, D177E, V179I, Q207E, R211K, L228R, V245K, D250E, I257L, A272P, K281R, L282C, T286A, E291A, I293VD
Wallis (2014)4108241082KM458607NRTINNRTIA62AV, K70KN, V75T, M184VK101E, Y181C, G190AV35I, K49R, T69TN, D121CY, K122E, E169D, T200M, Q207E, R211KD