<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation K238T
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 44
Isolates 44
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)PL5219498672 3TC, D4TEFVD67N, T69D, K70R, M184V, K219QK103N, V179E, K238TK20R, V35T, E36A, V60I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, E203K, Q207E, F214L, V245Q, S268C, A272P, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
Laurent (2006)CK22-7503CM2-75AM279460AZT, DDI, D4T, 3TCEFVD67N, K70R, M184V, T215F, K219EK103N, V108I, K238TV35T, T39L, K64R, D123E, I135T, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, S322T, I326V, G335D, R356K, M357K, R358K, G359S, K366R, T369V, A371V, I375V, K388R, K390R, K395R, E399D, A400T, T403M, E413D, E432DCRF02_AG
Hawkins (2009)Q186ZZQ186FJ931195D4T, 3TCNVPV75I, M184VA98G, K103N, K238TV35T, E53D, I132L, S162A, K173A, Q174K, D177E, G196E, T200A, Q207E, V245E, K281R, T286TA, V292I, I293V, E297K, S322TCRF02_AG
 Q584ZZQ584FJ931252D4T, 3TCNVPM184V, T215YK103N, K238TV35T, E36D, T39M, K49R, K122E, D123K, I135V, S162A, K166N, E169K, K173T, D177E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R118ZZR118FJ931314D4T, 3TCNVPM184V, T215YK103N, K238TK20R, V35T, E36D, I47L, K49R, E53D, V60I, K122E, D123E, I135V, A158AS, S162ADE, Q174A, D177E, T200A, Q207E, R211K, V245E, T286A, V292I, I293V, P294T, E297KR, S322T, I326VCRF02_AG
 R234ZZR234FJ931429D4T, 3TCNVPD67DN, K70R, M184V, K219QA98AG, K103N, K238TV35T, K49R, V60I, V90I, D123E, I135V, S162A, E169R, R172T, K173T, Q174E, D177E, T200A, E203EK, Q207E, R211K, V245Q, S251SN, K275KR, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
 R235ZZR235FJ931430D4T, 3TCNVPM184VK103N, K238TV35T, T39L, S68SG, V90I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, E203ED, Q207E, H221Y, V245Q, E248N, K277R, T286A, E291D, V292I, I293V, P294PT, S322TCRF02_AG
Charpentier (2011)CR-45CR-45FJ688251AZT, 3TCNNRTIM41L, D67N, K70R, M184V, T215Y, K219QA98AG, K103N, P225H, K238TK11A, T27S, E28EK, V35T, T39K, K43Q, V60I, I135V, S162A, K173T, D177E, I178M, T200A, Q207E, R211K, V245Q, D250E, S251N, L260I, A272P, K275R, K277R, Q278H, K281R, T286A, A288AT, I293V, E297A, S322TCRF02_AG
 CR-31CR-31FJ688237AZT, 3TCNNRTIK65R, D67N, T69~, V75VI, F77L, Q151M, K219EK103KN, Y181C, G190A, F227FL, K238TL34I, V35T, T39M, E40D, S68G, K101Q, K122E, I135IM, S162A, R172K, K173A, Q174K, N175Y, D177E, T200E, K201R, E203Q, Q207DN, F214L, K223EQ, L228LR, V245E, K249KR, T286A, E291D, I293V, P294T, S322ACRF02_AG
 CR-38CR-38FJ688244AZT, 3TCNNRTID67N, K70R, V75A, M184V, T215Y, K219QK103N, V108I, K238TV35T, E36D, K46Q, K49R, K73M, K122E, D123S, I135V, S162A, T165I, K173T, Q174K, N175Y, D177E, T200A, K201KR, Q207E, R211K, F214FL, H221Y, L228LH, V245Q, K275R, L283I, T286A, E291D, V292I, I293V, P294T, E297EK, E312A, S322ACRF02_AG
Fokam (2011)CIRCB-11745CIRCB-11745JQ796181D4T, 3TCNVPM184V, T215YK103N, K238TK20KR, V35T, S68SG, K122E, I135T, Q151QH, G155GR, S162SA, K173T, Q174K, D177E, T200A, E203D, Q207NY, R211T, V245Q, T286AS, E291ED, I293V, P294PT, S322ACRF02_AG
Aghokeng (2013)HJ3003HJ3003JX983005NRTINNRTIM184V, T215I, N348IK103N, K238TI31L, V35T, K43KT, V90I, K122E, I135IV, S162A, K173T, Q174K, D177E, T200A, Q207E, V245M, A272P, T286A, E291D, V292I, I293V, P294I, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375IV, S379SG, K390R, A400T, T403MCRF02_AG
Kebe (2013)SNA3-242SNA3-242HM002530AZT, 3TCNVPD67N, K70R, M184V, T215F, K219EK103N, Y181C, K238TV35T, E36D, T39A, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, A272PCRF02_AG
Nii-Trebi (2013)KF131KF131AB751484AZT, 3TCNVPM184V, T215YA98G, K103N, K238TV35T, V60I, S68G, D121Y, K122E, D123E, I135V, K173T, Q174K, N175NY, D177E, T200A, Q207E, R211K, V245Q, E248D, V261ICRF02_AG
 KF205KF205AB751487AZT, 3TCNVPD67N, K70R, M184V, T215YK103N, K238TK20R, V35T, V60I, I135V, S162T, K173M, Q174K, D177E, I178M, T200A, E203D, Q207E, R211K, P243T, V245QCRF02_AG
Rawizza (2013)PJ9681PJ9681KF241511NRTINNRTIA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219EK103N, V108I, K238TP14A, D17DE, V35T, E36D, E40K, K43Q, K46Q, K49R, T58N, S68G, K122E, D123N, I135IV, S162T, K173T, Q174K, D177E, I178IM, T200A, E203EK, Q207E, R211K, I244IT, V245E, A272P, Q278N, L283I, E291D, V292I, I293V, P294A, S322T, D324ECRF02_AG
Thiam (2013)2523-HALD2523-HALDJN673683NRTINNRTIV75I, M184V, T215YK103N, K238TV35T, G45GR, I132L, Y144X, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, V245Q, E291D, V292I, I293V, P294T, E312D, S322A, I326V, K331NCRF02_AG
 3249HALD3249HALDJX187618NRTINNRTIM184VA98G, K103N, K238TP4S, V35T, V60I, D123E, I135L, S162A, K173R, Q174K, D177E, G196E, T200A, Q207E, R211K, F214L, V245QCRF02_AG
 2594-HALD2594-HALDJN673691NRTINNRTID67N, K70G, M184V, T215IV, K219QK103N, V179E, K238TV35T, T39N, V60I, K64R, V90I, K122E, D123N, I135T, E138A, S162A, T165L, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K275R, T286A, A288T, E291D, V292I, I293V, P294T, S322T, D324DE, I326VCRF02_AG
Aghokeng (2014)CM-1-300CM-1-300KC350095NRTINNRTIL74LIV, M184V, T215FL100LI, K103N, K238TK20R, V35T, E36D, T39A, K122E, D123S, S162D, K173T, Q174R, D177E, I178IM, T200A, Q207E, R211K, P243T, V245K, D250E, K281R, T286A, E291D, V292I, I293V, P294TCRF02_AG
 CM-3-155CM-3-155KC350347NRTINNRTIV75I, F116Y, Q151M, M184VK103N, P225H, K238TA33AV, V35T, E36D, S68SG, K122E, D123S, S162A, K173T, Q174K, N175Y, D177E, I178IM, T200A, R211A, V245Q, E248D, K281KR, T286A, E291D, V292I, I293V, P294T, S322A, I326V, Q334H, G335DCRF02_AG
 TG-3-595TG-3-595KC350289NRTINNRTIM41ML, M184V, L210LRW, T215YA98G, K103N, K238TK11N, K20KR, V35T, E36D, V60I, D123N, I135L, E138Q, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, E297K, V317VA, S322T, I329V, K331KE, R356K, M357R, G359S, A360AT, T369V, A371V, Q373H, S379G, K390R, T403MCRF02_AG
 BF-1-106BF-1-106KC350372NRTINNRTIM184V, L210LRW, T215YK103N, K238TV35T, K122E, I135V, S162T, K173I, Q174K, D177E, I178M, T200A, Q207ECRF02_AG
 TG-3-141TG-3-141KC350209NRTINNRTIM184VK103N, K238TV35K, T39A, V60I, I135L, S162A, K173A, Q174K, N175Y, D177E, G196E, T200A, Q207E, V245E, K277R, L283I, V292I, I293V, S322A, G335D, R356RK, M357R, G359S, A371V, I375V, S379C, K390R, A400AITV, E413DCRF02_AG
 CI-1-559CI-1-559KC350403NRTINNRTIM184VK103N, K238TV35T, V60I, D121DN, I135M, S162A, E169G, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214LCRF02_AG
Jenabian (2015)DR25DR25KF735831NRTINNRTIK219RK103N, V179E, P225H, K238TV35T, T39L, V60VI, V90I, K122E, D123N, I135V, E138G, S162A, T165I, K173T, Q174K, D177E, T200TA, Q207E, D237N, V245Q, T286A, E291D, V292I, I293V, P294V, S322T, I326V, G335DCRF02_AG
 DR04DR04KF735815NRTINNRTIM41L, D67N, M184V, L210W, T215YK103NS, K238TV35T, E44D, K49KR, V60I, V111I, K122KE, I135T, S162A, K173T, Q174K, D177E, I178L, T200E, E203Q, Q207D, H208Y, R211K, V245K, A272P, T286A, I293V, P294T, S322A, G335DCRF02_AG
Konou (2015)H406H406KT316175NRTINNRTIM184VK103N, K238TV35T, V60I, V90I, K122E, D123N, I135V, E138G, S162A, T165L, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, V245QCRF02_AG
 H1592H1592KT316165NRTINNRTID67N, K70R, M184V, K219QK103N, P225H, K238TP1S, V35T, T39N, S162A, E169Q, K173T, Q174K, D177E, I178M, V189I, T200A, Q207E, R211A, F214L, L228H, D237N, V245QCRF02_AG
 H1421H1421KT316108NRTINNRTID67N, K70R, M184V, T215F, K219QK103N, P225H, K238TK20R, V35T, A98S, D123E, I135T, S162A, Q174N, D177E, T200A, I202V, Q207E, R211K, V245QCRF02_AG
 H464H464KT316065NRTINNRTIM184VK103N, P225H, K238TE28EK, V35T, E36D, K122E, D123E, I135V, S162A, K173T, Q174K, D177E, G196E, T200A, Q207E, R211K, V245QCRF02_AG
 H366H366KT316040NRTINNRTIM184VA98G, K103N, K238TE28K, K32KR, V35T, E40D, K101A, K122P, S162A, K173T, Q174N, D177E, T200A, Q207E, V245QCRF02_AG
 H854H854KT316038NRTINNRTID67N, K70R, M184V, T215I, K219EK103N, V108I, Y181YC, K238TE28Q, V35T, K43KR, V60I, V90I, D123E, I135T, S162A, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, L228H, V245KCRF02_AG
 H453H453KT316021NRTINNRTIM184VK103N, P225H, K238TV35T, E36D, V90I, D121Y, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, Q207E, R211K, V245QCRF02_AG
 H437H437KT316011NRTINNRTID67N, K70R, M184V, T215F, K219QK103N, K238TV35T, T39L, K46KQ, V90I, D121H, K122E, I135V, E138Q, S162A, Q174X, D177E, T200A, Q207E, V245QCRF02_AG
 H277H277KT316005NRTINNRTID67N, T69D, K70R, M184V, T215F, K219QK103N, P225H, K238TE28EA, V35T, E36D, V60I, A98S, K122P, S162A, K173A, Q174K, N175Y, D177E, T200E, E203K, Q207E, P243T, V245QCRF02_AG
Steegen (2016)GFGPB121GFGPB121KU127917AZT, 3TCEFV, NVPM41L, M184V, T215FA98G, K103N, K238TV35K, V60I, S68G, D123E, S162A, K173T, Q174K, D177E, T200A, Q207G, V245E, K249KT, D250E, S251D, A272P, K281R, T286A, E291D, I293V, P294T, S322T, G335D, R356K, M357R, G359S, T369V, A371V, I375V, A376S, K390R, K395R, A400T, T403M, E432DCRF02_AG
Chaplin (2017)NJIH0382NJIH0382MF622933NRTINNRTIM41L, D67N, M184V, L210W, T215YA98G, K103N, K238TK20R, V35T, T39K, K43E, E44D, V60I, V111I, D121H, K122E, K166KQ, K173T, Q174R, D177E, I178L, T200A, Q207E, H208HY, R211K, V245Q, D250E, S251NCRF02_AG
 NJIH0318NJIH0318MF622869NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EK103N, K238TV35K, T39A, E44D, S48T, V60I, A98S, D123E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, L210S, R211K, L228H, V245QCRF02_AG
 NJIH0317NJIH0317MF622868NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EK103N, K238TV35K, T39A, S48T, V60I, D123E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245QCRF02_AG
 NJIH0238NJIH0238MF622789NRTINNRTIM184VK103N, K238TV35T, E36D, T39K, E53D, V60I, S68G, V90I, I135V, T139M, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, V245ECRF02_AG
 NJIH0212NJIH0212MF622763NRTINNRTIM184V, T215YA98G, K103N, K238TV35T, E36D, V60VI, S68SG, I135V, S162T, K173X, Q174K, N175NY, D177E, I178M, G196E, T200A, K201X, E203ED, Q207E, R211K, P243H, V245E, S251HCRF02_AG
 NJIH0094NJIH0094MF622645NRTINNRTIK70E, M184I, K219RK103N, P225H, K238TV35T, T39Q, E40D, V90I, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, L228RCRF02_AG
 NJIH0093NJIH0093MF622644NRTINNRTIK70KE, M184IK103N, P225H, K238TV35T, T39Q, E40D, V90I, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, L228LR, V245E, T286A, E291D, V292I, I293V, P294T, L310I, K311R, S322T, I326V, G335DCRF02_AG