<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation P225H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 37
Isolates 43
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patSER00_SER718AJ578159AZT, DDC, D4T, 3TC, DDI, ABCEFVA62V, K65R, V75I, F77L, F116Y, Q151M, M184VK103N, P225HK20R, V35T, T39A, E40D, S68G, T69I, R125K, I135L, S162A, T165A, K173T, Q174K, T200A, I202V, Q207DCRF02_AG
Non-B Workgroup (2005)PL4113170774AY9017023TC, D4TEFVM184VA98AG, K103N, P225HV35M, E36D, T39A, K102KR, K122KE, I135LV, K173IM, Q174K, D177E, T200A, Q207EK, R211K, V245Q, T286A, E291D, V292I, I293V, P294A, L295X, S322T, I326VCRF02_AG
 TK1006TK1006a AZT, DDI, 3TC, D4T, ABCEFVM184VK103N, P225HT27S, V35T, T39TA, D123E, S162SA, K166KR, K173T, Q174E, D177E, I178M, T200A, E204R, Q207E, R211K, V245Q, K275R, K277Q, T286A, E291D, V292I, I293V, P294TCRF02_AG
  TK1006b AZT, DDI, 3TC, D4T, ABCEFVM184MV, K219KRK103N, P225HT27S, V35T, T39TA, D123E, K166KR, K173KT, Q174E, D177E, I178M, T200A, E204R, Q207E, R211K, V245Q, K275R, K277Q, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
  TK1006c AZT, DDI, 3TC, D4T, ABCEFV K103N, P225HT27S, V35T, D123E, S162A, K166KR, Q174E, D177E, I178M, V179VM, T200A, E204R, Q207E, R211K, V245Q, K275R, K277Q, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
 PL54810105668 AZT, 3TCEFVM184VK103N, P225HV35T, E36D, I135V, S162T, Q174K, D177E, T200A, Q207EG, R211K, V245Q, T286A, E291D, V292I, I293V, P294A, S322T, I326V, K331NCRF02_AG
Laurent (2006)CK2-2902CM-29AM279440AZT, 3TCEFVM184VK103N, P225HV21I, V35T, E36A, K122E, D123G, A158S, S162A, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, T369V, A371V, I375V, A376S, K390R, A400T, T403L, V435ICRF02_AG
Seyler (2007)205CS_205 AZT, 3TCEFVK70R, M184V, T215TFIS, K219QK103N, P225H, M230LV35T, E36A, T39K, K43E, K64KR, T69TAS, D123E, S162A, K173A, Q174K, D177E, T200TA, Q207A, R211K, L228R, P243H, V245QCRF02_AG
Zhong (2007)D000805CN_008EF199556NRTINVPM41L, T215YK103N, P225HL34I, V35T, T39K, K43E, V90I, K122E, D123S, I178M, K238R, V245E, V254A, N255DCRF02_AG
Sylla (2008)A1068A1068_C1DQ991621D4T, 3TCEFVM184VK103N, P225HI31L, V35T, E40D, K49R, I50V, K122P, S162A, E169K, K173T, Q174E, D177E, I178M, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357R, G359S, E370G, A371V, A376S, T377M, T386I, K390R, K395R, T403M, E432D, V435I, R461K, V467I, D471E, Q480H, L491S, K512S, L517I, S519N, Q520L, Q524E, K527G, E529D, A534SCRF02_AG
  A1068_C2DQ991622D4T, 3TCEFVM184VA98G, K103N, P225HI31L, V35T, E40D, K49R, I50V, K122P, S162A, E169K, K173T, Q174E, D177E, I178M, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357R, G359S, E370G, A371V, A376S, T377M, T386I, K390R, K395R, T403M, E432D, V435I, R461K, V467I, D471E, Q480H, L491S, K512S, L517I, S519N, Q520L, Q524E, K527G, E529D, A534SCRF02_AG
 A1177A1177_C1DQ991623AZT, 3TCEFVM184VK103N, P225HK20R, V35T, E36D, V60I, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, L228R, P243T, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376T, V381I, K390R, A400T, T403M, E432DCRF02_AG
  A1177_C2DQ991624AZT, 3TCEFVM184VK103N, P225HK20R, V35T, E36D, V60I, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, L228R, P243T, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376T, V381I, K390R, A400T, T403M, E432DCRF02_AG
 A2546A2546_C1DQ991629AZT, 3TCEFV, NVPM184V, T215FK103N, Y181C, P225HV35T, S68G, K122E, I135V, S162T, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V241I, P243T, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403R, E432D, V435M, V467I, T470S, D471E, Q480H, L491SCRF02_AG
  A2546_C2DQ991630AZT, 3TCEFV, NVPM184V, T215FK103N, Y181C, P225HV35T, S68G, K122E, I135V, S162T, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V241I, P243T, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403R, E432D, V435MCRF02_AG
 A2628A2628_C2DQ991634AZT, 3TCEFVM184VK103N, P225HV35T, K101Q, I135V, T139A, K173T, Q174K, D177E, I178M, I195L, T200A, Q207D, R211K, V245Q, E248D, T286A, V292I, I293V, S322A, I326V, G335D, Y342F, R356K, M357K, G359S, A371V, I375V, K390R, K395R, A400T, T403M, I411L, K431T, E432DCRF02_AG
 A2840A2840_C1DQ991637D4T, DDI, AZT, 3TCEFVM184VK103N, P225HV35T, E36D, K122E, I132V, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, T286A, V292I, I293V, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R, A400T, E432D, A446S, R448K, D471E, Q480H, H483Y, L491S, E492TCRF02_AG
  A2840_C2DQ991638D4T, DDI, AZT, 3TCEFVM184V, T215FK103N, P225HV35T, E36D, K122E, D123N, I132V, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, T286A, V292I, I293V, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R, A400T, E432D, A446S, R448K, D471E, Q480H, H483Y, L491S, E492TCRF02_AG
 A013A013_C2EF525644AZT, 3TCEFVM184V, N348IK103N, P225HV35T, E36D, I159L, S162A, K173T, Q174K, D177E, T200A, Q207E, V245K, E248D, D250E, S251H, A272P, K281R, T286A, V292I, I293V, P294T, R307K, S322T, I326V, G335D, R356K, M357Q, G359S, A371V, I375V, A376S, K390R, A400T, T403R, E432D, V435MCRF02_AG
Hawkins (2009)R132ZZR132FJ931328TDF, 3TCEFVL74I, M184VK103N, V179E, P225HK20R, V35T, E36D, V60I, D123E, I135V, E138G, S162A, K173I, Q174K, D177E, I178L, T200A, R211K, P243T, V245Q, E248D, K277R, T286A, E291D, V292I, I293V, P294T, L295M, S322TCRF02_AG
 R440ZZR440FJ931450NRTIEFV, NVPD67N, K70R, M184V, T215FSK103N, P225H, M230MLP4S, K20R, V35T, T39A, I135L, S162A, E169D, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, A272P, L283I, T286A, I293V, P294TCRF02_AG
Burda (2010)07BDHS07707BDHS077GQ344980D4T, 3TCNVPD67N, K70R, L74I, M184V, T215Y, K219EV106A, P225H, F227LV35T, R78P, L109I, K122E, I135V, S162A, K173I, Q174K, D177E, T200A, I202V, R211K, A272P, K275R, K277R, T286A, I293V, P294T, S322V, G335D, M357K, G359S, A371V, I375V, I382L, K390R, A400T, T403Q, E432D, V435E, A437VCRF02_AG
Charpentier (2011)CR-12CR-12FJ688218AZT, 3TCNNRTIM41ML, M184V, T215TNSYK103N, P225HI31L, V35T, T39A, E44ED, V60I, K122E, S162AT, K173T, Q174K, N175NY, D177E, T200A, Q207E, L228LHQR, V245Q, E248D, A272P, L283LI, T286A, E291D, V292VI, I293V, P294TCRF02_AG
 CR-45CR-45FJ688251AZT, 3TCNNRTIM41L, D67N, K70R, M184V, T215Y, K219QA98AG, K103N, P225H, K238TK11A, T27S, E28EK, V35T, T39K, K43Q, V60I, I135V, S162A, K173T, D177E, I178M, T200A, Q207E, R211K, V245Q, D250E, S251N, L260I, A272P, K275R, K277R, Q278H, K281R, T286A, A288AT, I293V, E297A, S322TCRF02_AG
 CR-28CR-28FJ688234AZT, 3TCNNRTIM41L, L74I, M184V, L210W, T215Y, K219KNA98G, K103N, P225H, M230LS3C, E6A, V35T, T39A, K43E, E44A, K64KR, K122E, S162A, I167IV, K173I, Q174K, D177E, I178M, T200A, Q207E, Q242QK, P243H, V245E, L283I, T286A, E291D, I293V, P294T, S322TCRF02_AG
 CR-17CR-17FJ688223AZT, 3TCNNRTIM41L, V75I, M184V, L210LRW, T215YK103N, P225HV35T, T39A, E44ED, V60I, V90I, K122E, D123DN, I132L, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, L228N, V245K, D250E, L283I, T286TS, A288T, E291D, V292VI, I293V, P294T, S322ATCRF02_AG
 CR-25CR-25FJ688231AZT, 3TCNNRTIM184V, T215YK103N, P225HE28KR, V35T, E36D, V60I, S68G, K101Q, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294T, E297EK, S322T, I326VCRF02_AG
 CR-6CR-6FJ688213AZT, 3TCNNRTIK70R, M184VK103N, P225HK11T, V35T, T39L, K64R, K82KNT, D123S, Q174E, D177E, T200A, Q207E, V245K, K277R, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
Aghokeng (2013)HJ3389HJ3389JX983004NRTINNRTIM41L, M184V, L210W, T215YA98G, K103N, V108VI, P225HS3C, I5V, V35T, T39N, S48E, V60I, L109I, K122E, D123N, I135V, S162A, S163T, K173T, Q174K, D177E, I178M, T200A, E204Q, Q207E, R211KN, V245Q, A272P, K275R, T286A, A288T, E291D, V292I, I293V, P294T, S322A, I326V, G335D, R356K, M357R, R358K, G359S, A371V, I375V, K390R, A400T, T403M, E404DCRF02_AG
 HJ3151HJ3151JX983000NRTINNRTI K103N, P225HV35T, T39A, S162A, K173T, Q174QR, D177E, I178M, T200A, Q207E, R211K, V245Q, E248S, K275Q, K277R, T286A, I293V, P294T, S322A, G335D, R356K, M357R, G359S, A371V, I375V, T377L, K390R, A400AT, T403MCRF02_AG
 HJ3133HJ3133JX983025NRTINNRTIM184V, N348NIK103N, P225HV35T, V60I, K64KR, V90I, I135IT, A158S, S162A, K173S, I195L, T200TA, Q207A, R211K, V245Q, A272P, Q278HN, T286A, E291D, V292I, I293V, P294T, S322A, G335D, R356K, M357R, G359T, T369ALSV, K390R, A400AITV, T403MCRF02_AG
Kebe (2013)SNA3-159SNA3-159HM002512AZT, 3TCEFVM184VY188L, P225HV35T, E36D, V60I, D123E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, V245ECRF02_AG
 SNA3-278SNA3-278JN193490AZT, 3TCEFVM184VK103N, P225HV35T, T39L, S68G, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207ECRF02_AG
Nii-Trebi (2013)KF327KF327AB751494D4T, 3TCEFVD67G, K70R, M184V, T215V, K219EK103N, P225HV35T, E36A, V60I, S68G, I135IM, S162A, K173T, Q174K, I178M, Q197E, T200K, K201R, Q207E, V241I, V245T, E248NCRF02_AG
 KF372KF372AB751498AZT, 3TCEFVM184VK103N, P225HV35T, E40D, K122P, A158S, S162A, K173T, Q174K, T200A, Q207E, R211K, V245KLMQ, E248EDKNCRF02_AG
Rawizza (2013)LN2369LN2369KF241493NRTINNRTIM41L, V75M, F77L, M184V, T215YK103N, P225HV35T, T39LS, I135V, S162A, K173T, Q174K, D177E, T200K, Q207E, R211A, V245Q, E248D, K281R, T286A, E291D, V292I, I293V, P294T, K311R, S322T, I326VCRF02_AG
Theys (2013)5503555035KC221678NRTI, TDFNNRTIF77FLK103N, V108I, P225H, F227CV60I, V90I, D123E, I135V, E138Q, S162A, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, H221YCRF02_AG
 32753275KC219245NRTI, TDFNNRTIT215FK103N, P225HP97PS, K122KE, I135V, S162T, K173I, Q174K, D177E, T200A, Q207G, R211KCRF02_AG
 90679067KC219649NRTI, TDFNNRTIM184IK103S, P225HS68G, K102KR, D123N, I135L, S162A, K173T, Q174K, D177E, T200A, Q207E, R211KCRF02_AG
 93009300KC219677NRTI, TDFNNRTIM184VK103N, P225HV60VI, K122E, S162T, K173R, D177E, T200A, Q207E, R211KCRF02_AG
 40694069KC219339NRTI, TDFNNRTIM184V, K219KRK103N, P225HK49KR, K101Q, K122N, I135T, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211RKCRF02_AG
Thiam (2013)6004HALD6004HALDJX187624NRTINNRTIM184VK103N, P225HI31L, V35A, T39M, K49R, D123E, I135L, S162A, E169Q, K173T, Q174K, D177E, T200A, Q207E, R211HQ, V245QCRF02_AG
 1916-HALD1916-HALDJN673606NRTINNRTIM184VK103N, P225HV35T, V60I, S68G, K101KQ, D123E, I135V, S162A, K173T, D177E, I178L, T200A, Q207G, R211K, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, S322T, I326VCRF02_AG