<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 29
Patients 128
Isolates 130
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M15M15AY010495ABC, AZT, 3TCNVPM41L, D67N, K70R, M184V, T215Y, K219EA98AG, Y181CV35T, E40D, E44EA, K49R, V60I, I135V, S162A, K173T, Q174E, D177E, I178M, T200A, E203D, E204K, Q207E, R211HQ, H221YCRF02_AG
Montes (2004)MB_patSCHE02_SCHE715AJ578156D4T, DDINVPM41L, T215YV108I, Y181CP4S, V35T, E36D, V90I, K104R, K122E, I135V, S162A, E169G, K173A, Q174K, D177E, I178M, V189I, T200A, Q207E, R211K, H221Y, F227ICRF02_AG
 MB_patPIA01_PIA731AJ577973AZT, DDI, 3TC, D4T, ABCNVP, EFVM41L, L74V, M184V, L210W, T215YL100I, K103NT27P, V35T, E36A, K122E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, H221YCRF02_AG
Non-B Workgroup (2005)PL3439255893AY901524D4T, DDINVP, EFVK70E, V75AA98G, K101E, Y181C, G190AV35T, K73Q, I135R, S162A, K173IT, Q174K, D177E, I178M, T200A, Q207EG, R211K, H221Y, L228R, V245Q, T286A, E291D, V292T, I293V, P294A, Y318T, S322TCRF02_AG
 PL55432107397 D4T, DDI, TDF, 3TCNVP, EFVK65R, M184VK103N, V108I, F227FL, M230LV35T, E36D, K49R, S68SG, K122N, I135V, S162A, K173T, Q174R, D177E, I178M, T200A, Q207G, H221Y, V245E, K275R, V276I, L283I, T286A, E291D, I293V, P294T, V317A, S322T, I326VCRF02_AG
 PL56223109575 D4T, DDINVP K103NK20R, V35IMT, E36D, V60I, A158S, S162A, K173R, Q174K, D177E, I178M, T200A, Q207E, H221Y, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, P294TCRF02_AG
Weber (2005)30239393023939AY677612AZT, DDI, D4T, 3TCEFVM41L, D67E, K70G, L210W, T215YK101E, Y181C, Y188LV8VG, T27S, V35T, T69S, W88C, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178LM, V179M, T200A, Q207D, H221Y, L228H, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E297K, V317VA, S322T, I326VCRF02_AG
Baxter (2006)12-31973197-30821DQ880374NRTINNRTID67G, T69DV179E, Y181IT39A, V60I, S68G, K122KE, E138A, S162A, K173T, Q174K, N175Y, T200A, Q207E, R211K, F214L, H221Y, V245QCRF02_AG
Delgado (2008)GH_212GH_212EU178041AZT, 3TCNVPD67E, M184V, T215TNSYY181CV35T, E36D, V60I, V106I, K122E, D123K, I135V, S162T, K166R, K173T, Q174K, D177E, I178L, T200A, Q207D, H221Y, V245Q, T286A, E291D, I293V, P294T, S322TCRF02_AG
Sylla (2008)A039A039_C2DQ991618AZT, 3TCNVP, EFVM184VK103N, M230L, L234IV35T, K122Q, I135V, S162A, K173S, Q174K, D177E, V179I, Q207A, F214L, H221Y, V245E, K281R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T377L, E399D, A400T, W410C, E432D, D471E, Q480H, H483Y, L491S, E492T, V496I, Q507HCRF02_AG
 A2546A2546_C1DQ991629AZT, 3TCEFV, NVPM184V, T215FK103N, Y181C, P225HV35T, S68G, K122E, I135V, S162T, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V241I, P243T, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403R, E432D, V435M, V467I, T470S, D471E, Q480H, L491SCRF02_AG
  A2546_C2DQ991630AZT, 3TCEFV, NVPM184V, T215FK103N, Y181C, P225HV35T, S68G, K122E, I135V, S162T, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V241I, P243T, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403R, E432D, V435MCRF02_AG
Hawkins (2009)P614ZZP614FJ931128D4T, 3TCNVPA62AV, V75I, Y115F, M184VV106A, Y181CK20R, V21I, V35T, E36D, V60VI, V90I, D121H, K122E, D123E, I135V, S162A, K173T, Q174K, D177E, I178IM, T200A, Q207E, R211K, H221Y, P243T, V245Q, K277Q, T286A, E291D, I293V, E297R, S322T, I326VCRF02_AG
 P632ZZP632FJ931138D4T, 3TCEFV, NVPK70KR, M184VK103N, V108VI, Y181CP1PA, I5IM, T7TI, V35T, K43N, K49R, K122KE, D123DE, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E297D, S322T, I326IVCRF02_AG
 P647ZZP647FJ931151D4T, 3TCNVPM184V, T215YV108I, Y181CV35T, K49R, D123E, E169Q, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, T253S, T286A, E291D, V292I, I293V, P294T, V317A, S322A, I326IVCRF02_AG
 Q179ZZQ179FJ931193D4T, 3TCNVPM184VY181CV35T, E36D, K122E, I135V, S162A, K173T, Q174N, D177E, I178M, T200A, Q207E, R211K, H221Y, V245E, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q195ZZQ195FJ931202D4T, 3TCNVPA62AV, M184VY181CE6N, M16V, I31L, V35T, T39M, A98S, K103E, K122E, D123E, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, H221Y, V245Q, K281R, T286A, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q210ZZQ210FJ931212D4T, 3TCNVPM184VK103KN, V108VI, Y181CK20KR, V35T, E36D, V60I, D123E, I135V, S162A, K173T, Q174R, D177E, T200A, Q207E, F214FL, H221Y, P243T, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, S322T, I326VCRF02_AG
 Q410ZZQ410FJ931231D4T, 3TCNVPK65R, T69~, K219RK103N, Y181CK11Q, V21VI, L34LI, V35T, T39A, S68SN, V90I, K122KE, D123N, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214FL, D218DY, H221Y, V245T, D250E, S251C, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q578ZZQ578FJ931239D4T, 3TCNVPK65R, T69~, V75M, F77FL, Q151M, K219RY181CL34I, V35T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, A272P, T286A, E291D, I293V, S322T, I326VCRF02_AG
 Q440ZZQ440FJ931262D4T, 3TCNVPM41L, D67DN, M184V, L210W, T215YV106A, F227LV35T, K49R, L109I, V118VI, K122E, S162A, K173T, Q174K, D177E, T200A, I202V, E203K, Q207E, H208HY, H221Y, V245EK, E248D, A272P, T286A, V292I, I293V, S322TCRF02_AG
 R116ZZR116FJ931312AZT, D4T, 3TCNVPM184V, T215TNK103N, Y181CE6K, E28EK, V35T, K122E, I135V, S162A, K173A, Q174N, D177E, I178V, T200A, Q207E, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294A, S322ACRF02_AG
 R117ZZR117FJ931313AZT, D4T, 3TCNVPM184V, T215YY181CV35T, E36D, T39A, S48T, K49R, E53D, K122E, I135V, T139R, S162T, K173A, Q174K, D177E, T200A, E203D, Q207E, R211K, H221Y, V245E, T286A, A288AT, E291D, V292I, I293V, P294V, E297K, S322T, I326VCRF02_AG
 Q958ZZQ958FJ931326D4T, 3TCNVPM184V, T215YV108VI, Y181CV35T, E36D, K64KR, D123E, I135V, S162T, K173A, Q174K, D177E, T200A, Q207HP, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, S322T, I326VCRF02_AG
 R121ZZR121FJ931330D4T, 3TCNVPM184V, T215YV108I, Y181CT7I, V35T, E36D, V90I, K122E, I135V, S162A, K173T, Q174E, D177E, V179VI, T200A, Q207E, R211K, H221Y, V245Q, K281R, T286A, K287KR, E291D, V292I, I293V, P294T, E297EK, S322T, I326VCRF02_AG
 Q111ZZQ111FJ931341D4T, 3TCNVPM184VY181CV21I, V35T, T39A, E40D, I135T, S162A, K173T, Q174K, N175Y, D177E, T200E, Q207E, R211K, F214FL, H221Y, V245M, A272P, T286A, A288AT, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R150ZZR150FJ931346D4T, 3TCNVPF116Y, Q151M, M184VV108I, Y181CK20K*, V35T, K102R, K104KQ, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, P243Q, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297K, I329VCRF02_AG
 R11ZZR11FJ931362AZT, 3TCNVPM184VY181CK13KR, V35T, E36D, T39M, D123E, I135V, S162T, K173T, Q174K, D177E, T200A, Q207E, H221Y, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326IVCRF02_AG
 R23ZZR23FJ931363AZT, 3TCNVPM184VV108I, Y181CV35T, E36D, V90I, I135V, T139TK, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, H221Y, V245K, S251N, K275R, V276I, T286A, E291D, V292I, I293V, S322TCRF02_AG
 R216ZZR216FJ931369NRTINVPL74V, Y115YF, M184VK103N, Y181CP4PS, E28A, V35T, E36D, V60I, I135V, T139TA, S162A, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, H221Y, L228LH, V245Q, A272G, L283I, T286A, V292I, I293V, S322T, I326VCRF02_AG
 R350ZZR350FJ931377NRTINVPD67DN, K70R, M184VY181CT7TA, V21I, V35T, T39A, E40D, V60I, I135T, S162A, K173T, Q174K, D177E, T200A, Q207A, R211K, H221Y, V245E, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R468ZZR468FJ931392D4T, 3TCNVPA62AV, V75VI, F77FL, Q151M, M184V, K219QV108I, Y181CK20R, V35T, E36D, T39A, K43E, K49R, K64R, K122E, I135V, S162A, E169EA, K173A, Q174K, N175Y, D177E, T200A, Q207E, H221Y, L228LR, V245Q, E248D, K281R, E291D, I293V, P294T, S322T, I329VCRF02_AG
 R375ZZR375FJ931412AZT, 3TCNVPM184VY181CV35K, T39A, S68G, D121Y, K122E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, F214L, H221Y, P243S, V245Q, K281R, T286A, E291D, V292VI, I293V, P294T, V317A, S322T, I326VCRF02_AG
 R357ZZR357FJ931414NRTIEFVD67DN, K70R, M184V, T215TFISA98AG, K101H, Y181C, G190AP4S, V35T, D123E, I135V, S162A, K173T, Q174E, D177E, T200A, E204K, Q207E, R211K, F214L, K219G, H221Y, P243T, V245Q, A272P, K281KR, T286TA, E291D, V292VI, I293V, S322T, I326VCRF02_AG
 R364ZZR364FJ931421NRTINVPM41L, M184V, L210LRW, T215YA98AG, V108I, Y181CV35T, T39R, K43E, K122E, D123N, I135L, S162A, K173T, Q174K, D177E, I178V, T200A, Q207E, R211K, H221Y, L228Q, V245Q, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R235ZZR235FJ931430D4T, 3TCNVPM184VK103N, K238TV35T, T39L, S68SG, V90I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, E203ED, Q207E, H221Y, V245Q, E248N, K277R, T286A, E291D, V292I, I293V, P294PT, S322TCRF02_AG
 R236ZZR236FJ931431NRTIEFV, NVPM41L, K70R, M184V, K219QA98G, K103N, V108I, Y181C, G190AV35T, E36D, V60I, T69N, V106VI, D123E, I135V, S162A, K173A, Q174R, D177E, I178M, V179I, T200A, Q207E, R211K, F214L, H221Y, L228R, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R474ZZR474FJ931436D4T, 3TCNVPM184V, T215YV108I, Y181CV35T, K49R, V60I, S68G, D123E, I135V, S162D, E169K, K173T, Q174E, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, K281KR, T286A, E291ED, V292VI, I293V, P294T, S322T, I326VCRF02_AG
Burda (2010)06LPH20SC06LPH20SCGQ344969D4T, 3TCNVPF116Y, Q151M, M184VV108I, Y181C, F227LK20R, V35T, E36D, T39L, K49R, S68G, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, E224D, P243H, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, D320DE, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403MCRF02_AG
Zolfo (2010)A13458A13458RSHM565593D4T, 3TCNVPM184V, T215TFISY181CK49KR, S68G, K101KR, I135V, S162AT, K173T, Q174R, D177E, I178M, T200TA, Q207DE, L210LM, H221Y, P243T, V245QCRF02_AG
  A13458M30HM565508D4T, 3TCNVPM184V, T215TFISY181CK49R, S68G, K101KR, I135V, S162T, K173T, Q174R, D177E, I178M, Q207ADE, L210LM, H221Y, P243T, V245QCRF02_AG
Aghokeng (2011)SK8020-M18SK8020-M18HQ864454D4T, 3TCNVPM184V, T215TNSYY181CV35T, K43KN, K49R, S68SG, K122KE, I135V, S162D, K173I, Q174K, V179I, T200A, Q207E, R211K, H221Y, P243T, V245Q, K281R, T286A, E291D, V292I, I293V, P294TCRF02_AG
Charpentier (2011)CR-29CR-29FJ688235AZT, 3TCNNRTIL74V, V75T, Y115F, M184VY181IK20KR, V35T, E36D, T39L, F61L, T69N, K122I, I132L, S162A, K173T, Q174K, D177E, V179VIM, G196E, T200E, E203Q, Q207E, F214L, H221Y, V245Q, E248N, D250E, S251SC, T286A, I293V, P294T, S322TCRF02_AG
 CR-9CR-9FJ688215AZT, 3TCNNRTIM184VV108VI, Y181CE6D, V35T, E36ED, K46Q, S162AD, K173T, Q174K, N175Y, T200A, Q207E, H221Y, V245Q, A272P, K277KR, T286A, E291D, V292I, I293V, P294AT, S322A, I326VCRF02_AG
 CR-38CR-38FJ688244AZT, 3TCNNRTID67N, K70R, V75A, M184V, T215Y, K219QK103N, V108I, K238TV35T, E36D, K46Q, K49R, K73M, K122E, D123S, I135V, S162A, T165I, K173T, Q174K, N175Y, D177E, T200A, K201KR, Q207E, R211K, F214FL, H221Y, L228LH, V245Q, K275R, L283I, T286A, E291D, V292I, I293V, P294T, E297EK, E312A, S322ACRF02_AG
Dagnra (2011)08TG.T304608TG.T3046FR715261D4T, 3TCNVPD67G, K70R, M184V, T215F, K219EV108I, Y181CK20R, V35T, K64H, L109I, K122E, D123N, I135T, S162A, E169Q, K173T, Q174K, N175Y, D177E, T200A, I202V, Q207E, R211K, F214L, H221Y, L228H, V245E, E248D, D250E, L283I, T286A, E291D, V292I, I293V, P294T, S322T, D324E, I326V, G335D, R356K, M357R, G359S, A371V, I375V, A376T, T377I, K390R, A400T, T403MCRF02_AG
 08TG.T306908TG.T3069FR715266D4T, 3TCNVPD67G, T69D, K70R, M184V, K219QY181C, G190AK20R, V35T, V60I, K122P, I135V, S162A, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, T377V, K390R, A400T, E432DCRF02_AG
 08TG.C702408TG.C7024FR715292D4T, 3TCNVPD67G, T69D, K70R, M184V, K219QY181C, G190AK20R, E28EK, V35T, V60I, R78RK, K122P, I135V, S162A, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, F214FL, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, T377V, K390R, A400T, E432D, V435TCRF02_AG
 08TG.C704408TG.C7044FR715295D4T, 3TCNVPM184VY181CK20R, V35T, T39N, V60I, K122P, I135V, T139I, I159V, S162A, K173T, Q174N, D177E, T200A, Q207E, H221Y, V245Q, T286A, I293V, P294T, S322T, I326V, G335D, N348H, R356K, M357R, G359S, A371V, I375V, T403M, E432D, V435ACRF02_AG
Sigaloff (2011)HIV103561HIV103561JN132347AZT, 3TCNVPM184VA98AG, V179E, Y181CV35T, E36D, E53D, V90I, D123EK, I135V, S162A, K173T, Q174K, D177E, I178V, T200A, Q207E, F214FL, H221Y, V245M, A272P, K275R, T286A, A288AT, E291D, V292K, I293V, P294T, E297K, E312Q, S322TCRF02_AG
 HIV103634HIV103634JN132356AZT, 3TCNVPD67N, K70R, M184VY181CV35K, K43N, K49R, K101R, K122E, I135V, S162T, K173T, Q174E, D177E, T200A, Q207N, R211K, H221Y, V245Q, D250E, K277R, K281R, T286A, E291D, V292I, I293VCRF02_AG
 HIV105131HIV105131JN132366D4T, 3TCNVPM184VV108VI, Y181CV21VI, V35T, K49KR, E53D, K104T, L109LI, D121H, K122E, I135V, S162AT, K166Q, Q174KR, D177E, T200A, Q207E, R211K, H221Y, E248D, A272P, K277R, L283LI, T286A, E291D, I293V, P294T, E297R, E312Q, S322TCRF02_AG
 HIV105190HIV105190JN132374TDF, FTCNVPK70E, M184VK103N, Y181CV35T, V60I, V90I, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, L228R, V245E, E248D, K275R, V276I, T286A, E291D, V292T, I293V, P294V, V314A, Y319D, S322TCRF02_AG
Hamers (2012)CP076306419CP076306419JQ480192TDF, FTCNVPM184VY181CK20KR, V35T, V60VI, K173A, Q174K, D177E, T200A, Q207N, R211K, F214L, H221Y, V245Q, E248D, A272P, T286A, A288AS, E291D, V292I, I293V, E297EK, E308X, I309V, E328D, K331R, Q332KCRF02_AG
Mollan (2012)MK26MK26w62 ABC, 3TCEFVL74LV, M184VL100I, K103NV35T, T39M, I135T, I142V, S162A, K173T, Q174K, T200A, Q207E, R211K, H221Y, V245E, E248A, K281R, T286A, E291D, V292I, I293VCRF02_AG
Aghokeng (2013)HJ3115HJ3115JX983015NRTINNRTIM184VV108I, Y181CE6D, V35T, E36D, T39A, K122E, D123GS, I135V, T139TK, S162A, K173T, D177E, T200A, Q207E, H221Y, V245Q, K277R, T286A, V292I, I293V, S322T, G335E, P345Q, R356K, M357K, G359S, A371V, I375V, K390R, A400AT, T403MCRF02_AG
 HJ3034HJ3034JX983021NRTINNRTIM184VY181CT7TP, I31IL, V35T, D121H, K122E, Q145C, S162AT, K173T, Q174K, D177E, G196E, T200A, Q207E, R211K, H221Y, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, P294T, S322A, G335D, R356K, M357K, G359S, K366R, T369V, A371T, I375V, K390R, A400AT, T403MCRF02_AG
 HJ3188HJ3188JX982995NRTINNRTIM184V, T215FK103N, V108I, M230L, L234IV35T, E36D, R78RK, K122E, D123S, I135M, S162A, K173T, Q174K, D177E, I178L, V189VI, T200A, Q207E, R211RK, H221Y, L228LH, V245EK, T286A, E291D, V292I, I293V, S322T, G335D, R356K, M357K, G359S, A360T, I375V, T377L, K390R, K395RCRF02_AG
Kebe (2013)SNA3-127SNA3-127HM002539AZT, 3TCNVPM41L, V75I, M184V, L210LW, T215FA98G, Y181CV35T, E36D, T39A, V60I, I132L, I135L, S162A, K173T, Q174K, D177E, Y183Y*, T200A, Q207E, H221Y, V245K, K249Q, A272P, K275KR, R284K, T286A, E291D, V292I, I293V, P294A, S322TCRF02_AG
 SN626HALDSN626HALDHM002506NRTINVPK70TY181CV35T, E36D, K49R, V60I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, L228R, V245Q, E248DCRF02_AG
Pircher (2013)B1125B1125JX110225D4T, 3TC, AZTNVPL74I, M184V, T215FY, K219KNA98G, K101E, V108I, M230LK22R, V35T, T39L, S68G, K104R, K122E, D123S, E138A, S162A, Q174K, T200A, E203D, Q207D, H221Y, V245QCRF02_AG
 B1151B1151JX110247D4T, 3TC, AZTNVPD67DN, K70R, M184V, K219KQV108I, Y188W, F227LV35T, T39A, E40D, V60VI, D121H, K122E, I135T, T139KR, K173T, Q174K, D177E, T200A, Q207E, R211RK, H221Y, V245QCRF02_AG
 B1155B1155JX110250D4T, 3TC, AZTNVPD67N, K70R, M184V, T215F, K219EK103N, V108VI, Y181CE6D, L34I, V35T, V60I, K64KR, K122P, I135T, S162A, Q174A, D177EG, V179VI, V189VI, G196E, T200A, E203EG, Q207E, R211K, H221Y, V245QCRF02_AG
Rawizza (2013)LL4419LL4419KF241465NRTINNRTIA62V, V75I, F77L, Q151MK103N, Y181CA33V, V35T, T39L, T69N, K101KR, V111I, V118VI, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178M, G196E, T200A, Q207E, F214L, H221Y, L228R, P243H, V245E, E248D, K275R, T286A, E291D, P294T, V317A, D320DE, S322T, I329VCRF02_AG
Theys (2013)39543954KC219325TDF, 3TCEFVK65R, K70KT, Y115FY181YC, G190VE40D, K49R, K66R, S68G, E89Q, V90I, K101Q, K122E, I135K, S162A, E169D, K173R, Q174K, D177E, T200A, Q207G, R211K, H221YCRF02_AG
 33253325KC219252NRTI, TDFNNRTIK65R, M184VK103N, V108I, F227FL, M230LK49R, S68SG, K122N, I135V, S162A, K173T, Q174R, D177E, I178M, T200A, Q207G, H221YCRF02_AG
 2788827888KC220538NRTI, TDFNNRTIM41L, D67N, V75T, M184V, T215Y, K219EV108I, Y181CK49R, I135V, S162A, K166E, E169K, K173T, Q174N, D177E, I178M, T200A, Q207E, R211K, F214FL, H221YCRF02_AG
 2618226182KC220408NRTI, TDFNNRTIM41L, D67N, V75T, M184V, T215Y, K219EV108I, Y181CK49R, I135V, S162A, K166E, E169K, K173T, Q174N, D177E, I178M, T200A, Q207E, R211K, H221YCRF02_AG
 5503555035KC221678NRTI, TDFNNRTIF77FLK103N, V108I, P225H, F227CV60I, V90I, D123E, I135V, E138Q, S162A, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, H221YCRF02_AG
Theys (2013)146060146060 AZT, 3TCNVPM184VY181CP4S, K11N, V21VI, V35T, K49R, D123N, I135T, S162A, K173T, Q174K, D177E, T200A, I202V, Q207E, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, V317A, S322T, I326VCRF02_AG
Thiam (2013)418-HALD418-HALDJN673621NRTINNRTIL74V, M184VV108I, Y181CV35I, V90I, K122E, D123N, I135L, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, I244IV, V245K, D250E, S251I, K275KQ, K281KR, T286A, A288T, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 2187HALD2187HALDJX187615NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EA98G, V108I, Y181CV35T, E36D, E44D, V60I, D123E, S162D, K173T, Q174K, D177E, I178M, T200A, Q207G, R211K, H221Y, L228H, V245Q, P247ACRF02_AG
Aghokeng (2014)TG-5-406TG-5-406KC350300NRTINNRTIM41L, L74LV, M184V, L210W, T215YK103N, V108VI, Y181CV35T, E44D, V118I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, V179VI, T200A, E203EK, Q207E, R211K, K220KQ, H221Y, L228LR, P243H, V245E, E248D, K259KN, T286A, E291D, V292I, I293V, S322T, G335D, N348NT, R356K, M357R, G359S, A371V, I375V, A376S, T386TI, K390R, E399D, A400T, T403M, E413DCRF02_AG
 TG-3-132TG-3-132KC350312NRTINNRTIM184V, N348IK103N, V108I, Y181CV35T, E36A, T39K, K43E, K49R, D121H, I135IV, I142V, I159IL, S162D, K173S, Q174K, I178L, V179I, T200A, Q207E, R211K, H221Y, V245Q, A272P, T286A, E291D, V292I, I293V, S322A, I326V, G335D, M357R, G359S, K366R, T369V, A371V, I375V, A376I, T403M, W410C, E413D, E432DCRF02_AG
 BF-1-557BF-1-557KC350085NRTINNRTIM184VK103NK32R, V35T, T39A, E40D, K102R, D121H, E138EQ, S162T, K166E, E169K, K173T, Q174K, D177E, I178M, T200A, Q207E, R211RH, K220KR, H221YCRF02_AG
 TG-1-020TG-1-020KC350096NRTINNRTIM184VY181CI31L, V35T, E36D, T39A, D123E, I135V, S162A, K173T, Q174K, D177E, I178L, T200A, E204Q, Q207D, H221Y, V245KCRF02_AG
 TG-4-642TG-4-642KC350295NRTINNRTIK70R, M184V, K219KQ, N348ITV108I, Y181CV35K, E36D, K49R, V60I, K64KR, K102Q, K122E, D123N, I135V, T139I, S162A, E169D, K173T, Q174K, D177E, T200A, R211K, F214L, H221Y, V245Q, D250DG, K281R, T286A, E291D, I293V, P294T, S322T, I326V, A327V, G335D, F346L, R356K, M357R, G359S, A371L, I375V, A376S, T377V, K390R, A400TCRF02_AG
 TG-2-287TG-2-287KC350197NRTINNRTIM41L, V75T, M184V, T215YY181CE28K, K32E, V35T, I132L, S162Y, K173T, Q174K, T200A, Q207N, R211K, H221Y, P243T, V245Q, K249Q, Q278N, T286A, E291D, V292I, I293V, P294T, L310I, S322A, I326V, R356K, M357K, G359S, A371V, I375V, T377V, K390R, E399D, A400T, T403MCRF02_AG
 TG-4-631TG-4-631KC350277NRTINNRTIM184V, N348IY181CE6D, V35T, K122E, D123DE, I135V, S162T, K173IT, Q174K, T200A, Q207E, R211K, H221Y, V245Q, N255NY, T286A, P294T, S322A, G335D, F346Y, R356K, M357K, G359S, K366R, T377R, K390R, E399D, A400VCRF02_AG
 TG-2-405TG-2-405KC350167NRTINNRTIV75I, M184V, N348NIK103N, Y181YCV35T, K122E, D123S, I132L, I135V, I142V, S162A, K173A, Q174K, N175NY, D177E, T200A, Q207K, R211N, F214L, H221Y, V245Q, E248N, T286A, A288S, I293V, P294T, E312D, I326IV, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T386TA, K390R, A400T, T403MR, W410CY, E432DCRF02_AG
 TG-5-189TG-5-189KC350306NRTINNRTIM184VV179E, Y181CK20KR, V21VI, V35T, T39L, K102Q, I135T, S162A, K173A, Q174N, D177E, T200A, Q207E, H221Y, P243T, V245Q, E248D, K275Q, T286A, E291D, I293V, P294T, E297K, S322T, G335D, R356K, M357K, G359S, T377L, K390R, A400AITVCRF02_AG
 CI-1-114CI-1-114KC350035NRTINNRTIT215YK103N, V179E, Y181CV35T, T39L, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V245ECRF02_AG
 CM-3-163CM-3-163KC350354NRTINNRTIM41ML, D67G, K70A, M184V, L210LW, T215YY181CE6K, T7TA, V35T, E40ED, S68G, K122E, D123S, S162D, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248DN, T286A, E291D, V292I, I293V, E297D, S322A, I326V, G335DCRF02_AG
 TG-3-120TG-3-120KC350313NRTINNRTIM184VK103N, Y181CK20R, V35T, E53D, V60I, S68G, K122E, I135V, E138T, S162A, K173T, Q174K, V179L, T200A, Q207E, R211K, F214L, H221Y, V245Q, I257IV, T286A, A288T, E291D, V292I, I293V, S322A, G335D, R356K, M357R, G359S, K366KN, T369A, E370EQ, V372VA, I375V, A376S, T377M, K390R, K395R, T397TA, T403MCRF02_AG
 TG-1-034TG-1-034KC350210NRTINNRTIM184V, T215FK103N, Y181CV35T, D123E, I135V, Q174E, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, K277R, T286A, I293V, P294T, S322T, I326V, G335DCRF02_AG
 TG-4-633TG-4-633KC350287NRTINNRTIM41L, D67N, L74V, M184V, L210RW, T215FK103N, Y181CK20R, V35T, E36D, T39A, R78RK, V118I, D123E, I135V, S162T, K173A, Q174K, D177E, I178V, T200A, Q207E, H208HY, R211K, H221Y, V245K, A272P, K281R, T286A, E291D, I293V, P294TCRF02_AG
 TG-1-191TG-1-191KC350082NRTINNRTIA62V, Q151M, M184IV108I, Y181CI2V, V35T, T39L, V90I, K122E, D123N, I135R, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, V245Q, A272P, K275Q, K277R, Q278N, E291D, V292I, P294T, S322T, I326V, G335D, P345L, R356K, M357R, G359FCRF02_AG
 CI-1-256CI-1-256KC350034NRTINNRTIK65KR, M184MVK103N, Y181GVV21I, A33T, V35T, V60I, I135V, S162A, K173T, Q174E, D177E, T200A, Q207E, R211K, H221Y, P236PR, D237DH, V245Q, D250ECRF02_AG
 TG-3-307TG-3-307KC350223NRTINNRTIM184VY181CK32E, V35T, E36A, K49R, V60I, S68G, I135R, S162A, K173A, Q174K, D177E, T200A, Q207E, F214L, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, K311R, S322A, I329V, G335D, R356K, M357R, G359S, T369TA, A371V, A376CS, K390R, A400T, T403MCRF02_AG
 CM-3-158CM-3-158KC350351NRTINNRTIM184V, T215FY181CK20R, V35T, E36D, T39LS, K49R, A98S, K101KQ, I135V, S162T, K166KN, F171Y, Q174N, D177E, I178M, T200A, R211K, H221Y, P243H, V245Q, Y271F, V276I, L283I, T286A, E291D, I293V, P294T, S322T, G335DCRF02_AG
 CI-1-512CI-1-512KC350395NRTINNRTIM184VK103KN, Y181CV35K, K49R, K122E, D123E, I135V, S162A, E169Q, K173T, Q174K, D177E, I178M, I195L, T200A, Q207E, R211K, H221YCRF02_AG
 CI-1-235CI-1-235KC350083NRTINNRTIM184VK103KN, Y181CV35T, E36D, C38CR, T39K, K49R, V60I, I135T, I142V, S162D, F171Y, R172RK, K173T, Q174K, D177E, I178M, G196E, T200A, Q207E, R211K, F214L, H221Y, P243S, V245E, D250TCRF02_AG
 SN-1-258SN-1-258KC349989NRTINNRTIM41ML, M184I, K219KEY181CE29D, V35T, T39A, E40D, V90VI, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, Y232YH, V245QCRF02_AG
 SN-1-033SN-1-033KC349986NRTINNRTIM184VY181CK20R, V35T, T39L, V60I, S68SG, A98AS, I135V, S162A, K173T, Q174K, Q207D, H221YCRF02_AG
 TG-5-478TG-5-478KC350302NRTINNRTIM41L, L74V, M184V, L210W, T215YV106A, V179E, F227LK20R, V35T, E36D, L109I, V118I, D123E, I135V, S162A, K173A, Q174K, D177E, T200A, E203K, Q207D, H208Y, R211K, H221Y, V245K, K281R, T286A, E291D, I293V, P294T, S322T, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R, E399D, A400T, T403TM, E432DCRF02_AG
 TG-1-383TG-1-383KC350077NRTINNRTIM41ML, D67DN, K70R, M184V, T215F, K219EQA98G, K103KN, V108I, Y181C, M230MLV35T, E36D, K49R, V106VI, K122E, D123N, I135IV, S162A, E169A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, L228R, V245Q, L283LI, T286A, E291D, V292I, I293V, P294T, S322T, I326V, Q334QP, G335D, R356K, M357R, G359S, V365I, A371V, I375V, A376G, K390R, T403M, Y405H, E432DCRF02_AG
Jenabian (2015)DR29DR29KF735835NRTINNRTID67N, K70R, M184V, K219QY181CV35T, E36D, T39S, E40D, S48T, K49R, V60I, I135V, S162A, K173AT, Q174K, N175Y, D177E, T200E, Q207E, H221Y, P243T, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335DCRF02_AG
 DR15DR15KF735825NRTINNRTIM184V, T215YY181CV35T, T39S, S68G, K122KE, I135V, S162T, D177E, V179I, T200A, Q207E, H221Y, P243H, V245Q, N265NK, Y271F, A272P, T286A, E291D, V292I, I293V, S322T, G335DCRF02_AG
Konou (2015)H1450H1450KT316174NRTINNRTIM41L, D67N, M184I, L210W, T215Y, K219NA98G, K101KE, V108I, Y181C, G190AV35T, T39L, E44D, V90I, V118I, D123E, I135T, S162A, T165I, K173A, Q174K, D177E, I178M, G196GE, T200A, E203D, Q207E, R211K, D218DE, H221YCRF02_AG
 H1550H1550KT316152NRTINNRTIM41L, M184V, T215YA98G, Y181CV35T, T39A, E44D, S68G, I135T, S162A, T165I, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, F214L, H221Y, W229W*, V245QCRF02_AG
 H685H685KT316135NRTINNRTID67N, M184V, L210W, T215YV108I, Y181CL34I, V35T, T39D, E44D, K101Q, V111I, I135T, S162A, K173R, Q174D, D177E, T200A, E203D, Q207E, R211RK, K219X, H221Y, V245X, L246ICRF02_AG
 H547H547KT316131NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215F, K219QA98G, V108I, Y181CK20R, L34I, V35T, T39E, K122P, S162A, K173T, Q174A, D177E, T200A, Q207E, F214L, H221Y, V245X, L246MCRF02_AG
 H476H476KT316121NRTINNRTID67G, K70R, M184V, T215F, K219EV108I, Y181CP1PS, G18GA, V35T, E36D, V60I, S68G, D123E, I135V, S162A, T165V, K173T, Q174K, D177E, T200A, Q207E, H221Y, V245QCRF02_AG
 H1591H1591KT316093NRTINNRTIA62V, K65R, K70T, V75I, F77L, Y115F, F116Y, Q151M, M184VK103N, Y181CK20R, V35T, T39A, S68G, T69TI, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178X, T200A, I202IV, Q207E, F214FL, H221Y, V245Q, E248ED, D250ECRF02_AG
 H1499H1499KT316085NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219EK103N, V108I, V179E, Y181CE6D, V35T, T39A, E44D, V60I, A98S, V118I, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248DCRF02_AG
 H675H675KT316080NRTINNRTIM41L, D67DN, M184V, L210W, T215YA98AG, K101N, K103KN, V108VI, Y181C, G190AE28K, K32X, V35T, T39A, E44D, K49KR, K102KR, V106VI, K122E, D123Q, I135V, S162A, E169Q, K173T, Q174E, D177E, T200A, E203ED, Q207E, R211K, H221Y, V245Q, E248DCRF02_AG
 H460H460KT316071NRTINNRTID67N, K70R, M184V, T215F, K219QV108I, Y181CE6K, K20KR, E29EK, V35T, T39A, E40D, T69X, K122E, D123E, I135V, S162X, K173T, Q174K, D177E, G196E, T200A, Q207A, R211K, F214L, H221Y, L228H, Q242H, V245QCRF02_AG
 H325H325KT316056NRTINNRTIM184VK101E, V108I, Y181CV35T, T39A, D123E, I135V, T139K, S162A, K173T, Q174K, D177E, I178L, T200A, K201KR, Q207X, R211RK, H221Y, V245QCRF02_AG
 H906H906KT316049NRTINNRTIM41L, M184V, L210W, T215YA98G, V108I, Y181CV35T, E36D, K43Q, K49R, D121H, K122E, I135T, S162A, F171Y, K173A, Q174K, D177G, I178L, V179I, T200A, E203K, Q207E, R211K, H221Y, L228H, V245Q, D250ECRF02_AG
 H924H924KT316046NRTINNRTIM41L, M184V, T215YV108I, Y181CV35L, E44D, S68G, I135V, S162A, K173T, Q174K, D177E, I178M, V179I, T200A, E203K, Q207E, R211K, H221Y, V241I, P243H, V245ECRF02_AG
 H870H870KT316028NRTINNRTIA62V, T69D, K70Q, V75T, Q151M, M184VV108I, Y181C, G190A, F227LI31L, V35K, E36D, T39A, K101T, L109I, D123E, I142V, S162A, K173T, Q174K, D177E, T200A, Q207A, F214L, H221YCRF02_AG
 H363H363KT316019NRTINNRTIM41L, M184V, T215YV108I, Y181CT7A, V35T, T39M, V60I, S68G, V90I, I94L, T107S, L109I, K122P, I135V, S162A, K173T, Q174X, D177E, I178L, T200A, Q207E, R211RK, H221Y, V241I, V245QCRF02_AG
 H443H443KT316013NRTINNRTIM41L, M184V, T215FV106A, F227LV35T, T39A, S68G, K101Q, D123E, I135V, I142V, S162A, Q174E, D177E, V179I, T200A, I202V, Q207K, R211A, H221Y, W229R, P243T, V245QCRF02_AG
 H431H431KT316010NRTINNRTIM41L, L74LI, M184V, L210W, T215YV108I, Y181CM16T, K20R, V35T, T39A, K43KE, E44ED, V118I, K122P, I135T, S162A, K173T, Q174K, D177E, T200A, E203D, R211K, H221Y, L228R, K238KR, V245E, E248DCRF02_AG
Lam (2016)2101201221012012KR867956TDF, FTCNVPD67N, K70EG, M184V, T215FV106A, Y181C, F227LT7TA, K20KR, V35T, S105T, L109I, D121H, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, I202IV, Q207A, R211EK, H221Y, P225S, V245Q, T286A, E291D, V292I, I293V, P294T, E312D, S322T, I326V, G335DCRF02_AG
 2103100721031007KR868130TDF, FTCNVPK70N, L74V, Y115F, M184VY181CK20R, V35K, T39A, V60I, K122P, D123E, I135T, S162A, K173A, Q174K, D177E, I178ILV, V179IL, T200AE, Q207E, R211K, F214L, H221Y, V245Q, E248DN, A272P, K275KR, E291D, V292I, I293V, P294T, S322AT, I326V, G335DCRF02_AG
Chaplin (2017)NJIH0366NJIH0366MF622917NRTINNRTIM184VA98G, Y181CK20R, V21I, K49R, K122E, D123E, I135IT, S162X, K173T, Q174K, D177E, T200A, I202V, Q207E, R211K, F214FL, T215X, H221Y, P243H, V245Q, D250ECRF02_AG
 NJIH0260NJIH0260MF622811NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215YA98G, Y181CT7TA, V35T, E44D, V60I, K64KR, D121H, K122E, D123S, I135V, S162T, S163C, K173T, Q174K, D177E, T200A, Q207E, H208HY, R211K, H221Y, V245E, L260ICRF02_AG
 NJIH0259NJIH0259MF622810NRTINNRTIM41ML, K70R, M184V, T215SA98G, Y181CV35T, V60I, K64R, D121H, K122E, D123S, I135V, S162T, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245E, A272P, T286A, V292I, I293V, S322T, I326V, G335DCRF02_AG
 NJIH0250NJIH0250MF622801NRTINNRTIM41L, M184V, T215YA98G, K103NV21VI, V35T, T39A, S48T, V60I, K122P, I132V, S162A, K173T, Q174N, D177E, I178IL, T200A, Q207K, R211N, H221Y, V245Q, E248DCRF02_AG
 NJIH0249NJIH0249MF622800NRTINNRTIM184VK103NV21I, V35T, T39A, S48T, V60I, R83RK, K122P, I132V, S162A, K173T, Q174N, D177E, I178L, T200A, Q207K, R211K, F214L, H221Y, V245Q, E248D, A272P, K275Q, V276I, T286A, E291D, V292I, I293V, P294T, S322T, G335DCRF02_AG
 NJIH0247NJIH0247MF622798NRTINNRTIM184V V35T, K49R, V60I, K102KR, K122Q, D123E, I135V, Q161QH, S162X, E169Q, K173T, Q174E, D177E, G190X, T200A, R206RS, Q207E, H221Y, V245Q, T286A, E291D, V292I, I293V, S322T, D324E, I326V, G335DCRF02_AG
 NJIH0210NJIH0210MF622761NRTINNRTIM184VA98G, Y181CI31L, V35X, E36D, T39TA, K49R, V60I, R83RK, D123E, K173I, Q174K, D177E, I178IM, T200A, Q207K, R211A, H221Y, V245Q, E248D, S251DCRF02_AG
 NJIH0134NJIH0134MF622685NRTINNRTIK70E, M184VY181CI31L, V35T, E36D, T39A, V106I, K122E, I135IV, I142V, S162A, K173R, Q174E, D177E, T200A, Q207G, R211K, F214L, H221Y, L228RCRF02_AG
 NJIH0114NJIH0114MF622665NRTINNRTIK70KQ, M184V V35T, D123E, S162X, K173T, Q174K, D177E, Y181X, G196E, T200A, E203EK, Q207E, H221Y, P243S, V245QCRF02_AG
 NJIH0070NJIH0070MF622621NRTINNRTIK70E, Y115YF, M184VV108I, Y181CE6N, K11T, V35T, E36A, T39K, K43E, K101KQ, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, L228R, V245K, D250E, S251HCRF02_AG
 NJIH0069NJIH0069MF622620NRTINNRTIM184VV108I, Y181CE6N, K11T, V35T, E36A, T39K, K43E, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V245K, L283I, I293V, P294T, S322T, G335DCRF02_AG
 NJIH0042NJIH0042MF622593NRTINNRTIK65R, M184V, K219EK101E, V108I, Y181CK20KR, V35T, V60I, S68X, L109LI, D121Y, K122E, I135R, S162A, K173T, Q174K, D177E, V179VM, G196GR, T200A, I202V, E204M, Q207E, R211K, F214L, H221Y, V245QCRF02_AG
 NJIH0041NJIH0041MF622592NRTINNRTIK65R, M184VV108I, Y181CV35T, V60I, K82R, D121Y, K122E, I135R, S162A, K173T, Q174K, D177E, V179X, G196E, T200A, I202V, E204M, Q207E, R211K, F214L, H221Y, V245Q, Q278E, T286A, E291D, V292I, I293V, P294T, E297R, S322T, G335DCRF02_AG
Nii-Trebi (2017)09GH.NJ6309GH.NJ63LC269867NRTINNRTIM184VG190GA, M230MLV35T, V90I, D123E, I135T, S162A, K173T, Q174K, D177E, V179I, Q207E, H221Y, I244V, V245Q, E248NCRF02_AG