<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation H221Y
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 19
Patients 58
Isolates 60
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M15M15AY010495ABC, AZT, 3TCNVPM41L, D67N, K70R, M184V, T215Y, K219EA98AG, Y181CV35T, E40D, E44EA, K49R, V60I, I135V, S162A, K173T, Q174E, D177E, I178M, T200A, E203D, E204K, Q207E, R211HQ, H221YCRF02_AG
Montes (2004)MB_patSCHE02_SCHE715AJ578156D4T, DDINVPM41L, T215YV108I, Y181CP4S, V35T, E36D, V90I, K104R, K122E, I135V, S162A, E169G, K173A, Q174K, D177E, I178M, V189I, T200A, Q207E, R211K, H221Y, F227ICRF02_AG
 MB_patKON00_KON723AJ577921AZT, DDI, 3TC, D4T, DDC, ABCNVPM41L, L74V, M184V, T215FY181C, G190AV35T, E36A, T39K, K43E, D121H, K122E, D123S, I142V, S162F, K173S, Q174K, D177E, I178L, V179I, T200A, E203K, Q207D, H208Y, H221Y, K223NCRF02_AG
 MB_patPIA01_PIA731AJ577973AZT, DDI, 3TC, D4T, ABCNVP, EFVM41L, L74V, M184V, L210W, T215YL100I, K103NT27P, V35T, E36A, K122E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, H221YCRF02_AG
Non-B Workgroup (2005)PL3439255893AY901524D4T, DDINVP, EFVK70E, V75AA98G, K101E, Y181C, G190AV35T, K73Q, I135R, S162A, K173IT, Q174K, D177E, I178M, T200A, Q207EG, R211K, H221Y, L228R, V245Q, T286A, E291D, V292T, I293V, P294A, Y318T, S322TCRF02_AG
 PL55432107397 D4T, DDI, TDF, 3TCNVP, EFVK65R, M184VK103N, V108I, F227FL, M230LV35T, E36D, K49R, S68SG, K122N, I135V, S162A, K173T, Q174R, D177E, I178M, T200A, Q207G, H221Y, V245E, K275R, V276I, L283I, T286A, E291D, I293V, P294T, V317A, S322T, I326VCRF02_AG
 PL56223109575 D4T, DDINVP K103NK20R, V35IMT, E36D, V60I, A158S, S162A, K173R, Q174K, D177E, I178M, T200A, Q207E, H221Y, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, P294TCRF02_AG
Weber (2005)30239393023939AY677612AZT, DDI, D4T, 3TCEFVM41L, D67E, K70G, L210W, T215YK101E, Y181C, Y188LV8VG, T27S, V35T, T69S, W88C, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178LM, V179M, T200A, Q207D, H221Y, L228H, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E297K, V317VA, S322T, I326VCRF02_AG
Baxter (2006)12-31973197-30821DQ880374NRTINNRTID67G, T69DV179E, Y181IT39A, V60I, S68G, K122KE, E138A, S162A, K173T, Q174K, N175Y, T200A, Q207E, R211K, F214L, H221Y, V245QCRF02_AG
Delgado (2008)GH_212GH_212EU178041AZT, 3TCNVPD67E, M184V, T215TNSYY181CV35T, E36D, V60I, V106I, K122E, D123K, I135V, S162T, K166R, K173T, Q174K, D177E, I178L, T200A, Q207D, H221Y, V245Q, T286A, E291D, I293V, P294T, S322TCRF02_AG
Sylla (2008)A039A039_C2DQ991618AZT, 3TCNVP, EFVM184VK103N, M230L, L234IV35T, K122Q, I135V, S162A, K173S, Q174K, D177E, V179I, Q207A, F214L, H221Y, V245E, K281R, T286A, E291D, V292I, I293V, P294T, I326V, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T377L, E399D, A400T, W410C, E432D, D471E, Q480H, H483Y, L491S, E492T, V496I, Q507HCRF02_AG
 A2546A2546_C1DQ991629AZT, 3TCEFV, NVPM184V, T215FK103N, Y181C, P225HV35T, S68G, K122E, I135V, S162T, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V241I, P243T, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403R, E432D, V435M, V467I, T470S, D471E, Q480H, L491SCRF02_AG
  A2546_C2DQ991630AZT, 3TCEFV, NVPM184V, T215FK103N, Y181C, P225HV35T, S68G, K122E, I135V, S162T, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, H221Y, V241I, P243T, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, P294T, L295M, S322A, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403R, E432D, V435MCRF02_AG
Hawkins (2009)P614ZZP614FJ931128D4T, 3TCNVPA62AV, V75I, Y115F, M184VV106A, Y181CK20R, V21I, V35T, E36D, V60VI, V90I, D121H, K122E, D123E, I135V, S162A, K173T, Q174K, D177E, I178IM, T200A, Q207E, R211K, H221Y, P243T, V245Q, K277Q, T286A, E291D, I293V, E297R, S322T, I326VCRF02_AG
 P632ZZP632FJ931138D4T, 3TCEFV, NVPK70KR, M184VK103N, V108VI, Y181CP1PA, I5IM, T7TI, V35T, K43N, K49R, K122KE, D123DE, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, V245Q, T286A, E291D, V292I, I293V, P294T, E297D, S322T, I326IVCRF02_AG
 P647ZZP647FJ931151D4T, 3TCNVPM184V, T215YV108I, Y181CV35T, K49R, D123E, E169Q, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, T253S, T286A, E291D, V292I, I293V, P294T, V317A, S322A, I326IVCRF02_AG
 Q179ZZQ179FJ931193D4T, 3TCNVPM184VY181CV35T, E36D, K122E, I135V, S162A, K173T, Q174N, D177E, I178M, T200A, Q207E, R211K, H221Y, V245E, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q195ZZQ195FJ931202D4T, 3TCNVPA62AV, M184VY181CE6N, M16V, I31L, V35T, T39M, A98S, K103E, K122E, D123E, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, H221Y, V245Q, K281R, T286A, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q210ZZQ210FJ931212D4T, 3TCNVPM184VK103KN, V108VI, Y181CK20KR, V35T, E36D, V60I, D123E, I135V, S162A, K173T, Q174R, D177E, T200A, Q207E, F214FL, H221Y, P243T, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, S322T, I326VCRF02_AG
 Q410ZZQ410FJ931231D4T, 3TCNVPK65R, T69~, K219RK103N, Y181CK11Q, V21VI, L34LI, V35T, T39A, S68SN, V90I, K122KE, D123N, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214FL, D218DY, H221Y, V245T, D250E, S251C, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q578ZZQ578FJ931239D4T, 3TCNVPK65R, T69~, V75M, F77FL, Q151M, K219RY181CL34I, V35T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, A272P, T286A, E291D, I293V, S322T, I326VCRF02_AG
 Q440ZZQ440FJ931262D4T, 3TCNVPM41L, D67DN, M184V, L210W, T215YV106A, F227LV35T, K49R, L109I, V118VI, K122E, S162A, K173T, Q174K, D177E, T200A, I202V, E203K, Q207E, H208HY, H221Y, V245EK, E248D, A272P, T286A, V292I, I293V, S322TCRF02_AG
 R116ZZR116FJ931312AZT, D4T, 3TCNVPM184V, T215TNK103N, Y181CE6K, E28EK, V35T, K122E, I135V, S162A, K173A, Q174N, D177E, I178V, T200A, Q207E, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, P294A, S322ACRF02_AG
 R117ZZR117FJ931313AZT, D4T, 3TCNVPM184V, T215YY181CV35T, E36D, T39A, S48T, K49R, E53D, K122E, I135V, T139R, S162T, K173A, Q174K, D177E, T200A, E203D, Q207E, R211K, H221Y, V245E, T286A, A288AT, E291D, V292I, I293V, P294V, E297K, S322T, I326VCRF02_AG
 Q958ZZQ958FJ931326D4T, 3TCNVPM184V, T215YV108VI, Y181CV35T, E36D, K64KR, D123E, I135V, S162T, K173A, Q174K, D177E, T200A, Q207HP, R211K, H221Y, V245Q, T286A, E291D, V292I, I293V, S322T, I326VCRF02_AG
 R121ZZR121FJ931330D4T, 3TCNVPM184V, T215YV108I, Y181CT7I, V35T, E36D, V90I, K122E, I135V, S162A, K173T, Q174E, D177E, V179VI, T200A, Q207E, R211K, H221Y, V245Q, K281R, T286A, K287KR, E291D, V292I, I293V, P294T, E297EK, S322T, I326VCRF02_AG
 Q111ZZQ111FJ931341D4T, 3TCNVPM184VY181CV21I, V35T, T39A, E40D, I135T, S162A, K173T, Q174K, N175Y, D177E, T200E, Q207E, R211K, F214FL, H221Y, V245M, A272P, T286A, A288AT, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R11ZZR11FJ931362AZT, 3TCNVPM184VY181CK13KR, V35T, E36D, T39M, D123E, I135V, S162T, K173T, Q174K, D177E, T200A, Q207E, H221Y, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326IVCRF02_AG
 R23ZZR23FJ931363AZT, 3TCNVPM184VV108I, Y181CV35T, E36D, V90I, I135V, T139TK, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, H221Y, V245K, S251N, K275R, V276I, T286A, E291D, V292I, I293V, S322TCRF02_AG
 R216ZZR216FJ931369NRTINVPL74V, Y115YF, M184VK103N, Y181CP4PS, E28A, V35T, E36D, V60I, I135V, T139TA, S162A, K173A, Q174K, D177E, T200A, Q207E, R211RK, F214L, H221Y, L228LH, V245Q, A272G, L283I, T286A, V292I, I293V, S322T, I326VCRF02_AG
 R350ZZR350FJ931377NRTINVPD67DN, K70R, M184VY181CT7TA, V21I, V35T, T39A, E40D, V60I, I135T, S162A, K173T, Q174K, D177E, T200A, Q207A, R211K, H221Y, V245E, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R468ZZR468FJ931392D4T, 3TCNVPA62AV, V75VI, F77FL, Q151M, M184V, K219QV108I, Y181CK20R, V35T, E36D, T39A, K43E, K49R, K64R, K122E, I135V, S162A, E169EA, K173A, Q174K, N175Y, D177E, T200A, Q207E, H221Y, L228LR, V245Q, E248D, K281R, E291D, I293V, P294T, S322T, I329VCRF02_AG
 R375ZZR375FJ931412AZT, 3TCNVPM184VY181CV35K, T39A, S68G, D121Y, K122E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, F214L, H221Y, P243S, V245Q, K281R, T286A, E291D, V292VI, I293V, P294T, V317A, S322T, I326VCRF02_AG
 R357ZZR357FJ931414NRTIEFVD67DN, K70R, M184V, T215TFISA98AG, K101H, Y181C, G190AP4S, V35T, D123E, I135V, S162A, K173T, Q174E, D177E, T200A, E204K, Q207E, R211K, F214L, K219G, H221Y, P243T, V245Q, A272P, K281KR, T286TA, E291D, V292VI, I293V, S322T, I326VCRF02_AG
 R364ZZR364FJ931421NRTINVPM41L, M184V, L210LRW, T215YA98AG, V108I, Y181CV35T, T39R, K43E, K122E, D123N, I135L, S162A, K173T, Q174K, D177E, I178V, T200A, Q207E, R211K, H221Y, L228Q, V245Q, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R235ZZR235FJ931430D4T, 3TCNVPM184VK103N, K238TV35T, T39L, S68SG, V90I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, E203ED, Q207E, H221Y, V245Q, E248N, K277R, T286A, E291D, V292I, I293V, P294PT, S322TCRF02_AG
 R236ZZR236FJ931431NRTIEFV, NVPM41L, K70R, M184V, K219QA98G, K103N, V108I, Y181C, G190AV35T, E36D, V60I, T69N, V106VI, D123E, I135V, S162A, K173A, Q174R, D177E, I178M, V179I, T200A, Q207E, R211K, F214L, H221Y, L228R, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R474ZZR474FJ931436D4T, 3TCNVPM184V, T215YV108I, Y181CV35T, K49R, V60I, S68G, D123E, I135V, S162D, E169K, K173T, Q174E, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, K281KR, T286A, E291ED, V292VI, I293V, P294T, S322T, I326VCRF02_AG
Burda (2010)06LPH20SC06LPH20SCGQ344969D4T, 3TCNVPF116Y, Q151M, M184VV108I, Y181C, F227LK20R, V35T, E36D, T39L, K49R, S68G, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, E224D, P243H, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, D320X, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403MCRF02_AG
Zolfo (2010)A13458A 13458 RSHM565593D4T, 3TCNVPM184V, T215TFISY181CK49KR, S68G, K101KR, I135V, S162AT, K173T, Q174R, D177E, I178M, T200TA, Q207DE, L210LM, H221Y, P243T, V245QCRF02_AG
  A 13458 M30HM565508D4T, 3TCNVPM184V, T215TFISY181CK49R, S68G, K101KR, I135V, S162T, K173T, Q174R, D177E, I178M, Q207ADE, L210LM, H221Y, P243T, V245QCRF02_AG
Aghokeng (2011)SK8020-M18SK8020-M18HQ864454D4T, 3TCNVPM184V, T215TNSYY181CV35T, K43KN, K49R, S68SG, K122KE, I135V, S162D, K173I, Q174K, V179I, T200A, Q207E, R211K, H221Y, P243T, V245Q, K281R, T286A, E291D, V292I, I293V, P294TCRF02_AG
Charpentier (2011)CR-29CR-29FJ688235AZT, 3TCNNRTIL74V, V75T, Y115F, M184VY181IK20KR, V35T, E36D, T39L, F61L, T69N, K122I, I132L, S162A, K173T, Q174K, D177E, V179VIM, G196E, T200E, E203Q, Q207E, F214L, H221Y, V245Q, E248N, D250E, S251SC, T286A, I293V, P294T, S322TCRF02_AG
 CR-9CR-9FJ688215AZT, 3TCNNRTIM184VV108VI, Y181CE6D, V35T, E36ED, K46Q, S162AD, K173T, Q174K, N175Y, T200A, Q207E, H221Y, V245Q, A272P, K277KR, T286A, E291D, V292I, I293V, P294AT, S322A, I326VCRF02_AG
 CR-38CR-38FJ688244AZT, 3TCNNRTID67N, K70R, V75A, M184V, T215Y, K219QK103N, V108I, K238TV35T, E36D, K46Q, K49R, K73M, K122E, D123S, I135V, S162A, T165I, K173T, Q174K, N175Y, D177E, T200A, K201KR, Q207E, R211K, F214FL, H221Y, L228LH, V245Q, K275R, L283I, T286A, E291D, V292I, I293V, P294T, E297EK, E312A, S322ACRF02_AG
Dagnra (2011)08TG.T304608TG.T3046FR715261D4T, 3TCNVPD67G, K70R, M184V, T215F, K219EV108I, Y181CK20R, V35T, K64H, L109I, K122E, D123N, I135T, S162A, E169Q, K173T, Q174K, N175Y, D177E, T200A, I202V, Q207E, R211K, F214L, H221Y, L228H, V245E, E248D, D250E, L283I, T286A, E291D, V292I, I293V, P294T, S322T, D324E, I326V, G335D, R356K, M357R, G359S, A371V, I375V, A376T, T377I, K390R, A400T, T403MCRF02_AG
 08TG.T306908TG.T3069FR715266D4T, 3TCNVPD67G, T69D, K70R, M184V, K219QY181C, G190AK20R, V35T, V60I, K122P, I135V, S162A, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, T377V, K390R, A400T, E432DCRF02_AG
 08TG.C700408TG.C7004FR715287D4T, 3TCNVPM184VK103N, Y181CP4T, V35T, E36D, V60I, V90VI, D121H, K122E, I135V, S162A, K173I, Q174K, D177E, I178L, T200A, Q207E, H221Y, P243T, V245K, T286A, E291D, V292I, I293V, E297V, S322T, I326V, G335D, F346Y, R356K, M357R, G359S, T377R, S379C, K390R, A400T, E432D, V435ICRF02_AG
 08TG.C702408TG.C7024FR715292D4T, 3TCNVPD67G, T69D, K70R, M184V, K219QY181C, G190AK20R, E28EK, V35T, V60I, R78RK, K122P, I135V, S162A, K173T, Q174K, D177E, T200A, E203K, Q207E, R211K, F214FL, H221Y, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, T377V, K390R, A400T, E432D, V435TCRF02_AG
 08TG.C704408TG.C7044FR715295D4T, 3TCNVPM184VY181CK20R, V35T, T39N, V60I, K122P, I135V, T139I, I159V, S162A, K173T, Q174N, D177E, T200A, Q207E, H221Y, V245Q, T286A, I293V, P294T, S322T, I326V, G335D, N348H, R356K, M357R, G359S, A371V, I375V, T403M, E432D, V435ACRF02_AG
Mollan (2012)MK26MK26w62 ABC, 3TCEFVL74LV, M184VL100I, K103NV35T, T39M, I135T, I142V, S162A, K173T, Q174K, T200A, Q207E, R211K, H221Y, V245E, E248A, K281R, T286A, E291D, V292I, I293VCRF02_AG
Aghokeng (2013)HJ3115HJ3115JX983015NRTINNRTIM184VV108I, Y181CE6D, V35T, E36D, T39A, K122E, D123GS, I135V, T139TK, S162A, K173T, D177E, T200A, Q207E, H221Y, V245Q, K277R, T286A, V292I, I293V, S322T, G335E, P345Q, R356K, M357K, G359S, A371V, I375V, K390R, A400AT, T403MCRF02_AG
 HJ3034HJ3034JX983021NRTINNRTIM184VY181CT7TP, I31IL, V35T, D121H, K122E, Q145C, S162AT, K173T, Q174K, D177E, G196E, T200A, Q207E, R211K, H221Y, V245Q, A272P, K281R, T286A, E291D, V292I, I293V, P294T, S322A, G335D, R356K, M357K, G359S, K366R, T369V, A371T, I375V, K390R, A400AT, T403MCRF02_AG
 HJ3188HJ3188JX982995NRTINNRTIM184V, T215FK103N, V108I, M230L, L234IV35T, E36D, R78RK, K122E, D123S, I135M, S162A, K173T, Q174K, D177E, I178L, V189VI, T200A, Q207E, R211RK, H221Y, L228LH, V245EK, T286A, E291D, V292I, I293V, S322T, G335D, R356K, M357K, G359S, A360T, I375V, T377L, K390R, K395RCRF02_AG
Kebe (2013)SNA3-127SNA3-127HM002539AZT, 3TCNVPM41L, V75I, M184V, L210LW, T215FA98G, Y181CV35T, E36D, T39A, V60I, I132L, I135L, S162A, K173T, Q174K, D177E, Y183Y*, T200A, Q207E, H221Y, V245K, K249Q, A272P, K275KR, R284K, T286A, E291D, V292I, I293V, P294A, S322TCRF02_AG
 SN626HALDSN626HALDHM002506NRTINVPK70TY181CV35T, E36D, K49R, V60I, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, L228R, V245Q, E248DCRF02_AG
Pircher (2013)B1125B1125JX110225D4T, 3TC, AZTNVPL74I, M184V, T215FY, K219KNA98G, K101E, V108I, M230LK22R, V35T, T39L, S68G, K104R, K122E, D123S, E138A, S162A, Q174K, T200A, E203D, Q207D, H221Y, V245QCRF02_AG
Rawizza (2013)LL4419LL4419KF241465NRTINNRTIA62V, V75I, F77L, Q151MK103N, Y181CA33V, V35T, T39L, T69N, K101KR, V111I, V118VI, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178M, G196E, T200A, Q207E, F214L, H221Y, L228R, P243H, V245E, E248D, K275R, T286A, E291D, P294T, V317A, D320DE, S322T, I329VCRF02_AG
Thiam (2013)418-HALD418-HALDJN673621NRTINNRTIL74V, M184VV108I, Y181CV35I, V90I, K122E, D123N, I135L, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, I244IV, V245K, D250E, S251I, K275KQ, K281KR, T286A, A288T, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 2187HALD2187HALDJX187615NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EA98G, V108I, Y181CV35T, E36D, E44D, V60I, D123E, S162D, K173T, Q174K, D177E, I178M, T200A, Q207G, R211K, H221Y, L228H, V245Q, P247ACRF02_AG