<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation Y188L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 16
Patients 36
Isolates 38
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Yahi (2001)NY_M31M31AY010491NoneNVPK65RY181C, Y188LW24WR, V35T, E40D, V60I, K122E, I135L, S162H, K173I, Q174K, D177E, I178M, V179M, T200A, Q207K, R211S, H221HY, K223KTCRF02_AG
Weber (2005)30239393023939AY677612AZT, DDI, D4T, 3TCEFVM41L, D67E, K70G, L210W, T215YK101E, Y181C, Y188LV8VG, T27S, V35T, T69S, W88C, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178LM, V179M, T200A, Q207D, H221Y, L228H, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E297K, V317VA, S322T, I326VCRF02_AG
Baxter (2006)48-32243224-30624DQ878131NRTINNRTIM184V, L210W, T215YY188LV35T, E36D, T39A, V90VI, V118I, K122P, I135V, T139A, S162A, Q174E, D177E, T200A, E203K, Q207E, K223E, V245Q, K277R, L283I, R284K, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357R, G359S, A371V, I375V, K390R, K395R, E399DCRF02_AG
 48-42214221-30429DQ878456NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EK103N, Y188LV35T, T39TA, S68SG, I94L, S105T, K122E, I135V, S162A, K173T, D177G, T200A, I202V, Q207E, P243Q, V245Q, K281R, T286A, E291D, I293V, P294T, P313T, S322T, I326IV, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R, K395KRCRF02_AG
 48-50755075-30807DQ878585NRTINNRTIM41L, D67N, L210W, T215YV179E, Y188LV35T, K43E, E44A, V60I, K104R, V118I, K122E, I135T, K173A, Q174K, D177E, G196E, T200A, E203A, Q207D, R211K, V245Q, A272P, K275KR, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359S, A371V, K390R, K395RCRF02_AG
Laurent (2006)CK2-4402CM-44AM279441AZT, 3TCEFVK70R, M184VK103N, Y188LV35T, T39A, K102Q, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, E248K, K275R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, A371V, I375A, K390R, K395R, T403M, E432D, V435ACRF02_AG
 CK22-47A03CM2-47AM279457AZT, 3TCEFVD67N, K70R, M184V, T215F, K219QK103N, Y188LV35T, T39A, K102Q, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, F214L, V245Q, K275R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, A371V, I375A, K390R, K395R, T403M, E432DCRF02_AG
Sylla (2008)A2608A2608_C1DQ991631AZT, 3TCEFV, NVPM184VK103N, Y188L, M230LV35T, K49R, V60I, S105T, I135V, S162A, K173A, Q174K, D177E, G196E, T200A, Q207E, V245Q, E248D, I257V, A272P, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, K390R, A400T, T403M, E432D, V435ACRF02_AG
  A2608_C2DQ991632AZT, 3TCEFV, NVPM184V, T215YK103N, Y188L, M230LV35T, K49R, V60I, S105T, I135V, S162A, K173A, Q174K, D177E, G196E, T200A, Q207E, V245Q, I257V, A272P, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, K390R, A400T, T403M, E432D, V435A, S468T, T470P, D471E, Q480H, L491S, K512R, S519N, Q524KCRF02_AG
 A2536A2536_C1EF525652AZT, 3TCEFVD67N, K70R, M184V, K219Q, N348IK103N, Y188LK11Q, V35T, T39L, K49R, K122E, D123N, S134R, I135V, N136I, I159L, S162A, E169Q, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, P243Q, V245Q, T286A, E291D, I293V, P294T, S322T, G335D, R356K, M357R, G359S, A371V, I375V, A376T, T377M, T386A, K390R, T403M, E432DCRF02_AG
  A2536_C2EF588326AZT, 3TCEFVD67N, K70R, M184V, K219Q, N348IK103N, Y188LK11Q, V35T, T39L, K49R, K122E, D123N, S134R, I135V, S162A, E169Q, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, P243Q, V245Q, T286A, E291D, I293V, P294T, S322T, G335D, R356K, M357R, G359S, A371V, I375V, A376T, T377M, T386A, K390R, T403M, E432DCRF02_AG
 A1469A1469_C2EF525656D4T, 3TCNVPM184VK103N, Y188LV21I, V35T, K49R, V60I, V90I, K122E, I135V, S162A, E169Q, K173T, Q174E, D177E, I178L, V189I, T200A, Q207E, R211K, V245Q, D250E, K275R, T286A, E291D, V292I, I293V, P294T, S322A, I326V, R356K, M357K, G359S, A371V, I375V, V381I, K390R, T403M, E432DCRF02_AG
Hawkins (2009)Q209ZZQ209FJ931211D4T, 3TCNVPK70KE, V75VA, F116FY, M184V, T215TFISY188LV35T, E36EK, V60I, K73LQ, K104KQ, L109LI, D123E, I135L, S162A, K173I, Q174K, D177E, I178L, T200A, Q207E, R211K, D218DE, V245E, V276I, K277R, L283I, T286A, E291D, I293V, P294T, V317A, S322TCRF02_AG
 Q804ZZQ804FJ931254TDF, AZT, D4T, 3TCNVPM184VY188LV35T, T39A, V60I, D121Y, K122E, I135V, S162A, K173I, Q174K, D177E, I178M, Q207E, L228LR, P243T, V245Q, E248D, V276VI, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
 R223ZZR223FJ931382NRTINVPM184VA98AG, Y188LK20R, V35L, D123E, S162A, K173T, Q174K, D177E, T200A, E203A, R211N, F214FL, V245K, D250E, A272G, T286A, E291D, I293V, P294T, S322TCRF02_AG
 R372ZZR372FJ931410AZT, 3TCEFV, NVPM184VY188LV35T, E36D, T39M, K122E, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, K275Q, T286A, V292I, I293V, P294T, S322T, I326VCRF02_AG
Germanaud (2010)54925492 AZT, 3TCNVPM184VY188LV21I, V35T, E36D, T39A, V60I, K122E, D123S, I135V, S162A, K173S, Q174K, D177E, T200A, Q207G, R211KCRF02_AG
 55315531 AZT, 3TCNVPK70R, M184VY188LV35T, T39A, V60I, K64R, K102E, D123E, I135V, S162A, K173A, Q174K, D177E, I178L, T200A, Q207ECRF02_AG
Charpentier (2011)CR-36CR-36FJ688242AZT, 3TCNNRTIM184V, L210W, T215YY188LV35K, T39A, K43E, K49KR, S68G, K122E, D123S, I135L, S162A, K173T, Q174K, D177E, I178IM, V179VIM, T200A, Q207E, V245E, L283I, T286A, E291D, V292I, I293V, P294T, K311KR, S322A, I326IVCRF02_AG
 CR-19CR-19FJ688225AZT, 3TCNNRTIM184V, L210W, T215YK101E, Y188LS3C, E28A, V35K, T39A, S48E, V60I, S68SG, A98S, I135T, S162A, Q174E, D177E, I178M, T200A, Q207D, P243T, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
Dagnra (2011)08TG.E504408TG.E5044FR715280D4T, 3TCNVPM184VY188LP4PS, I5V, K20R, V35T, V60I, D123E, I135V, S162A, K166R, K173T, D177E, T200A, I202V, Q207E, R211K, F214L, V245VEKM, S251SC, A272P, K277R, L283I, T286A, I293V, P294AT, S322A, G335D, R356K, M357K, G359S, A371V, I375V, S379G, E399ED, A400T, E432D, V435XCRF02_AG
Fokam (2011)CIRCB-1641CIRCB-1641JQ796145AZT, 3TCNVPM41L, M184V, T215FY188LV35T, E36D, G45GE, K122E, S162A, K173I, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, N265I, W266G, T286A, E291D, V292I, I293V, P294TCRF02_AG
 CRICB-9078CIRCB-9078JQ796157AZT, 3TCNVPM41ML, M184VY188LE28A, V35T, E36D, V60I, I135V, S162A, K173T, Q174E, D177E, I178M, T200A, I202V, E204K, Q207E, F214L, V245Q, A272P, K275KR, Q278N, L283I, V292I, I293V, S322T, I326IV, G335DCRF02_AG
 CIRCB-10398CIRCB-10398JQ796170D4T, 3TCEFVM184VY188LV35T, K122E, D123S, S162A, K173I, Q174K, D177E, T200A, Q207A, R211K, F214L, I244V, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, S322A, G335DCRF02_AG
 CIRCB-11058CIRCB-11058JQ796178AZT, 3TCNVPM184VY188LE29D, V35T, E36D, T39L, I135V, S162A, K173T, Q174K, N175Y, D177E, T200A, Q207EG, R211K, F214FL, V245Q, E248D, A272P, K275KR, Q278H, T286A, A288T, I293V, P294T, E297R, K311KQCRF02_AG
Aghokeng (2013)HJ3309HJ3309JX982996NRTINNRTIM184VY188LV35T, V60I, K64R, R78RK, K122P, I135V, S162A, E169EK, K173T, Q174K, D177E, I178IM, T200A, Q207E, R211K, P243H, V245E, K281R, T286A, E291D, P294T, S322T, G335D, R356K, M357K, G359S, A360T, K366R, A371V, I375V, A376T, T377M, T386P, K390R, E399D, A400T, T403MCRF02_AG
 HJ3293HJ3293JX982994NRTINNRTI Y188LV35T, T39L, V106I, K122P, D123E, I135V, I159IL, S162A, K173T, Q174K, N175Y, P176Q, V189VI, T200A, Q207E, R211K, F214FL, V245Q, E248Q, D250E, K281R, T286A, E291D, I293V, P294T, S322T, I326V, G335D, I341V, R356K, M357K, G359S, K366R, T369V, A371V, I375V, K390R, T403MCRF02_AG
Kebe (2013)SNA3-159SNA3-159HM002512AZT, 3TCEFVM184VY188L, P225HV35T, E36D, V60I, D123E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, V245ECRF02_AG
 SN1921HALDSN1921HALDHM002533NRTIEFVM184VY188LK43Q, S68SG, V106I, D123E, I135T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245K, D250E, A272P, K277R, T286A, E291D, V292I, I293V, S322TCRF02_AG
 SNA3-286SNA3-286JN193498NRTIEFVK70KR, M184VV179E, Y188LK20R, V35T, T39M, V60I, D123E, I135V, I142V, S162A, K173T, Q174K, D177E, S191SF, T200A, Q207E, R211K, F214LCRF02_AG
 SNA3-276SNA3-276JN193499NRTIEFVD67N, K70R, M184V, T215F, K219EY188LV21I, V35T, T39S, V60I, K122E, D123S, S162A, K173T, Q174K, D177E, I178V, T200A, Q207ECRF02_AG
 SNA3-185SNA3-185HM002514NRTIEFVM184V, T215FY188LV35T, E36D, S68SG, L109LI, K122E, I135L, S162A, T165I, K173T, Q174K, D177E, G196E, T200A, I202V, Q207G, R211RS, V245Q, E248DCRF02_AG
Nii-Trebi (2013)KF229KF229AB751488D4T, 3TCEFVM184VY188LV35T, E36D, K122E, I135V, S162A, K173T, Q174N, D177E, T200A, Q207E, Y232H, V245Q, E248TCRF02_AG
Rawizza (2013)LL5299LL5299KF241461NRTINNRTIM41L, M184V, T215YY188LV35T, E36D, K49R, V60I, K122E, D123E, I135V, S162A, E169K, K173T, Q174AE, D177E, T200A, Q207E, K238R, V245Q, E248D, A272P, K281R, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
Theys (2013)4617846178KC221352TDF, FTCEFVM184VA98G, K103KN, Y188LV60VI, K102KR, K122P, D123A, I135V, S162A, Q174N, D177E, E203K, Q207E, R211KCRF02_AG
 41684168KC219347NRTI, TDFNNRTIM184V, T215YA98G, K103N, Y188LK49R, S68G, D123E, S134R, I135V, S162A, K173M, Q174K, D177E, T200A, Q207E, R211KCRF02_AG
 93309330KC219686NRTI, TDFNNRTIM41L, M184V, T215FV179E, Y188LV90I, V106I, K122E, I135V, A158S, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214LCRF02_AG
Thiam (2013)3307-HALD3307-HALDJN673617NRTINNRTIM184V, T215YY188LV35T, T39E, V60VI, S68G, K104R, I135V, S162A, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, S251N, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG