<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation E138Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 9
Patients 27
Isolates 27
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Seyler (2007)535CS_535 AZT, 3TC, DDIEFVM41L, D67N, L210W, T215CK101P, K103NV35T, C38CS, K43N, V60I, D123N, E138Q, S162A, Q174E, D177E, T200A, Q207E, R211K, Y232M, E233N, L234S, V245ECRF02_AG
Hawkins (2009)Q735ZZQ735FJ931245AZT, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K103NK32R, V35T, V60I, K122E, D123N, I135M, E138Q, K173I, Q174K, D177E, I178L, T200A, Q207E, R211K, I244V, V245K, D250DE, Q278QH, T286A, E291D, I293V, P294T, L295M, S322T, I326VCRF02_AG
 R70ZZR70FJ931269D4T, 3TCNVPD67G, K70R, M184V, K219QK103NM16L, K20R, V35T, E36ED, T39M, V60VI, S68G, I135T, E138Q, S162A, S163G, Q174E, D177E, I178M, V189VI, T200A, E204K, Q207E, F214L, P243T, V245Q, Q278QH, K281R, L283LI, T286A, A288AT, E291D, V292I, I293V, P294T, L295M, S322T, I326VCRF02_AG
 R122ZZR122FJ931331D4T, 3TCNVPM184VK103NK20KR, V35T, E36A, K82R, K122Q, I135L, E138Q, S162T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, D250E, V261I, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R462ZZR462FJ931388AZT, D4T, 3TCNVPM41L, D67N, K70R, V75M, M184V, L210W, T215YK103NV35I, E36D, K64KN, V111I, K122P, E138Q, A158S, S162T, E169D, K173T, Q174R, D177E, I178L, G196E, T200A, Q207E, R211K, P243H, V245E, E248D, Y271F, A272P, V276I, T286A, E291D, V292I, P294T, S322TCRF02_AG
 R467ZZR467FJ931391D4T, 3TCNVPD67DN, K70R, M184V, K219KEY181YC, G190GAT27S, V35T, T39L, T69S, I135T, E138Q, S162A, K173T, Q174K, D177E, T200A, E203EK, Q207E, R211K, V245VEIK, E248ED, S251SC, T286A, V292I, I293V, P294T, S322TCRF02_AG
Germanaud (2010)55195519 AZT, 3TCNVPM184VK103NV35T, E36D, V60I, V90I, I135V, E138Q, S162A, K173T, Q174K, D177E, I178L, T200A, Q207E, R211KCRF02_AG
Rawizza (2013)LN3579LN3579KF241472NRTINNRTIM41L, D67N, T69D, K70R, M184V, T215Y, K219QA98G, K103N, Y318FV35T, E36D, E40D, V60I, D121H, K122E, I135T, E138Q, S162A, K173T, Q174K, D177E, I195L, G196E, T200A, E203K, Q207E, R211K, F214L, L228H, V245Q, E248D, D250E, K275R, T286A, E291D, V292I, I293V, P294T, E297EK, S322T, L325I, I326VCRF02_AG
Theys (2013)2355223552KC220198TDF, 3TCEFVD67N, K70R, L74I, M184V, T215F, K219QL100I, K103N, V179VEGK64KR, E138Q, S162A, K166KR, K173T, Q174R, D177E, I178IM, G196GE, T200A, E203EK, Q207E, F214L, L228HCRF02_AG
 5503555035KC221678NRTI, TDFNNRTIF77FLK103N, V108I, P225H, F227CV60I, V90I, D123E, I135V, E138Q, S162A, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, H221YCRF02_AG
Thiam (2013)2667-HALD2667-HALDJN673611NRTINNRTIM41L, D67N, K70R, M184V, T215F, K219QK101E, G190AV35T, T39A, V60VI, D121DN, K122PQ, I135L, E138Q, S162A, K173T, Q174K, D177EK, I178L, T200A, I202IV, Q207E, R211K, P243A, V245K, A272P, V292I, I293V, P294T, K311KR, S322T, I326VCRF02_AG
Aghokeng (2014)CI-1-401CI-1-401KC350381NRTINNRTIM184VV106AV90I, K122E, E138Q, S162A, K173T, Q174A, I178M, T200A, Q207E, I244V, V245QCRF02_AG
 TG-1-207TG-1-207KC350219NRTINNRTIM184VK103NE29EK, V35T, V60I, K122P, I135L, E138Q, S162A, K173T, Q174R, D177E, I178M, T200A, Q207E, R211K, V241I, V245ECRF02_AG
 TG-3-595TG-3-595KC350289NRTINNRTIM41ML, M184V, L210LRW, T215YA98G, K103N, K238TK11N, K20KR, V35T, E36D, V60I, D123N, I135L, E138Q, S162A, K173T, Q174K, D177E, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, E297K, V317VA, S322T, I329V, K331KE, R356K, M357R, G359S, A360AT, T369V, A371V, Q373H, S379G, K390R, T403MCRF02_AG
 TG-1-044TG-1-044KC350212NRTINNRTIM184VK101E, G190AV35T, E53D, D123E, I135V, E138Q, S162A, K173A, Q174E, D177E, T200A, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376S, S379C, K390R, K395R, T403M, E432DCRF02_AG
Konou (2015)H708H708KT316161NRTINNRTIM184VA98G, K103NV35T, E36D, K49R, V60I, V90I, K102R, D123E, I135L, E138Q, S162A, K173A, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, T240S, V245ECRF02_AG
 H522H522KT316126NRTINNRTID67N, K70R, M184V, K219QK103N, V179EV35T, E36D, T39K, K43E, V60I, D121H, K122E, I135T, E138Q, I142V, S162A, Q174E, D177E, T200A, Q207E, V245ECRF02_AG
 H1549H1549KT316089NRTINNRTIA62V, V75I, F77L, F116Y, Q151M, M184VK103N, V108IV35T, T39A, S68G, T69TI, E79EK, G93GE, K122P, R125RK, I135V, E138Q, S162A, T165TI, K173T, Q174N, D177E, I178M, T200X, Q207A, R211K, F214L, K219KT, V245Q, E248D, D250ECRF02_AG
 H967H967KT316037NRTINNRTID67DN, K70R, M184V, K219KQV106A, F227LK20KR, V35T, T39TA, V60I, K122E, I135L, E138Q, I142IV, S162A, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, Q222H, K223N, V245QCRF02_AG
 H459H459KT316023NRTINNRTIM184VK103NV35T, V60I, R83K, V90I, K122X, I135T, E138Q, S162A, K173A, Q174K, I178M, T200A, Q207E, R211K, V245Q, E248D, N255NICRF02_AG
 H437H437KT316011NRTINNRTID67N, K70R, M184V, T215F, K219QK103N, K238TV35T, T39L, K46KQ, V90I, D121H, K122E, I135V, E138Q, S162A, Q174X, D177E, T200A, Q207E, V245QCRF02_AG
Chaplin (2017)NJIH0298NJIH0298MF622849NRTINNRTIM184V, L210W, T215F, K219WK103NV35T, T39A, S68SG, I94IL, A98S, D123E, I135IV, E138Q, S162T, Q174E, D177E, I178M, T200A, Q207E, H208HY, R211K, V245QCRF02_AG
 NJIH0297NJIH0297MF622848NRTINNRTIM184V, L210W, T215FK103NV35T, E36D, T39A, D123E, I135V, E138Q, S162T, Q174E, D177E, I178M, T200A, Q207E, R211K, V245QCRF02_AG
 NJIH0246NJIH0246MF622797NRTINNRTIM41L, L74I, M184V, L210W, T215YA98G, K103NK20KR, V35X, E36ED, T39X, E40ED, V60I, D123E, I135L, E138Q, S162A, K173R, Q174K, D177E, Q197P, T200A, Q207E, V245QCRF02_AG
 NJIH0198NJIH0198MF622749NRTINNRTIM41ML, M184V, T215FK103NV35T, E36D, T39TM, V60I, S68SG, A98S, K122E, D123S, I135IV, E138Q, S162X, K173T, Q174K, D177E, I178M, T200A, Q207E, V245Q, D250E, S251DCRF02_AG
 NJIH0197NJIH0197MF622748NRTINNRTIM184VK103ND17Y, V35T, E36D, T39M, V60I, A62S, K122E, D123S, I135V, E138Q, S162A, S163R, K173T, Q174K, D177E, I178M, T200A, Q207E, F214L, V245Q, S251D, T286A, E291D, V292I, I293V, P294T, E312D, S322T, I326V, G335DCRF02_AG
 NJIH0024NJIH0024MF622575NRTINNRTIA62V, K65R, Y115YF, M184VY181CK20R, V35X, K46KQ, K49KR, V90I, A98S, K101KR, K104R, K122KE, I135T, E138Q, S162A, K173A, Q174K, D177E, I178V, V179I, T200A, I202V, Q207X, R211K, V245Q, D250ECRF02_AG