<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation E138A
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 14
Patients 22
Isolates 23
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Baxter (2006)12-31973197-30821DQ880374NRTINNRTID67G, T69DV179E, Y181IT39A, V60I, S68G, K122KE, E138A, S162A, K173T, Q174K, N175Y, T200A, Q207E, R211K, F214L, H221Y, V245QCRF02_AG
  3197-40128DQ880375NRTINNRTID67G, T69D, K70R, M184MV, T215FV179ET39A, V60I, S68SG, K122KE, E138A, T139TM, S162A, K173T, Q174K, N175Y, Y181X, T200A, Q207E, R211K, F214L, H221HY, V245QCRF02_AG
Zhong (2007)D007005CN_070EF199599NRTINVP  V35T, E36A, K43Q, K49R, V60I, K122E, D123S, E138A, K173T, Q174K, D177E, Q207A, R211K, V241A, V245Q, E248D, D250E, S251N, I257LCRF02_AG
Sylla (2008)B7156B7156_C1EF525659AZT, 3TCNVP  K20R, V35T, E36D, K49R, V60I, I135V, E138A, T139A, S162A, K173A, Q174K, D177E, I178M, T200A, Q207D, R211K, V245E, T253S, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, T369A, I375V, K390R, K395R, T403M, E432D, V435ACRF02_AG
Hawkins (2009)Q187ZZQ187FJ931196D4T, 3TCNVPA62AV, M184VV106A, F227FLV35T, T39TA, E40D, K43R, S68SG, I135V, E138A, S162A, K173T, Q174K, T200E, Q207D, R211K, V245E, S251SR, K275R, T286A, E291D, I293V, P294T, E312EG, V317VA, S322T, I326VCRF02_AG
 Q944ZZQ944FJ931288D4T, 3TCNVPD67DN, K70R, M184V, K219QK101E, G190AP4S, V35T, V60I, K64R, V90I, I135V, E138A, S162A, K173T, Q174K, D177E, V179M, T200A, Q207D, R211K, D218DE, V245K, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R28ZZR28FJ931370TDF, 3TCNVPK65R, M184VK103N, Y181CK20KR, T27S, V35T, E36D, T39K, K43KE, K49KR, V60I, S68G, V90VI, K122E, D123G, I135T, E138A, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, V245E, D250E, S251H, K281KR, T286A, E291D, I293V, P294T, L295M, K311KR, S322TCRF02_AG
 R444ZZR444FJ931455D4T, 3TCNVPA62V, V75IT, M184VK101E, G190AI31L, V35T, E36D, T39N, E53D, D123E, I132IV, E138A, S162A, K173T, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291ED, I293V, P294PT, S322TCRF02_AG
Germanaud (2010)56215621 AZT, 3TCNVPL210WK103NV21G, L26W, V35T, E36D, K122P, I135V, E138A, S162A, K173T, Q174N, D177E, I178M, T200A, Q207E, R211T, V245QCRF02_AG
Charpentier (2011)CR-8CR-8FJ688214AZT, 3TCNNRTI V179EK20KR, V35Q, V60I, K102E, K122E, D123S, E138A, I142IV, A158AS, S162SACG, T165TI, K173A, Q174K, D177E, I178MV, T200A, Q207D, V245K, T286A, E291D, V292I, I293V, P294T, S322ACRF02_AG
Fourati (2012)90301899030189JQ396156NRTINNRTI  V35T, E40D, D86E, W88C, I135V, E138A, S162A, K173T, Q174K, D177E, G196E, T200AE, I202IL, E204K, Q207DE, R211K, F214FLCRF02_AG
 90102299010229JQ396159NRTINNRTI K103KN, V179VE, P225PHV35T, E36ED, T39N, V60I, K102R, I135IT, E138A, S162A, K173T, Q174K, G196E, T200A, Q207E, F214L, L228LHCRF02_AG
Aghokeng (2013)HJ3208HJ3208JX983023NRTINNRTI  V35T, V60I, K122P, I135V, E138A, S162A, K173T, Q174K, D177E, I178M, G196E, T200A, Q207E, F214L, V245Q, A272P, T286A, E291D, V292I, I293V, P294T, A304E, S322T, I326V, G335D, R356K, M357R, G359S, T369V, A371V, I375V, K390R, T403MCRF02_AG
Kebe (2013)SNA3-274SNA3-274HM002545NRTINVP K101KEV35T, E36A, T39K, K43E, V60I, K122E, D123N, I135T, E138A, I142V, S162A, K173V, Q174K, D177E, I178V, V179I, G196E, Q197QR, T200A, Q207D, R211K, F214L, V245Q, A272P, I274V, K275KR, Q278H, K281R, R284K, T286A, E291D, V292I, I293V, P294T, I326VCRF02_AG
Pircher (2013)B1125B1125JX110225D4T, 3TC, AZTNVPL74I, M184V, T215FY, K219KNA98G, K101E, V108I, M230LK22R, V35T, T39L, S68G, K104R, K122E, D123S, E138A, S162A, Q174K, T200A, E203D, Q207D, H221Y, V245QCRF02_AG
Rawizza (2013)PJ0771PJ0771KF241503NRTINNRTIM184VK101E, G190AK11A, V35T, E36A, T39K, K43E, V60VI, K122KE, D123N, E138A, I142V, S162T, F171Y, K173T, Q174K, D177E, I178M, T200A, Q207K, R211N, V245E, D250E, S251H, K281R, T286A, E291D, V292I, I293V, P294T, P313S, V317EG, S322T, I326VCRF02_AG
Theys (2013)3728637286KC221063NRTI, TDFNNRTI  K122KQ, D123DGNS, I135V, E138A, T139S, I142V, S162A, K173T, Q174K, D177E, T200A, I202V, Q207DEG, R211RK, F214LCRF02_AG
 3410334103KC220927NRTI, TDFNNRTIM184V K43DE, K49R, V60I, V90I, D123E, I135V, E138A, S162A, K173T, Q174K, D177G, T200E, Q207D, E224EKCRF02_AG
 1993219932KC219988NRTI, TDFNNRTI V179VEV60VI, K122E, I135V, E138A, I142A, S162A, K173T, Q174K, D177DEG, T200TA, Q207E, R211K, F214LCRF02_AG
Thiam (2013)2750-HALD2750-HALDJN673612NRTINNRTI K103KN, V108VI, V179EV35T, E36ED, V60I, S68SG, V90VI, L109LI, K122KPQT, D123E, I135V, E138A, S162A, T165L, K173T, Q174R, D177E, T200A, Q207D, R211K, F214FL, V245Q, E248D, A272P, V276I, K277R, L283I, T286A, E291D, I293V, P294T, V317A, S322T, I326VCRF02_AG
 2594-HALD2594-HALDJN673691NRTINNRTID67N, K70G, M184V, T215IV, K219QK103N, V179E, K238TV35T, T39N, V60I, K64R, V90I, K122E, D123N, I135T, E138A, S162A, T165L, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K275R, T286A, A288T, E291D, V292I, I293V, P294T, S322T, D324DE, I326VCRF02_AG
 685HALD685HALDJX187626NRTINNRTI  V35T, T39S, S68G, K122Q, I135V, E138A, T139A, S162A, K173T, D177E, I178M, I195L, T200A, Q207E, V245QCRF02_AG
Lam (2016)2101200721012007KR867944TDF, FTCEFVM41L, A62V, K65R, L74I, V75I, Y115F, M184V, K219NG190E, P225PHK20KR, V35I, S68G, W88WS, K102R, D123E, E138A, S162D, K173A, Q174K, D177E, G196GE, T200A, Q207EG, R211K, F214L, V245K, D250E, S251N, A272P, K275R, T286A, E291D, V292I, I293V, P294T, E297K, S322T, G335DCRF02_AG