<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF02_AG
Gene RT
Mutation V108I
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 19
Patients 54
Isolates 56
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patSCHE02_SCHE715AJ578156D4T, DDINVPM41L, T215YV108I, Y181CP4S, V35T, E36D, V90I, K104R, K122E, I135V, S162A, E169G, K173A, Q174K, D177E, I178M, V189I, T200A, Q207E, R211K, H221Y, F227ICRF02_AG
 MB_patROU00_ROUX701AJ577987AZT, Unknown, DDI, 3TCUnknown, NVPM41L, D67N, K70R, M184V, T215Y, K219EA98G, V108I, Y181CV60I, L109I, I135V, S162A, K173T, Q174E, D177E, T200A, I202V, Q207E, V245A, E248K, D250ECRF02_AG
Non-B Workgroup (2005)PL5171397428 3TC, D4TNVP, EFVM184VK103KN, V108I, V179VE, Y181CK20KR, V35T, A98S, D123E, I135T, S162A, E169D, K173R, Q174A, D177E, T200A, Q207E, R211K, F214L, L228R, V245Q, A272P, T286A, E291D, V292I, I293V, E297A, I329LCRF02_AG
 PL55432107397 D4T, DDI, TDF, 3TCNVP, EFVK65R, M184VK103N, V108I, F227FL, M230LV35T, E36D, K49R, S68SG, K122N, I135V, S162A, K173T, Q174R, D177E, I178M, T200A, Q207G, H221Y, V245E, K275R, V276I, L283I, T286A, E291D, I293V, P294T, V317A, S322T, I326VCRF02_AG
Baxter (2006)48-12261226-30417DQ877758NRTINNRTIM41L, D67N, K70R, V75M, L210W, T215Y, K219EK103S, V108I, G190AP4Q, K20R, V35T, T39A, E44D, V60I, V118I, K122E, D123N, I135V, S162A, K173V, Q174K, D177E, I178M, Q197L, T200A, E203V, Q207E, K223Q, L228H, P243T, V245Q, T286A, I293V, P294T, S322A, G335D, M357K, R358K, G359S, A371V, I375V, A376T, T377M, T386A, K390R, E399DCRF02_AG
 48-30363036-30310DQ877947NRTINNRTID67N, T69D, K70R, M184I, K219HA98G, V108I, Y181C, G190AV35T, E36A, T39K, K46M, V60I, V90I, K101R, K122E, D123S, S162A, S163T, T165I, Q174E, D177E, T200A, E203N, Q207K, L210I, D218E, V245Q, K275KQ, K277R, T286A, E291D, I293V, P294T, E297EK, E300EQ, S322T, G335D, R356K, M357K, G359S, A360I, A371V, I375V, K390R, K395RCRF02_AG
 48-30903090-30925DQ877999NRTINNRTIM41L, D67N, T69D, K70R, L74I, M184V, L210W, T215F, K219QA98G, K103N, V108I, Y181CV35T, T39A, K49R, V60I, V90I, K122E, I135V, S162E, E169K, K173T, Q174K, D177E, I178M, T200A, E203D, Q207E, D218E, L228H, V245Q, E248D, D250E, L283I, A288T, E291D, V292I, I293V, P294T, S322T, G335D, M357Q, G359S, A371V, I375V, A376S, K390R, K395RCRF02_AG
Laurent (2006)CK22-7503CM2-75AM279460AZT, DDI, D4T, 3TCEFVD67N, K70R, M184V, T215F, K219EK103N, V108I, K238TV35T, T39L, K64R, D123E, I135T, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, V245Q, T286A, E291D, V292I, I293V, S322T, I326V, G335D, R356K, M357K, R358K, G359S, K366R, T369V, A371V, I375V, K388R, K390R, K395R, E399D, A400T, T403M, E413D, E432DCRF02_AG
Sylla (2008)D673D673_C1DQ991672AZT, 3TCNVPM41L, T69D, M184V, T215YV106A, V108I, F227L, M230LV35T, E44D, S105V, L109I, K122E, D123N, S162A, S163R, M164H, T165D, K173T, Q174K, D177E, T200A, I202V, Q207G, R211K, K223Q, L228R, P243S, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, A371V, I375V, T386I, K390R, E399D, A400T, E432D, V467I, T470P, D471E, Q480H, H483Y, L491S, S519N, Q524K, K527G, E529D, A534S, A554N, K558RCRF02_AG
  D673_C2DQ991673AZT, 3TCNVPM41L, T69D, M184V, T215YV106A, V108I, F227L, M230LV35T, E44D, S105V, L109I, K122E, D123N, S162A, S163R, M164H, T165D, K173T, Q174K, D177E, T200A, I202V, Q207G, R211K, K223Q, L228R, P243S, V245Q, T286A, E291D, V292I, I293V, P294T, S322T, G335D, R356K, M357K, G359S, A371V, I375V, T386I, K390R, E399D, A400T, E432D, V467I, T470P, D471E, Q480H, H483Y, L491S, S519N, Q524K, K527G, E529D, A534SCRF02_AG
 A2619A2619_C1EF525657AZT, 3TCEFVD67N, K70R, M184V, T215Y, K219EA98G, V108I, V179E, Y181CV35T, E36D, V90I, L109I, D121Y, K122E, I135V, T139S, S162A, K173T, Q174N, D177E, T200A, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, K395R, E399D, T403M, E432D, V435LCRF02_AG
  A2619_C2EF525658AZT, 3TCEFVD67N, K70R, M184V, T215Y, K219EA98G, V108I, V179E, Y181CV35T, E36D, V90I, L109I, D121Y, K122E, I135V, T139S, S162A, K173T, Q174N, D177E, T200A, Q207E, R211K, V245Q, K281R, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, K395R, E399D, T403M, E432D, V435LCRF02_AG
Hawkins (2009)P647ZZP647FJ931151D4T, 3TCNVPM184V, T215YV108I, Y181CV35T, K49R, D123E, E169Q, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, T253S, T286A, E291D, V292I, I293V, P294T, V317A, S322A, I326IVCRF02_AG
 Q172ZZQ172FJ931190D4T, 3TCNVPM184VV108I, Y181C, G190GAV35T, K49R, D123E, I135V, S162A, E169K, K173T, Q174E, D177E, T200A, Q207E, R211K, H221HY, V245Q, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q771ZZQ771FJ931244AZT, 3TCEFVD67T, K70R, L74LI, M184V, T215F, K219EK103N, V108I, Y181C, G190GAV35T, E36D, T69N, K101KR, D123E, I135V, S162A, K173T, Q174R, D177E, T200A, Q207E, R211K, D218E, L228H, P243S, V245T, K277R, L283I, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q434ZZQ434FJ931266D4T, 3TCNVPM184VA98AG, V108I, Y181CV35I, V60VI, I135V, S162A, K173T, Q174K, D177E, V179I, V189I, T200A, I202V, Q207E, R211K, T215X, V245Q, E248DN, S251H, A272P, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 Q960ZZQ960FJ931289AZT, D4T, 3TCNVPK70R, L74LI, M184V, T215F, K219QK103N, V108I, M230LV35T, E36D, K64KR, T69N, V90I, K122M, S162A, K173T, Q174K, D177E, I178L, Q207E, R211K, L228Q, Q242K, V245Q, K275KR, K281KR, L283I, T286A, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R121ZZR121FJ931330D4T, 3TCNVPM184V, T215YV108I, Y181CT7I, V35T, E36D, V90I, K122E, I135V, S162A, K173T, Q174E, D177E, V179VI, T200A, Q207E, R211K, H221Y, V245Q, K281R, T286A, K287KR, E291D, V292I, I293V, P294T, E297EK, S322T, I326VCRF02_AG
 R23ZZR23FJ931363AZT, 3TCNVPM184VV108I, Y181CV35T, E36D, V90I, I135V, T139TK, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, H221Y, V245K, S251N, K275R, V276I, T286A, E291D, V292I, I293V, S322TCRF02_AG
 R215ZZR215FJ931368AZT, 3TCEFVM41L, D67N, K70R, V75VL, M184V, L210W, T215F, K219EK101E, V108I, Y181C, G190AV35IT, E36D, T39TA, K43Q, V60I, D123E, T139R, S162A, K173T, Q174K, D177E, I178M, T200A, Q207A, R211K, L228H, P243H, V245E, E248D, T286A, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 R468ZZR468FJ931392D4T, 3TCNVPA62AV, V75VI, F77FL, Q151M, M184V, K219QV108I, Y181CK20R, V35T, E36D, T39A, K43E, K49R, K64R, K122E, I135V, S162A, E169EA, K173A, Q174K, N175Y, D177E, T200A, Q207E, H221Y, L228LR, V245Q, E248D, K281R, E291D, I293V, P294T, S322T, I329VCRF02_AG
 R469ZZR469FJ931393D4T, 3TCNVPM41L, D67DG, T69TADN, M184V, T215YK101E, V108I, Y181C, G190AE28R, K32E, V35T, E36D, E44ED, K49R, E53D, V60VI, V90I, L109I, I135V, S162A, K173T, Q174E, D177E, I178IM, T200A, E203ED, Q207EK, H208HY, R211K, W212WR, H221HY, V245K, A272P, K281R, T286A, E291D, V292I, I293V, E297Q, S322T, I326VCRF02_AG
 R364ZZR364FJ931421NRTINVPM41L, M184V, L210LRW, T215YA98AG, V108I, Y181CV35T, T39R, K43E, K122E, D123N, I135L, S162A, K173T, Q174K, D177E, I178V, T200A, Q207E, R211K, H221Y, L228Q, V245Q, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R236ZZR236FJ931431NRTIEFV, NVPM41L, K70R, M184V, K219QA98G, K103N, V108I, Y181C, G190AV35T, E36D, V60I, T69N, V106VI, D123E, I135V, S162A, K173A, Q174R, D177E, I178M, V179I, T200A, Q207E, R211K, F214L, H221Y, L228R, V245Q, A272P, K275R, K277R, T286A, E291D, V292I, I293V, P294T, S322TCRF02_AG
 R474ZZR474FJ931436D4T, 3TCNVPM184V, T215YV108I, Y181CV35T, K49R, V60I, S68G, D123E, I135V, S162D, E169K, K173T, Q174E, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, K281KR, T286A, E291ED, V292VI, I293V, P294T, S322T, I326VCRF02_AG
 R439ZZR439FJ931449AZT, 3TCNVPM41L, L74LI, M184V, L210W, T215YK103N, V108IV35T, E44ED, V90I, D123E, I135IT, S162A, K166R, K173T, Q174R, D177E, I178L, T200A, Q207E, R211K, V245E, A272P, K277R, K281R, L283I, T286A, E291D, V292I, I293V, I326VCRF02_AG
Burda (2010)06LPH20SC06LPH20SCGQ344969D4T, 3TCNVPF116Y, Q151M, M184VV108I, Y181C, F227LK20R, V35T, E36D, T39L, K49R, S68G, K122E, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, H221Y, E224D, P243H, V245Q, K281R, L283I, T286A, E291D, V292I, I293V, D320X, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403MCRF02_AG
Aghokeng (2011)SK2047-M12SK2047-M12HQ864447AZT, 3TCNVPD67N, K70R, M184V, T215F, K219EK103N, V108IV35T, E36D, T39M, K122E, I135T, S162A, Q174E, D177E, T200A, Q207K, R211A, V245Q, E248DN, A272P, T286A, E291D, V292I, I293V, P294TCRF02_AG
Charpentier (2011)CR-41CR-41FJ688247AZT, 3TCNNRTIA62V, K70KN, V75I, F116Y, Q151M, M184V, T215SK103N, V108IV35T, K43KNRS, I47IL, K49R, S68G, T69TI, K122E, D123S, I135L, S162D, K173I, Q174K, D177E, Q197K, T200A, I202IV, R211K, V245Q, A272P, K281KR, V292I, I293V, S322A, I326VCRF02_AG
 CR-38CR-38FJ688244AZT, 3TCNNRTID67N, K70R, V75A, M184V, T215Y, K219QK103N, V108I, K238TV35T, E36D, K46Q, K49R, K73M, K122E, D123S, I135V, S162A, T165I, K173T, Q174K, N175Y, D177E, T200A, K201KR, Q207E, R211K, F214FL, H221Y, L228LH, V245Q, K275R, L283I, T286A, E291D, V292I, I293V, P294T, E297EK, E312A, S322ACRF02_AG
Dagnra (2011)08TG.T304608TG.T3046FR715261D4T, 3TCNVPD67G, K70R, M184V, T215F, K219EV108I, Y181CK20R, V35T, K64H, L109I, K122E, D123N, I135T, S162A, E169Q, K173T, Q174K, N175Y, D177E, T200A, I202V, Q207E, R211K, F214L, H221Y, L228H, V245E, E248D, D250E, L283I, T286A, E291D, V292I, I293V, P294T, S322T, D324E, I326V, G335D, R356K, M357R, G359S, A371V, I375V, A376T, T377I, K390R, A400T, T403MCRF02_AG
 08TG.E501308TG.E5013FR715271D4T, 3TCNVPM184VV108I, Y181CV35T, T69N, K122E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, E224EK, V245Q, E248EK, I257V, R284RG, T286A, E291D, V292I, I293V, P294T, S322T, K331KN, G335D, R356K, M357K, G359S, K366R, A371V, I375V, A376T, T377L, S379C, V381I, K390R, E396D, E432DCRF02_AG
Fokam (2011)CIRCB-10124CIRCB-10124JQ796164AZT, 3TCNVPM184VA98G, K103N, V108IV35T, T39A, V90I, K122KE, D123T, I135V, S162A, K173T, Q174K, D177E, T200A, Q207N, R211K, V245Q, E248D, K275Q, V276I, T286A, E291D, V292VI, I293V, P294T, E300K, S322TCRF02_AG
Fourati (2012)90301169030116JQ396041NRTINNRTIM184V, L210LW, T215SYK103N, V108IK20R, V21I, V35LR, E36ED, T39A, S68G, L109I, I135V, S162T, K173T, Q174K, D177E, I178M, V189I, T200A, E203K, Q207E, R211KCRF02_AG
Aghokeng (2013)HJ3115HJ3115JX983015NRTINNRTIM184VV108I, Y181CE6D, V35T, E36D, T39A, K122E, D123GS, I135V, T139TK, S162A, K173T, D177E, T200A, Q207E, H221Y, V245Q, K277R, T286A, V292I, I293V, S322T, G335E, P345Q, R356K, M357K, G359S, A371V, I375V, K390R, A400AT, T403MCRF02_AG
 HJ3188HJ3188JX982995NRTINNRTIM184V, T215FK103N, V108I, M230L, L234IV35T, E36D, R78RK, K122E, D123S, I135M, S162A, K173T, Q174K, D177E, I178L, V189VI, T200A, Q207E, R211RK, H221Y, L228LH, V245EK, T286A, E291D, V292I, I293V, S322T, G335D, R356K, M357K, G359S, A360T, I375V, T377L, K390R, K395RCRF02_AG
 HJ3168HJ3168JX982991NRTINNRTIM184VK103N, V108IV35T, V60I, D121H, K122E, I135V, T139TK, A158AS, S162ST, K173N, Q174K, D177E, T200A, Q207E, R211K, H221HY, P243T, V245H, T286A, E291D, I293V, P294A, S322T, I326V, R356K, M357K, G359S, A371V, I375V, T377V, K390R, E399D, T403M, E413DCRF02_AG
 HJ3059HJ3059JX983018NRTINNRTIK70R, M184V, T215F, K219QK103N, V108I, M230LV35T, T69N, K122E, D123N, I135V, S162A, K173T, Q174E, D177E, T200E, E203Q, Q207E, R211K, L228R, V245T, A272P, K281R, L283I, T286A, A288T, I293V, P294T, S322A, I326IV, G335D, R356K, M357K, G359S, A371V, I375V, T377L, S379G, K390R, T403MCRF02_AG
Kebe (2013)SNA3-214SNA3-214HM002516NRTINNRTIA62V, K65R, V75I, F116Y, Q151M, M184V, K219EV108I, Y181CI31L, V35T, E36D, V60I, K64R, S68R, N81NT, V118I, K122E, R143R*, S162A, K173T, Q174K, D177E, T200A, Q207K, R211S, F214L, V245QCRF02_AG
 SNA3-139SNA3-139JN193500NRTINVPM184VA98AG, K101E, V108I, G190AV35T, E36D, V60I, K102Q, V106I, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, T200A, Q207ECRF02_AG
Nii-Trebi (2013)KF128KF128AB751483AZT, 3TCNVPD67N, T69DN, K70R, M184V, T215F, K219QV108I, Y181CK20R, K32E, V35T, E36A, T39K, K43A, V60I, L109I, D121H, K122E, I135R, T139R, S162A, K173T, Q174K, D177E, T200A, I202V, Q207E, R211K, F214L, L228H, V245QCRF02_AG
 775775AB751454D4T, 3TCEFVM184VK101E, V108I, G190SK13KN, V35T, E36D, K49R, V106VI, K122P, I135V, S162A, T165I, E169D, K173A, Q174R, D177E, I178L, T200A, Q207E, R211K, V245QCRF02_AG
Pircher (2013)B1137B1137JX110237D4T, 3TC, AZTNVPM41ML, M184V, L210W, T215YA98G, K103N, V108IK20R, V35T, E36D, T39LS, K43KE, V60VI, L109LI, D123E, I135T, S162AT, K173T, Q174K, N175NY, D177E, G196E, T200A, Q207E, R211K, V245QCRF02_AG
 B1125B1125JX110225D4T, 3TC, AZTNVPL74I, M184V, T215FY, K219KNA98G, K101E, V108I, M230LK22R, V35T, T39L, S68G, K104R, K122E, D123S, E138A, S162A, Q174K, T200A, E203D, Q207D, H221Y, V245QCRF02_AG
Rawizza (2013)PJ9681PJ9681KF241511NRTINNRTIA62V, V75I, F77L, Y115F, F116Y, Q151M, M184V, K219EK103N, V108I, K238TP14A, D17DE, V35T, E36D, E40K, K43Q, K46Q, K49R, T58N, S68G, K122E, D123N, I135IV, S162T, K173T, Q174K, D177E, I178IM, T200A, E203EK, Q207E, R211K, I244IT, V245E, A272P, Q278N, L283I, E291D, V292I, I293V, P294A, S322T, D324ECRF02_AG
Theys (2013)33253325KC219252NRTI, TDFNNRTIK65R, M184VK103N, V108I, F227FL, M230LK49R, S68SG, K122N, I135V, S162A, K173T, Q174R, D177E, I178M, T200A, Q207G, H221YCRF02_AG
 2788827888KC220538NRTI, TDFNNRTIM41L, D67N, V75T, M184V, T215Y, K219EV108I, Y181CK49R, I135V, S162A, K166E, E169K, K173T, Q174N, D177E, I178M, T200A, Q207E, R211K, F214FL, H221YCRF02_AG
 2618226182KC220408NRTI, TDFNNRTIM41L, D67N, V75T, M184V, T215Y, K219EV108I, Y181CK49R, I135V, S162A, K166E, E169K, K173T, Q174N, D177E, I178M, T200A, Q207E, R211K, H221YCRF02_AG
 5503555035KC221678NRTI, TDFNNRTIF77FLK103N, V108I, P225H, F227CV60I, V90I, D123E, I135V, E138Q, S162A, K173S, Q174K, D177E, V179I, G196E, T200A, Q207A, H221YCRF02_AG
 4625246252KC221354NRTI, TDFNNRTIM41L, D67G, L74I, M184V, L210W, T215Y, K219NA98G, V108IE44D, S68G, L109I, V118I, D123E, S162A, K173T, Q174E, D177E, T200A, E203K, Q207E, H208Y, R211K, D218E, K223QCRF02_AG
 2276922769KC220150NRTI, TDFNNRTI V108IE40D, V90VI, K122P, D123E, S162A, K173T, Q174K, P176PST, D177E, V189VI, T200A, Q207E, R211RK, D237NCRF02_AG
Thiam (2013)3105-HALD3105-HALDJN673614NRTINNRTIM184VK103N, V108I, K238KITK20R, V35T, T39M, V60I, V90I, K122P, I135V, T139R, S162A, K173T, Q174K, D177EK, G196E, T200A, Q207E, R211K, D237DN, P243PCRS, V245Q, L246LV, E248DGNS, D250DGNS, S251SI, T253TS, K281R, T286A, E291D, V292I, I293V, P294T, E297R, S322T, I326VCRF02_AG
 418-HALD418-HALDJN673621NRTINNRTIL74V, M184VV108I, Y181CV35I, V90I, K122E, D123N, I135L, S162A, K173T, Q174K, D177E, T200A, Q207E, H221Y, I244IV, V245K, D250E, S251I, K275KQ, K281KR, T286A, A288T, E291D, V292I, I293V, P294T, S322T, I326VCRF02_AG
 2187HALD2187HALDJX187615NRTINNRTIM41L, D67N, K70R, M184V, T215Y, K219EA98G, V108I, Y181CV35T, E36D, E44D, V60I, D123E, S162D, K173T, Q174K, D177E, I178M, T200A, Q207G, R211K, H221Y, L228H, V245Q, P247ACRF02_AG
 3210-HALD3210-HALDJN673615NRTINNRTID67G, K70R, M184V, T215F, K219EA98G, K103N, V108IV35T, E36D, T39L, K49R, S68G, K101KR, K122E, I135V, S162A, E169K, K173T, Q174E, D177E, I178M, T200A, E203K, Q207E, R211K, K223E, P243S, V245Q, E248D, T286A, E291D, I293IV, P294T, L295LM, S322T, I326V, I329IVCRF02_AG
 2841-HALD2841-HALDJN673708NRTINNRTIM41L, L74I, M184V, L210W, T215YA98G, K103N, V108IE28K, K32I, V35T, T39K, K43E, V60I, K101A, V118I, K122E, D123S, K173T, Q174K, D177E, T200A, E203K, Q207D, R211K, K223E, L228R, V245Q, T286A, E291D, I293V, P294TCRF02_AG