<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation A98G
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 11
Patients 73
Isolates 81
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Montes (2004)MB_patBRI00_BRI706AJ577745DDI, 3TC, D4T, AZTNVPM41L, M184V, L210W, T215YA98G, G190AE6D, K20E, V35T, T39R, K43E, E44D, S68G, K122E, D123S, K173T, Q174K, D177E, V179I, T200A, Q207A, R211E, E224K, L228PCRF01_AE
  01_BRI705AJ577746DDI, 3TC, D4T, AZTNVPM41L, M184V, L210W, T215YA98G, G190AE6D, K11T, V35I, T39R, K43E, E44D, S68G, V118I, K122E, D123S, K173T, Q174K, D177E, V179I, T200A, E203K, Q207D, L228HCRF01_AE
Hsu (2005)BAA161440BAA161440AY870236AZT, 3TCEFVM41L, M184V, L210W, T215FA98G, Y188L, Y318FE6D, K11T, V35T, E36A, T39K, K43E, K122E, D123S, I135L, K173T, Q174K, D177E, V179I, G196E, Q207A, R211S, V245K, E291D, V292I, I293V, E312T, I326V, G335D, Y342F, M357K, G359S, K366R, T369A, A371V, K390R, K395RCRF01_AE
Non-B Workgroup (2005)TH_201TH_201AY6056063TC, D4TEFV, NVPM41L, D67N, K70R, M184I, T215F, K219QA98G, V179D, Y181C, G190AV35T, T39K, K43E, K102R, V106I, K122E, D123S, K173I, Q174K, D177E, I178L, E203K, Q207A, R211S, K223Q, K238R, V245ECRF01_AE
 TH_227TH_227AY605633D4T, DDIEFVD67N, K70R, L74I, V75T, T215F, K219QA98G, K103N, V179E, Y181C, P225HV35T, T39K, E42D, K43E, K122E, D123S, K173I, Q174K, D177E, T200A, Q207A, R211S, D218E, V245ECRF01_AE
 TH_505TH_505AY901864D4T, 3TCNVPM41L, D67N, K70R, M184I, L210W, T215V, K219QA98G, Y181C, G190A, F227LV35T, T39K, K43E, V60I, K122E, D123N, K173I, Q174K, D177E, I178M, T200A, E203K, Q207A, R211S, K223E, K238R, V245ECRF01_AE
 TH_523TH_523AY901866D4T, DDINVPD67N, K70R, T215F, K219QA98G, K103N, Y181CV35T, T39K, K43E, T69N, K122E, D123S, I135L, R172K, K173I, Q174K, D177E, G196E, Q207A, R211S, D218E, V245ECRF01_AE
 TH_527TH_527AY901869D4T, 3TCNVPM41L, D67N, K70R, L74I, M184I, T215F, K219QA98G, K101E, G190AV35T, T39K, K43E, V60I, V90I, K122E, D123S, I135L, R172K, K173I, Q174K, D177E, I178M, Q207A, R211S, D218E, V245E, D250YCRF01_AE
 TH_774TH_774AY901952D4T, 3TCNVPM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, K101E, G190AV35T, T39D, K122E, D123S, E138G, K173T, Q174K, D177E, I178M, T200A, Q207A, R211N, D218E, K238R, V245K, E248DCRF01_AE
Tee (2006)MYKL135104MYKL1351.1AY960910NRTI, AZT, 3TCEFVM184VA98G, K103N, P225HK20R, V35T, T39K, K43E, S68G, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245ECRF01_AE
 MYKL140204MYKL1402.1AY960912AZT, 3TCEFVM184VA98G, K103N, V108IK20R, V35T, T39K, K43E, T69P, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, E224D, V245ECRF01_AE
  04MYKL1402.2AY960913AZT, 3TCEFVM184VA98G, K103N, V108IK20R, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, E224D, V245ECRF01_AE
 MYKL151803MYKL1518AY960892D4T, DDIEFVM41L, D67N, L210W, T215YA98G, Y188LV35T, T39K, K43E, E44D, V106I, V118I, K122E, D123S, I135V, R172K, K173I, Q174K, D177E, I178M, T200I, I202V, Q207A, R211N, K238R, V245ECRF01_AE
  03MYKL1518.1AY960920D4T, DDIEFVM41L, D67N, L210W, T215YA98G, Y188LV35T, T39K, K43E, E44D, V106I, V118I, K122E, D123S, I135V, R172K, K173I, Q174K, D177E, I178M, T200I, I202V, Q207A, R211N, K238R, V245ECRF01_AE
Zhong (2007)D002205CN_022EF199565NRTINVPF116Y, Q151MA98G, K103NE6D, K11T, K20R, V35T, T39E, S68G, K122E, D123S, I135L, E138G, R172K, K173A, Q174K, D177E, I178M, T200I, Q207A, R211S, V241C, V245ECRF01_AE
Manosuthi (2010)14N069414N0694 D4T, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K101N, Y181C, G190AT39K, K43E, K49R, V60I, K122E, D123S, K173IM, Q174K, D177E, I178M, T200A, Q207A, R211S, D218E, V245ECRF01_AE
 142933142933 D4T, 3TCNVPM184VA98G, K101E, K103KNRS, G190AT39K, K43E, K122E, D123S, K173AV, Q174K, D177E, V179I, T200I, Q207A, R211S, K238R, V245ECRF01_AE
 250826250826 D4T, 3TCNVP A98G, K103NT39N, D123S, I135L, R172K, K173L, Q174K, D177E, Q207N, R211K, V245KCRF01_AE
 25-067425-0674 D4T, 3TCNVPM184VA98G, K103N, V108IT39K, K43E, K104R, K122E, D123S, I135L, S162C, K173I, Q174K, D177E, Q207A, R211S, K238R, V245ECRF01_AE
 250796250796 D4T, 3TCNVPM184V, T215TFISA98G, K101E, Y181C, G190AT39K, K43E, K122E, D123NS, K173I, Q174K, D177E, I178M, I202V, Q207K, R211S, H221Y, V245ECRF01_AE
 250752250752 D4T, 3TCNVPK70R, L74V, M184V, K219QA98G, K103N, P225H, M230LT39K, K43E, S68G, T69N, K122E, D123S, I135L, R172K, K173I, Q174K, D177E, I178M, T200A, E203K, Q207AT, R211KCRF01_AE
 25-065125-0651 D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, K103N, P225HT39K, K43E, V60I, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, L228H, K238R, V245ECRF01_AE
 143229143229 D4T, 3TCNVPL74I, M184VA98G, K101E, G190ST39K, K43E, K122E, D123S, I135L, E138G, R172K, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 250870250870 D4T, 3TCNVPM41L, M184V, T215TFISA98G, K103N, Y181CT39K, K43E, V60I, S68G, K122E, D123S, I135L, I142V, K173I, Q174K, D177E, T200A, Q207A, R211S, V245QCRF01_AE
 25-046125-0461 D4T, 3TCNVPM41L, D67N, K70R, L74V, T215F, K219QA98G, G190ET39K, K43E, V60I, K64R, T69N, K122IV, D123N, I135V, S163A, K173I, Q174K, D177E, Q207A, R211N, D218E, K238R, V245ECRF01_AE
 250788250788 D4T, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K101E, Y181CT39K, K43E, V60I, T69N, V111I, K122E, D123S, I135T, I142T, K166R, I167V, K173I, Q174K, D177E, I178M, T200A, I202V, Q207A, R211S, H221Y, V245ECRF01_AE
Zolfo (2010)A12855A 12855 M12HM565546D4T, 3TCNVPV75M, M184VA98G, Y181CT39K, K43E, K122E, D123N, I135IV, K173L, Q174K, D177E, V179I, Q207A, R211S, H221HY, K238R, V245ICRF01_AE
 A13748A 13748 M24HM565512D4T, 3TC, AZTNVPM184VA98G, V108I, Y181CT39K, K43E, T69N, V111I, K122E, D123N, A158T, K173I, Q174K, D177E, V189VI, I202V, E203KQ, Q207D, R211S, H221HY, V245ECRF01_AE
 A12757A 12757 RSHM565605D4T, 3TCNVPM41L, V75M, M184V, L210LW, T215FA98G, K103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
  A 12757 M24HM565518D4T, 3TCNVPM41L, V75M, M184V, L210W, T215FA98G, K103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 A13530A 13530 RSHM565610D4T, 3TCNVP, EFVM184VA98GT39E, K122E, D123S, S162C, K173I, Q174K, D177E, I178L, V179I, T200I, Q207A, R211S, K238R, V245ECRF01_AE
  A 13530 M12HM565535D4T, 3TCNVP, EFVM184VA98G, K103KNT39E, V106VI, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, I178L, V179I, T200I, Q207A, R211S, K238R, V245ECRF01_AE
  A 13530 M18HM565534D4T, 3TC, AZTNVP, EFVK70KT, M184VA98G, K103NT39E, K122E, D123S, I135ILPT, S162C, K173IR, Q174K, D177E, I178L, V179I, T200I, Q207A, R211S, K238R, V245ECRF01_AE
  A 13530 M24HM565533D4T, 3TC, AZTNVP, EFVV75M, M184VA98G, K103N, P225HT39E, K122E, D123GS, I135ILPT, S162C, K173R, Q174K, D177E, I178L, V179I, T200I, Q207A, R211S, V245ECRF01_AE
 A14428A 14428 RSHM565611D4T, 3TCNVPM41L, D67N, L74I, M184V, L210W, T215Y, K219NA98G, L100LI, K101E, V108I, Y181I, G190AT39K, K43E, E44A, V60I, V106VI, V118I, K122E, D123S, I135T, S162N, K166R, K173I, Q174K, D177E, V179I, T200I, I202V, Q207A, R211N, V245ECRF01_AE
 A12589A 12589 RSHM565612D4T, 3TCNVPM184V, T215YA98G, K101E, Y181CK49KR, S68G, K122E, D123S, I135T, E138EQ, K173I, Q174K, D177E, I178L, D192DN, T200L, Q207A, R211S, V245ECRF01_AE
  A 12589 M42HM565537D4T, 3TC, AZTNVPM41ML, M184V, T215YA98G, K101E, Y181CV60VI, S68SG, K122E, D123S, I135T, E138EQ, K173I, Q174K, D177E, I178L, T200L, Q207A, R211S, V245ECRF01_AE
Bunupuradah (2011)079-003-007079-003-007 D4T, 3TC, AZTNVPM41L, D67N, K70R, L74I, M184I, L210W, T215Y, K219QA98G, K101E, G190AK20R, V35T, T39K, K43E, V60I, K122E, D123N, S162C, K173I, Q174K, D177E, I178M, T200I, Q207A, R211N, K238R, V245ECRF01_AE
 079-010-007079-010-007 D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, K101E, G190AV35T, T39K, K43A, V60I, K122E, D123N, I135L, K173L, Q174K, D177E, T200A, Q207A, R211S, V245QCRF01_AE
 079-010-010079-010-010 D4T, 3TCNVPM184VA98G, K101E, G190AV35T, T39K, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, Q207T, R211S, V245ECRF01_AE
 079-004-001079-004-001 D4T, 3TC, AZTNVPD67N, T69D, M184V, L210W, T215FA98G, Y181CI31L, V35T, T39K, K43E, K49R, V118I, K122E, D123N, S162A, K173A, Q174K, D177E, I202V, Q207A, R211S, K238RCRF01_AE
 079-010-019079-010-019 D4T, 3TCNVP, EFVM184IA98G, K101E, Y181C, G190AV35T, T39K, K43E, S68G, V90I, K122E, D123N, I135T, S162A, T165L, K173T, Q174K, D177E, I178M, Q207A, R211S, F214L, V245ECRF01_AE
 079-005-002079-005-002 D4T, 3TC, AZTNVPM41L, D67N, M184V, L210W, T215FA98G, K101E, G190AE28K, K32E, V35T, T39K, K43E, V118I, K122E, D123E, S162C, E169A, K173A, Q174K, N175Y, D177E, Q207A, R211S, K223Q, K238R, V245ECRF01_AE
 079-004-011079-004-011 D4T, 3TC, DDINVPD67N, K70G, M184V, K219QA98G, K101E, G190AV35T, T39K, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 079-011-003079-011-003 D4T, 3TCNVPM184VA98G, K101E, Y181CV35T, T39K, K43E, K122E, D123N, K166R, K173I, Q174K, D177E, I178M, Q207A, R211S, L228R, V245ECRF01_AE
 079-010-026079-010-026 D4T, 3TC, AZTNVPM41L, D67N, K70R, M184V, T215F, K219QA98G, Y181CK20R, V35T, T39K, K43E, V60I, T69N, V111I, K122E, D123S, I135T, K173A, Q174K, D177E, V179I, T200I, Q207A, R211S, F214L, D218E, L228R, K238R, V245ECRF01_AE
 079-003-010079-003-010 D4T, 3TC, AZTNVP, EFVD67N, K70R, M184V, T215I, K219QA98G, K101P, Y188CV35T, T39K, K43E, V106I, K122E, D123S, K173I, Q174K, V179I, T200A, Q207A, R211S, F214L, V245ECRF01_AE
 079-005-013079-005-013 D4T, 3TCNVPD67N, K70R, M184V, K219EA98G, K103NK20R, V35T, T39K, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, D218E, V245ACRF01_AE
 079-008-001079-008-001 D4T, 3TCNVP, EFVM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219QA98G, L100I, K101E, V108IV35T, E36D, T39K, K43E, V60I, K122E, D123S, K173R, Q174K, D177E, V179I, T200A, Q207A, R211N, H221Y, L228H, K238R, V245KCRF01_AE
 079-010-039079-010-039 D4T, 3TCNVP, EFVD67N, K70R, M184V, T215F, K219QA98G, G190AK20R, V35T, T39K, K43E, K101Q, K122E, D123S, E138Q, K173I, Q174K, D177E, I178M, V179I, T200I, I202V, Q207A, R211S, V245KCRF01_AE
 079-005-025079-005-025 D4T, 3TCNVPM184VA98G, Y181CV35M, T39K, K43E, K49R, K64R, K122E, D123N, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, V245ECRF01_AE
 079-003-041079-003-041 D4T, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K101E, G190SV35T, T39K, K43E, K49R, V60I, K122E, D123N, I135L, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 079-006-010079-006-010 D4T, 3TCNVPM184VA98G, G190AV35T, T39K, K43E, V60I, S68G, K122E, D123N, I135T, K173M, Q174K, D177E, I178M, T200E, E203K, Q207A, R211S, V245ECRF01_AE
 079-003-047079-003-047 D4T, 3TCNVPM184VA98G, Y181CV35T, T39K, K43E, K122E, D123S, I135T, K173A, Q174K, D177E, I178V, V179L, G196E, I202V, Q207A, R211S, K238R, V245ECRF01_AE
 079-011-039079-011-039 D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, K101E, Y181CP25A, V35T, T39E, K122E, D123S, I135R, K173I, Q174K, D177E, I202V, Q207A, R211N, H221Y, V245KCRF01_AE
 079-010-047079-010-047 D4T, 3TC, AZTNVPM184VA98G, K103NK20R, V35T, T39K, K43A, K49R, K101Q, K122E, D123N, I135L, S162A, R172K, K173R, Q174K, D177E, I178M, V179I, T200I, Q207D, V245ECRF01_AE
Ferradini (2011)440011RTHM026304AZT, 3TCNVPD67N, K70R, M184V, T215F, K219QA98G, K103N, Y181YCV35T, T39E, K122E, D123S, I135V, S163A, K173R, Q174K, D177E, Q207G, R211S, K238RCRF01_AE
 420239RTHM026307AZT, 3TCNVPD67N, K70R, V75M, M184V, L210W, T215F, K219EA98G, Y181CE28A, V35T, T39E, K101Q, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238RCRF01_AE
 70262RTHM026310D4T, 3TCEFVD67N, K70R, M184V, K219QA98G, K103N, P225HK20R, V35T, T39N, K122E, D123S, S162T, K173I, Q174K, D177E, I178M, T200A, Q207S, R211S, L228R, K238RCRF01_AE
 140116RTHM026317AZT, 3TCNVPD67N, M184VA98G, K103NV35T, T39E, K122E, D123S, I135T, K173I, Q174K, D177E, T200A, Q207A, R211S, K238RCRF01_AE
 150030RTHM026318AZT, 3TCNVPM41L, K70R, M184V, T215F, K219QA98G, K101E, V108I, Y181C, G190AL34I, V35T, T39E, T69N, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, T200A, E203D, Q207D, R211K, H221Y, L228R, K238RCRF01_AE
 160191RTHM026319AZT, 3TCEFVM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, K101P, K103NV35T, T39K, K43E, V60I, K122E, D123N, I142V, K173A, Q174K, D177E, I178M, T200A, E203D, Q207A, R211S, K238RCRF01_AE
 170113RTHM026320AZT, 3TCNVPM41L, D67N, K70R, V75I, M184V, T215F, K219EA98G, K103N, V108I, M230LV35T, T39K, K43E, W88S, K122E, D123N, Q174R, D177E, Q207A, R211S, K238RCRF01_AE
 200330RTHM026323AZT, 3TCNVPM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, V108VI, G190AV35T, T39K, K43E, V60VI, K122E, D123S, K173T, Q174K, N175Y, Q197E, Q207A, R211N, D218E, K238RCRF01_AE
 250656RTHM026328D4T, 3TCEFVM41L, D67N, K70R, L74I, M184V, T215F, K219QA98G, G190SV35T, T39E, V106I, K122E, D123S, S162Y, K173T, Q174K, D177E, I178M, V179I, G196E, E203K, Q207A, H208Y, R211S, K223Q, F227Y, L228H, K238RCRF01_AE
 370352RTHM026340D4T, 3TCEFVM41L, L74V, M184VA98G, Y181C, G190SK20KR, V35T, T39K, T69N, V106I, V111I, K122E, D123S, I135T, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, F214L, K238RCRF01_AE
Ngo-Giang-Huong (2011)PHPT0057PHPT0057RTHQ996414D4T, 3TCNVPM41L, D67N, K70R, M184V, T215FY, K219EA98G, Y181C, G190AK43E, V60I, K101Q, V118I, K122E, D123N, I142V, K173A, Q174K, D177E, I178M, Q207A, L210FY, R211NS, L228HCRF01_AE
 PHPT0649PHPT0649RTHQ996421AZT, DDIEFVM41ML, T215YA98G, K103N, Y181YCL34I, V35T, T39K, K43E, S68SG, K122E, D123S, S162A, K173I, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
 PHPT0652PHPT0652RTHQ996422TDF, 3TCNVPM184V, T215FA98G, V108I, G190AV35T, T39K, K43E, K122KE, D123S, K173I, Q174K, D177E, V179I, Q207A, R211S, F214L, K238RCRF01_AE
 PHPT1210PHPT1210RTHQ996439D4T, 3TCNVPD67N, M184VA98G, K101E, Y181CE6D, K11T, K20R, K22N, Q23QL, V35T, T39K, K43E, K122E, D123N, I135T, S162C, K173I, Q174K, D177E, T200I, Q207A, R211S, Q222QL, P225PL, L228LF, D237DG, K238RCRF01_AE
 PHPT1263PHPT1263RTHQ996440AZT, 3TCNVPD67DN, K70KR, M184V, T215Y, K219KEA98G, Y181CV35T, T39K, K43E, T107S, K122E, D123S, K173IV, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
 PHPT3742PHPT3742RTHQ996462D4T, 3TCNVPM184MIA98G, K101KHNQ, Y181CK43E, K122E, D123N, K173T, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 PHPT3773PHPT3773RTHQ996464D4T, 3TCNVPM184VA98G, K101KEQ, G190AV8VL, V35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174K, D177E, E203D, Q207A, R211S, K238RCRF01_AE
 PHPT3896PHPT3896RTHQ996472AZT, 3TCNVPM184VA98G, K101H, Y181CT39K, K43E, K49KR, K122E, D123S, I135T, K173I, Q174K, D177E, T200I, Q207A, R211S, K238RCRF01_AE
 PHPT1279PHPT1279RTHQ996493AZT, 3TCEFVV75I, M184VA98G, K103NV35T, T39E, K122E, D123S, I132L, K173I, Q174K, D177E, H198D, Q207A, R211S, K238RCRF01_AE
 PHPT4484PHPT4484PR-RTHQ996505TDF, FTCNVPK65KR, M184VA98G, Y181C, G190GAE6D, T27S, V35T, T39K, K43E, V111I, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, P313T, I326V, I329VCRF01_AE
 PHPT4352PHPT4352PR-RTHQ996515TDF, FTCEFVL74I, M184VA98G, K103N, P225HE6D, K11T, V35T, T39K, K43E, V60I, S68G, K122E, D123S, I135T, S162A, K173I, Q174K, D177E, I178L, T200A, Q207A, R211S, V245E, K287R, E291D, V292I, I293V, E312N, I326V, I329VCRF01_AE
Coetzer (2013)KH041KH041KC533611D4T, 3TCNVPM184VA98G, Y181CV35T, T39N, K122E, D123N, I135IT, K173I, Q174K, D177E, T200MR, Q207A, R211S, F214L, K238RCRF01_AE
 KH010KH010KC533622D4T, 3TCNVPD67N, K70R, M184V, T215F, K219EA98G, V108I, Y181CV35T, T39K, K43E, T69N, K122E, D123S, K173A, Q174K, D177E, T200A, Q207A, R211RS, L228HCRF01_AE
 KH003KH003KC533639D4T, 3TCNVPD67DN, M184VA98G, Y181CV35T, T39K, K43E, K122E, D123S, K173T, Q174K, D177E, T200A, E203EK, Q207A, R211S, F214FL, K238RCRF01_AE
 KH001KH001KC533645D4T, 3TCNVPM184VA98G, K101E, Y181CV35T, T39K, K43E, K64R, K122E, D123N, K173I, Q174K, D177E, I178M, Q207A, R211S, H221YCRF01_AE

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