<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation F227L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 35
Isolates 35
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Chantratita (2005)25-000725-0007DQ131068NRTINNRTIV75M, M184VK103N, V108I, F227LT39K, K43E, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, H221Y, K238R, V245DCRF01_AE
 G511G511DQ130517NRTINNRTIV75L, M184VV106M, V179D, F227LT39K, K43E, K103R, D123S, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
 G558G558DQ130558NRTINNRTID67N, T69D, K70R, M184V, T215F, K219QK103N, V108I, F227L, M230LT39K, K43E, N57D, D123N, Q174K, D177E, I178L, Q207A, R211S, V245KCRF01_AE
 G701G701DQ130688NRTINNRTIM41L, D67N, V75M, M184I, L210W, T215Y, K219RK101E, Y188L, F227LT39K, K43E, E44D, V60I, V118I, K122E, D123S, K173I, Q174K, D177E, I178M, G196E, E203K, Q207A, R211S, K223E, V245ECRF01_AE
 G719G719DQ130701NRTINNRTIM184VV106M, F227LT39K, K43E, E79G, A98S, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245RCRF01_AE
 NP231NP231DQ130827NRTINNRTIM41L, D67N, V75M, L210W, T215YV106A, G190A, F227LT39Q, K43E, E44A, V60I, S105T, L109I, V118I, K122E, D123S, K173T, Q174K, D177E, I178L, G196E, E203D, Q207A, H208F, R211D, V245ECRF01_AE
 NP302NP302DQ130895NRTINNRTIV75IK103N, V106M, V179D, G190A, F227LT39K, K43E, K122E, D123S, K166R, K173I, Q174K, D177G, T200A, Q207A, R211S, I244V, V245ECRF01_AE
Non-B Workgroup (2005)TH_505TH_505AY901864D4T, 3TCNVPM41L, D67N, K70R, M184I, L210W, T215V, K219QA98G, Y181C, G190A, F227LV35T, T39K, K43E, V60I, K122E, D123N, K173I, Q174K, D177E, I178M, T200A, E203K, Q207A, R211S, K223E, K238R, V245ECRF01_AE
 TH_695TH_695AY901926AZT, 3TCEFVM41L, D67N, M184V, T215FV106M, F227LV35T, T39K, K43E, K101Q, K122E, D123S, I135M, K173T, Q174K, D177E, Q207A, K238R, V245ECRF01_AE
Manosuthi (2010)250816250816 D4T, 3TCNVPD67N, K70E, Y115F, M184VV106M, V179D, F227LT39K, K43E, V118I, K122E, D123N, I142V, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
 25-044425-0444 D4T, 3TCNVPM41L, D67DGNS, K70R, M184V, T215I, K219EV106M, V179D, G190A, F227LT39K, K43E, S68G, K122E, D123S, I135T, I142V, K173I, Q174K, N175Y, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 25-027525-0275 D4T, 3TCNVPK70R, V75M, M184VY181C, F227LK43E, S68G, K101Q, V106I, K122E, D123S, K173T, Q174K, N175K, I178M, Q207A, R211S, H221Y, K238R, V245ECRF01_AE
 25-027625-0276 D4T, 3TCNVPA62V, V75I, M184VV106A, F227LT39K, K49R, V111I, K122E, D123S, I135T, K173I, Q174K, D177E, I178L, T200I, I202V, Q207A, R211S, F214L, V245DCRF01_AE
Bunupuradah (2011)079-003-013079-003-013 D4T, 3TCNVPD67N, K70R, F116Y, Q151M, M184V, K219QY181C, F227LV35T, T39K, K43E, V60I, T69N, V106I, K122E, D123S, I135T, G152E, K173I, Q174K, D177E, I178M, T200A, I202V, Q207A, R211S, F214L, H221Y, K238R, V245ECRF01_AE
 079-011-040079-011-040 D4T, 3TCNVPK70R, V75M, M184VV106A, F227LV35T, T39E, D121H, K122E, K173A, Q174K, D177E, I178L, T200A, E203K, Q207D, R211S, V245TCRF01_AE
 079-008-020079-008-020 D4T, 3TC, AZTNVPM184VY181C, F227LV35T, T39K, K43E, V60I, S68G, T107S, V118I, K122E, D123S, K173R, Q174N, D177E, Q207A, R211S, F214L, H221Y, V245E, T253NCRF01_AE
Jiamsakul (2013)R72037R72037KJ868999D4T, 3TCNVPM184VY181C, F227LT39K, K43E, V60I, S68G, T107S, V118I, K122E, D123S, K173R, Q174N, D177E, Q207A, R211S, F214FL, H221Y, V245ECRF01_AE
Nouhin (2013)T1001102T1001102KF292698NRTINNRTIL74I, V75M, M184V, L210W, T215Y, K219NA98G, K103N, F227L, K238TK20I, K30I, V35A, I37F, T39E, M41V, I47L, T69N, I94L, I135M, K173T, Q174K, D177E, I178M, T200A, Q207A, R211N, L228P, M230ICRF01_AE
 U0720072U0720072KF292803NRTINNRTI V106A, F227LV35T, T39K, E40Q, K43E, K49R, S68G, A98S, K122E, D123S, S162N, K173I, Q174K, D177E, T200E, Q207D, R211K, K238RCRF01_AE
 S0418148S0418148KF292530NRTINNRTIM41L, L74I, V75M, M184V, L210W, T215FV106A, F227LV35T, T39K, E44D, L109I, V118I, K122E, D123S, K173I, Q174K, D177E, I178L, V179I, T200K, I202V, Q207A, R211S, K238RCRF01_AE
 Q0324095Q0324095KF292359NRTINNRTIM184V, L210W, T215FK101E, V106M, Y181V, G190A, F227LT39R, K43E, E44D, K49R, T69N, L109I, K122E, D123S, I135T, E138A, S162C, K173T, Q174K, N175Y, V179IT, T200A, I202V, E203K, Q207D, R211K, H221Y, K238RCRF01_AE
 R0103153R0103153KF292438NRTINNRTID67N, M184V, T215F, K219RV106A, F227LK20R, V35T, T39K, K43E, K49R, V60VI, K122E, D123S, I135T, K173R, Q174K, D177E, T200A, Q207A, H208Y, R211K, K223ECRF01_AE
 S0806097S0806097KF292578NRTINNRTID67N, T69D, M184V, L210W, T215YY181C, F227LV35T, T39K, K49E, V106I, T107S, V118I, K122E, D123S, I135T, S162Y, K173I, Q174K, D177E, I178M, V179I, T200A, E203K, Q207A, R211S, H221Y, K223QCRF01_AE
 Q0817130Q0817130KF292403NRTINNRTID67N, K70R, M184V, T215F, K219EG190A, F227L, M230LV35T, T39K, K43E, K122E, D123S, R125RK, K173I, Q174K, D177E, T200M, Q207A, R211S, K238RCRF01_AE
 T0304254T0304254KF292617NRTINNRTIM41L, D67N, T69D, M184I, L210W, T215YA98G, K101E, Y181C, G190A, F227LE28K, K32E, V35T, T39A, K43E, E44A, K122E, D123S, K166R, R172K, Q174E, D177E, I178M, G196E, T200A, I202V, E203K, E204K, Q207D, R211N, K223ECRF01_AE
Wallis (2014)4105841058KM458500NRTINNRTIM41L, D67N, M184V, L210W, T215F, K219KRV106M, V179D, F227LE6D, K11T, K32KE, V35T, T39K, K43E, V60I, K102KR, K103R, V118I, K122E, D123S, E138Q, S162SN, K173I, Q174K, N175NY, D177E, T200A, I202V, Q207A, R211N, K223QCRF01_AE
Zain (2015)MYHIVDR105MYHIVDR105KT281517NRTINNRTIM184V, T215FV106M, V179D, F227LE6D, K11T, E28K, K32E, V35T, T39K, K43AE, S68G, K101Q, K122E, D123S, K173L, Q174K, D177E, I178M, Q207A, R211S, F214L, V245E, E291D, V292I, I293V, E312TCRF01_AE
Lam (2016)1202200812022008KR867828D4T, 3TCNVPD67N, M184V, L210W, K219KRV106A, F227LP4HQ, E6D, K20KR, V21VI, V35T, T39K, K43E, K49R, V60I, A98S, K122E, D123S, I135L, E138A, T165I, R172K, K173A, Q174KR, D177E, I178L, T200I, I202V, Q207A, R211S, F214FL, V245E, A272P, L283I, E291D, I293V, E312T, I326V, I329V, G335DCRF01_AE
 1202200412022004KR867885AZT, 3TCNVPM41L, M184V, L210W, T215YV106A, F227LE6D, K11KT, V35T, T39K, K43E, K49R, S68G, L109I, K122E, D123S, Q174E, D177E, I178L, T200A, I202V, E203D, E204K, Q207A, R211S, H221Y, V245E, V276I, T286A, E291D, V292I, I293IV, K311R, E312T, I326V, I329V, G335DCRF01_AE
 90120099012009KR867873AZT, 3TCEFVD67N, K70R, M184V, T215F, K219QV106M, G190A, F227LE6D, K11T, K20R, V35T, E36D, T39K, K43E, D121H, K122E, D123S, K173T, Q174K, D177E, I178V, V179I, I202V, Q207A, R211S, V245E, E291D, V292I, I293V, E312AT, I326V, I329V, G335DCRF01_AE
Rhee (2017)95449544KY358895TDF, 3TCEFVM184VV106M, V179D, F227LV35T, T39K, K43E, K122E, D123N, I135T, K173L, Q174K, D177E, T200I, Q207A, R211S, V245ECRF01_AE
 1180611806KY358926TDF, 3TCEFVV75L, M184VV106M, V179D, F227LK20R, V35T, T39K, K43E, E79D, R83RK, K122E, D123S, K173I, Q174K, D177E, T200A, Q207A, R211S, K238RCRF01_AE
 1135911359KY359002TDF, 3TCEFVD67DG, K70KE, L74LI, Y115F, M184VV106M, V179D, F227LV35T, T39K, K43KE, K122E, K173I, Q174K, D177E, T200TA, Q207A, R211S, F214L, D237DN, K238R, V245ECRF01_AE
 1064010640KY359042TDF, 3TCNVPK65RV106M, G190GA, F227LV35T, T39E, K103R, K122E, D123S, I135T, I142T, K173T, Q174K, V179I, T200A, Q207A, R211S, V245ECRF01_AE
 1208112081KY359047TDF, 3TCEFVL74I, Y115F, M184VV106M, V179D, F227LK22R, V35T, T39K, K43E, S68G, K103R, K122E, D123S, T165TI, K173I, Q174K, D177E, I178L, T200R, Q207A, R211S, V245E, D250ECRF01_AE