<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation P225H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 19
Patients 78
Isolates 80
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Chantratita (2005)14-003314-0033DQ131035NRTINNRTIM184VK103N, V108I, P225HT39K, K43E, S68G, K101Q, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 14-011114-0111DQ131024NRTINNRTIV75M, M184V, K219EK103N, V108I, P225HT39K, K43E, V60I, V90I, K122E, D123S, I135L, K173T, Q174K, D177E, I178M, Q207A, E224K, F227S, V245ECRF01_AE
 14-011814-0118DQ131031NRTINNRTIM184VK103N, P225HT39K, K43Q, S68G, K122E, D123S, S162C, K173I, Q174K, D177E, I178L, Q207A, R211S, K238R, V245ECRF01_AE
 14-013714-0137DQ131051NRTINNRTIM184V, T215FK103N, P225HT39K, K43E, S68G, K122E, D123S, E138Q, S162T, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, V245ECRF01_AE
 G520G520DQ130524NRTINNRTID67N, K70R, T215NG190A, P225HT39K, K43E, V60I, D123N, I135T, K173I, Q174K, D177E, I178M, V179I, G196E, T200I, Q207A, R211S, V245ECRF01_AE
 G534G534DQ130537NRTINNRTIM184VK103N, P225HT39K, K43E, S68G, K122E, D123S, I135T, K173I, Q174K, D177E, T200I, Q207A, R211N, K238R, I244V, V245ECRF01_AE
 G565G565DQ130565NRTINNRTIV75M, M184VK103N, P225HT39K, K43E, K122E, D123N, K173T, Q174K, D177E, I178M, G196E, Q207A, K238R, V241I, V245ECRF01_AE
 G568G568DQ130567NRTINNRTIL74VK103N, V108I, G190A, P225HT39K, K43E, V60I, K122E, D123N, K173T, Q174K, D177E, I178M, Q207K, R211N, V245ECRF01_AE
 G570G570DQ130569NRTINNRTI K103N, P225HT39K, K43A, V60I, K122E, D123S, S162C, K173A, Q174K, D177E, Q207A, R211K, H221Y, K238R, V245ECRF01_AE
 G586G586DQ130584NRTINNRTIM41L, D67N, K70R, L74I, T215F, K219QK103N, P225H, M230LT39K, K43E, V60I, K64R, T69N, A98S, K122E, D123S, K173I, Q174K, N175Y, D177E, K201I, Q207A, R211S, K238R, V245ECRF01_AE
 G602G602DQ130599NRTINNRTID67N, K70R, M184V, T215V, K219QK103N, P225HT39K, K43E, K64R, K122E, D123S, I135T, K173T, Q174K, D177E, G196E, T200I, Q207A, F214L, L228H, K238R, V245ECRF01_AE
 G626G626DQ130622NRTINNRTI K103N, P225HK43E, V60I, K122E, D123S, K173I, Q174K, I178M, V179I, T200I, Q207A, K238R, V241A, V245ECRF01_AE
 G717G717DQ130700NRTINNRTIM184VK103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, V179I, V189I, T200A, Q207A, R211S, K238S, V245MCRF01_AE
 NP246NP246DQ130841NRTINNRTID67N, K70R, M184V, K219QK103N, P225H, K238TT39K, K43E, D121H, K122E, D123S, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 NP332NP332DQ130924NRTINNRTIM41L, V75M, M184V, L210WK103N, V106A, P225HT39K, K43E, E44A, K122E, D123N, K173I, Q174K, D177E, T200A, Q207A, R211S, L228R, K238R, V245ECRF01_AE
Non-B Workgroup (2005)TH_227TH_227AY605633D4T, DDIEFVD67N, K70R, L74I, V75T, T215F, K219QA98G, K103N, V179E, Y181C, P225HV35T, T39K, E42D, K43E, K122E, D123S, K173I, Q174K, D177E, T200A, Q207A, R211S, D218E, V245ECRF01_AE
 TH_706TH_706AY901932AZT, 3TCEFVD67N, K70R, M184V, K219QK103N, P225HV35T, T39K, K43E, D123N, K173V, Q174K, D177E, Q207A, R211S, K238R, V245E, E248QCRF01_AE
Tee (2006)MYKL135103MYKL1351AY960874NRTI, AZT, 3TCEFVM184VK103N, P225HV35T, T39K, K43E, S68G, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, V179I, T200I, Q207A, K238R, V245ECRF01_AE
  04MYKL1351.1AY960910NRTI, AZT, 3TCEFVM184VA98G, K103N, P225HK20R, V35T, T39K, K43E, S68G, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245ECRF01_AE
 MYKL143903MYKL1439AY960886AZT, 3TCEFV K103N, Y181C, P225HK20R, V35T, T39N, V90I, K122E, D123S, K166R, K173I, Q174K, I178L, E194A, T200I, Q207A, R211S, L228R, K238R, V245ECRF01_AE
 MYKL195804MYKL1958AY960909NRTI, AZT, 3TCEFVL74VL100I, K103N, P225HV35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
Manosuthi (2010)250752250752 D4T, 3TCNVPK70R, L74V, M184V, K219QA98G, K103N, P225H, M230LT39K, K43E, S68G, T69N, K122E, D123S, I135L, R172K, K173I, Q174K, D177E, I178M, T200A, E203K, Q207AT, R211KCRF01_AE
 250741250741 D4T, 3TCNVPD67N, K70R, K219QK103N, P225HT39K, K43E, K64N, K122E, D123S, S162CY, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 142371142371 D4T, 3TCNVPM184VK103N, P225HT39R, K43A, K102Q, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, I178L, G196A, Q207A, R211S, V245ACRF01_AE
 25-065125-0651 D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, K103N, P225HT39K, K43E, V60I, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, L228H, K238R, V245ECRF01_AE
 14N112814N1128 D4T, 3TCNVPM184VK103N, P225HK43E, K122E, D123S, S162A, K173T, Q174K, D177E, T200IM, Q207A, R211S, K238R, V245QCRF01_AE
Puthanakit (2010)CR3237CR3237 AZT, 3TCNVPM184VK103N, P225HI31L, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211K, V245ECRF01_AE
Zolfo (2010)A12757A12757RSHM565605D4T, 3TCNVPM41L, V75M, M184V, L210LW, T215FA98G, K103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
  A12757M24HM565518D4T, 3TCNVPM41L, V75M, M184V, L210W, T215FA98G, K103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 A13530A13530M24HM565533D4T, 3TC, AZTNVP, EFVV75M, M184VA98G, K103N, P225HT39E, K122E, D123GS, I135ILPT, S162C, K173R, Q174K, D177E, I178L, V179I, T200I, Q207A, R211S, V245ECRF01_AE
Bunupuradah (2011)079-001-012079-001-012 D4T, 3TC, AZTNVP, EFVD67G, T69D, K70R, M184VG190A, P225HV35T, T39K, K43E, S68G, K122E, D123S, I135T, K166R, K173I, Q174K, D177E, V189I, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 079-004-009079-004-009 D4T, 3TCNVPL74V, M184V, L210W, T215YK103N, P225H, M230LV35M, T39K, K43E, S68G, V118I, K122E, D123S, I135L, E138A, K173I, Q174K, Q207A, R211S, V245ECRF01_AE
 079-011-029079-011-029 ABC, 3TC, DDIEFVL74V, Y115F, M184VV106A, V179D, P225HV35T, T39K, K43E, S68G, V90I, K103R, V111I, K122E, D123N, S162A, K173I, Q174K, D177E, T200A, Q207A, R211N, V245ECRF01_AE
 079-003-035079-003-035 D4T, 3TC, AZTEFVM184VK103N, P225H, M230LV35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174R, D177E, I178L, T200A, Q207A, L210M, R211S, K238R, V245ECRF01_AE
 079-005-032079-005-032 D4T, 3TCEFVL74I, M184VK103N, V108I, P225HV35T, T39E, V60I, K102Q, K122E, D123S, I142V, K166R, F171Y, K173I, Q174K, D177E, I178M, T200E, Q207A, V245ECRF01_AE
Ferradini (2011)70262RTHM026310D4T, 3TCEFVD67N, K70R, M184V, K219QA98G, K103N, P225HK20R, V35T, T39N, K122E, D123S, S162T, K173I, Q174K, D177E, I178M, T200A, Q207S, R211S, L228R, K238RCRF01_AE
 100080RTHM026313D4T, 3TCEFVM184V, T215YK103N, P225HI31L, V35T, T39E, V90VI, K122E, D123S, E138EG, K173I, Q174K, D177E, T200A, Q207S, R211SCRF01_AE
 240554RTHM026327AZT, 3TCEFVM41L, V75M, M184V, L210W, T215YA98AG, K103N, P225HV35T, T39K, K43E, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 280424RTHM026331D4T, 3TCEFVA62V, K70KN, V75VI, F77L, F116Y, Q151M, M184VK101E, Y181C, G190A, P225HE28K, V35T, T39E, T58TN, V111I, K122E, D123S, M164L, K173I, Q174K, D177E, G196E, Q207G, R211S, K238RCRF01_AE
Ngo-Giang-Huong (2011)PHPT3582PHPT3582RTHQ996453AZT, 3TCEFVV75I, M184VK103N, P225HV35T, T39K, K43E, K122E, D123N, I132L, K173A, Q174K, D177E, I178M, T200A, E203D, Q207A, R211KCRF01_AE
 PHPT1247PHPT1247RTHQ996492AZT, 3TCEFVM184VK103N, Y181C, P225HV35T, T39K, K43E, V90I, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, L228R, K238RCRF01_AE
 PHPT4703PHPT4703PR-RTHQ996501TDF, FTCEFVM184VK103N, P225HE6D, V35T, T39K, K43E, V90VI, K122E, D123S, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312N, I329VCRF01_AE
 PHPT4016PHPT4016PR-RTHQ996504AZT, 3TCEFV K103N, V106VA, P225HE6D, V35T, T39K, K43E, K122E, D123S, K173M, Q174K, D177E, Q207A, R211S, K238KR, I244V, V245E, V276VI, T286A, E291D, V292I, I293V, E297EA, A304E, E312T, I326V, I329VCRF01_AE
 PHPT4352PHPT4352PR-RTHQ996515TDF, FTCEFVL74I, M184VA98G, K103N, P225HE6D, K11T, V35T, T39K, K43E, V60I, S68G, K122E, D123S, I135T, S162A, K173I, Q174K, D177E, I178L, T200A, Q207A, R211S, V245E, K287R, E291D, V292I, I293V, E312N, I326V, I329VCRF01_AE
Jiamsakul (2013)R73159R73159KJ869029AZT, 3TCEFVM41ML, D67N, K70R, L74I, M184V, T215F, K219QK103N, P225HE6D, K20R, V35T, T39K, K43E, V60I, T69N, K102R, K122E, D123N, K173M, Q174K, D177E, I178M, V189I, G196E, T200A, Q207A, R211N, L228V, K238R, T240M, V245EKCRF01_AE
 R81009R81009KJ869049AZT, 3TCEFVM41L, D67N, T69D, K70R, L74I, M184V, T215F, K219QK101E, G190A, P225HE6D, K11T, K20R, E28K, K32I, V35T, T39K, K43E, F61L, K122E, D123N, I167V, K173T, Q174K, D177E, I178M, V179I, Q197E, T200K, K201R, Q207A, R211RK, V245K, A272P, T286A, E291D, V292I, I293V, E312T, I326V, I329VCRF01_AE
 R71180R71180KJ868989TDF, 3TCEFV A98G, K103N, P225HV35T, T39K, K43E, V60I, S68G, V90I, K122E, D123S, I135T, K173I, Q174K, D177E, T200A, Q207A, R211S, K238RCRF01_AE
Nouhin (2013)S0609144S0609144KF292558NRTINNRTID67N, K70R, M184V, T215I, K219EA98AG, K103N, V108I, P225HV35M, G112A, K122E, D123N, I135T, K173M, Q174K, D177E, V179I, T200I, Q207A, R211S, K238RSCRF01_AE
 Q0510104Q0510104KF292384NRTINNRTIV75M, M184VA98AG, K103N, P225HT39E, K122E, D123S, I135T, K173I, Q174K, D177E, Q207A, R211S, L228R, K238RCRF01_AE
 R0405122R0405122KF292461NRTINNRTIM184VK103N, P225HV35T, K122E, D123S, K173I, Q174K, D177E, G196E, Q207A, R211SCRF01_AE
 N0815223N0815223KF292338NRTINNRTIA62V, V75VI, F77L, F116Y, Q151M, M184VK101E, Y181C, G190A, P225HE28K, V35T, T39E, T58TN, V111I, K122E, D123S, M164L, K173I, Q174K, D177E, G196E, Q207G, R211S, K238RCRF01_AE
 04-055404-0554KF292332NRTINNRTIM41L, V75M, M184V, L210W, T215YA98AG, K103N, P225HV35T, T39K, K43E, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 S0603090S0603090KF292551NRTINNRTIM184VK103N, P225HV35T, T39E, K122E, D123S, I135T, K166Q, K173R, Q174K, D177E, I178M, T200A, Q207A, K238RCRF01_AE
 03-038103-0381KF292331NRTINNRTIM184V, K219RK103N, P225HV35T, T39K, K43E, K122E, D123S, I135L, I142T, K173I, Q174K, D177E, I178M, Q207A, R211S, L228R, K238RCRF01_AE
 T0811233T0811233KF292696NRTINNRTIV75M, M184VK103N, V108I, P225HV35T, T39K, K66R, S68G, V90I, K122E, D123N, S162N, T165IM, K173T, Q174K, D177E, I178M, E194KT, T200A, Q207A, R211N, E224EK, K238RCRF01_AE
 S0813191S0813191KF292678NRTINNRTID67DN, K70R, M184V, K219QK103N, P225HK20R, V35T, T39K, K43E, V60VI, K122E, D123S, K173IR, Q174K, D177E, I178M, Q207A, K238SCRF01_AE
 U0210068U0210068KF292751NRTINNRTIA62V, V75I, F77L, F116Y, Q151M, M184V, K219NK101E, Y181C, G190A, P225HV35T, T39K, S68G, T69N, K102Q, K122E, D123N, I132V, K173IL, Q174K, D177E, V179I, T200A, I202V, E204D, Q207A, R211S, F214L, K238RCRF01_AE
 Q0126228Q0126228KF292350NRTINNRTI P225HV35T, T39DE, K122E, D123S, I142V, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 T0814213T0814213KF292663NRTINNRTIM184V, K219RK103N, P225HK20R, E29K, V35T, T39L, D123E, I135T, S162C, K173T, Q174K, T200I, I202V, Q207D, R211K, L228H, K238RCRF01_AE
 U0923020U0923020KF292816NRTINNRTIM184V, K219RK103N, P225HV35T, T39E, K122E, D123S, I135T, K173R, Q174K, D177E, I178M, T200I, Q207A, K238RCRF01_AE
 03-008003-0080KF292340NRTINNRTIM184V, T215YK103N, P225HI31L, V35T, T39E, V90VI, K122E, D123S, E138EG, K173I, Q174K, D177E, T200A, Q207S, R211SCRF01_AE
 S0606352S0606352KF292564NRTINNRTIV75M, M184VK103N, P225HV35T, T39E, K102M, K122E, D123S, I135T, K173I, Q174K, D177E, T200TI, I202V, Q207DG, R211S, K238RCRF01_AE
 03-026203-0262KF292323NRTINNRTID67N, K70R, M184V, K219QA98G, K103N, P225HK20R, V35T, T39N, K122E, D123S, S162T, K173I, Q174K, D177E, I178M, T200A, Q207S, R211S, L228R, K238RCRF01_AE
 R0510174R0510174KF292477NRTINNRTI K103N, P225HV35T, T39K, K43E, K122E, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 Q0705150Q0705150KF292396NRTINNRTIM184VK103N, P225HV35T, T39K, K43E, S68G, D121H, K122E, D123S, I135T, T165L, K173T, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
 U0222253U0222253KF292762NRTINNRTIM184V, K219RK103N, P225HK20R, V35T, T39R, K43E, K101KQ, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, L228LH, K238RCRF01_AE
Theys (2013)5647456474KC221785NRTI, TDFNNRTI K103N, P225HK43E, K122E, D123N, I135T, I142V, S162A, K173A, D177E, V179I, Q207A, R211KCRF01_AE
 1476914769KC219821NRTI, TDFNNRTIV75L, M184VK103N, P225HK43E, K122E, D123S, I135L, S162C, K173T, Q174K, D177E, Q207A, R211S, K238RCRF01_AE
 2768627686KC220514NRTI, TDFNNRTI K103N, P225HK43E, K122E, D123N, I135T, I142V, S162A, K173A, D177E, V179I, Q207A, R211KCRF01_AE
Aghokeng (2014)VN-1-655VN-1-655KC350262NRTINNRTIV75M, M184VK103N, P225HE6D, K11T, V35T, T39K, K122E, D123S, I135T, S162C, K173I, Q174K, D177DE, Q207S, R211S, K238R, V245ECRF01_AE
Khairunisa (2014)TD1TD1KM212829AZT, 3TCEFVM41L, L74I, M184V, L210W, T215YA98G, K103N, P225HK11T, V35T, T39K, K43E, E44D, S68G, V111I, K122E, D123N, I142T, K173A, Q174K, D177E, I178M, V189I, G196E, T200A, Q207A, H208Y, R211N, L228V, K238R, V245ECRF01_AE
Nerrienet (2014)R0712188R0712188JN675818NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219RK103N, P225H, K238TV35T, T39E, V60I, V111I, D121H, K122E, I135T, I142V, K173T, Q174K, D177E, I178IM, D192N, T200A, Q207A, R211NCRF01_AE
Wallis (2014)4144041440KM458519NRTINNRTID67N, K70R, M184V, K219QK103N, P225HE6D, K11T, V35T, T39K, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
 4143041430KM458515NRTINNRTIK70KN, L74I, M184V, K219KRK103N, P225HK20R, V35T, T39K, K43KE, V60I, K101Q, K122E, D123S, S162F, K173R, Q174K, D177E, I178M, G196E, Q207A, R211N, L228RCRF01_AE
Zain (2015)MYHIVDR014MYHIVDR014KT281506NRTINNRTIM184VK103N, P225HE6D, V35T, T39K, K43E, K101KQ, K122E, D123S, I135IM, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E297ACRF01_AE
Lam (2016)90320089032008KR867943D4T, 3TCEFVM184VK103N, P225HE6ED, K20KR, V35T, T39E, K101Q, K122E, D123S, I135T, S162C, K173A, Q174KR, D177E, I178M, T200I, Q207A, R211RS, K238R, V245E, A272P, L283I, I293V, E312N, I329V, G335DCRF01_AE
 90120039012003KR867769AZT, 3TCEFVM41L, D67N, K70R, L74LI, V75L, F77L, M184V, T215F, K219QK103N, P225H, K238TE6D, K11T, V35T, T39N, I94IL, K101Q, K122E, D123S, K173T, Q174K, D177E, I178IM, T200A, Q207A, R211S, D218DE, L228H, V245EK, T286A, E291D, V292I, I293V, E312AT, I326V, I329V, G335DCRF01_AE
 90210039021003KR867988TDF, FTCEFVL74LI, M184V, K219KRK103N, P225HE6D, K11T, V35T, T39K, K43E, V111I, K122E, D123S, T139V, S163ST, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, L228LR, V245T, E291D, V292I, I293V, E297A, K311N, E312N, I326V, I329V, G335DCRF01_AE
 1301200213012002KR867768AZT, 3TCNVPM41L, D67N, K70R, L74I, V75L, F77L, M184V, T215F, K219QK103N, P225H, K238TE6D, K11T, V35T, T39N, K101Q, K122E, D123S, K173T, Q174K, D177E, I178IM, T200A, Q207A, R211S, L228H, V245E, T286A, E291D, V292I, I293V, E312AT, I326V, I329V, G335DCRF01_AE
Kityo (2017)8309083090KY061648NRTINNRTID67DN, K70KR, M184V, T215TNSY, K219KQK103N, P225H, K238TK49KR, V60VI, K122E, D123S, I135IT, D177E, I178M, T200A, Q207ACRF01_AE