<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation P225H
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 15
Patients 57
Isolates 59
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Non-B Workgroup (2005)TH_227TH_227AY605633D4T, DDIEFVD67N, K70R, L74I, V75T, T215F, K219QA98G, K103N, V179E, Y181C, P225HV35T, T39K, E42D, K43E, K122E, D123S, K173I, Q174K, D177E, T200A, Q207A, R211S, D218E, V245ECRF01_AE
 TH_706TH_706AY901932AZT, 3TCEFVD67N, K70R, M184V, K219QK103N, P225HV35T, T39K, K43E, D123N, K173V, Q174K, D177E, Q207A, R211S, K238R, V245E, E248QCRF01_AE
Tee (2006)MYKL135103MYKL1351AY960874NRTI, AZT, 3TCEFVM184VK103N, P225HV35T, T39K, K43E, S68G, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, V179I, T200I, Q207A, K238R, V245ECRF01_AE
  04MYKL1351.1AY960910NRTI, AZT, 3TCEFVM184VA98G, K103N, P225HK20R, V35T, T39K, K43E, S68G, K122E, D123S, K166R, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245ECRF01_AE
 MYKL143903MYKL1439AY960886AZT, 3TCEFV K103N, Y181C, P225HK20R, V35T, T39N, V90I, K122E, D123S, K166R, K173I, Q174K, I178L, E194A, T200I, Q207A, R211S, L228R, K238R, V245ECRF01_AE
 MYKL195804MYKL1958AY960909NRTI, AZT, 3TCEFVL74VL100I, K103N, P225HV35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
Manosuthi (2010)250752250752 D4T, 3TCNVPK70R, L74V, M184V, K219QA98G, K103N, P225H, M230LT39K, K43E, S68G, T69N, K122E, D123S, I135L, R172K, K173I, Q174K, D177E, I178M, T200A, E203K, Q207AT, R211KCRF01_AE
 250741250741 D4T, 3TCNVPD67N, K70R, K219QK103N, P225HT39K, K43E, K64N, K122E, D123S, S162CY, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 142371142371 D4T, 3TCNVPM184VK103N, P225HT39R, K43A, K102Q, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, I178L, G196A, Q207A, R211S, V245ACRF01_AE
 25-065125-0651 D4T, 3TCNVPD67N, K70R, M184V, K219QA98G, K103N, P225HT39K, K43E, V60I, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, L228H, K238R, V245ECRF01_AE
 14N112814N1128 D4T, 3TCNVPM184VK103N, P225HK43E, K122E, D123S, S162A, K173T, Q174K, D177E, T200IM, Q207A, R211S, K238R, V245QCRF01_AE
Puthanakit (2010)CR3237CR3237 AZT, 3TCNVPM184VK103N, P225HI31L, V35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, T200I, Q207A, R211K, V245ECRF01_AE
Zolfo (2010)A12757A 12757 RSHM565605D4T, 3TCNVPM41L, V75M, M184V, L210LW, T215FA98G, K103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
  A 12757 M24HM565518D4T, 3TCNVPM41L, V75M, M184V, L210W, T215FA98G, K103N, P225HT39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 A13530A 13530 M24HM565533D4T, 3TC, AZTNVP, EFVV75M, M184VA98G, K103N, P225HT39E, K122E, D123GS, I135ILPT, S162C, K173R, Q174K, D177E, I178L, V179I, T200I, Q207A, R211S, V245ECRF01_AE
Bunupuradah (2011)079-001-012079-001-012 D4T, 3TC, AZTNVP, EFVD67G, T69D, K70R, M184VG190A, P225HV35T, T39K, K43E, S68G, K122E, D123S, I135T, K166R, K173I, Q174K, D177E, V189I, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 079-004-009079-004-009 D4T, 3TCNVPL74V, M184V, L210W, T215YK103N, P225H, M230LV35M, T39K, K43E, S68G, V118I, K122E, D123S, I135L, E138A, K173I, Q174K, Q207A, R211S, V245ECRF01_AE
 079-011-029079-011-029 ABC, 3TC, DDIEFVL74V, Y115F, M184VV106A, V179D, P225HV35T, T39K, K43E, S68G, V90I, K103R, V111I, K122E, D123N, S162A, K173I, Q174K, D177E, T200A, Q207A, R211N, V245ECRF01_AE
 079-003-035079-003-035 D4T, 3TC, AZTEFVM184VK103N, P225H, M230LV35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174R, D177E, I178L, T200A, Q207A, L210M, R211S, K238R, V245ECRF01_AE
 079-005-032079-005-032 D4T, 3TCEFVL74I, M184VK103N, V108I, P225HV35T, T39E, V60I, K102Q, K122E, D123S, I142V, K166R, F171Y, K173I, Q174K, D177E, I178M, T200E, Q207A, V245ECRF01_AE
Charpentier (2011)CR-27CR-27FJ688233AZT, 3TCNNRTIM184VK103N, P225H, K238KTK11E, T27S, V35T, T39R, K43E, S68G, D121Y, K122E, D123G, I135T, K173A, Q174K, D177E, G196E, T200A, Q207A, R211S, V245Q, D250E, A272P, T286TA, E291D, I293V, E312DCRF01_AE
Ferradini (2011)70262RTHM026310D4T, 3TCEFVD67N, K70R, M184V, K219QA98G, K103N, P225HK20R, V35T, T39N, K122E, D123S, S162T, K173I, Q174K, D177E, I178M, T200A, Q207S, R211S, L228R, K238RCRF01_AE
 100080RTHM026313D4T, 3TCEFVM184V, T215YK103N, P225HI31L, V35T, T39E, V90VI, K122E, D123S, E138EG, K173I, Q174K, D177E, T200A, Q207S, R211SCRF01_AE
 240554RTHM026327AZT, 3TCEFVM41L, V75M, M184V, L210W, T215YA98AG, K103N, P225HV35T, T39K, K43E, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 280424RTHM026331D4T, 3TCEFVA62V, K70KN, V75VI, F77L, F116Y, Q151M, M184VK101E, Y181C, G190A, P225HE28K, V35T, T39E, T58TN, V111I, K122E, D123S, M164L, K173I, Q174K, D177E, G196E, Q207G, R211S, K238RCRF01_AE
Ngo-Giang-Huong (2011)PHPT3582PHPT3582RTHQ996453AZT, 3TCEFVV75I, M184VK103N, P225HV35T, T39K, K43E, K122E, D123N, I132L, K173A, Q174K, D177E, I178M, T200A, E203D, Q207A, R211KCRF01_AE
 PHPT1247PHPT1247RTHQ996492AZT, 3TCEFVM184VK103N, Y181C, P225HV35T, T39K, K43E, V90I, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, L228R, K238RCRF01_AE
 PHPT4703PHPT4703PR-RTHQ996501TDF, FTCEFVM184VK103N, P225HE6D, V35T, T39K, K43E, V90VI, K122E, D123S, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312N, I329VCRF01_AE
 PHPT4016PHPT4016PR-RTHQ996504AZT, 3TCEFV K103N, V106VA, P225HE6D, V35T, T39K, K43E, K122E, D123S, K173M, Q174K, D177E, Q207A, R211S, K238KR, I244V, V245E, V276VI, T286A, E291D, V292I, I293V, E297EA, A304E, E312T, I326V, I329VCRF01_AE
 PHPT4352PHPT4352PR-RTHQ996515TDF, FTCEFVL74I, M184VA98G, K103N, P225HE6D, K11T, V35T, T39K, K43E, V60I, S68G, K122E, D123S, I135T, S162A, K173I, Q174K, D177E, I178L, T200A, Q207A, R211S, V245E, K287R, E291D, V292I, I293V, E312N, I326V, I329VCRF01_AE
Nouhin (2013)S0609144S0609144KF292558NRTINNRTID67N, K70R, M184V, T215I, K219EA98AG, K103N, V108I, P225HV35M, G112A, K122E, D123N, I135T, K173M, Q174K, D177E, V179I, T200I, Q207A, R211S, K238RSCRF01_AE
 Q0510104Q0510104KF292384NRTINNRTIV75M, M184VA98AG, K103N, P225HT39E, K122E, D123S, I135T, K173I, Q174K, D177E, Q207A, R211S, L228R, K238RCRF01_AE
 R0405122R0405122KF292461NRTINNRTIM184VK103N, P225HV35T, K122E, D123S, K173I, Q174K, D177E, G196E, Q207A, R211SCRF01_AE
 N0815223N0815223KF292338NRTINNRTIA62V, V75VI, F77L, F116Y, Q151M, M184VK101E, Y181C, G190A, P225HE28K, V35T, T39E, T58TN, V111I, K122E, D123S, M164L, K173I, Q174K, D177E, G196E, Q207G, R211S, K238RCRF01_AE
 04-055404-0554KF292332NRTINNRTIM41L, V75M, M184V, L210W, T215YA98AG, K103N, P225HV35T, T39K, K43E, K122E, D123S, I135L, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 S0603090S0603090KF292551NRTINNRTIM184VK103N, P225HV35T, T39E, K122E, D123S, I135T, K166Q, K173R, Q174K, D177E, I178M, T200A, Q207A, K238RCRF01_AE
 03-038103-0381KF292331NRTINNRTIM184V, K219RK103N, P225HV35T, T39K, K43E, K122E, D123S, I135L, I142T, K173I, Q174K, D177E, I178M, Q207A, R211S, L228R, K238RCRF01_AE
 T0811233T0811233KF292696NRTINNRTIV75M, M184VK103N, V108I, P225HV35T, T39K, K66R, S68G, V90I, K122E, D123N, S162N, T165IM, K173T, Q174K, D177E, I178M, E194KT, T200A, Q207A, R211N, E224EK, K238RCRF01_AE
 S0813191S0813191KF292678NRTINNRTID67DN, K70R, M184V, K219QK103N, P225HK20R, V35T, T39K, K43E, V60VI, K122E, D123S, K173IR, Q174K, D177E, I178M, Q207A, K238SCRF01_AE
 U0210068U0210068KF292751NRTINNRTIA62V, V75I, F77L, F116Y, Q151M, M184V, K219NK101E, Y181C, G190A, P225HV35T, T39K, S68G, T69N, K102Q, K122E, D123N, I132V, K173IL, Q174K, D177E, V179I, T200A, I202V, E204D, Q207A, R211S, F214L, K238RCRF01_AE
 Q0126228Q0126228KF292350NRTINNRTI P225HV35T, T39DE, K122E, D123S, I142V, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 T0814213T0814213KF292663NRTINNRTIM184V, K219RK103N, P225HK20R, E29K, V35T, T39L, D123E, I135T, S162C, K173T, Q174K, T200I, I202V, Q207D, R211K, L228H, K238RCRF01_AE
 S1124162S1124162KF292606NRTINNRTIK65KN, V75M, F77L, F116FY, Q151M, M184VK103N, V108VI, P225HV35T, T39N, S68SG, V90I, A98S, K102KR, K122E, D123S, A158T, S162A, T165L, K173R, Q174K, N175Y, D177E, T200K, K201I, Q207V, R211N, F214L, L228R, K238RCRF01_AE
 U0923020U0923020KF292816NRTINNRTIM184V, K219RK103N, P225HV35T, T39E, K122E, D123S, I135T, K173R, Q174K, D177E, I178M, T200I, Q207A, K238RCRF01_AE
 03-008003-0080KF292340NRTINNRTIM184V, T215YK103N, P225HI31L, V35T, T39E, V90VI, K122E, D123S, E138EG, K173I, Q174K, D177E, T200A, Q207S, R211SCRF01_AE
 S0606352S0606352KF292564NRTINNRTIV75M, M184VK103N, P225HV35T, T39E, K102M, K122E, D123S, I135T, K173I, Q174K, D177E, T200TI, I202V, Q207DG, R211S, K238RCRF01_AE
 03-026203-0262KF292323NRTINNRTID67N, K70R, M184V, K219QA98G, K103N, P225HK20R, V35T, T39N, K122E, D123S, S162T, K173I, Q174K, D177E, I178M, T200A, Q207S, R211S, L228R, K238RCRF01_AE
 R0510174R0510174KF292477NRTINNRTI K103N, P225HV35T, T39K, K43E, K122E, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, K238RCRF01_AE
 T0526166T0526166KF292635NRTINNRTIA62V, V75I, F77L, F116Y, Q151M, M184VK103N, V106A, P225HK20R, V21I, V35T, T39E, V111IM, K122E, D123S, S163I, K166R, K173T, Q174R, D177E, G196E, T200A, I202V, Q207A, R211SCRF01_AE
 Q0705150Q0705150KF292396NRTINNRTIM184VK103N, P225HV35T, T39K, K43E, S68G, D121H, K122E, D123S, I135T, T165L, K173T, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
 U0222253U0222253KF292762NRTINNRTIM184V, K219RK103N, P225HK20R, V35T, T39R, K43E, K101KQ, K122E, D123S, I135T, S162C, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, L228LH, K238RCRF01_AE
Pircher (2013)B1147B1147JX110245D4T, 3TC, AZTNVPM184VK103N, P225HI5V, K11T, K20R, V35T, T39N, E40D, V60I, K102Q, D121H, K122E, D123S, I135L, K173A, Q174K, D177E, G196E, Q207A, R211K, V245K, E248D, D250ECRF01_AE
Theys (2013)37843784KC219302NRTI, TDFNNRTIM184VK103N, P225HK43E, W88WC, V90VI, A98AS, K102KR, K122E, D123S, S162H, K173S, D177E, V179I, T200A, I202V, Q207A, R211TCRF01_AE
 5647456474KC221785NRTI, TDFNNRTI K103N, P225HK43E, K122E, D123N, I135T, I142V, S162A, K173A, D177E, V179I, Q207A, R211KCRF01_AE
 1476914769KC219821NRTI, TDFNNRTIV75L, M184VK103N, P225HK43E, K122E, D123S, I135L, S162C, K173T, Q174K, D177E, Q207A, R211S, K238RCRF01_AE
 2768627686KC220514NRTI, TDFNNRTI K103N, P225HK43E, K122E, D123N, I135T, I142V, S162A, K173A, D177E, V179I, Q207A, R211KCRF01_AE
Thiam (2013)619-HPD619-HPDJQ855853NRTINNRTIL74V, M184VK103N, P225HV35T, K102Y, K122E, I135T, I142V, S162Y, K173S, Q174K, D177E, V179I, Q207A, R211K, V245QCRF01_AE
Khairunisa (2014)TD1TD1KM212829AZT, 3TCEFVM41L, L74I, M184V, L210W, T215YA98G, K103N, P225HK11T, V35T, T39K, K43E, E44D, S68G, V111I, K122E, D123N, I142T, K173A, Q174K, D177E, I178M, V189I, G196E, T200A, Q207A, H208Y, R211N, L228V, K238R, V245ECRF01_AE
Nerrienet (2014)R0712188R0712188JN675818NRTINNRTIM41L, D67N, V75M, M184V, L210W, T215Y, K219RK103N, P225H, K238TV35T, T39E, V60I, V111I, D121H, K122E, I135T, I142V, K173T, Q174K, D177E, I178IM, D192N, T200A, Q207A, R211NCRF01_AE