<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation Y188L
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 10
Patients 46
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ariyoshi (2003)JPN45JPN45BAY901411AZT, D4T, DDI, 3TCEFVM41L, D67S, L74V, L210W, T215YY188LE6D, K11T, V35T, T39K, K43E, S68T, T69S, W88S, V106L, V118I, K122E, D123S, I135V, S162C, K173I, Q174K, D177E, G196E, Q207T, R211N, K238R, P243H, V245ECRF01_AE
Hsu (2005)BAA154763BAA154763AY870164D4T, DDI, AZT, 3TCEFVM41L, D67N, M184V, T215YY188LS3SG, E6D, V35M, T39K, K43E, E44EA, K64R, V90I, K122E, D123S, I135T, K173T, Q174K, N175NY, D177E, T200A, Q207A, D218E, V245E, K281R, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D, Y342F, M357K, R358RG, G359S, K366R, T369AV, A371V, A376T, K390R, K395RCRF01_AE
 BAA161440BAA161440AY870236AZT, 3TCEFVM41L, M184V, L210W, T215FA98G, Y188L, Y318FE6D, K11T, V35T, E36A, T39K, K43E, K122E, D123S, I135L, K173T, Q174K, D177E, V179I, G196E, Q207A, R211S, V245K, E291D, V292I, I293V, E312T, I326V, G335D, Y342F, M357K, G359S, K366R, T369A, A371V, K390R, K395RCRF01_AE
 BAA161447BAA161447AY870240D4T, DDI, AZT, 3TCNVP, EFVM41L, D67N, T69D, L210W, T215FK101E, Y188LE6D, E28K, K32E, V35I, T39E, V60I, V90I, V106L, V118I, K122E, D123S, I135T, R172K, K173I, Q174K, D177E, I178L, V189I, G196E, E203K, Q207A, R211N, K223KQ, K238R, V245E, K275R, T286A, E291D, I293V, E312T, I326IV, I329V, G335D, M357K, G359S, K366R, A371V, A376C, K390R, K395RCRF01_AE
Non-B Workgroup (2005)TH_440TH_440AY901843AZT, 3TCNVPD67N, K70R, M184V, K219QY188LV35T, K122E, D123S, Y146S, P157A, T165I, K173R, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 TH_459TH_459AY901849AZT, DDIEFVM41L, D67N, L210W, T215YK101E, Y188L, G190AV35T, T39K, K43E, V60I, V106I, V118I, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
 TH_578TH_578AY901881AZT, DDIEFVM41L, D67E, L210W, T215YY188LV35T, T39K, K43E, E44A, V60I, S68G, K102M, V106L, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, G196E, Q207A, R211S, V245ECRF01_AE
 TH_600TH_600AY901890D4T, DDINVPK65R, V75I, Q151MY188LV35T, T39K, K43E, S68G, K122E, D123S, S162C, K173R, Q174K, D177E, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 TH_602TH_602AY901892D4T, DDIEFVM41L, D67N, L210W, T215YV179E, Y188LV35T, T39K, K43E, E44D, V106I, V118I, K122E, D123S, I135T, K173I, Q174K, D177E, E203K, Q207A, R211N, K223Q, D237E, V245KCRF01_AE
 TH_670TH_670 AZT, DDINVPD67N, K70R, T215F, K219EY188LV35T, T39K, K43E, K122E, D123S, S163T, M164I, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
 TH_675TH_675 AZT, 3TC, D4TEFVM184VV179D, Y188LV35T, T39K, K43E, K103R, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, K238R, V245ECRF01_AE
 TH_704TH_704AY901931AZT, 3TCEFVM41L, D67N, M184V, L210W, T215FY188LV35T, T39K, K43E, K64R, V106L, V118I, D123N, K166R, K173I, Q174K, D177E, G196E, Q207A, R211N, K238R, V245ECRF01_AE
 TH_737TH_737AY9019433TC, D4TEFVM41L, D67N, K70R, V75M, M184V, T215F, K219QY188LV35T, T39K, K43E, V60I, K64Y, K122E, D123S, I135T, S162Y, K173I, Q174K, D177E, V179I, Q207A, R211S, D218E, L228H, V245ECRF01_AE
 TH_789TH_789AY901958AZT, 3TCNVPD67N, K70R, M184V, T215Y, K219EY188LV35T, T39K, K43E, K122E, D123S, S162A, K173I, Q174K, D177E, I178M, V189I, G196E, T200A, E203D, Q207A, R211S, V245ECRF01_AE
 TK5004TK5004a AZT, 3TC, D4TEFVM41L, D67N, M184V, L210W, T215YK103N, Y188LE6D, E28K, K32E, V35M, T39K, K43E, E44D, V118I, K122E, D123S, I135T, S162C, K173T, Q174K, Q207A, R211N, D218E, V245E, E291D, I293V, E312T, I326V, I329V, G335DCRF01_AE
Tee (2006)MYKL139203MYKL1392AY960880AZT, 3TCEFV K103N, Y188LK20R, V35T, T39K, K122E, D123S, I135L, R172K, K173I, Q174K, D177E, T200A, Q207D, R211K, K238R, V245ECRF01_AE
  03MYKL1392.1AY960911AZT, 3TCEFV K103N, Y188LK122E, D123S, I135L, R172K, K173I, Q174K, D177E, T200A, Q207D, R211K, K238R, V245ECRF01_AE
 MYKL150903MYKL1509AY960890D4T, DDIEFVD67N, K70RY188LV35T, T39K, K43E, K101Q, V106I, K122E, D123S, S162A, K173I, Q174K, D177E, I178V, V179N, Q207A, R211S, K238R, V245ECRF01_AE
  04MYKL1509.1AY960919D4T, DDIEFVD67N, K70R, K219QY188LV35T, T39K, K43E, K101Q, V106I, K122E, D123S, S162A, K173I, Q174K, D177E, I178V, V179I, Q207A, R211S, K238R, V245ECRF01_AE
 MYKL151803MYKL1518AY960892D4T, DDIEFVM41L, D67N, L210W, T215YA98G, Y188LV35T, T39K, K43E, E44D, V106I, V118I, K122E, D123S, I135V, R172K, K173I, Q174K, D177E, I178M, T200I, I202V, Q207A, R211N, K238R, V245ECRF01_AE
  03MYKL1518.1AY960920D4T, DDIEFVM41L, D67N, L210W, T215YA98G, Y188LV35T, T39K, K43E, E44D, V106I, V118I, K122E, D123S, I135V, R172K, K173I, Q174K, D177E, I178M, T200I, I202V, Q207A, R211N, K238R, V245ECRF01_AE
 MYKL157003MYKL1570AY960894AZT, 3TCEFVM41L, D67N, M184V, L210W, T215FV179E, Y188LV35T, T39K, K43E, E44D, K64R, V111I, V118I, K122E, D123S, K173I, Q174K, D177E, I178M, V189I, G196E, T200A, Q207A, H208Y, R211S, W212C, K238R, V245ECRF01_AE
 MYKL162304MYKL1623AY960897NoneEFV V179D, Y188LV35T, T39K, K43E, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245ECRF01_AE
Liu (2007)fj10fj10EF432719D4T, 3TCNVP Y188LE6D, K11T, V35T, T39E, D86G, F87L, W88L, V106I, T107S, K122E, D123S, S163C, K173I, Q174K, D177E, V179ICRF01_AE
Manosuthi (2010)143163143163 D4T, 3TCNVPM184VK103N, Y188LT39K, V118I, K122E, D123S, I135T, I142T, T165I, K173I, Q174K, D177E, I178M, T200A, I202V, Q207A, R211S, F214L, K238R, T240A, V245ECRF01_AE
 250764250764 D4T, 3TCNVPD67N, M184V, T215YY188LT39K, K43E, V60I, K122E, D123S, K173T, Q174K, D177E, I178M, V189I, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 250861250861 D4T, 3TCNVPM184VY188LT39K, K43E, V60I, K101Q, V106I, K122E, D123S, I135ILPT, K173I, Q174K, D177E, T200A, Q207A, R211S, K238R, T240K, V245ECRF01_AE
 25-043025-0430 D4T, 3TCNVPM41L, D67N, T69D, M184V, L210W, T215Y, K219NY188LT39K, K43E, E44A, L109I, V118I, K122E, D123S, I135T, S162C, K173A, Q174K, D177E, T200I, Q207A, R211S, D218E, K238R, V245ECRF01_AE
Zolfo (2010)A15427A 15427 M6HM565564D4T, 3TCNVPM184VY188LT39K, K43E, K64KR, K122E, D123N, S162C, E169D, Q174N, D177E, I202IV, Q207A, V245ECRF01_AE
  A 15427 M12HM565490D4T, 3TCNVPD67DN, M184VY188LT39K, K43E, E89EG, K122E, D123N, S162CY, E169D, Q174NS, D177E, I178IL, Q207A, K220KR, V245ECRF01_AE
 A14843A 14843 M6HM565578D4T, 3TCNVPM184IVY188LT39E, V60I, K122E, D123S, I135K, K173R, Q174K, D177E, I178M, T200A, Q207S, R211S, V245ECRF01_AE
  A 14843 M12HM565549D4T, 3TCNVPM184VY188LT39E, V60I, K122E, D123S, I135K, K173R, Q174K, D177E, I178M, T200A, Q207S, R211S, V245ECRF01_AE
 A13557A 13557 M24HM565532D4T, 3TCNVP, EFVM184VY188LT39K, K43E, S68G, V106I, K122E, D123N, I135T, K173MV, Q174K, T200K, Q207A, R211S, K238K*R, V245ECRF01_AE
  A 13557 M30HM565529D4T, 3TCNVP, EFVM184VV179VD, Y188LT39K, K43E, S68G, K103KR, V106VI, K122E, D123N, I135T, K173M, Q174K, T200EK, Q207A, L210LS, R211S, K238KR, V245ECRF01_AE
 A14127A 14127 RSHM565602D4T, 3TCNVPM184VY188LT39K, K122E, D123S, S162C, K173L, Q174K, D177E, I178M, Q207G, R211S, K238R, V245ECRF01_AE
  A 14127 M18HM565501D4T, 3TC, AZTNVPM184VY188LT39K, K101KQ, K122E, D123S, S162CY, K173L, Q174K, D177E, I178IM, T200TA, Q207G, R211S, K238R, V245ECRF01_AE
Bunupuradah (2011)079-001-001079-001-001 D4T, 3TCNVPY115YF, M184V, T215FY188LV35T, T39K, K43E, S68G, K122E, D123S, S162C, K173I, Q174K, D177E, I178M, Q207A, R211S, T240K, V245ECRF01_AE
 079-010-011079-010-011 D4T, 3TCNVP, EFVM184VY188LV35T, T39K, K43E, T69N, K102Q, K122E, D123S, S162Y, K173V, Q174K, D177E, T200I, R206K, Q207A, R211S, K238R, V245ECRF01_AE
 079-004-003079-004-003 D4T, 3TCEFVM184VY188LV35T, T39K, K43E, V106I, K122E, D123S, K173I, Q174K, I178M, Q207A, L210M, R211SCRF01_AE
 079-001-011079-001-011 D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YY188LV35T, T39K, K43E, W88C, V118I, K122E, D123N, I135T, K173I, Q174K, N175Y, I178M, V179I, T200E, K201R, E203K, Q207D, R211S, H221Y, K238RCRF01_AE
 079-005-009079-005-009 D4T, 3TCNVPM41L, D67N, M184I, L210W, T215F, K219RY188LV35T, T39E, K43E, G45R, V60I, V118I, K122E, D123S, K173I, Q174K, D177E, I178M, G196E, T200A, Q207A, R211S, D218E, K238R, V245ECRF01_AE
 079-005-022079-005-022 D4T, 3TC, AZTNVPM41L, D67N, M184V, L210W, T215YY188LE28K, K32E, V35T, T39K, K43Q, E44D, V118I, K122E, D123N, I135T, S162Y, I167L, K173V, Q174K, D177E, V179I, V189I, G196E, Q207A, R211S, W212C, K238R, V245E, E248VCRF01_AE
 079-008-008079-008-008 D4T, 3TC, AZTEFVM41L, M184V, T215FK101E, Y188LV35T, T39E, S68G, K122E, D123N, Y127F, I135R, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245E, E248DCRF01_AE
 079-003-031079-003-031 D4T, 3TCNVPD67N, K70R, V75M, F77L, M184V, K219QY188LV21I, V35T, T39K, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, I202V, Q207A, R211S, H221Y, V245ECRF01_AE
 079-007-021079-007-021 3TC, D4TNVP, EFVM184VY188LK32R, V35T, T39K, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, T200E, Q207A, R211S, K238R, V245E, S251CCRF01_AE
 079-011-034079-011-034 D4T, 3TCNVP, EFVM184VY188LV35T, T39K, K43Q, K122E, D123S, K166R, K173I, Q174K, D177E, Q207A, R211S, V245E, K249RCRF01_AE
 079-001-025079-001-025 D4T, 3TC, AZTNVPD67N, F77L, F116Y, Q151M, M184IY188LV35T, T39K, V60I, K101Q, V118I, K122E, D123S, T165I, K173I, Q174K, T200I, I202V, Q207A, R211S, F214L, V245ECRF01_AE
 079-005-038079-005-038 D4T, 3TCNVPM184VY188LV35T, T39K, K43E, V60I, K122E, D123N, K173T, Q174K, D177E, I178M, G196T, R206K, Q207A, R211T, K238R, V245ECRF01_AE
Ferradini (2011)310056RTHM026334AZT, 3TCEFVM184VY188LV21I, T27A, K30KE, V35T, T39K, K43E, V106I, K122E, D123S, S162C, K173A, Q174K, D177E, T200A, Q207A, R211S, K238RCRF01_AE
 330357RTHM026336AZT, 3TCNVPM184VY188LV35T, T39K, K43E, V106I, K122E, D123S, I135M, I142V, K173I, Q174K, D177E, I178L, Q207A, R211S, K238RCRF01_AE
Ngo-Giang-Huong (2011)PHPT3913PHPT3913RTHQ996474D4T, 3TCNVPM184VY188LT39K, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, I178M, Q207A, R211S, L228RCRF01_AE
 PHPT3992PHPT3992RTHQ996475D4T, 3TCNVPM184VY188LE6D, K11T, V35T, T39K, K43E, K101R, K122E, D123S, K173I, Q174K, D177E, Q207A, R211S, K238RCRF01_AE
 PHPT0773PHPT0773PR-RTHQ996522D4T, 3TCNVPM184IY188LE6D, V8VI, V35T, T39K, K43E, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E, I274V, T286A, I293V, P294T, E312T, V317A, I326V, I329VCRF01_AE

Database

Resources

Team