<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation E138Q
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 8
Patients 41
Isolates 41
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Manosuthi (2010)250728250728 D4T, 3TCNVPD67N, K70R, M184VG190AT39K, K43E, K122E, D123S, E138Q, S162C, K173I, Q174K, D177E, V179I, T200A, Q207S, R211S, K238R, V245ECRF01_AE
 25-026325-0263 D4T, 3TCNVPD67G, K70R, M184V, T215F, K219EK103N, Y181FT39K, K43E, V60I, S68G, K122E, D123S, E138Q, K173V, Q174K, D177E, I178M, Q197E, T200A, Q207A, K238R, V245ECRF01_AE
 250878250878 D4T, 3TCNVPA62V, M184VV179D, G190AT39K, K43E, K122E, D123N, I135T, E138Q, K173I, Q174K, D177E, T200I, Q207A, R211S, V245ECRF01_AE
Puthanakit (2010)CR2544CR2544 D4T, 3TCNVPM184VK103NV35T, T39K, K43E, T69S, K122E, D123S, E138Q, S162C, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 CR3290CR3290 D4T, 3TCNVPM41L, D67N, M184V, L210W, T215YG190AV35T, T39K, K43E, E44D, K101A, K102Q, V118I, D121H, K122E, D123S, E138Q, S162C, K173I, Q174K, D177E, T200A, Q207A, R211N, K238R, V245ECRF01_AE
Bunupuradah (2011)079-003-002079-003-002 D4T, 3TCNVPD67N, M184VK103N, Y181CE28K, K32E, V35T, T39N, K122E, D123S, I135V, E138Q, K173M, Q174K, D177E, T200A, Q207D, R211K, F214L, H221Y, V245ECRF01_AE
 079-003-006079-003-006 D4T, 3TCNVPM41L, M184V, L210W, T215YK103N, K238TV35T, T39K, K43E, V60I, S68G, K122E, D123S, I135T, E138Q, T165I, K173S, Q174K, D177E, I178M, T200A, Q207A, R211S, V245ECRF01_AE
 079-010-015079-010-015 D4T, 3TCNVPD67N, K70R, L74V, M184V, K219QK103NK20R, V35T, T39R, K43E, V60I, K64N, K122E, D123S, E138Q, Q174K, D177E, I178M, T200A, E203D, Q207A, K238RCRF01_AE
 079-011-013079-011-013 D4T, 3TCNVPA62V, D67N, V75I, F77L, Q151M, M184V, K219EG190AV35T, T39K, K43E, D121H, K122E, I135T, E138Q, K173T, Q174K, D177E, V179I, I202V, Q207A, R211S, V245E, V261MCRF01_AE
 079-004-008079-004-008 D4T, 3TC, AZTNVPM41L, D67N, M184V, L210W, T215FK103N, K238TV35M, T39K, K43E, V118I, K122E, D123S, E138Q, S162C, K173A, Q174K, N175Y, Q207A, R211S, V245ECRF01_AE
 079-011-017079-011-017 D4T, 3TCNVP, EFVD67N, K70R, M184V, K219QK101P, K103NV35T, T39K, K43E, V60I, T69N, K122E, D123S, E138Q, I142V, S162N, Q174K, D177E, I178M, Q207A, R211S, L228H, K238RCRF01_AE
 079-010-039079-010-039 D4T, 3TCNVP, EFVD67N, K70R, M184V, T215F, K219QA98G, G190AK20R, V35T, T39K, K43E, K101Q, K122E, D123S, E138Q, K173I, Q174K, D177E, I178M, V179I, T200I, I202V, Q207A, R211S, V245KCRF01_AE
 079-001-015079-001-015 D4T, 3TC, AZTNVP Y181CV35T, T39R, K122E, D123S, I135T, E138Q, I159V, Q174E, D177E, V179I, G196E, I202V, Q207A, V245E, E248NCRF01_AE
 079-003-024079-003-024 D4T, 3TCNVPM184VK103N, K238TV35T, T39N, K122E, D123S, E138Q, K166R, K173I, Q174K, D177E, T200K, Q207A, R211S, V245ECRF01_AE
 079-001-022079-001-022 3TC, D4TNVPM41L, V75M, T215YV179DV35T, T39K, K43E, K122E, D123S, E138Q, K173I, Q174K, D177E, Q207A, R211S, V245ECRF01_AE
Ferradini (2011)180194RTHM026321AZT, 3TCNVPM41L, M184V, T215FK103NV35T, T39K, K43E, S68G, A98S, K122E, D123S, E138Q, K173I, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
Ngo-Giang-Huong (2011)PHPT0026PHPT0026RTHQ996409D4T, 3TCNVPM184VK103NV35T, T39K, K43E, V60I, K122E, D123S, E138Q, I142V, S162A, K173I, Q174K, D177E, I178M, Q207A, R211SCRF01_AE
Coetzer (2013)KH004KH004KC533601D4T, 3TCNVPD67N, M184VK103N, K238TV35T, T39K, K43E, V60I, K122E, D123S, I135T, E138Q, S162C, K173I, Q174K, D177E, V179VI, T200A, Q207A, R211SCRF01_AE
 KH018KH018KC533617D4T, 3TCNVPV75VI, F116Y, Q151M, M184VK103NA33AV, V35T, T39TK, S68G, K122E, D123S, E138Q, S162C, K173I, Q174K, D177E, Q207A, R211SCRF01_AE
Nouhin (2013)T0820251T0820251KF292676NRTINNRTIM41L, D67G, M184V, T215YK103NL34I, V35T, T39K, K43E, S68G, D121H, K122E, D123S, I135T, E138Q, S162A, S163T, T165I, K173T, Q174K, D177E, I178M, G196E, T200A, E203D, Q207A, K238RCRF01_AE
 S1002281S1002281KF292585NRTINNRTIK70R, V75M, M184V, K219QK103NV35T, T39E, K64N, T69S, K122E, D123S, I135T, E138Q, S162C, K173R, Q174K, D177E, I178M, E203D, Q207A, R211RS, L228R, K238RCRF01_AE
 Q0628136Q0628136KF292393NRTINNRTID67N, M184V, T215YK103NV35T, T39E, K102R, K122E, D123S, E138Q, S162T, K173I, Q174K, D177E, Q207A, R211S, K238RCRF01_AE
 U1202045U1202045KF292828NRTINNRTID67N, K70R, M184V, T215FI, K219QK103N, V106IM, G190GAV35T, T39K, K122E, D123S, I135T, E138Q, S162C, K173A, Q174K, D177E, I178M, T200A, Q207A, R211S, K238RCRF01_AE
 S1016197S1016197KF292604NRTINNRTID67N, M184VK103N, K238TV35T, T39K, K43E, K122E, D123N, I135L, E138Q, S162C, K173I, Q174K, D177E, T200A, Q207A, R211SCRF01_AE
 T1030364T1030364KF292720NRTINNRTID67G, K70R, M184VK101E, Y188LE28K, K32E, V35T, T39N, S68G, V106I, K122E, D123N, E138Q, I142IV, S162C, K173R, Q174K, D177E, I178F, V179L, I195L, G196E, Q207A, R211S, F214FL, K219G, L228H, K238RCRF01_AE
 U0813060U0813060KF292798NRTINNRTIM41L, D67DN, V75M, M184V, T215YK103N, V108IV35T, T39K, K43E, E44EA, V60I, K102Q, K122E, D123S, I135L, E138Q, S162C, Q174K, D177E, I178M, T200A, E203K, Q207A, R211N, K223KE, K238RCRF01_AE
 T0813138T0813138KF292662NRTINNRTIM184VG190AV35T, T39K, K43E, V60I, K122E, D123S, E138Q, S162D, K173IT, Q174K, D177E, I178M, V179I, T200I, Q207A, R211S, K238RCRF01_AE
 T1203128T1203128KF292725NRTINNRTID67N, K70GR, M184V, K219QV179E, Y181CD17V, K20R, K22V, W24C, E28D, V35T, T39K, K43E, I50IN, V60I, T69N, V90VI, K122E, D123S, E138Q, S162SN, K173R, Q174K, Q207A, R211S, D218E, L228LH, K238RCRF01_AE
 T1016131T1016131KF292705NRTINNRTIM184VK103NV35T, T39D, V60I, K122E, D123N, I135T, E138Q, T165L, F171FY, K173R, Q174K, D177E, I178M, V179I, G196E, T200I, Q207S, R211S, L228NCRF01_AE
 U11115076U11115076KF292826NRTINNRTIM41L, D67N, V75M, M184V, T215YK101E, V108I, G190AV35T, T39E, K122E, D123S, E138Q, K166R, K173I, Q174K, D177E, I178M, V179I, E203V, Q207A, L210T, R211S, K223Q, K238RCRF01_AE
 Q1020154Q1020154KF292422NRTINNRTIM41L, D67N, V75M, F77L, M184V, T215YK101E, G190AE28K, K32E, V35T, T39K, K43E, E44A, K122E, D123N, I135T, E138Q, K173T, Q174K, D177E, I178M, V179I, Q207A, L210F, R211NS, K238RCRF01_AE
 T0707078T0707078KF292686NRTINNRTIM184V, L210LW, T215TSK103NK20R, V35T, T39K, K43E, K122E, D123S, E138Q, S162C, K173I, Q174K, T200A, E203D, Q207A, R211S, K238RCRF01_AE
 R0320197R0320197KF292456NRTINNRTIV75M, M184VK101E, G190AV35T, T39E, K122E, D123S, E138Q, K173I, Q174K, D177E, I178M, T200I, R206K, Q207E, R211S, F214FL, K238RCRF01_AE
 Q1227166Q1227166KF292441NRTINNRTIV75M, F77L, Q151M, M184VK103NV35T, T39E, K122E, D123S, E138Q, K173T, Q174K, D177E, I178L, T200A, Q207A, R211S, K238RCRF01_AE
 Q0817107Q0817107KF292427NRTINNRTIM41L, M184V, T215FK103NV35T, T39K, K43E, S68G, A98S, K122E, D123S, E138Q, K173I, Q174K, D177E, I178M, T200A, Q207A, R211SCRF01_AE
 S0828085S0828085KF292582NRTINNRTIM41L, D67N, V75I, M184I, L210W, T215Y, K219NY181CV35T, T39K, K43Q, K49R, V60I, V90I, V118I, K122E, D123S, I132L, E138Q, K173A, Q174K, D177E, I178M, V179I, G196GE, T200A, Q207A, R211D, D218E, K238RCRF01_AE
 S0602176S0602176KF292561NRTINNRTIM184V, T215FK101E, G190AV35T, T39K, K43E, S68G, V106I, K122E, D123S, I135T, E138Q, S162C, R172RK, Q174K, D177E, I178L, V179I, T200A, Q207A, R211S, K238RCRF01_AE
 S1125239S1125239KF292592NRTINNRTID67N, M184VK103N, K238TV35T, T39K, K43E, V60I, K122E, D123S, I135T, E138Q, S162C, K173I, Q174K, D177E, V179VI, T200A, Q207A, R211SCRF01_AE
 Q0404197Q0404197KF292360NRTINNRTID67N, K70R, M184V, T215F, K219QK103NV35T, T39E, V60I, K122E, D123S, I135T, E138Q, S162T, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, D218E, K238SCRF01_AE
 T1202120T1202120KF292723NRTINNRTIM41L, D67N, V75M, F77L, Q151M, M184V, T215YK101E, G190A, K238TW24WCG, V35I, T39N, V111I, K122E, D123S, E138Q, K166R, F171Y, K173R, Q174K, D177E, I178M, V179I, E203D, Q207D, F214L, T216TSCRF01_AE
Rusine (2013)468H468HKC841711AZT, 3TCNVPM184VK103NK20KR, V35T, I47L, K49KR, I50V, V60I, A98AS, K102KN, K122E, D123NS, I135T, E138Q, I142IV, K173S, Q174K, D177E, V179I, E194D, T200A, Q207A, R211S, F214FL, V245E, T286A, I293V, P294T, E312D, I326ITCRF01_AE