<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Reverse Transcriptase Inhibitors

Subtype CRF01_AE
Gene RT
Mutation E138A
Rx >= 1 NNRTI
(+/- NRTI)
IncludeMixtures No
References 8
Patients 18
Isolates 19
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# NRTIs NNRTIsNRTIDRMs NNRTIDRMs OtherMutSubtype
Ly (2007)NL_KHM_HM16HM16W2RDQ831369NoneNVP  V35I, T39A, K64R, K122E, D123S, I135T, E138A, I142V, K173T, Q174K, D177G, I202IV, Q207A, R211S, V245ECRF01_AE
  HM16W6RDQ831435NoneNVP  V35I, T39A, K64R, K122E, D123S, I135T, E138A, I142V, K173T, Q174K, D177G, I202V, Q207A, R211S, V245ECRF01_AE
Germanaud (2010)55135513 AZT, 3TCNVP  V21I, V35T, T39A, V60I, D121Y, K122E, E138A, I142V, S162Y, K173S, Q174K, D177E, T200I, Q207A, R211KCRF01_AE
 55785578 AZT, 3TCNVPT215P V35T, E36A, T39K, K43E, V60I, S68G, V106T, K122P, D123N, I135V, E138A, T139A, I142V, S162H, K173S, Q174H, D177E, I178L, V179M, E194Q, T200I, Q207ACRF01_AE
Manosuthi (2010)250865250865 D4T, 3TCNVPK65R, L74V, Y115FG190ET39K, K43E, S68G, K102R, K122E, D123S, E138A, K166R, E169D, K173M, Q174K, D177E, Q207A, R211S, H221Y, V245ECRF01_AE
 250748250748 D4T, 3TCNVPM184VK103N, M230LT39K, K43E, K122E, D123S, E138A, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, H221Y, V245ECRF01_AE
Bunupuradah (2011)079-004-009079-004-009 D4T, 3TCNVPL74V, M184V, L210W, T215YK103N, P225H, M230LV35M, T39K, K43E, S68G, V118I, K122E, D123S, I135L, E138A, K173I, Q174K, Q207A, R211S, V245ECRF01_AE
 079-007-008079-007-008 D4T, 3TCNVPM184VK101E, G190AV35T, T39K, K43E, V60I, S68G, K122E, D123S, I135T, E138A, K173I, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, K238R, V245ECRF01_AE
 079-004-016079-004-016 D4T, 3TCNVPD67G, K70R, F116Y, Q151M, M184V, K219QK101H, G190AK20R, I31L, V35T, T39E, V60I, S68G, V106I, K122E, D123S, E138A, S162Y, R172K, K173M, Q174K, D177E, I178M, T200A, Q207A, R211S, F214L, K223Q, E224G, P226T, F227Y, K238R, V245ECRF01_AE
Fourati (2012)1007076310070763JQ396161NRTINNRTIL74V, M184V V35T, K122E, D123N, I135T, E138A, S162A, K173S, V179I, E204G, Q207A, F214LCRF01_AE
Nouhin (2013)Q0324095Q0324095KF292359NRTINNRTIM184V, L210W, T215FK101E, V106M, Y181V, G190A, F227LT39R, K43E, E44D, K49R, T69N, L109I, K122E, D123S, I135T, E138A, S162C, K173T, Q174K, N175Y, V179IT, T200A, I202V, E203K, Q207D, R211K, H221Y, K238RCRF01_AE
 S0605246S0605246KF292560NRTINNRTID67DN, V75M, M184V, T215F, K219KNA98G, V179F, Y181C, G190GAL34I, V35T, T39E, L109I, K122E, D123S, I135L, E138A, T165I, K173I, Q174K, D177E, T200A, Q207AT, R211S, K238RCRF01_AE
 Q1010031Q1010031KF292417NRTINNRTIM41L, L74I, M184V, L210W, T215FA98G, K101E, G190AV35T, T39K, K43E, E44A, S68G, V118I, K122E, D123S, E138A, S162C, K173I, Q174K, I178M, V179I, T200A, Q207T, R211NCRF01_AE
 Q0425120Q0425120KF292380NRTINNRTIM184VY188LV35T, T39L, K122E, D123S, E138A, K173A, Q174K, D177E, I178M, T200A, Q207A, R211KCRF01_AE
 Q1128149Q1128149KF292434NRTINNRTIM41L, D67N, M184V, L210W, T215FA98G, K101E, G190AV35T, T39K, K43E, V60VI, V118I, K122E, D123S, I135T, E138A, S162C, K173I, Q174K, T200I, Q207A, R211SCRF01_AE
 U0629187U0629187KF292789NRTINNRTIK70KTK101KE, G190GAV35IM, T39A, W88WS, E138A, I142IV, K173T, Q174K, D177E, I178IM, V179VI, T200A, Q207A, R211RSCRF01_AE
Theys (2013)4082440824KC221210NRTI, TDFNNRTIA62V V90I, K122E, D123N, E138A, K173L, Q174K, Q207A, R211SCRF01_AE
Nerrienet (2014)Q0908133Q0908133JN675887NRTINNRTI  V35T, T39K, K122E, D123S, I135T, E138A, S162C, Q174N, G196E, T200A, Q207G, R211S, K238RCRF01_AE
 Q0502189Q0502189JN675885NRTINNRTIM184VV108I, Y181IK32I, V35T, T39K, T58TI, S68G, K122E, D123S, I135T, E138A, K173I, Q174K, V179I, G196Q, Q207A, R211S, F214L, H221Y, K238RCRF01_AE